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Evidence for two binding sites on membrane-bound angiotensin-converting enzymes (ACE) for exogenous inhibitors except in testis.

Abstract：

:It was possible to assess that ACE inhibitors bound to two different sites on the enzymes which consist in two homologous domains. Accordingly, it was also shown that testis ACE which consists in a single domain exhibits only one site for inhibitors. The common binding site of both enzymes contains Zn2+, bears the enzymatic activity, is less sensitive to added Zn2+ and Cl- and has a lower affinity for inhibitors than the first one, found only in duplicated domain enzymes and highly sensitive to the effect of ions.

journal_name

Life Sci

journal_title

Life sciences

authors

Brée F,Hamon G,Tillement JP

doi

10.1016/0024-3205(92)90489-c

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

787-94

issue

10

eissn

0024-3205

issn

1879-0631

pii

0024-3205(92)90489-C

journal_volume

51

pub_type

杂志文章

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