Cholecystokinin receptor mediated hydrolysis of inositol phospholipids in guinea pig gastric glands.

abstract：AIMS:Obesity represents a global health problem. Excessive caloric intake promotes the release of inflammatory mediators by hypertrophic adipocytes and obesity-induced inflammation is now recognized as a risk factor for the development of several diseases, such as cardiovascular diseases, insulin resistance, type-II di...

journal_title：Life sciences

authors： Sardi C,Martini E,Mello T,Camelliti S,Sfondrini L,Marcucci F,Kallikourdis M,Sommariva M,Rumio C

更新日期：2021-01-01 00:00:00

abstract：:The effect on thermonociceptive threshold of intrathecally (i.t.) administered angiotensin II (Ang II) was assessed in the rat tail-flick test. Rats were pretreated, 15 min earlier, with i.t. naloxone (opiate antagonist), losartan (Ang II selective antagonist at AT1 receptor) or [Sar1, Leu8] Ang II (non selective Ang ...

journal_title：Life sciences

authors： Toma N,Sgambato V,Couture R

更新日期：1997-01-01 00:00:00

abstract：:Proteinaceous inhibitors with high inhibitory activities against human neutrophil elastase (HNE) were found in seeds of the Tamarind tree (Tamarindus indica). A serine proteinase inhibitor denoted PG50 was purified using ammonium sulphate and acetone precipitation followed by Sephacryl S-300 and Sephadex G-50 gel filt...

journal_title：Life sciences

authors： Fook JM,Macedo LL,Moura GE,Teixeira FM,Oliveira AS,Queiroz AF,Sales MP

更新日期：2005-05-06 00:00:00

abstract：AIMS:Several experimental studies have demonstrated that removal of the spleen accelerates liver regeneration after partial hepatectomy. While the mechanism of splenectomy promotes liver regeneration by the improvement of the formation of tight junction and the establishment of hepatocyte polarity is still unknown. MA...

journal_title：Life sciences

authors： Liu G,Xie C,Fang Y,Qian K,Liu Q,Liu G,Cao Z,Du H,Fu J,Xu X

更新日期：2018-01-01 00:00:00

abstract：:Previous studies have shown that cytochrome P450-Arachidonic Acid (P450-AA) metabolites modify the vascular tone of several vessels and that vasopressin (AVP) stimulates P450-AA metabolism. Thus, in the present study, we decided to investigate if the vasoconstrictor effect of AVP is related to activation of P450-AA me...

journal_title：Life sciences

authors： Vazquez B,Rios A,Escalante B

更新日期：1995-01-01 00:00:00

abstract：:Convulsive seizures are a potential side effect of antidepressant drug treatment and can be produced by all classes of antidepressants. It is also known that some convulsant and anticonvulsant drug actions are mediated by the GABA-receptor chloride-ionophore complex. Drugs acting at this complex appear to induce convu...

journal_title：Life sciences

authors： Malatynska E,Knapp RJ,Ikeda M,Yamamura HI

更新日期：1988-01-01 00:00:00

abstract：:The multidrug transporter MDR1 (P-glycoprotein)-mediated interaction between digoxin and 29 antihypertensive drugs of various types was examined by using the MDR1 overexpressing LLC-GA5-COL150 cells, which were established by transfecting MDR1 cDNA into porcine kidney epithelial LLC-PK1 cells. These cells construct mo...

journal_title：Life sciences

authors： Takara K,Kakumoto M,Tanigawara Y,Funakoshi J,Sakaeda T,Okumura K

更新日期：2002-02-15 00:00:00

abstract：:Of primary interest for every enzyme is the identification of its physiological substrates. However, the vast structural diversity of endogenous metabolites, coupled with the overlapping activities of numerous enzymes, makes it difficult to deduce the identity of natural substrates for a given enzyme based on in vitro...

journal_title：Life sciences

authors： Saghatelian A,Cravatt BF

更新日期：2005-08-19 00:00:00

abstract：:The effects of methylprednisolone (m-PSL) on IL-1beta-induced neutrophil-endothelial cell interactions, which are normally mediated by increased expression of both intercellular adhesion molecule-1 (ICAM-1) and E-selectin on endothelial cells, were examined using an in vitro flow system. Human neutrophilic polymorphon...

journal_title：Life sciences

authors： Yoshida N,Yoshikawa T,Nakamura Y,Takenaka S,Sakamoto K,Manabe H,Nakagawa S,Kondo M

更新日期：1997-01-01 00:00:00

abstract：:Nitric oxide (NO) plays a critical role in the pathogenesis of endotoxin-induced uveitis (EIU). Since NO is a labile free radical, it is difficult to examine the dynamics of NO directly in vivo. In this study, we established a system for direct monitoring of the dynamics of NO and partial pressure of oxygen (pO(2)) in...

journal_title：Life sciences

authors： Yomura Y,Shoji Y,Asai D,Murakami E,Ueno S,Nakashima H

更新日期：2007-03-27 00:00:00

abstract：:Phosphoesterase complex (Pho), a major active component of barley malt, has been demonstrated to be clinically effective in relieving alcoholic fatty liver disease (AFLD), and several lines of evidence have suggested that microbial dysbiosis, caused by chronic alcohol overconsumption, plays a key role in the progressi...

journal_title：Life sciences

authors： Ma D,Hu J,Xu W,Wang Y,Wang J,Li L,Wang S,Zhou H,Li Y,Liu L

更新日期：2020-12-01 00:00:00

abstract：:We investigated the effects of the chronic administration of hesperetin on the activation of the antioxidant defence system in mice in which oxidative stress had been induced by 7,12-dimethylbenz(a)anthracene (DMBA). Mice were divided randomly into three treatment groups. Hesperetin was administered orally to two of t...

journal_title：Life sciences

authors： Choi EJ

更新日期：2008-05-23 00:00:00

abstract：:Losartan, a recently developed nonpeptide angiotensin II (Ang II) receptor antagonist, was administered orally to 10-week-old spontaneously hypertensive rats (SHR) for 2 weeks. Cardiac weight and tissue Ang II, as well as plasma renin activity (PRA) and Ang II, were determined. Treatment with Losartan (10 mg/kg per da...

journal_title：Life sciences

authors： Mizuno K,Tani M,Hashimoto S,Niimura S,Sanada H,Watanabe H,Ohtsuki M,Fukuchi S

更新日期：1992-01-01 00:00:00

abstract：:According to recent epidemiological reports, almost 40% of American population use complimentary and alternative medicine (CAM) during their lifetime. Patients detected with HIV or cancer often consume herbal products especially St. John's wort (SJW) for antidepressants in combination with prescription medicines. Such...

journal_title：Life sciences

authors： Pal D,Mitra AK

更新日期：2006-03-27 00:00:00

abstract：:Binding studies conducted on membrane preparation from human platelets using (3H) Ro5-4864 and (3H) diazepam showed specific and saturable binding. Scatchard analysis revealed a single class of binding sites with KD = 10.8 +/- 0.9 nM and Bmax = 775 +/- 105 fmol/mg protein for (3H) Ro5-4864 and KD = 10.5 +/- 1.1 nM and...

journal_title：Life sciences

authors： Moingeon P,Dessaux JJ,Fellous R,Alberici GF,Bidart JM,Motté P,Bohuon C

更新日期：1984-11-12 00:00:00

abstract：:Administration of a high dose of hydrocortisone hemisuccinate sodium (0.25 mumol/egg) to 15-day-old fertilized hen's eggs caused accumulation of biliverdin in the embryonic liver. The responses were 10 to 20-fold higher than controls within 48 hr as a result of stimulation of biliverdin synthesis in the liver and the ...

journal_title：Life sciences

authors： Nishigori H,Ishida O,Ogihara-Umeda I

更新日期：1993-01-01 00:00:00

abstract：:In the biosynthesis of adrenomedullin (AM), glycine-extended AM, an intermediate form (iAM) processed from proAM is converted to AM[1-52]-NH2, the bioactive mature form of AM (mAM), by enzymatic amidation. We earlier showed that both molecular forms of AM circulate in human plasma. In the present study, to investigate...

journal_title：Life sciences

authors： Hirayama N,Kitamura K,Imamura T,Kato J,Koiwaya Y,Eto T

更新日期：1999-01-01 00:00:00

abstract：AIMS:This study was designed to investigate the molecular mechanisms underlying the anti-inflammatory and anti-fibrosis effects of Berberine hydrochloride (BBR) following canalicular laceration (CL) surgical repair. MAIN METHODS:We used a rabbit CL model in this study. BBR and the control medicine were administered du...

journal_title：Life sciences

authors： Bai F,Tao H,Wang P,Wang L,Zhou X,Wang F,Liu C,Huang Y

更新日期：2020-11-15 00:00:00

abstract：:We administered intravenous adenosine to 11 neonatal rabbits. Adenosine depressed respiration in 10 of 11 rabbits. For the group as a whole the adenosine-induced respiratory depression was highly significant (p less than 0.001). After aminophylline administration to the same animals the respiratory effect of intraveno...

journal_title：Life sciences

authors： Watt AH,Buss DC,Routledge PA

更新日期：1987-01-05 00:00:00

abstract：:Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. First isolated from bovine adrenal medulla, the peptide was also shown to be present in the pituitary, brain, adrenal glands, blood plasma, lungs and spleen. At the subcellular level, hist...

journal_title：Life sciences

authors： Lemaire S,Rogers C,Dumont M,Shukla VK,Lapierre C,Prasad J,Lemaire I

更新日期：1995-03-03 00:00:00

abstract：:The effects of environmental cues explicitly paired or unpaired with pentobarbital on the thermic effects of pentobarbital and amphetamine were investigated. Rats received 19 injections of pentobarbital in a distinctive environment and were subsequently tested for the thermic effects of pentobarbital and amphetamine i...

journal_title：Life sciences

authors： Hinson RE,Rhijnsburger M

更新日期：1984-06-25 00:00:00

abstract：:The role of the autonomic nervous system in the modulation of the immune response to emotional stimuli, was established in rats subjected to the passive avoidance test. An increase in splenic primary antibody response directed against SRBC was found after exposure of rats to the passive avoidance apparatus (novelty). ...

journal_title：Life sciences

authors： Croiset G,Heijnen CJ,van der Wal WE,de Boer SF,de Wied D

更新日期：1990-01-01 00:00:00

abstract：AIMS:Metformin is an insulin sensitizing agent with beneficial effects in diabetic patients on glycemic levels and in the cardiovascular system. We examined whether the metabolic changes and the vascular dysfunction in monosodium glutamate-induced obese non-diabetic (MSG) rats might be improved by metformin. MAIN METH...

journal_title：Life sciences

authors： Lobato NS,Filgueira FP,Hagihara GN,Akamine EH,Pariz JR,Tostes RC,Carvalho MH,Fortes ZB

更新日期：2012-01-30 00:00:00

abstract：:Reportedly, excitatory amino acids are involved in the control of gonadotropin secretion of rats and non-human primates. The aim of this study was to investigate the effect of chronic blockade of NMDA (N-methyl-D-aspartic acid) receptors by the non competitive receptor antagonist MK-801 on gonadotropin secretion and t...

journal_title：Life sciences

authors： Veneroni O,Cocilovo L,Müller EE,Cocchi D

更新日期：1990-01-01 00:00:00

abstract：:The α chain of interleukin 3 receptor (IL-3Rα or CD123), together with the common β (βc) subunit, forms a high-affinity IL-3R with biological function. In recent years, emerging research has found that CD123 is highly expressed on the surface of various cells (e.g., leukemia stem cells, LSCs), and it is associated wit...

journal_title：Life sciences

authors： Liu K,Zhu M,Huang Y,Wei S,Xie J,Xiao Y

更新日期：2015-02-01 00:00:00

abstract：:The conversion of lyso-platelet activating factor (lyso-PAF) to PAF in cultured paranasal sinus mucosa obtained from normal human subjects was studied. The PAF concentration in the medium was determined after addition of lyso-PAF. PAF became detectable at 10 minutes after the addition of 10(-8)M lyso-PAF, and reached ...

journal_title：Life sciences

authors： Inoue H,Ganbo T,Hisamatsu K,Ishida H

更新日期：1993-01-01 00:00:00

abstract：AIMS:Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K+ currents via voltage-gated potassium (Kv) channels and inward rectifi...

journal_title：Life sciences

authors： Li W,Dong M,Guo P,Liu Y,Jing Y,Chen R,Zhang M

更新日期：2019-03-15 00:00:00

abstract：AIMS:The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role of serotonergic descending inhibitory pain pathways in antihyperalgesic effectiveness of zonisamide i...

journal_title：Life sciences

authors： Bektas N,Arslan R,Ozturk Y

更新日期：2014-01-24 00:00:00

abstract：:In the present study, we investigated the effects of calmodulin, adenosine 5'-triphosphate (ATP) and pertussis toxin (PT) on phorbol ester (PMA) (a protein kinase C activator) induced inhibition of ANF-stimulated cyclic GMP formation in cells from the human renal cell line, SK-NEP-1. PMA inhibited ANF-stimulated guany...

journal_title：Life sciences

authors： Sekiya M,Frohlich ED,Cole FE

更新日期：1991-01-01 00:00:00

abstract：AIMS:We performed a systematic review and meta-analysis on the effect of HIV infection and antiretroviral therapy (ART) on carotid intima-media thickness (cIMT) to elucidate the role of HIV infection and ART. Also, an analysis on the role of ethnicity and gender on cIMT in HIV-infected populations was performed. MAIN ...

journal_title：Life sciences

authors： Msoka TF,Van Guilder GP,van Furth M,Smulders Y,Meek SJ,Bartlett JA,Vissoci JRN,van Agtmael MA

更新日期：2019-10-15 00:00:00