Abstract:
:Anti-cancer and anti-angiogenesis effects of green tea catechins have been demonstrated. It has been found that chemical modification of tea catechins improves their biological activities. We examined the chemical modification of epicatechin enhanced anti-cancer and anti-angiogenic effects. Epicatechin conjugated with fatty acid (acyl-catechin) strongly inhibited DNA polymerase activity, HL-60 cancer cell growth and angiogenesis. Epicatechin conjugated with palmitic acid ((2R,3R)-3',4',5,7-tetrahydroxyflavan-3-yl hexadecanoate, epicatechin-C16) was the strongest inhibitor in DNA polymerase alpha, beta, lambda and angiogenesis assays. Epicatechin-C16 also suppressed human endothelial cell (HUVEC) tube formation on reconstituted basement membrane, suggesting that it affected not only DNA polymerase activity but also the signal transduction pathways needed for the tube formation in HUVECs. These results suggest that acylation of epicatechin is an effective chemical modification to improve the anti-cancer activity of epicatechin.
journal_name
Life Scijournal_title
Life sciencesauthors
Matsubara K,Saito A,Tanaka A,Nakajima N,Akagi R,Mori M,Mizushina Ydoi
10.1016/j.lfs.2007.01.049subject
Has Abstractpub_date
2007-04-03 00:00:00pages
1578-85issue
17eissn
0024-3205issn
1879-0631pii
S0024-3205(07)00118-Xjournal_volume
80pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::In vitro effects of medicinal plant extracts from the pericarpium of Citrus reticulata (cv Jiao Gan) (PCRJ) on the growth and differentiation of a recently characterized murine myeloid leukemic cell clone WEHI 3B (JCS) were investigated. Extracts of PCRJ not only inhibited the proliferation of JCS cells in a dose depe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00088-4
更新日期:1996-01-01 00:00:00
abstract::Free radicals induced by cerebral ischemia-reperfusion injury can trigger lipid peroxidation, leading to the production of malondialdehyde (MDA) and 4-hydroxy-2(E)-nonenal (4-HNE). Post-ischemia electroacupuncture (EA) therapy was able to reduce extent of lipid peroxidation. However, the effect of pre-ischemic EA ther...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.02.025
更新日期:2004-07-30 00:00:00
abstract::The purpose of the this study was to characterize the putative anxiolytic-like effects of the aqueous extract of Albizzia julibrissin stem bark using the elevated plus maze (EPM) in rats. The water extract of Albizzia julibrissin was orally administered at 10, 50, 100 or 200 mg/kg to adult male SD rats, 1 h before beh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.05.024
更新日期:2004-10-22 00:00:00
abstract::We studied the effect of interleukin-1 alpha (IL-1) on corticotropin-releasing hormone (CRH) secretion by explanted rat hypothalami in vitro. We also assessed possible mediation of arachidonic acid metabolites on IL-1-stimulated CRH secretion, by preincubating hypothalami with the cyclooxygenase inhibitor indomethacin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90190-3
更新日期:1990-01-01 00:00:00
abstract::Despite the considerable number of published studies in the field of S-nitrosothiols (RSNO), the determination of these compounds in biological samples still represents an analytical challenge, due to several technical obstacles and often long sample preparation procedures. Other problems derive from the intrinsic lab...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2010.10.024
更新日期:2011-01-17 00:00:00
abstract::The acute dose-dependent effects of epinephrine and cocaine on heart rate and coronary flow rate (CFR) were examined in isolated, perfused (Langendorff) rat hearts from animals: i) pretreated with daily cocaine injections (20 mg/kg/day) for 8 weeks; ii) after 2-day withdrawal from 8-week cocaine pretreatment; iii) veh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90390-d
更新日期:1990-01-01 00:00:00
abstract:AIMS:Tetramethylpyrazine (TMP), one of the active ingredients isolated from a Chinese herbal prescription, possesses protective effects against oxidative stress caused by high glucose in endothelial cells. In this study, the role of TMP in preventing muscle cells from palmitate-induced oxidative damage was investigated...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.02.025
更新日期:2011-04-25 00:00:00
abstract:AIMS:Evidence suggests that hypobaric hypoxia (HH) exposure causes biochemical and molecular level perturbations in brain resulting in associated cognitive dysfunction. However, the possible effect of HH on amygdala and the associated limbic regions based functions remains elusive. Regulated fear expression is essentia...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117555
更新日期:2020-08-01 00:00:00
abstract::In order to estimate the intestinal stability of ebiratide [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8-NH2], a novel adrenocorticotropic hormone (ACTH) analogue, after oral administration, the hydrolytic properties of ebiratide were determined in the rat small intestinal fluid and mucosal homogenates. Ebiratide was extr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00674-1
更新日期:1994-01-01 00:00:00
abstract::SGK1 is one of the protein-serine/threonine kinases that is activated by insulin in a PI3K-dependent manner. Although SGK1 mediates a variety of biological activities, the mechanisms regulating its activity remain unclear. In this study, we examined the potential roles of calcium signaling in the activation of SGK1. T...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00092-4
更新日期:2003-04-04 00:00:00
abstract:PURPOSE:Doxorubicin, as an effective chemotherapeutic drug, is commonly used for combating various solid and hematological tumors. However, doxorubicin-induced cardiotoxicity is considered as a serious adverse effect, and it limits the clinical use of this chemotherapeutic drug. The use of melatonin can lead to a decre...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.117173
更新日期:2020-01-15 00:00:00
abstract::Using hot plate method, analgesia induced by noncatecholic phenylethylamines, phenethylamine, phenylethanolamine and amphetamine, was inhibited by naloxone, reserpine, apomorphine and p-chlorophenylalanine, while potentiated by haloperidol. These results suggest that phenylethylamines induced analgesia involves centra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90347-2
更新日期:1982-09-20 00:00:00
abstract::Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the mesenteric hyperemia after intraduodenal acidification. The hyperemia plays a role in protecting the duodenal mucosa against acid damage. We tested the hypothesis that bradykinin contributes to this protective hyperemia. A specific antagonist...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01455-2
更新日期:2002-01-04 00:00:00
abstract::Cachexia is a complex medical condition characterized by significant weight loss associated with decreased body fat and protein; the condition may present itself with or without anorexia. We have isolated and partially characterized a proteoglycan (azaftig) from the urine of cancer and AIDS patients experiencing weigh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00069-7
更新日期:1999-01-01 00:00:00
abstract::Chronopharmacokinetics deals with the study of the temporal changes in absorption, distribution, metabolism and elimination and thus takes into account the influence of time of administration on these different steps. In the last decade, numerous studies have been devoted to chronokinetics: recent advances will be rev...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(93)90001-j
更新日期:1993-01-01 00:00:00
abstract::Effects of amphetamine on concentrations of dopamine, norepinephrine and serotonin in several monoamine-containing cell body and terminal regions were examined left and right separately in rats. Results suggest that amphetamine reduced the L-R asymmetry of most of these measures, and this effect is more significant in...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90334-1
更新日期:1987-04-06 00:00:00
abstract:AIMS:We tested the hypothesis that an in vivo gene delivery of the pro-survival protein XIAP (X-chromosome linked inhibitor of apoptosis protein) protects against myocardial apoptosis and infarction following ischemia/reperfusion. MAIN METHODS:Nineteen rabbits were chronically instrumented with a hydraulic occluder pl...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.01.019
更新日期:2011-03-28 00:00:00
abstract::The experiments were designed to study whether the inhibitors of the uptake of serotonin (5-HT) potentiated the prejunctional effects of 5-HT on peripheral sympathetic nerves. The effect of two selective 5-HT uptake inhibitors, citalopram and fluoxetine, were studied on the presynaptic actions of 5-HT in the cat isola...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90438-8
更新日期:1986-07-07 00:00:00
abstract::Bupleuri radix, a traditional Chinese herb, has been widely used to treat liver diseases such as hepatitis and cirrhosis. The acetone extract of Bupleurum scorzonerifolium (AE-BS) showed a dose-dependently antiproliferative effect on the proliferation of A549 human lung cancer cells. The IC(50) of AE-BS, i.e., the con...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00648-9
更新日期:2003-09-19 00:00:00
abstract:AIMS:The aim of the present study was to investigate the protective effects of AGK2 as a selective SIRT2 inhibitor on thioacetamide (TAA)-induced acute liver failure (ALF) in mice and its potential mechanism. MAIN METHODS:All male C57BL/6 mice were separated into control, TAA, AGK2 + TAA, and AGK2 groups. The histolog...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.05.061
更新日期:2019-08-01 00:00:00
abstract::In order to determine the effect of relaxin and estradiol on collagen and noncollagen synthesis by mammary gland fibroblasts, fibroblasts isolated from guinea pig mammary glands were grown on plastic or Cytodex-3 collagen coated microcarriers. On plastic, estradiol (600 pg/ml) increased the incorporation of tritiated ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90460-0
更新日期:1984-11-26 00:00:00
abstract::The rate of oxidation of sparteine by the 9000 x g supernatant fraction of a human liver was measured in the presence of various drugs which exert cardiovascular effects. Hexamethonium, ouabain, caffeine and isoproterenol had no effect on this rate, while alprenolol, metoprolol, oxprenolol, propranolol, timolol, pindo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90332-1
更新日期:1984-01-02 00:00:00
abstract::Arsenic has been proposed as a chemotherapeutic agent for leukemia and other solid tumors. However, its environmental exposure has been linked epidemiologically with an elevated carcinoma risk (i.e. skin, bladder and lung), with cellular oxidative stress being implicated in both induced-arsenic toxicity and carcinogen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.09.008
更新日期:2007-10-13 00:00:00
abstract::Rats administered cocaine 10 mg/kg i.p. exhibited hyperlocomotion which occurred within 5 min post injection. Subsequently, rats were injected with 10 mg/kg cocaine and brain and serum concentrations of cocaine were measured at 5, 10, and 20 min post injection. Within this time frame, cocaine concentration in limbic b...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00339-4
更新日期:1994-01-01 00:00:00
abstract::Two breeds of rats, Charles River Wistar [Crl(Wi)Br.] and HSD Wistar [Wistar per LATI (Budapest) Br.], with remarkable difference in learning performance were selected. The rats were trained in the shuttle box with 100 trials per day and the number of conditioned avoidance responses (CARs), the escape failures (EFs) t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00037-9
更新日期:1996-01-01 00:00:00
abstract::Despite reductions in beta-adrenoreceptor (beta-AR)-mediated inotropic effects induced by sustained sympathetic activation in cardiac disease, whether these changes necessarily result in reductions in systolic function under resting conditions (baseline function) is not clear. Moreover, possible compensatory mechanism...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.04.047
更新日期:2005-12-12 00:00:00
abstract::Human UDP-glucuronosyltransferases (UGTs) 1A6 and 1A9 were expressed using Semliki Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with recombinant SFV-UGT viruses resulted in efficient protein expression as detected by metabolic labeling, Western blot analyses and immunofluorescence...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00831-6
更新日期:2000-10-06 00:00:00
abstract::Kappa (kappa) opioid agonists induce a water diuresis and inhibit vasopressin (AVP) secretion. Hypothalamic and neurohypophysial sites have both been implicated in the response. The present study was designed to ascertain if kappa-agonist inhibition of osmotically-stimulated AVP secretion is associated with parallel c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00931-4
更新日期:1997-01-01 00:00:00
abstract::Diabetes mellitus is a metabolic disorder in which the glucose level in blood exceeds beyond the normal level. Persistent hyperglycemia leads to diabetes late complication and obviously account for a large number of morbidity and mortality worldwide. Numerous therapeutic options are available for the treatment of diab...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2017.10.025
更新日期:2018-01-15 00:00:00
abstract::The cardio- and neuroprotective effect of the pyridoindole stobadine (S) is conditioned mainly by its good radical scavenging properties. It has been showed by EPR experiment, that the ultimate product of the reaction of stobadine with hydroxyl radical is the nitroxyl radical. However, for the unsaturated dehydrostoba...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00440-3
更新日期:1999-01-01 00:00:00