Effects of lysophosphoglycerides on cardiac arrhythmias.

abstract：:In vivo microdialysis was used to investigate the effects of acute injections of norharman on extraneuronal concentrations of dopamine (DA) in the nucleus accumbens of rats. Administration of norharman (2.44 and 43.97 mumol/kg, i.p.) elicited an increase of the DA efflux by 70% and 160% respectively which returned to ...

journal_title：Life sciences

authors： Baum SS,Hill R,Rommelspacher H

更新日期：1995-01-01 00:00:00

abstract：:NMDA receptors are glutamate-regulated ion channels of critical importance for many neurophysiological and neuropathological processes. Mg2+ blocks the NMDA receptor by binding to the channel pore with an apparent affinity that depends on the membrane potential. We have investigated the effect of NMDA and the required...

journal_title：Life sciences

authors： Liu Y,Hill RH,Arhem P,von Euler G

更新日期：2001-03-09 00:00:00

abstract：:A review of the rapidly accumulating data in the literature continues to support the notion that catecholamines regulate ovarian function, and extends the complexity of catecholaminergic effects on the ovary via interactions with pituitary and adrenal hormones. It is clear that catecholamines affect growth and differe...

journal_title：Life sciences

authors： Spicer LJ

更新日期：1986-11-10 00:00:00

abstract：:Endothelin-1 (ET-1) is produced from its precursor, big endothelin-1 (BigET-1), by a putative endothelin-converting enzyme (ECE), but it is not known whether the enzyme is present in the brain. This study was conducted to examine the central hemodynamic effects of BigET-1 and to indirectly determine the presence of an...

journal_title：Life sciences

authors： Hashim MA,Tadepalli AS

更新日期：1991-01-01 00:00:00

abstract：:Daily s.c. injection of (-)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furthermore, the activity of catalase (but not of glutathione peroxidase) was a...

journal_title：Life sciences

authors： Carrillo MC,Kanai S,Nokubo M,Kitani K

更新日期：1991-01-01 00:00:00

abstract：AIM:Over-expression of histone deacetylase 8 (HDAC8) has been demonstrated in breast cancer. But the underlying molecular mechanism of HDAC8 on the progression of breast cancer remains unknown. MicroRNAs (miRs) are proposed as important molecules in cancer progression by targeting specific oncogenes or tumor-suppressor...

journal_title：Life sciences

authors： Menbari MN,Rahimi K,Ahmadi A,Elyasi A,Darvishi N,Hosseini V,Mohammadi-Yeganeh S,Abdi M

更新日期：2019-11-15 00:00:00

abstract：:Cigarette smoke (CS) inhalation stimulates C-fibers to release sensory neuropeptides which mediate airway reflex responses to prevent irritants from entering the lower airways. When CS is inhaled via the upper airways, these airway defense responses may modulate the effect of CS on airway NEP activity and related airw...

journal_title：Life sciences

authors： Kuo HP,Lu LC

更新日期：1995-01-01 00:00:00

abstract：:Diabetes mellitus is a metabolic disorder in which the glucose level in blood exceeds beyond the normal level. Persistent hyperglycemia leads to diabetes late complication and obviously account for a large number of morbidity and mortality worldwide. Numerous therapeutic options are available for the treatment of diab...

journal_title：Life sciences

authors： Marya,Khan H,Nabavi SM,Habtemariam S

更新日期：2018-01-15 00:00:00

abstract：:The effects of a newly synthesized compound, 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)-2(1H)-quinolinone (OPC-4392), on tyrosine hydroxylation in situ and in vitro were studied using rat striatal slices and tyrosine hydroxylase (TH) purified from bovine adrenal medulla, respectively. OPC-4392 dose-dependently i...

journal_title：Life sciences

authors： Kiuchi K,Hirata Y,Minami M,Nagatsu T

更新日期：1988-01-01 00:00:00

abstract：:The N-terminus portion of the POMC leader sequence (signal peptide) was synthesized, and an antiserum was raised against it. A radioimmunoassay was developed which is effective at a dilution of 1:500,000, and sensitive at less than 1 fmole/tube. Since leader sequences often exhibit structural homologies, and since syn...

journal_title：Life sciences

authors： Akil H,Shiomi H,Thompson R,Lax S,Coy D,Watson S

更新日期：1982-11-15 00:00:00

abstract：:It was examined whether the digoxin-like immunoreactive substance (DLIS) extracted from cord blood has a natriuretic activity. The DLIS was prepared from cord blood of healthy fullterm infants by acetone-HCl extraction and a gel filtration column. A solution (solution A) containing 1.0 ng/ml of DLIS or another solutio...

journal_title：Life sciences

authors： Ebara H,Suzuki S,Nagashima K,Kuroume T

更新日期：1988-01-01 00:00:00

abstract：:While in vivo electrochemistry has been shown to be useful for discovering new neurophysiological phenomena, there is still considerable controversy about the identity of the compounds being measured and the concentration of those compounds in extracellular fluid in brain. We have found that carbon paste electrodes un...

journal_title：Life sciences

authors： Echizen H,Freed CR

更新日期：1986-07-07 00:00:00

abstract：:The inhibitory activity of methylguanidine, guanidine and their precursors, creatine and creatinine, on both the neuronal constitutive and lung inducible isoforms of nitric oxide synthase were examined in this study. Methylguanidine and guanidine (0.01-3 mM) significantly (P<0.01) inhibited in a concentration-dependen...

journal_title：Life sciences

authors： Sorrentino R,Sautebin L,Pinto A

更新日期：1997-01-01 00:00:00

abstract：:The purpose of this research is to elucidate the pharmacological mechanism mediating vesicating effects of sulfur mustard (HD) and identify an antidote to its action. HD causes blisters because epithelial cells lose their attachments. Epithelial cell adhesion is under control of the local cytotransmitter acetylcholine...

journal_title：Life sciences

authors： Grando SA

更新日期：2003-03-28 00:00:00

abstract：AIMS:The goal of the current study was to evaluate the impact of maternal sodium intake during gestation on the systemic and renal renin-angiotensin-aldosterone-system (RAAS) of the adult offspring. MAIN METHODS:Female Wistar rats were fed high- (HSD-8.0% NaCl) or normal-sodium diets (NSD-1.3% NaCl) from 8 weeks of ag...

journal_title：Life sciences

authors： Ramos DR,Costa NL,Jang KL,Oliveira IB,da Silva AA,Heimann JC,Furukawa LN

更新日期：2012-05-22 00:00:00

abstract：:The study was designed to investigate the role of molybdenum iron-sulfur flavin hydroxylases in the pathogenesis of liver injuries induced by structurally and mechanistically diverse hepatotoxicants. While carbon tetrachloride (CCl4), thioacetamide (TAA) and chloroform (CHCl3) inflict liver damage by producing free ra...

journal_title：Life sciences

authors： Ali S,Pawa S,Naime M,Prasad R,Ahmad T,Farooqui H,Zafar H

更新日期：2008-03-26 00:00:00

abstract：:Ozone is a highly efficient disinfectant which may have significant advantages in water treatment compared to chlorine. It has, however, been shown that mutagenic and possibly carcinogenic byproducts may be produced under certain conditions of ozonation. Light chlorination following ozonization may meet the highest st...

journal_title：Life sciences

authors： Carmichael NG,Winder C,Borges SH,Backhouse BL,Lewis PD

更新日期：1982-01-11 00:00:00

abstract：:This study was designed to document possible changes in bupivacaine and its main metabolite, des-butyl-bupivacaine (PPX) kinetics in mice after a single 5 mg/kg injection of diltiazem. After a single 20 mg/kg i.p. dose of bupivacaine, kinetic parameters of bupivacaine were not statistically different but the ratio AUC...

journal_title：Life sciences

authors： Bruguerolle B,Lorec AM

更新日期：1994-01-01 00:00:00

abstract：:The purpose of this study was to characterize behavioral interactions between glutamatergic and serotonergic 5-HT2 receptors. Both competitive (AP-5 [D-2-amino-5-phosphovalerate] and D-CPP [3-(2carboxypiperazine-4yl)-propylphosphonate]) and noncompetitive (MK-801 [dizocilpine], ketamine, dextrorphan and dextromethorph...

journal_title：Life sciences

authors： Kim HS,Park IS,Park WK

更新日期：1998-01-01 00:00:00

abstract：AIM:This study was undertaken to examine the effect of cyclooxygenase (COX) 2 inhibition on the development of muscular insulin resistance in high-fat-induced obese rats. MAIN METHODS:The rats were on a regular chow diet (C) or high-fat enriched diet (HFD) energy-restrictedly (HFr), or ad libitum (HFa) for 12weeks. Th...

journal_title：Life sciences

authors： Tian YF,Hsia TL,Hsieh CH,Huang DW,Chen CH,Hsieh PS

更新日期：2011-07-18 00:00:00

abstract：:The pigeon crop-sac is a well-known target organ of prolactin (PRL). Pukac and Horseman (Endocrinology 114: 1718, 1984) reported that injections of the hormone caused changes in the expression of several specific proteins in that organ. We investigated the possibility that measuring the amounts of three of these prote...

journal_title：Life sciences

authors： Lebovic DI,Nicoll CS

更新日期：1992-01-01 00:00:00

abstract：:During the myocardial protection induced by ischemic preconditioning a reduction in myocardial metabolism occurs due to activation of the A1 adenosine receptors. This study investigates whether preconditioning changes both resting coronary flow and the magnitude of coronary reactive hyperemia and whether A1 adenosine ...

journal_title：Life sciences

authors： Pagliaro P,Penna C,Gattullo D

更新日期：1999-01-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), the major secretory product of the human adrenal cortex, significantly declines with advanced age. We have previously demonstrated that DHEA prevents the reduction in non-amyloidogenic APP processing, following prolonged stimulation of the muscarinic receptor, in PC12 cells that express ...

journal_title：Life sciences

authors： Danenberg HD,Haring R,Fisher A,Pittel Z,Gurwitz D,Heldman E

更新日期：1996-01-01 00:00:00

abstract：:The effect of several anti-inflammatory drugs (NSAIDs), the calmodulin inhibitor W-7 and cortisol on vanadate-induced tonic contraction and on calmodulin dependent cAMP-phosphodiesterase activity have been assayed. Indomethacin, diclofenac, phenylbutazone, mefenamic acid, naproxen, tolmetin, piroxicam, aspirin and W-7...

journal_title：Life sciences

authors： Cantabrana B,Perez Vallina JR,Menéndez L,Hidalgo A

更新日期：1995-01-01 00:00:00

abstract：:Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melano...

journal_title：Life sciences

authors： Castrucci AM,Lebl M,Hruby VJ,Matsunaga TO,Hadley ME

更新日期：1989-01-01 00:00:00

abstract：:There is increasing evidence that the 5'UTR of mRNAs affects regulation of gene expression in eukaryotic cells. We examined the overexpression of the mu-opioid receptor in High Five insect cells, employing rat mu-receptor cDNA linked to variable lenghts of their native 5'UTR. The sequences employed consist of either 2...

journal_title：Life sciences

authors： Belke-Louis GF,Wehmeyer A,Schulz R

更新日期：1999-01-01 00:00:00

abstract：:The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response ...

journal_title：Life sciences

authors： Schedel JM,Tanaka H,Kiyonaga A,Shindo M,Schutz Y

更新日期：1999-10-29 00:00:00

abstract：:Growth-related oncogene protein-alpha (GRO-alpha) is a member of the C-X-C chemokine family with a wide variety of biological activities. We studied the production of GRO-alpha by human umbilical vein endothelial cells (HUVEC) in response to the stimulation with soluble form of interleukin-6 receptor alpha (sIL-6R). s...

journal_title：Life sciences

authors： Matsumiya T,Imaizumi T,Itaya H,Shibata T,Yoshida H,Sakaki H,Kimura H,Satoh K

更新日期：2002-05-17 00:00:00

abstract：:The herbal medicine, Echinacea, is used for treatment and prevention of upper respiratory tract infections. Among the phytochemicals found in Echinacea, the bioavailable alkylamides are thought to be the compounds responsible for its effects on the human immune system. Cytochrome P450 enzymes (P450s) appear to be the ...

journal_title：Life sciences

authors： Toselli F,Matthias A,Gillam EM

更新日期：2009-07-17 00:00:00

abstract：:Prenatal exposure to nicotine has been shown to produce postnatal up-regulation of central nervous system nicotinic receptors and to alter subsequent differentiation of neural tissues. In the current study, pregnant rats received nicotine infusions of 6 mg/kg/day throughout gestation, administered by osmotic minipump ...

journal_title：Life sciences

authors： Slotkin TA,Lappi SE,Tayyeb MI,Seidler FJ

更新日期：1991-01-01 00:00:00