Abstract：
AIMS:Individual susceptibility to develop obesity may impact the development of cardio-metabolic risk factors that lead to obesity-related comorbid conditions. Obesity-prone Osborne-Mendel (OM) rats expressed higher levels of visceral adipose inflammation than obesity-resistant, S5B/Pl (S5B) rats. However, the consumption of a high fat diet (HFD) differentially affected OM and S5B rats and induced an increase in visceral adipose inflammation in S5B rats. The current study examined the effects of HFD consumption on cardio-metabolic risk factors in OM and S5B rats. MATERIALS & METHODS:Glucose regulation and circulating levels of lipids, adiponectin and C-reactive protein were assessed following 8 weeks of HFD or low fat diet (LFD) consumption. Left ventricle hypertrophy and mRNA expression of cardiovascular disease biomarkers were also quantified in OM and S5B rats. KEY FINDINGS:Circulating levels of triglycerides were higher, while HDL cholesterol, adiponectin and glycemic control were lower in OM rats, compared to S5B rats. In the left ventricle, BNP and CTGF mRNA expression were higher in OM rats and IL-6, IL-1β, VEGF, and iNOS mRNA expression were higher in S5B rats. SIGNIFICANCE:These findings support the hypothesis that cardio-metabolic risk factors are increased in obesity-prone individuals, which may increase the risk for the development of obesity-related comorbidities. In the current models, obesity-resistant S5B rats also exhibited cardiovascular risk factors supporting the importance of monitoring cardiovascular health in individuals characterized as obesity-resistant.
journal_name
Life Scijournal_title
Life sciencesauthors
Poret JM,Battle C,Mouton AJ,Gaudet DA,Souza-Smith F,Gardner JD,Braymer HD,Harrison-Bernard L,Primeaux SDdoi
10.1016/j.lfs.2019.03.022subject
Has Abstractpub_date
2019-04-15 00:00:00pages
95-101eissn
0024-3205issn
1879-0631pii
S0024-3205(19)30180-8journal_volume
223pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:These experiments were designed to test the hypothesis that cyclosporine A (CSA) inhibits renin secretion and stimulates renal prostaglandin E2 (PGE2) release in vitro. In rat renal cortical slices incubated at 37 degrees C in a buffered and oxygenated physiological saline solution containing 4 mM KCl, CSA concentrati...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90187-v
更新日期：1990-01-01 00:00:00
abstract：:Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors, CysLT1 and CysLT2, have been cloned and functionally characterised using potent CysLT1 receptor antagonists and the dual CysLT1/CysLT2 receptor...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(02)01733-2
更新日期：2002-06-28 00:00:00
abstract：:The α chain of interleukin 3 receptor (IL-3Rα or CD123), together with the common β (βc) subunit, forms a high-affinity IL-3R with biological function. In recent years, emerging research has found that CD123 is highly expressed on the surface of various cells (e.g., leukemia stem cells, LSCs), and it is associated wit...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2014.10.013
更新日期：2015-02-01 00:00:00
abstract：AIMS:Poly (ADP-ribose) polymerase- (PARP)-1 is predominantly triggered by DNA damage. Overexpression of PARP-1 is known for its association with the pathogenesis of several CNS disorders, such as Stroke, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington (HD) and Amyotrophic lateral sclerosis (ALS). NAD+ de...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118975
更新日期：2021-02-15 00:00:00
abstract：:From the fruiting bodies of the edible mushroom Flammulina velutipes a single-chained ribosome inactivating protein with a molecular weight of 13.8 kDa was isolated with a procedure involving ion exchange chromatography on DEAE-cellulose and SP-Sepharose and affinity chromatography on Affi-gel blue gel. The protein wa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01023-2
更新日期：2001-03-23 00:00:00
abstract：:Kappa (kappa) opioid agonists induce a water diuresis and inhibit vasopressin (AVP) secretion. Hypothalamic and neurohypophysial sites have both been implicated in the response. The present study was designed to ascertain if kappa-agonist inhibition of osmotically-stimulated AVP secretion is associated with parallel c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00931-4
更新日期：1997-01-01 00:00:00
abstract：:Nitric oxide (NO) is a potent regulator in the cardiovascular system; it is generated by the nitric oxide synthase (NOS) family of proteins. NO produced in endothelial cells plays a crucial role in vascular functions. The aim of this study was to clarify the effect of diabetes on aortic NO synthesis in a model of gene...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.02.010
更新日期：2005-07-15 00:00:00
abstract：:To evaluate the relative contributions of the ovarian inhibin and estradiol-17 beta (E) on the regulation of FSH secretion, inhibin and E in ovarian venous plasma (OVP) and FSH and LH in peripheral plasma were simultaneously measured using superovulating rats with special reference to follicular maturation. By the tra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90445-5
更新日期：1986-07-14 00:00:00
abstract：:Nucleotides, e.g. ATP and ADP, are important signaling molecules, which elicit several biological responses. The degradation of nucleotides is catalyzed by a family of enzymes called NTPDases (nucleoside triphosphate diphosphohydrolases). The present study reports the enzymatic properties of a NTPDase (CD39, apyrase, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00596-4
更新日期：2003-09-05 00:00:00
abstract：:Propentofylline (PPF) is a xanthine derivative with pharmacological effects that are distinct from those of classic methylxanthines. It depresses the activation of microglial cells and astrocytes, which is associated with neuronal damage during neural inflammation and hypoxia. Our previous studies showed that PPF impr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.02.028
更新日期：2016-03-01 00:00:00
abstract：AIMS:Antitumour effects of pentapeptide (LH) derived from donkey serum albumin hydrolysates were tested against tumour cells both in vitro and in vivo. The mechanism of LH induced tumour cell apoptosis was investigated. MAIN METHODS:Human promyelocytic leukaemia cells (HL 60) were cultured to observe inhibition in vit...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.02.013
更新日期：2013-05-20 00:00:00
abstract：:The antinociceptive and temperature responses to morphine were compared in male and female rats from two different strains. Males of both the Sprague-Dawley and Wistar-Furth strains were slightly more responsive to the acute actions of morphine than were females of the same strain. However, Wistar-Furth animals requir...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90633-7
更新日期：1984-04-23 00:00:00
abstract：AIMS:Antenatal glucocorticoid therapy has been shown to prevent acute diseases including infant respiratory distress syndrome and reduce mortality, although little is known about the effects on cardiac function-related proteins in the fetus or neonate. We investigated whether cardiac function-related proteins were alte...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.06.017
更新日期：2009-10-21 00:00:00
abstract：:Flavonoids are frequently found in fruits and vegetables, and are currently under investigation as potential chemopreventive agents. The present study reports the inhibitory effects of six flavonoids, quercetin, genistein, daidzein, equol, (+)-catechin and flavone, on sulphation of p-nitrophenol, a model substrate for...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00423-3
更新日期：1999-01-01 00:00:00
abstract：AIMS:To establish the differential cytoprotective activity against arsenic (As) toxicity of the flavonoids silymarin (S), which is without protective effects on cancer cells, and quercetin (Q). Arsenic (As) has a paradoxical biomedical role: it causes oxidative damage to normal cells leading to death or malignant trans...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.07.007
更新日期：2010-08-28 00:00:00
abstract：:The COVID-19 pandemic raised by SARS-CoV-2 is a public health emergency. However, lack of antiviral drugs and vaccine against human coronaviruses demands a concerted approach to challenge the SARS-CoV-2 infection. Under limited resource and urgency, combinatorial computational approaches to identify the potential inhi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118080
更新日期：2020-09-15 00:00:00
abstract：:Alpha adrenergic agonists and antagonists as clonidine, guanfacine, yohimbine, phenylephrine and prazosin inhibited the [3H]-QNB binding to rat brain cortex muscarinic acetylcholine receptor (mAChR, M-1 subtype), heart (M-2 subtype) and parotid gland homogenate (M-3 subtype) in a dose-dependent competitive fashion. Ki...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90436-u
更新日期：1990-01-01 00:00:00
abstract：:Coxsackievirus B3 (CVB3) is a major pathogen for acute and chronic viral myocarditis. The aim of this study was to investigate the antiviral effects of sophoridine, an alkaloid extracted from Chinese medicinal herb, Sophora flavescens, against CVB3, and the underlying pharmacokinetics. First, we determined the antivir...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.09.034
更新日期：2006-03-20 00:00:00
abstract：:The aim of this study was to investigate whether the A1/A2 receptor agonist, 5'-N-ethylcarboxamidoadenosine (NECA), and the selective A1 agonist, N6-cyclopentyladenosine (CPA), induced physical dependence by quantifying specific antagonist-precipitated withdrawal syndromes in conscious rats. In addition, the presence ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01155-9
更新日期：2001-07-06 00:00:00
abstract：:An in vitro perifusion system was used to investigate the effects of GnRH stimulation on LH, ACTH, and immunoreactive beta-endorphin (i beta-END) release from ovariectomized (1 week) rat anterior hemipituitaries. Either 0, 8 or 80 nM GnRH was administered as a 15 min pulse followed 30 min later by a prolonged 45 min i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90175-0
更新日期：1988-01-01 00:00:00
abstract：:The Ca2+ ionophore A23187 (0.2-5 microM) stimulates the phosphorylation of the substrates of protein kinase C (40,000 dalton protein) and myosin light chain kinase (20,000 dalton protein) in the presence or absence of cyclooxygenase inhibitors. In the presence of cyclooxygenase inhibitors or millimolar Ca2+ there is n...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90024-x
更新日期：1986-08-25 00:00:00
abstract：:SDZ PGU 693 acts as a hypoglycemic agent by stimulating glucose utilisation in insulin-sensitive peripheral tissues, such as skeletal muscle and fat. In a 28 day toxicity study the compound was found to induce hepatocellular hypertrophy in Wistar rats treated with 300 mg/kg/day. To gain insights into the pathomechanis...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00509-8
更新日期：1998-01-01 00:00:00
abstract：AIMS:microRNA-96 (miR-96) is considered as a tumor suppressor in multiple malignancies. Some studies have indicated that EZRIN could be regulated by the miR-96 in several kinds of cancer cells. However, the function of miR-96 in human osteosarcoma has not been investigated intensively so far. In this study, we mainly e...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.04.012
更新日期：2018-06-15 00:00:00
abstract：:Diabetes mellitus is a metabolic disorder in which the glucose level in blood exceeds beyond the normal level. Persistent hyperglycemia leads to diabetes late complication and obviously account for a large number of morbidity and mortality worldwide. Numerous therapeutic options are available for the treatment of diab...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2017.10.025
更新日期：2018-01-15 00:00:00
abstract：:In this study, we investigated the effects of zinc L-carnosine, an anti-ulcer drug, on acetic acid-induced colonic mucosal injury and the correlation of these effects with expression of 72-kDa heat shock proteins (HSP72) and nuclear factor kappa B (NF-kappaB) activation in rat colonic mucosa in vivo. After intrarectal...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.07.032
更新日期：2006-11-10 00:00:00
abstract：:Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT(1A) and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that stre...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00084-2
更新日期：1997-01-01 00:00:00
abstract：:Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can trigger fre...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02169-0
更新日期：2002-11-08 00:00:00
abstract：:The reproductive system effects of cocaine were studied in male rats. The analysis included measurements of circulating levels of luteinizing hormone (LH) and testosterone (T) by radioimmunoassay (RIA). The weights of the testes and sex accessory organs were also assessed and compared with control animals. Dosage leve...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90440-2
更新日期：1989-01-01 00:00:00
abstract：:We investigated the effects of genistein and genistin on proliferation and apoptosis of human ovarian SK-OV-3 cells and explored the mechanism for these effects. SK-OV-3 cells were treated with genistein and genistin at various concentrations (ranging from 1 to 100 muM) either alone or in combination for 24 and 48 h. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.12.031
更新日期：2007-03-20 00:00:00
abstract：:We evaluated the effects of FR901533, endothelin converting enzyme inhibitor, on development of right ventricular overload and medial thickening of pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension. Pulmonary hypertension was induced by a single injection of monocrotaline (80 mg/kg). Twenty-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00347-6
更新日期：1998-01-01 00:00:00
