Abstract:
:Comparison of neuronal and non-neuronal membrane transport of, and neuroexcitation by, the dicarboxylic amino acids bring out provocative similarities in structural selectivity, and hence in the strategies for studying them. Parallel anomalies in stereoselectivity show for both phenomena that the recognition sites are indeed chiral, as expected for biological functions, even though both fail in special instances to discriminate between DL pairs. High and low affinity, or Na+-dependence or Na+-independence, are not fully reliable bases for discriminating receptor sites serving one of these functions. Tolerance of N-methylation of the amino acid serves in discriminating families of recognition sites for both phenomena, as does substitution of the sulfonate or sulfinate for the distal carboxylate group, or other structural changes. Analogs in which the functional groups of aspartate or glutamate are presented in restrained arrays serve for both, although they have so far suggested identity neither of recognition sites for transport and excitation, nor of the events consequent to binding for these two phenomena.
journal_name
Life Scijournal_title
Life sciencesauthors
Christensen HN,Makowske Mdoi
10.1016/0024-3205(83)90258-8subject
Has Abstractpub_date
1983-12-05 00:00:00pages
2255-67issue
23eissn
0024-3205issn
1879-0631pii
0024-3205(83)90258-8journal_volume
33pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract::The scientific interest in irisin, a myokine discovered in 2012, has grown exponentially in recent years. Irisin, which is mainly produced in skeletal muscle, influences the browning process of adipose tissue and lipid and energy metabolism. Recent discoveries highlight that the potential of this hormone may have been...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.118954
更新日期:2021-02-15 00:00:00
abstract:BACKGROUND:The prevalence and mortality of the outbreak of the COVID-19 pandemic show marked geographic variation. The presence of several subtypes of the coronavirus and the genetic differences in the populations could condition that variation. Thus, the objective of this study was to propose variants in genes that en...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118313
更新日期:2020-11-01 00:00:00
abstract::Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the protective mesenteric hyperemia after intraduodenal acidification. Mechanisms associated the sensory neuropeptides, e.g. calcitonin gene-related peptide (CGRP), substance P, and ruthenium red-sensitive cation channels contribute to acid-induc...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02106-9
更新日期:2002-10-18 00:00:00
abstract::Using in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of L-dihydroxyphenylalanine (L-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00275-6
更新日期:1998-01-01 00:00:00
abstract:AIMS:Proton Nuclear Magnetic Resonance (NMR) based metabolomics analysis is extensively used to explore the metabolic profiling of biofluids. This approach was used for the analysis of metabolites in serum of patients with major types of muscular dystrophy in early phase of the disease. MATERIAL AND METHODS:Proton NMR...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.01.032
更新日期:2016-04-15 00:00:00
abstract::The metabolism of phosphoinositides plays an important role in the signal transduction pathways. We report here that naturally occurring polyamines affect the activities of phosphatidylinositol (PI) 3-kinase and PI 4-phosphate (PIP) 5-kinase differently. While polyamines inhibited the PI 3-kinase activity, they stimul...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00320-6
更新日期:1995-01-01 00:00:00
abstract::The use of neuroleptic drugs to treat schizophrenia is almost invariably associated with extrapyramidal movement disorders. One of these disorders, tardive dyskinesia (TD), can persist long after neuroleptic withdrawal suggesting that permanent neurological damage is produced. However, there appears to be no convincin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00442-2
更新日期:2000-02-25 00:00:00
abstract::Antinociceptive effect of nifedipine (15 mg/kg i.p.) and verapamil (10 mg/kg s.c.) was examined in rats chronically exposed to nicotine (6 mg/kg/day via Alzet osmotic pump for 28 days) and after nicotine withdrawal. Sham operated rats served as control for testing DMSO (dimethylsulfoxide, a solvent for nifedipine), ni...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00107-0
更新日期:1997-01-01 00:00:00
abstract::We hypothesized that the atheroinhibitory and cardioprotective effects of estrogen may be mediated in part through increased prostacyclin formation by the artery wall. Atherosclerotic abdominal aorta was collected at necropsy from ovariectomized female monkeys fed an atherogenic diet alone or with added Premarin. Basa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01131-6
更新日期:2001-06-15 00:00:00
abstract:AIMS:Induction of heme oxygenase-1 (HO-1) has been widely accepted to be neuro-protective. This study aimed to examine whether hemin (a HO-1 inducer) attenuates neuronal damage in the hippocampus induced by orthotopic autologous liver transplantation (OALT) in adult rats. MAIN METHODS:Rats were randomly allocated into...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.05.021
更新日期:2015-08-15 00:00:00
abstract::Time-course studies revealed the increased susceptibility of the gastric mucosa to noxious injury in portal hypertension correlates with the level of elevated portal venous pressure and hyperglucagonemia. Whether acute elevation of portal venous pressure by exogenous glucagon aggravates such injury is not known. We te...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00413-2
更新日期:2003-07-18 00:00:00
abstract::The compound (+)-MR200 [(+)-methyl (1R,2S)-2-{[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate] is a sigma ligand with increased affinity and selectivity compared to the structurally related ligand haloperidol. From the results of a previous study on the modulation of a systemically ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.10.005
更新日期:2006-04-18 00:00:00
abstract:AIMS:Benidipine is a dihydropyridine (DHP) derived Ca2+ antagonist, can block triple Ca2+ channels (L, N, and T). It has been used as a safety anti-hypertensive drug because of its long-acting relaxant effect on vascular smooth muscle (VSM). However, whether benidipine has similar pharmacological actions in airway smoo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.04.036
更新日期:2019-06-15 00:00:00
abstract:AIM:Beta asarone is the major constituent of oil obtained from Acorus calamus, the Indian traditional medicine plant. Several studies have shown that beta asarone causes liver and cardiac damages but the reproductive toxicity is not well understood. The present study was initiated to investigate whether beta asarone ha...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.08.021
更新日期:2017-03-15 00:00:00
abstract::Traditionally, Ehrlich's tumor is used in experimental oncology to investigate the therapeutic capacity of different synthetic chemotherapeutic agents or to evaluate the antitumoral activity of different substances of natural origin. However, the understanding of immune mechanisms during Ehrlich carcinogenesis is stil...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118578
更新日期:2021-01-01 00:00:00
abstract::In transversely sectioned rat hippocampal slices, population spikes and population "EPSPs" were recorded from CA1 neurones in response to the stimulation of Schaffer collateral and commissural inputs. High frequency tetanic stimulation (400 Hz, 200 pulses) of an input induced LLP of the homosynaptic response without s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90021-3
更新日期:1984-03-12 00:00:00
abstract::Reports indicate that the administration of tyrosine, the precursor amino acid for catecholaminergic neurotransmitters, may be beneficial under conditions of physiologic stress. We studied the effects of tyrosine on vulnerability to ventricular arrhythmia in conscious pigs with healing myocardial infarcts, and sham op...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90583-w
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. METHODS:A rat myocardial infarctio...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118015
更新日期:2020-09-15 00:00:00
abstract::When injected into the substantia nigra reticulata of naive rats, dynorphin-(1-17) caused a dose dependent contralateral rotation which was inhibited by naloxone in a dose dependent manner. Met-enkephalin injected in the same coordinates as the ones used with dynorphin also induced rotation but of lower intensity, whi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90563-5
更新日期:1983-01-01 00:00:00
abstract::Identifying factors that modulate cocaine self-administration is fundamental to the development of effective strategies to treat and prevent cocaine abuse. In the present study, the influence of an alternative reinforcer on the probability of cocaine use was examined in four adult humans under controlled laboratory co...
journal_title:Life sciences
pub_type: 临床试验,杂志文章
doi:10.1016/0024-3205(94)00878-7
更新日期:1994-01-01 00:00:00
abstract::New types of alpha1-adrenoceptor antagonists (tamsulosin, KMD-3213 and JTH-601) are currently receiving a great deal of attention, especially in terms of developing effective therapeutic agents to treat bladder outlet obstruction with less side effects, such as postural hypotension, in patients with benign prostatic h...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00111-8
更新日期:1998-01-01 00:00:00
abstract::Effects of 1-methyl-4-phenylpyridine(MPP+), a putative neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP), on the contents of dopamine were examined in the various regions of the rat brain. Under anesthesia with pentobarbital sodium and flunitrazepam, MPP+ 150 micrograms/rat was intracerebrove...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90625-5
更新日期:1989-01-01 00:00:00
abstract:AIMS:The present study aimed to verify changes in cerebellar and plasmatic expression of miRNAs after the chronic consumption of ethanol and caffeine in the UChB rat, an experimental model for alcoholism. MATERIAL AND METHODS:Male rats at 5 months of age, were divided into the following groups (n = 10/group): 1. Ethan...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.05.016
更新日期:2019-07-15 00:00:00
abstract::P-glycoprotein (P-gp) is found to play a very significant role in intestinal and biliary transport of irinotecan and its active metabolite, SN-38. This makes P-gp inhibition a logical strategy for improving irinotecan's oral efficacy and reducing its toxicity. The objective of the present study was to identify the mos...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.06.007
更新日期:2008-08-15 00:00:00
abstract::The effect of nimodipine on nitric oxide synthase (NOS) activities in brains in transient focal cerebral ischemia rats, in cultured mouse neurons and astroglial cells and bovine brain capillary endothelial cells (BCECs) was investigated. The administration of nimodipine (3 mg.kg(-1), p.o., twice a day, for 3 days) bef...
journal_title:Life sciences
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:AIMS:We tested the hypothesis that an in vivo gene delivery of the pro-survival protein XIAP (X-chromosome linked inhibitor of apoptosis protein) protects against myocardial apoptosis and infarction following ischemia/reperfusion. MAIN METHODS:Nineteen rabbits were chronically instrumented with a hydraulic occluder pl...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.01.019
更新日期:2011-03-28 00:00:00
abstract::The present study was designed to investigate the effects of the intrahippocampal co-injection of beta-amyloid protein1-40 (Abeta(1-40)) with ibotenic acid (Ibo) on learning and memory in normal and aging model rats, and to explore the mechanism underlying the effects of the co-injection. The normal and aging rats wer...
journal_title:Life sciences
pub_type: 杂志文章,收录出版
doi:10.1016/j.lfs.2004.05.039
更新日期:2005-01-28 00:00:00
abstract::Certain things have not changed since my colleague and I last reviewed the role of dietary salt in hypertension [Haddy, F.J., Pamnani, M.B., 1995. Role of dietary salt in hypertension. Journal of the American College of Nutrition 14, 428-438]. Over half of hypertensives are still salt sensitive, i.e., they respond to ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2006.05.017
更新日期:2006-09-20 00:00:00
abstract::Brief electrical pulses applied to the rat tail elicit a complex vocal response which includes audible (peeps, chatters) and ultrasonic (USV) components. Aspirin and amitriptyline had no effect on the vocal responses. Morphine showed a dose-dependent and naloxone reversible antinociceptive effect on the 1st and 2nd au...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00450-0
更新日期:1998-01-01 00:00:00
abstract::Insulin binding and 3-0-Methylglucose transport have been studied in erythrocyte- and reticulocyte-enriched fractions of blood cells in order to determine if the increased number of insulin binding sites in reticulocytes is associated with a glucose transport response to insulin. In these experiments rabbit reticulocy...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90588-4
更新日期:1982-07-19 00:00:00