Concanavalin A enhances ATP resynthesis via de novo pathway in postischemic rat hearts.

abstract：:Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potent...

journal_title：Life sciences

authors： Jain A,Rani V

更新日期：2018-07-15 00:00:00

abstract：:Castanospermine is a potent inhibitor of rat intestinal glycohydrolases in vitro and prevents the hyperglycemic response to an oral sucrose challenge in vivo. Among the glycohydrolases tested, castanospermine was most effective against sucrase with an IC50 of 1.1 x 10(-7) M. In vivo, a significant effect was seen at d...

journal_title：Life sciences

authors： Rhinehart BL,Robinson KM,Payne AJ,Wheatley ME,Fisher JL,Liu PS,Cheng W

更新日期：1987-11-16 00:00:00

abstract：:In the CNS, dopamine (DA) is a recognized neurotransmitter as well as a precursor for norepinephrine (NE) and epinephrine (EPI). In contrast to the CNS, DA has been assumed to be only a precursor in peripheral tissues. There is now, however, considerable evidence to support the hypothesis that it may function as a neu...

journal_title：Life sciences

authors： Lackovic Z,Neff NH

更新日期：1983-04-11 00:00:00

abstract：:This paper demonstrates marked differences between blood levels and those in the CSF for three anterior pituitary peptide hormones, prolactin, luteinizing hormone (LH) and adrenocorticotrophin (ACTH) in the rhesus monkey. CSF levels of endogenous prolactin (measured by radioimmunoassay) are about 20% of those in the b...

journal_title：Life sciences

authors： Dubey AK,Herbert J,Martensz ND,Beckford U,Jones MT

更新日期：1983-04-18 00:00:00

abstract：:Plasma and urinary levels of MHPG were determined in six normal volunteers. Samples were obtained at 3-hour intervals for plasma and at 12-hour intervals for urine. Acrophase, amplitude and period were determined for plasma MHPG levels. A sinusoidal pattern was obtained for diurnal plasma MHPG with a peak at 15:00 hrs...

journal_title：Life sciences

authors： DeMet EM,Halaris AE,Gwirtsman HE,Reno RM

更新日期：1985-11-04 00:00:00

abstract：AIMS:The present work evaluated the anti-inflammatory/antioxidant activity of a well characterized extract from Citrus bergamia Risso and Poiteau (CBE), containing neoeriocitrin, naringin, neohesperidin and other flavonoids, on human NCTC 2544 keratinocytes treated with interferon-gamma (IFN-γ) and histamine (H). MAIN...

journal_title：Life sciences

authors： Graziano AC,Cardile V,Crascì L,Caggia S,Dugo P,Bonina F,Panico A

更新日期：2012-06-27 00:00:00

abstract：AIMS:Aging and drug-induced side effects may contribute to deteriorate mitochondrial bioenergetics in many tissues, including kidney and liver. One possibility is that the combination of both aging and drug toxicity accelerates the process of mitochondrial degradation, leading to progressive bioenergetic disruption. We...

journal_title：Life sciences

authors： Rocha-Rodrigues S,Santos-Alves E,Coxito PM,Marques-Aleixo I,Passos E,Guimarães JT,Martins MJ,Oliveira PJ,Magalhães J,Ascensão A

更新日期：2013-09-03 00:00:00

abstract：:Voltage clamp recordings of GH3/B6 pituitary cells reveal the presence of non linear steady state membrane properties at the level of the resting potential (about -41 mV). Clamping the cells to potentials more depolarized than -60 mV is associated with a potential dependent increase in membrane conductance and membran...

journal_title：Life sciences

authors： Dufy B,Barker JL

更新日期：1982-05-31 00:00:00

abstract：:10(-4) M ouabain increases aldosterone production at 3.6 and 5.4 mM potassium concentrations, whereas at high potassium concentration (7 mM) even lower concentration of ouabain (10(-8) M) decreases it. As ouabain has been shown to be produced by the adrenal cortex, a local paracrine regulation of aldosterone productio...

journal_title：Life sciences

authors： Szalay KS

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:Metformin, introduced in 1957, is widely used as an anti-diabetic drug and has considerable benefits in cardiovascular disease reportedly, dependent or independent on its glucose-lowering effects. Aim of this study was to investigate the effect of metformin on gap junction and the inducibility of AF. METHODS...

journal_title：Life sciences

authors： Li J,Li B,Bai F,Ma Y,Liu N,Liu Y,Wang Y,Liu Q

更新日期：2020-08-01 00:00:00

abstract：:Vascular disease is one of the complicating features of diabetes mellitus. Magnesium deficiency has recently been proposed as a novel factor implicated in the pathogenesis of diabetes complications. Several studies have indicated that hypertension in diabetic patients is an independent altered reaction of blood vessel...

journal_title：Life sciences

authors： Soltani N,Keshavarz M,Sohanaki H,Dehpour AR,Zahedi Asl S

更新日期：2005-02-11 00:00:00

abstract：:We previously reported the discovery and partial characterization of bovine atrial granule serine proteinase, a candidate processing enzyme of pro-atrial natriuretic factor, which is associated with atrial granule membranes. We now report the physicochemical properties of electrophoretically homogeneous enzyme purifie...

journal_title：Life sciences

authors： Wypij DM,Harris RB

更新日期：1992-01-01 00:00:00

abstract：:This in vitro study was conducted to determine whether tachyphylaxis of guinea pig airway to furosemide occurs under conditions that produce tachyphylaxis to the beta 2-adrenoceptor agonist, salbutamol. Isometric tension was measured in tracheal rings bathed in HEPES buffer from 4-6 d newborn guinea pigs of either sex...

journal_title：Life sciences

authors： Iwamoto LM,Wilson VL,Lavallee SL,Fujiwara N,Ayau EL,Nakamura KT

更新日期：1996-01-01 00:00:00

abstract：:Chromogranin A (CgA) is an acidic protein co-released with catecholamines during exocytosis from sympathetic nerve terminals and chromaffin cells. Previous work has demonstrated that large scale perturbations in sympathetic nervous system (SNS) functioning result in corresponding changes in CgA levels in plasma. Littl...

journal_title：Life sciences

authors： Dimsdale JE,O'Connor DT,Ziegler M,Mills P

更新日期：1992-01-01 00:00:00

abstract：:The beta-endorphin, met5-enkephalin-arg6-phe7 (MEAP) and met5-enkephalin (ME) changes related to age and diurnal rhythms were studied in various regions of rat brain and in the pituitary by specific radioimmunoassays. The contents of MEAP, met5-enkephalin and beta-endorphin were higher in the pituitary of old rats (18...

journal_title：Life sciences

authors： Tang F,Tang J,Chou J,Costa E

更新日期：1984-08-27 00:00:00

abstract：:Decidualization of endometrial tissues, which is essential for implantation and the continuation of pregnancy, is induced by pituitary hormones that are regulated by gonadotropin releasing hormone (GnRH). Our objective was to determine the role of a direct action of GnRH on endometrial tissues by comparing the charact...

journal_title：Life sciences

authors： Takeuchi S,Futamura N,Minoura H,Toyoda N

更新日期：1998-01-01 00:00:00

abstract：AIM:Acute lung injury (ALI) is characterized by alveolar macrophage overactivation and uncontrolled pulmonary inflammation. Mitochondrial damage-associated molecular patterns (MTDs), one type of damage-associated molecular patterns (DAMPs) released from ruptured mitochondrial, can induce inflammation which participates...

journal_title：Life sciences

authors： Peng W,Peng F,Lou Y,Li Y,Zhao N,Shao Q,Chen J,Qian K,Zeng Z,Zhan Y,Jiang R,Liu F

更新日期：2021-01-15 00:00:00

abstract：:Previous studies have shown that cytochrome P450-Arachidonic Acid (P450-AA) metabolites modify the vascular tone of several vessels and that vasopressin (AVP) stimulates P450-AA metabolism. Thus, in the present study, we decided to investigate if the vasoconstrictor effect of AVP is related to activation of P450-AA me...

journal_title：Life sciences

authors： Vazquez B,Rios A,Escalante B

更新日期：1995-01-01 00:00:00

abstract：:The beta adrenoceptor antagonist radioligand [3H] dihydroalprenolol (DHA) has been used to characterise beta adrenoceptors in membranes prepared from rat renal glomeruli. Association of the ligand was rapid and had reached equilibrium within 10 mins at 37 degrees C. Dissociation occurred in two distinct phases, a rapi...

journal_title：Life sciences

authors： McPherson GA,Summers RJ

更新日期：1983-07-04 00:00:00

abstract：AIMS:The aim of this study was to investigate the molecular mechanism underlying preterm white matter injury (WMI) via the identification and functional analysis of differentially expressed long non-coding RNAs (lncRNAs) and mRNAs. MAIN METHODS:A neonatal rat model of preterm WMI was established by ligating the common...

journal_title：Life sciences

authors： Wang D,Ye X,Xie H,Liu Y,Xu Y,Wang Y,Zhou Y,Zhou N,Wang J

更新日期：2020-08-15 00:00:00

abstract：AIMS:Electromagnetic fields (EMFs) can act as inducers or mediators of stress response through the production of heat shock proteins (HSPs) that modulate immune response and thymus functions. In this study, we analyzed cellular stress levels in rat thymus after exposure of the rats to a 2.45 GHz radio frequency (RF) us...

journal_title：Life sciences

authors： Misa-Agustiño MJ,Leiro-Vidal JM,Gomez-Amoza JL,Jorge-Mora MT,Jorge-Barreiro FJ,Salas-Sánchez AA,Ares-Pena FJ,López-Martín E

更新日期：2015-04-15 00:00:00

abstract：:The present study shows that morphine reduces the pulmonary inflammatory response to intranasal influenza virus infection in rats. Rats were infected with rat-adapted influenza virus (RAIV), which is a unique infectious agent because normal rats develop an acute pulmonary inflammatory response to RAIV and rapidly clea...

journal_title：Life sciences

authors： Coussons-Read ME,Daniels M,Gilmour MI

更新日期：1999-01-01 00:00:00

abstract：:DCLHb, a hemoglobin based oxygen carrier, has been extensively studied for the treatment of hemorrhagic shock in both animal models and humans. Numerous accidents resulting in trauma are due to ethanol intoxication, in particular cases of car accidents. Therefore, trauma patients might be intoxicated with drugs of abu...

journal_title：Life sciences

authors： Palaparthy R,Saini BK,Gulati A

更新日期：2001-02-09 00:00:00

abstract：:Although the aging effect of dopamine D2 receptor in the striatum is well-documented, the effect of age on the extrastriatal dopamine D2 receptor has not been fully examined. Since the density of extrastriatal dopamine D2 receptor is very low, suitable ligands are limited. In this study, we used [11C]FLB 457 to quanti...

journal_title：Life sciences

authors： Inoue M,Suhara T,Sudo Y,Okubo Y,Yasuno F,Kishimoto T,Yoshikawa K,Tanada S

更新日期：2001-07-20 00:00:00

abstract：:The mechanism of the antithrombotic effects of heparin and the synthetic antithrombin agent argatroban was evaluated in a dog model. Thrombus formation following balloon injury was evaluated by angioscopy in the right iliac arteries of 20 dogs to serve as a control. After the evaluation of the growth of thrombus on th...

journal_title：Life sciences

authors： Tomaru T,Kawano HA,Tsujiuchi Y,Suzuki J,Nakajima T,Uchida Y

更新日期：2005-10-07 00:00:00

abstract：:Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS) - selected ion monitoring technique using deuterated internal standards in Long Evans rats chronically exposed to ethanol for ten months. Chronic ethanol exposure produced significant increases of dopamine and ...

journal_title：Life sciences

authors： Myers WD,Mackenzie L,Ng KT,Singer G,Smythe GA,Duncan MW

更新日期：1985-01-28 00:00:00

abstract：:Oxidative stress (free radical generation exceeds antioxidant defense) occurs in many diseases and after exposure to certain chemicals. We automated assays estimating the antioxidant status of serum and lipid hydroperoxide concentrations using the Syva-30R automated analyzer. In this assay, the antioxidant status of s...

journal_title：Life sciences

authors： Mahle C,Dasgupta A

更新日期：1997-01-01 00:00:00

abstract：:Alzheimer's disease (AD) as a dementia and neurodegenerative disease, is mostly prevalent among people more than 65 years. AD is mostly manifested in the form of degraded mental function, such as losing memory and impaired cognitive function. Due to inefficiency of traditional pharmacological therapeutic approaches wi...

journal_title：Life sciences

authors： Chakari-Khiavi F,Dolati S,Chakari-Khiavi A,Abbaszadeh H,Aghebati-Maleki L,Pourlak T,Mehdizadeh A,Yousefi M

更新日期：2019-08-15 00:00:00

abstract：:To establish a simple and sensitive quantitation of leukotriene B4 (LTB4), we developed a radioreceptor assay (RRA) using a highly specific [3H]leukotriene B4[( 3H]LTB4) binding to a guinea pig spleen homogenate. The assay detected LTB4 levels as low as 0.12 pmol per tube. Fifty percent inhibition of bound [3H]LTB4 wa...

journal_title：Life sciences

authors： Kohi F,Agrawal DK,Cheng JB,Bewtra A,Townley RG,Olesch JW

更新日期：1988-01-01 00:00:00

abstract：:Histamine is a biogenic amine that plays an essential role in controlling many physiological functions, both in the central nervous system (CNS) and the peripheral nervous system (PNS). Most of these physiological effects are mediated through interactions with four histamine receptor subtypes, all of which are members...

journal_title：Life sciences

authors： Micallef S,Stark H,Sasse A

更新日期：2013-10-10 00:00:00