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Plasma levels and biochemical characterisation of circulating met-enkephalin in canine endotoxin shock.

Abstract：

:Endogenous opioid peptides have been implicated in the pathophysiology of shock (1-5). In anaesthetised mongrel dogs, administration of E coli endotoxin caused a rise in plasma met-enkephalin-like immunoreactivity (MLI). Biochemical characterisation of MLI by gel filtration chromatography revealed various molecular forms: 31K, 8K, 3-5K and the native pentapeptide in approximately equal amounts. After enzymatic treatment of column fractions the 31K form predominated (90.7%). This is the first demonstration of elevated MLI in endotoxin shock.

journal_name

Life Sci

journal_title

Life sciences

authors

Evans SF,Medbak S,Hinds CJ,Tomlin SJ,Varley JG,Rees LH

doi

10.1016/0024-3205(84)90063-8

subject

Has Abstract

pub_date

1984-04-09 00:00:00

pages

1481-6

issue

15

eissn

0024-3205

issn

1879-0631

pii

0024-3205(84)90063-8

journal_volume

34

pub_type

杂志文章

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