当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Opposite caudal versus rostral brain nitric oxide synthase response to generalized seizures in a novel rodent model of reflex epilepsy.

Opposite caudal versus rostral brain nitric oxide synthase response to generalized seizures in a novel rodent model of reflex epilepsy.

Abstract：

AIMS:Nitric oxide (NO) is synthesized from L-arginine (L-Arg) by three different isoforms of NO synthase (NOS), i.e. the constitutive neuronal and endothelial NOS (nNOS and eNOS) and the inducible NOS (iNOS). NO has been involved in the pathophysiology of epilepsy, but available data are conflicting and the actual role of NO in epilepsy still remains to be clarified. In this study we investigated the basal and post-seizure levels of constitutive NOS (cNOS) activity as well as the expression of the cNOS isoforms across brain regions in a novel model of epilepsy. MAIN METHODS:cNOS activity was assessed in various brain areas along the rostro-caudal axis in control wild type hamsters, unstimulated generalized audiogenic seizure prone hamsters, Salamanca strain, GASH:Sal and GASH:Sal after 10 sound-induced epileptic seizures. Additionally, Western blot experiments for nNOS and eNOS were performed in those areas where relevant changes in cNOS activity were found. KEY FINDINGS:In the GASH:Sal, cNOS activity increased in the mesencephalic areas studied while cNOS activity decreased in both the striatum and cerebral cortex after 10 sound-induced epileptic seizures. nNOS (but not eNOS) expression paralleled the variations in cNOS activity. The same sound stimulation had no effect on control hamsters. SIGNIFICANCE:These results suggest a different NOS response in the regions close to the original epileptic focus (caudal, in our auditory model) versus the remote areas (rostral) possibly recruited at later stages or after repeated crises. These findings may account for some of the discrepancies found regarding the role of NO in epilepsy.

journal_name

Life Sci

journal_title

Life sciences

authors

Prieto-Martín AI,Llorens S,Pardal-Fernández JM,Muñoz LJ,López DE,Escribano J,Nava E,de Cabo C

doi

10.1016/j.lfs.2012.01.010

subject

Has Abstract

pub_date

2012-04-09 00:00:00

pages

531-7

issue

13-14

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(12)00060-4

journal_volume

90

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Gluten exorphin B5 stimulates prolactin secretion through opioid receptors located outside the blood-brain barrier.

    abstract：:Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten. We have recently shown that GE-B5 stimulates prolactin (PRL) secretion in rats; this effect is abolished by preadministration of the opioid receptor antagonist naloxone. However, since the structure of naloxone allows it...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.09.023

    authors： Fanciulli G,Dettori A,Demontis MP,Tomasi PA,Anania V,Delitala G

    更新日期：2005-02-25 00:00:00

  • Developmental changes of testicular activin and FSH receptor mRNA and plasma FSH and inhibin levels in the rat.

    abstract：:To investigate the changes in the FSH receptor and the activin receptor during sexual maturation in rat testes, we examined the mRNA levels of the receptors by Northern blot analysis. With a full length rat activin receptor cRNA probe in this study, Northern blot analysis revealed two activin receptor mRNAs (6Kb and 3...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90575-n

    authors： Ito I,Minegishi T,Hasegawa Y,Shinozaki H,Nakamura K,Igarashi S,Nakamura M,Miyamoto K,Ibuki Y

    更新日期：1993-01-01 00:00:00

  • Antipruritic effect of millimeter waves in mice: evidence for opioid involvement.

    abstract：:In our previous studies, exposure of mice to millimeter waves (MW) increased the duration of anesthesia caused by either ketamine or chloral hydrate, and this effect was blocked by naloxone. To further characterize the biological effects of MW, we have chosen a new animal model of experimental itch. Male Swiss albino ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00436-6

    authors： Rojavin MA,Cowan A,Radzievsky AA,Ziskin MC

    更新日期：1998-01-01 00:00:00

  • Calcium mediated neurohumoral inhibition of chicken enterocyte Na influx: role of phosphatidylinositol metabolites.

    abstract：:Carbachol (CCH), serotonin (5HT), divalent ionophore A23187, cAMP, and certain neuropeptides, i.e. substance P (SP), inhibit the initial rate of uptake (influx) of 22Na into isolated chicken villus enterocytes. All these agents also increase cytosolic Ca. However, the increases stimulated by CCH, 5HT, and cAMP are not...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90506-m

    authors： Chang EB,Musch MW

    更新日期：1990-01-01 00:00:00

  • Extractions of pyrroloquinoline quinone from crude biological samples.

    abstract：:The best conditions for extractions of free pyrroloquinoline quinone (PQQ) from crude biological samples were investigated with various organic solvents and Sep-Pak C18 cartridges. PQQ was measured with use of its native fluorescence in aqueous solution. PQQ was well extracted into n-butanol under acid conditions, and...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90313-g

    authors： Suzuki O,Kumazawa T,Seno H,Urakami T,Matsumoto T

    更新日期：1990-01-01 00:00:00

  • Dual in vitro effects of cortisol on cell turnover in the medaka esophagus via the glucocorticoid receptor.

    abstract：AIMS:Cortisol is a glucocorticoid in mammals, but has both gluco- and mineralocorticoid activities in teleost fish. Our previous in vivo studies on osmoregulatory esophagi of euryhaline fish showed that epithelial apoptosis for the simple epithelium in seawater and cell proliferation for the stratified epithelium in fr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2010.11.017

    authors： Takagi C,Takahashi H,Kudose H,Kato K,Sakamoto T

    更新日期：2011-01-31 00:00:00

  • Decreased total antioxidant capacity and elevated lipid hydroperoxide concentrations in sera of epileptic patients receiving phenytoin.

    abstract：:Oxidative stress (free radical generation exceeds antioxidant defense) occurs in many diseases and after exposure to certain chemicals. We automated assays estimating the antioxidant status of serum and lipid hydroperoxide concentrations using the Syva-30R automated analyzer. In this assay, the antioxidant status of s...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00401-3

    authors： Mahle C,Dasgupta A

    更新日期：1997-01-01 00:00:00

  • The effect of PKC activity on the TTX-R sodium currents from rat nodose ganglion neurons.

    abstract：:To determine how protein kinase C (PKC) activity influences properties of the tetrodotoxin-resistant sodium current (TTX-R I(Na)) in neonatal rat nodose ganglion (NG) neurons, we assessed the effects of phorbol,-12-myristate,13-acetate (PMA), one of the PKC activators, and staurosporine, one of the PKC inhibitors, on ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.04.053

    authors： Ikeda M,Yoshida S,Kadoi J,Nakano Y,Mastumoto S

    更新日期：2005-11-19 00:00:00

  • Melatonin: perspectives in the life sciences.

    abstract：:The pineal gland hormone melatonin is now considered an important neuroendocrine component of animal physiology. Although the functional status of melatonin has been well described for subhuman species, there is a paucity of data concerning the physiological role of this hormone in man. This paucity of data has much t...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0024-3205(89)90262-2

    authors： Miles A

    更新日期：1989-01-01 00:00:00

  • Hyperbaric oxygen induces placental growth factor expression in bone marrow-derived mesenchymal stem cells.

    abstract：:The bone marrow is home to mesenchymal stem cells (MSCs) that are able to differentiate into many different cell types. The effect of hyperbaric oxygen (HBO) on MSCs is poorly understood. Placental growth factor (PlGF) is an attractive therapeutic agent for stimulating revascularization of ischemic tissue. HBO has bee...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2008.05.005

    authors： Shyu KG,Hung HF,Wang BW,Chang H

    更新日期：2008-07-04 00:00:00

  • Development of a radioiodinated ligand for characterising alpha 1-adrenoceptors.

    abstract：:Two alpha-adrenoceptor antagonists, phentolamine and 2-(beta-(4-hydroxyphenyl)-ethylaminomethyl)-tetralone (BE 2254) which are phenolic derivatives were radioiodinated after chloramine-T oxidation of Na125I and the labelled material isolated by chromatography. 125I-phentolamine does not bind selectively to alpha-adren...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90623-3

    authors： Adams A,Jarrott B

    更新日期：1982-03-15 00:00:00

  • Sensory neuropeptides modulate cigarette smoke-induced decrease in neutral endopeptidase activity in guinea pig airways.

    abstract：:Cigarette smoke (CS) inhalation stimulates C-fibers to release sensory neuropeptides which mediate airway reflex responses to prevent irritants from entering the lower airways. When CS is inhaled via the upper airways, these airway defense responses may modulate the effect of CS on airway NEP activity and related airw...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)02210-a

    authors： Kuo HP,Lu LC

    更新日期：1995-01-01 00:00:00

  • Variations in concentration of oxytocin and vasopressin in the paraventricular nucleus of the hypothalamus during the estrous cycle in rats.

    abstract：:Oxytocin (OT) and arginine-8-vasopressin (AVP) were measured by radioimmunoassay in micropunched hypothalamic neurosecretory nuclei of estrous cycling female Sprague-Dawley rats. In the paraventricular nucleus (PVN): the concentration (pg/microgram protein) of OT was significantly higher in rats in diestrus than durin...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90638-7

    authors： Greer ER,Caldwell JD,Johnson MF,Prange AJ Jr,Pedersen CA

    更新日期：1986-06-23 00:00:00

  • Deciphering ophthalmic adaptive inhibitors targeting RON4 of Toxoplasma gondii: An integrative in silico approach.

    abstract：AIMS:Toxoplasma gondii (T. gondii) is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. Its parasitic invasion leads to encephalitis, uveitis, chorioretinitis and congenital infection. Host invasion by T. gondii is mediated by Moving junction (MJ) complex formed by secretory protei...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.10.022

    authors： Vetrivel U,Nagarajan H

    更新日期：2018-11-15 00:00:00

  • Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts.

    abstract：:Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90463-5

    authors： Glennon RA,Young R,Benington F,Morin RD

    更新日期：1982-02-01 00:00:00

  • Identification of SLC26A transporters involved in the Cl⁻/HCO₃⁻ exchange in proximal tubular cells from WKY and SHR.

    abstract：AIMS:slc26a proteins are responsible for a large number of functions either in normal physiology or in human disease. We have previously reported that proximal tubular epithelial (PTE) cells immortalized from spontaneously hypertensive rats (SHRs) were endowed with increased Cl(-)/HCO3(-) exchanger activity and slc26a6...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2013.07.026

    authors： Simão S,Gomes P,Pinho MJ,Soares-da-Silva P

    更新日期：2013-10-06 00:00:00

  • A glycosaminoglycan activator of lipoprotein lipase in human plasma.

    abstract：:By use of ion exchange chromatography we have isolated two discrete classes of "free" glycosaminoglycans (GAG) from human plasma. The GAG fractions were tested for their effects on two lipoprotein lipase (LPL) enzyme systems containing an apolipoprotein C-II activated emulsion as the triglyceride substrate and bovine ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90874-3

    authors： Felts JM,Staprans I,Gorman RA

    更新日期：1983-04-04 00:00:00

  • Insulin-like growth factor I (IGF-I) affects plasma lipid profile and inhibits the lipolytic action of growth hormone (GH) in isolated adipocytes.

    abstract：:The actions of insulin-like growth factor I (IGF-I) and growth hormone (GH) on lipid metabolism have been investigated in hormonally intact rats. The subcutaneous injection of IGF-I (100 micrograms) and GH (100 micrograms) lowered total cholesterol plasma levels. The in vitro assays on isolated rat adipocytes showed a...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)02067-s

    authors： Pascual M,Larralde J,Martínez JA

    更新日期：1995-01-01 00:00:00

  • Structure/function relationships of muscarinic acetylcholine receptors.

    abstract：:The regions of muscarinic receptors that specify G-protein-coupling and ligand-binding have been defined in several recent studies. Overall, these studies have shown that amino acids within the third cytoplasmic loop of the receptors define their selectivity for different G-proteins, and that multiple, discontinuous e...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0024-3205(93)90295-e

    authors： Brann MR,Klimkowski VJ,Ellis J

    更新日期：1993-01-01 00:00:00

  • Direct determination of homovanillic acid release from the human brain, an indicator of central dopaminergic activity.

    abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90593-z

    authors： Lambert GW,Eisenhofer G,Cox HS,Horne M,Kalff V,Kelly M,Jennings GL,Esler MD

    更新日期：1991-01-01 00:00:00

  • Effects of isatin on atrial natriuretic peptide-mediated accumulation of cGMP and guanylyl cyclase activity of PC12 cells.

    abstract：:We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations. In the present study the effe...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01270-x

    authors： Medvede AE,Abakumova OYu,Podobed OV,Tsvetkova TA,Sandler M,Glover V

    更新日期：2001-08-31 00:00:00

  • The gut cytokine balance as a target of lead toxicity.

    abstract：:The impact of exposure to lead on gut cytokine gene expression and oral tolerance was analyzed. Oral tolerization with ovalbumin (OVA) increased levels of IL-10 and TGF-beta in gut tissue while IFN-gamma mRNA levels remained unchanged in both autoimmune diabetes prone NOD and normal C57BL/6 mice. This shift towards Th...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00172-1

    authors： Goebel C,Kirchhoff K,Wasmuth H,Flohé S,Elliott RB,Kolb H

    更新日期：1999-01-01 00:00:00

  • Effect of lithium on norepinephrine metabolic pathways.

    abstract：:We investigated lithium-induced changes in norepinephrine (NE) catabolism. NE and its major metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenyl glycol (DHPG), ions such as lithium (Li(+)), magnesium (Mg(2+)), and potassium (K(+)) were measured in rat plasma and cerebral cortex using an HPLC meth...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.12.033

    authors： Sastre E,Nicolay A,Bruguerolle B,Portugal H

    更新日期：2005-07-01 00:00:00

  • Possible role of P-450-derived metabolites in endothelium-dependent relaxation of rat small mesenteric arteries.

    abstract：:We reported previously that acetylcholine (ACh)-induced endothelium-dependent relaxation of rat mesenteric microvessels depended both on nitric oxide (NO) and on a charybdotoxin (CTX)-sensitive endothelium-derived hyperpolarizing vasodilator. Cytochrome P450 (CYP)-dependent arachidonic acid metabolites act in some sys...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00413-6

    authors： Davidson-Garcia CA,Nalbantian-Brandt C,Umans JG

    更新日期：2000-02-11 00:00:00

  • Stability and distribution of orally administered epidermal growth factor in neonatal pigs.

    abstract：:Stability and distribution of orally administered epidermal growth factor (EGF) were examined in newborn and 5-day-old pigs. Forty-five minutes after oral administration of iodine-125 labeled EGF, 60 and 50% of the radioactivity administered were recovered from the internal organs in newborn and 5-day-old pigs, respec...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00337-3

    authors： Shen WH,Xu RJ

    更新日期：1998-01-01 00:00:00

  • Zinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation.

    abstract：:In this study, we investigated the effects of zinc L-carnosine, an anti-ulcer drug, on acetic acid-induced colonic mucosal injury and the correlation of these effects with expression of 72-kDa heat shock proteins (HSP72) and nuclear factor kappa B (NF-kappaB) activation in rat colonic mucosa in vivo. After intrarectal...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.07.032

    authors： Odashima M,Otaka M,Jin M,Wada I,Horikawa Y,Matsuhashi T,Ohba R,Hatakeyama N,Oyake J,Watanabe S

    更新日期：2006-11-10 00:00:00

  • Factors affecting in vivo electrochemistry: electrode-tissue interaction and the ascorbate amplification effect.

    abstract：:While in vivo electrochemistry has been shown to be useful for discovering new neurophysiological phenomena, there is still considerable controversy about the identity of the compounds being measured and the concentration of those compounds in extracellular fluid in brain. We have found that carbon paste electrodes un...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90440-6

    authors： Echizen H,Freed CR

    更新日期：1986-07-07 00:00:00

  • Hsa_circ_0029589 knockdown inhibits the proliferation, migration and invasion of vascular smooth muscle cells via regulating miR-214-3p and STIM1.

    abstract：AIMS:Circular RNAs (circRNAs) are relevant to atherosclerosis progression. However, the role and mechanism of circRNA hsa_circ_0029589 (circ_0029589) in atherosclerosis are not fully understood. This research aims to explore the function and mechanism of circ_0029589 in oxidized low-density lipoprotein (ox-LDL)-caused ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118251

    authors： Huang Z,Li P,Wu L,Zhang D,Du B,Liang C,Gao L,Zhang Y,Yao R

    更新日期：2020-10-15 00:00:00

  • Effect of cadmium on purified hepatic flavokinase: involvement of reactive -SH group(s) in the inactivation of flavokinase by cadmium.

    abstract：:The effect of cadmium (Cd2+) was studied in vitro on the flavokinase (ATP : riboflavin 5'-phosphotransferase, EC 2.7.1.26) activity purified from rat liver. Cadmium inhibited flavokinase activity in a concentration-dependent manner and the effect was completely reversed by increasing concentration of zinc (Zn2+), indi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00151-3

    authors： Bandyopadhyay D,Chatterjee AK,Datta AG

    更新日期：1997-01-01 00:00:00

  • Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier.

    abstract：:6-mercaptopurine (6-MP) has been used clinically for 40 years to maintain remission in patients with acute lymphoblastic leukemia (ALL). However, central nervous system (CNS) relapses frequently occur in patients with ALL who continuously receive anticancer drugs, including 6-MP, during remission maintenance therapy. ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00637-2

    authors： Deguchi Y,Yokoyama Y,Sakamoto T,Hayashi H,Naito T,Yamada S,Kimura R

    更新日期：2000-01-01 00:00:00