Biosynthetic arginine decarboxylase in phytopathogenic fungi.

abstract：:Effects of sub-acute cocaine treatment on 3H-naloxone binding to 6 brain regions were examined in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Cocaine hydrochloride (3 mg/kg, i.v.) was given by bolus injection daily for five days. Rats were decapitated 24 hr following the final injection and crude mem...

journal_title：Life sciences

authors： Ishizuka Y,Rockhold RW,Hoskins B,Ho IK

更新日期：1988-01-01 00:00:00

abstract：:Further confirmation that the LHRH/LHRH agonist-induced ovulation in the hypophysectomized (hypx) rat is due to a direct ovarian effect and not mediated by LH release from residual pituitary tissue or other CNS sites is provided by the persistence of this effect despite concomitant median eminence lesion or passive im...

journal_title：Life sciences

authors： Bex FJ,Corbin A

更新日期：1984-08-27 00:00:00

abstract：:Previous results demonstrated that estradiol (E2) treatment of ovariectomized-adrenalectomized (OVX-ADX) rats increased glucocorticoid (GC) binding in brain regions. The experimental protocol was extended to the spinal cord, a GC target tissue in which ornithine decarboxylase (ODC) is markedly induced by GC treatment....

journal_title：Life sciences

authors： Ferrini M,González S,De Nicola AF

更新日期：1993-01-01 00:00:00

abstract：:The protein inhibitor of nitric oxide synthase (PIN) was independently identified as an inhibitor of nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS), and as a member of the cellular dynein light chain family, dynein light chain 8 (LC8), responsible for intracellular protein trafficking. Mast cells ...

journal_title：Life sciences

authors： McCauley SD,Gilchrist M,Befus AD

更新日期：2007-02-13 00:00:00

abstract：:Several serotonin (5-HT) receptor antagonists with varying specificities for the 5-HT receptor types, were studied with regard to their effects on blood glucose levels in mice. The non-selective antagonists, metergoline and methysergide, proved to be hyperglycemic at doses commonly used to antagonize 5-HT receptors. I...

journal_title：Life sciences

authors： Wozniak KM,Linnoila M

更新日期：1991-01-01 00:00:00

abstract：:The cardio- and neuroprotective effect of the pyridoindole stobadine (S) is conditioned mainly by its good radical scavenging properties. It has been showed by EPR experiment, that the ultimate product of the reaction of stobadine with hydroxyl radical is the nitroxyl radical. However, for the unsaturated dehydrostoba...

journal_title：Life sciences

authors： Májeková M,Májek P,Mach P

更新日期：1999-01-01 00:00:00

abstract：:Based on our earlier animal study, we became interested to investigate if thromboxane A2 (TXA2) is involved in angiotensin converting enzyme (ACE) induced cough in man. To 11 patients with hypertension, who had developed cough induced by ACE inhibitors, a TXA2 synthetase inhibitor, ozagrel was given for 1 to 2 months ...

journal_title：Life sciences

authors： Umemura K,Nakashima M,Saruta T

更新日期：1997-01-01 00:00:00

abstract：:An in vitro preparation of rabbit thoracic aorta was tested in order to determine whether isometric contractile force induced by endothelin-1 (ET-1) in this preparation is changed when the tissue is exposed to ultraviolet (UV) light. After constriction of an aortic segment to a steady-state level of tension with ET-1,...

journal_title：Life sciences

authors： Nordberg LO,Raffa RB,Tallarida RJ

更新日期：1993-01-01 00:00:00

abstract：:Peptide nucleic acids (PNAs) are uncharged DNA analogs that hybridize to complementary sequences with high affinity and stability. We previously showed that PNAs, after intraperitoneal injection into rats, are effective antisense compounds in vivo. The present study was designed to test whether PNAs also have antigene...

journal_title：Life sciences

authors： McMahon BM,Stewart JA,Bitner MD,Fauq A,McCormick DJ,Richelson E

更新日期：2002-06-07 00:00:00

abstract：AIMS:Studies have associated obesity with a wide variety of cancers. Metformin, an anti-diabetic drug, has recently received attention as a potentially useful therapeutic agent for treating cancer. Therefore, the objective of this study was to analyze the mechanisms involved in the increase in tumor development and the...

journal_title：Life sciences

authors： de Queiroz EA,Akamine EH,de Carvalho MH,Sampaio SC,Fortes ZB

更新日期：2015-01-15 00:00:00

abstract：:In human tumors changes in angiogenesis and expression of extracellular matrix-degrading enzymes occur simultaneously during invasion and metastasis. Tissues from 20 biopsies of human neuroblastoma (NB) were investigated immunohistochemically by using an antibody against factor VIII to determine their microvessel numb...

journal_title：Life sciences

authors： Ribatti D,Surico G,Vacca A,De Leonardis F,Lastilla G,Montaldo PG,Rigillo N,Ponzoni M

更新日期：2001-01-26 00:00:00

abstract：:First isolated some 10 years ago as the endogenous ligand for the "orphan opioid receptor" (ORL-1, now designated NOP), nociceptin/orphanin FQ (N/OFQ) has proved to be a potent inhibitory neuropeptide found across the neuraxis. Because of the homologies between opioids and N/OFQ, functional studies of this peptide hav...

journal_title：Life sciences

authors： Heinricher MM

更新日期：2005-11-04 00:00:00

abstract：:Classical studies have demonstrated that the visual centers in primates consist of cortical areas V1, V2 and V4 and their branches. However, nothing is known about how these visual areas change in postnatal development. In the present studies, therefore, pigs aged 2, 4, and 6 months old, were stimulated visually with ...

journal_title：Life sciences

authors： Fang M,Li J,Rudd JA,Wai SM,Yew JC,Yew DT

更新日期：2006-02-09 00:00:00

abstract：:Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute liver injury mediated by reactive oxygen species (ROS) as normal metabolites in hepatocytes. In this study, the molecular process in this type of liver injury was analyzed from the aspect of liver function and regulatory factor...

journal_title：Life sciences

authors： Taniguchi M,Takeuchi T,Nakatsuka R,Watanabe T,Sato K

更新日期：2004-08-13 00:00:00

abstract：:A new simplified procedure for determination of nitric oxide (NO) in biological solutions is described utilizing a new reducing system of nitric oxide prior to chemiluminescence. Advantages of the new method makes heating of the reducing solution unnecessary and avoids cooling and condensation of generated vapors. Onl...

journal_title：Life sciences

authors： Termin A,Hoffmann M,Bing RJ

更新日期：1992-01-01 00:00:00

abstract：AIMS:Amino acids, especially branched chain amino acids (BCAAs), have important regulatory roles in protein synthesis. Recently studies revealed that BCAAs protect against ischemia/reperfusion (I/R) injury. We studied the signaling pathway and mitochondrial function affecting a cardiac preconditioning of BCAAs. MAIN M...

journal_title：Life sciences

authors： Satomi S,Morio A,Miyoshi H,Nakamura R,Tsutsumi R,Sakaue H,Yasuda T,Saeki N,Tsutsumi YM

更新日期：2020-03-15 00:00:00

abstract：:Trimidox (3,4,5-trihydroxybenzohydroxamidoxime), a recently synthesized inhibitor of ribonucleotide reductase (RR), was shown to exert anti-proliferative activities in HL-60 and K562 human leukemia cell lines and to prolong the life span of mice inoculated with L1210 mouse leukemia cells. Here we test whether trimidox...

journal_title：Life sciences

authors： Rosenberger G,Fuhrmann G,Grusch M,Fassl S,Elford HL,Smid K,Peters GJ,Szekeres T,Krupitza G

更新日期：2000-11-17 00:00:00

abstract：:Responses of atrial mRNA, atrial peptide and plasma peptide of atrial natriuretic factor (ANF) to treatments to alter fluid volume were studied in rats using RNA dot hybridization assay and radioimmunoassay. Specific changes in the level of ANF mRNA relative to total atrial RNA were observed in atria from sodium restr...

journal_title：Life sciences

authors： Takayanagi R,Tanaka I,Maki M,Inagami T

更新日期：1985-05-13 00:00:00

abstract：AIMS AND METHODS:We previously reported that angiotensin II (AngII) restores the vascular reactivity diminished by hemorrhagic shock. In this study, we investigated whether the beneficial effects of AngII are related to regulation of gap junctions (GJs) and connexin43 (Cx43), and the implication of MAPK signaling and m...

journal_title：Life sciences

authors： Lei Y,Peng X,Li T,Liu L,Yang G

更新日期：2019-01-01 00:00:00

abstract：:In order to further elucidate a possible role of neuropeptides and GABA in the pathogenesis of febrile convulsions, we studied changes of immunoreactive-arginine vasopressin (IR-AVP), IR-somatostatin (IR-SRIF) and gamma-aminobutyric acid (GABA) in the rat brain after febrile convulsions induced by ultra-red light (UR)...

journal_title：Life sciences

authors： Nagaki S,Nagaki S,Minatogawa Y,Sadamatsu M,Kato N,Osawa M,Fukuyama Y

更新日期：1996-01-01 00:00:00

abstract：:The validity of a photoelectric method for continuous cerebral blood volume (CBV) measurement was tested and modified for the rat's brain. A new way of introducing a miniature light source between the two hemispheres and fixing a light sensitive silicone blue cell to the outer surface of the parietal bone was develope...

journal_title：Life sciences

authors： Sandor P,Cox-van Put J,de Jong W,de Wied D

更新日期：1986-11-03 00:00:00

abstract：:Recently, single-dose drug packaging systems, allowing the administration of multiple drugs in a single pill, have become popular for the convenience of the patient. The quality of drugs and an accurate measurement of their photostabilities within this system, however, have not been carefully addressed. Drugs that are...

journal_title：Life sciences

authors： Uwai K,Tani M,Ohtake Y,Abe S,Maruko A,Chiba T,Hamaya Y,Ohkubo Y,Takeshita M

更新日期：2005-12-12 00:00:00

abstract：AIMS:Endothelin-1 (ET-1) and endothelin-2 (ET-2; Trp(6)Leu(7)ET-1) are expressed by different cell types, but are considered to display identical pharmacological properties on endothelin receptors. We studied agonist-dependent aspects of endothelin(A) (ET(A))-receptor function and the importance of amino acids 6 and 7 ...

journal_title：Life sciences

authors： Compeer MG,Suylen DP,Hackeng TM,De Mey JG

更新日期：2012-10-15 00:00:00

abstract：:The sphincter of Oddi (SO) plays an important role in regulating the bile flow into the duodenum. This study was designed to investigate the effect of Chinese Medicinal Herbs Muh-Shiang-Bin-Lang-Wan (MSBLW) and their mechanism of action on regulating the motility of SO in rabbits. The activity of SO in anesthetized ra...

journal_title：Life sciences

authors： Kuo YI,Chiu JH,Lin JG,Hsieh CL,Wu CW

更新日期：2003-12-12 00:00:00

abstract：:The effects of methyl vitamin B12 (5-6 mg/kg, p.o.) on the entrainment of circadian running wheel activity rhythm to a new lighting schedule were measured in rats. After the light-dark (LD) cycle was abruptly reversed, rats given vitamin B12 took less time to entrain their circadian locomotor activity rhythm to the ne...

journal_title：Life sciences

authors： Tsujimaru S,Ida Y,Satoh H,Egami H,Shirao I,Mukasa H,Nakazawa Y

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have demonstrated that Galactooligosaccharides (GOS), known as "bifidus factor", has anti-inflammatory effects. Colitis, a kind of colonic inflammatory damage could be induced by different chemicals. The pathogenesis and mechanism of colitis remains unclear, and may be related to intest...

journal_title：Life sciences

authors： Chu H,Tao X,Sun Z,Hao W,Wei X

更新日期：2020-02-01 00:00:00

abstract：:Synthetic nitric oxide donors are known to protect the gastric mucosa from damage and dietary nitrate is known to release NO in the stomach. Mast cells have been found to be involved in gastric mucosal damage in humans or in rodents, and recent studies have pointed out the possibility of nitric oxide from endogenous o...

journal_title：Life sciences

authors： Larauche M,Buéno L,Fioramonti J

更新日期：2003-08-08 00:00:00

abstract：:In this study, we have characterized quinone reductase (QR), glutathione (GSH), glutathione S-transferase (GST) and their induction by a chemoprotector, 1,2-dithiole-3-thione (D3T), in the human myeloid cell lines ML-1 and HL-60. In addition, we also examined the toxicity of hydroquinone (HQ), a benzene metabolite, to...

journal_title：Life sciences

authors： Li Y,Lafuente A,Trush MA

更新日期：1994-01-01 00:00:00

abstract：:We have reported that Sho-saiko-to (TJ-9) prevents liver fibrosis in vivo. To gain further insights into the effect of TJ-9, the matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) balance was examined. Hepatic stellate cells (HSCs) were isolated from male Wistar rats and cultured with TJ-...

journal_title：Life sciences

authors： Sakaida I,Hironaka K,Kimura T,Terai S,Yamasaki T,Okita K

更新日期：2004-03-19 00:00:00

abstract：:The effects of pyrroloquinoline quinone (PQQ) and PQQ-oxazole (PQQ-glycine adduct) on DNA synthesis were examined using cultured human fibroblasts. Confluent fibroblasts were cultured in serum-free Dulbecco's modified Eagle's media, and various concentrations of PQQ and PQQ-oxazole were added to the media. After incub...

journal_title：Life sciences

authors： Naito Y,Kumazawa T,Kino I,Suzuki O

更新日期：1993-01-01 00:00:00