Abstract：
:The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus. The dose response relationships for LSD alone and in combination with either (+)- or (-)-fluoxetine were determined. In both instances, the LSD dose response relationship was shifted to the left. However, statistical significance was observed only for the (+)- enantiomer. It is concluded that the effects of LSD as a discriminative stimulus are potentiated by the acute administration of fluoxetine. These results are consistent with anecdotal reports of interactions between LSD and acutely administered SSRIs in humans.
journal_name
Life Scijournal_title
Life sciencesauthors
Fiorella D,Helsley S,Rabin RA,Winter JCdoi
10.1016/0024-3205(96)00490-0subject
Has Abstractpub_date
1996-01-01 00:00:00pages
PL283-7issue
18eissn
0024-3205issn
1879-0631pii
0024320596004900journal_volume
59pub_type
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