Abstract：
:This study was conducted to investigate SAFB-induced apoptosis of mast cells as it pertains to both its basic drug mechanism and the potential therapeutics of the pathologic conditions accompanying mast cell proliferation. SAFB induced many apoptotic manifestations as evidenced by changes in cell morphology, generation of DNA fragmentation, activation of caspase 3, and DNA hypoploidy. The reduction of mitochondrial membrane potential and the release of cytochrome c to cytosol were also demonstrated. However, reduction of mitochondrial membrane potential and cytochrome c release were not prevented by caspase inhibitor zVAD-fmk or PTP blockers such as bongkrekic acid and cyclosporin A. Expression levels of Bcl-2 and Fas remained unchanged following SAFB treatment. This results suggest that the clinical effect of SAFB may depend on the pharmacological mechanism regulating the demise of mast cells.
journal_name
Life Scijournal_title
Life sciencesauthors
Park HI,Jeong MH,Lim YJ,Park BS,Kim GC,Lee YM,Kim HM,Yoo KS,Yoo YHdoi
10.1016/s0024-3205(01)01140-7subject
Has Abstractpub_date
2001-06-22 00:00:00pages
553-66issue
5eissn
0024-3205issn
1879-0631pii
S0024320501011407journal_volume
69pub_type
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