Benzodiazepine agonists reverse the effects of noise exposure on central benzodiazepine receptors and cardiac responsiveness.

Abstract:

:Rats were submitted to 110 dB white noise exposure for 1, and 6 hours and brain alpha 1, beta 1 and benzodiazepine receptor binding was evaluated with selective ligands. An increase in cerebral benzodiazepine receptor (CBR) concentration, without any significant change in affinity constant, occurred after the 6 h treatment; no change was observed in adrenergic receptor binding at any period of exposure. Both diazepam and clonazepam pre-treatment reversed the effects of noise on CBR binding, confirming a role of these receptors in the response to noise stress. Furthermore, these benzodiazepine agonists influenced the response of cardiac and aortic tissues, which are known to be changed by stress exposure. Diazepam and clonazepam pre-treatment protected cardiac tissue from the effects of 6h noise stress, and a potentiation of aortic responses was detected, although at different times of exposure. The differences between the responses of these peripheral tissues to benzodiazepine treatment suggest that the expression depends on the tissue examined and the period of exposure.

journal_name

Life Sci

journal_title

Life sciences

authors

Breschi MC,Martini C,Scatizzi R,Cristofani R,Giannaccini G,Martinotti E,Lucacchini A

doi

10.1016/0024-3205(95)02058-q

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

1131-40

issue

11

eissn

0024-3205

issn

1879-0631

pii

002432059502058Q

journal_volume

57

pub_type

杂志文章
  • Chronic intermittent hypobaric hypoxia protects vascular endothelium by ameliorating autophagy in metabolic syndrome rats.

    abstract:AIMS:The study aimed to investigate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) on endothelium function and relaxation of mesenteric artery in metabolism syndrome (MS) rats. MAIN METHODS:Male adult Sprague-Dawley rats were randomly divided into control (CON), CIHH (treated with 28-days hypob...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2018.05.008

    authors: Cui F,Guan Y,Guo J,Tian YM,Hu HF,Zhang XJ,Zhang Y

    更新日期:2018-07-15 00:00:00

  • The effects of verapamil and ethanol on body temperature and motor coordination.

    abstract::Male, adult mice of the Binghamton heterogeneous stock received one of two doses of ethanol (1.0 g/kg or 2.0 g/kg in saline) alone or in combination with the calcium (Ca2+) slow channel blocker, verapamil (5.45 mg/kg in 25% v/v ethanol in saline). Hypothermic responses and motor incoordination were assessed in terms o...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(86)90357-7

    authors: Johnston JE,Draski LJ,Molina JC,Burright RG,Reynoso G,Calendrillo BA,Isaacson RL

    更新日期:1986-12-01 00:00:00

  • Bacterial endotoxin lipopolysaccharide induces up-regulation of glyceraldehyde-3-phosphate dehydrogenase in rat liver and lungs.

    abstract::Bacterial endotoxin or lipopolysaccharide (LPS) can trigger inflammatory responses and cause damage in organs such as liver and lungs when it is introduced into mammals, but the exact molecular events that mediate these responses have remained obscure. In this study, by using 2D gel electrophoresis and cDNA microarray...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2006.06.018

    authors: Xie W,Shao N,Ma X,Ling B,Wei Y,Ding Q,Yang G,Liu N,Wang H,Chen K

    更新日期:2006-10-04 00:00:00

  • Serotonin uptake inhibitors and the prejunctional effects of serotonin on peripheral sympathetic nerves.

    abstract::The experiments were designed to study whether the inhibitors of the uptake of serotonin (5-HT) potentiated the prejunctional effects of 5-HT on peripheral sympathetic nerves. The effect of two selective 5-HT uptake inhibitors, citalopram and fluoxetine, were studied on the presynaptic actions of 5-HT in the cat isola...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(86)90438-8

    authors: Adler-Graschinsky E,Butta NV,Elgoyhen AB

    更新日期:1986-07-07 00:00:00

  • Characterization of monoamine oxidase isoforms in human islets of Langerhans.

    abstract::In this paper, we describe the characterization of the expression of monoamine oxidase (MAO) in whole pancreas and in isolated islets of Langerhans from human. Classical monamine oxidase activity assays reveal that both isoforms A & B are present in human pancreas. Two complementary approaches indicated that both MAO ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(99)00265-9

    authors: Pizzinat N,Chan SL,Remaury A,Morgan NG,Parini A

    更新日期:1999-01-01 00:00:00

  • Verapamil counteracts depression but not long-lasting potentiation of the hippocampal population spike.

    abstract::In transversely sectioned rat hippocampal slices, population spikes and population "EPSPs" were recorded from CA1 neurones in response to the stimulation of Schaffer collateral and commissural inputs. High frequency tetanic stimulation (400 Hz, 200 pulses) of an input induced LLP of the homosynaptic response without s...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(84)90021-3

    authors: Sastry BR,Chirwa SS,Goh JW,Maretic H,Pandanaboina MM

    更新日期:1984-03-12 00:00:00

  • The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease.

    abstract:AIM:The aim of the present study was to assess and compare the effect of 17β-estradiol and two different selective estrogen receptor modulators (SERMs), tamoxifen and raloxifene, as well as a selective estrogen receptor alpha agonist, propyl-pyrazole-triol (PPT) and a selective estrogen receptor beta agonist, diarylpro...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2011.03.010

    authors: Baraka AM,Korish AA,Soliman GA,Kamal H

    更新日期:2011-05-09 00:00:00

  • The negative effect of dexamethasone on calcium-processing gene expressions is associated with a glucocorticoid-induced calcium-absorbing disorder.

    abstract:AIMS:Although dexamethasone (Dex) is used widely as an anti-inflammatory and immunosuppressive drug, Dex appears to have severe side-effects, including osteoporosis. This study determined the effects of Dex on duodenal and renal expressions of the calcium-processing genes transient receptor potential cation channel, su...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2009.05.013

    authors: Kim MH,Lee GS,Jung EM,Choi KC,Jeung EB

    更新日期:2009-07-17 00:00:00

  • Mechanism of wortmannin-induced inhibition of secretory responses in rat adrenal medullary cells.

    abstract::The effect of wortmannin (WT), an inhibitor of myosin light chain kinase (MLCK) as well as PI3-kinase, on catecholamine (CA) secretion in the perfused rat adrenal medulla was studied. After a 35-min application of 10 microM WT, secretory response to repetitive stimulation with 30 mM extracellular K+ was reduced to 30%...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(00)00842-0

    authors: Warashina A

    更新日期:2000-10-13 00:00:00

  • Effects of acute exhaustive physical exercise upon glutamine metabolism of lymphocytes from trained rats.

    abstract::Transitory immunosupression is reported after intense exercise, especially after an increase in training overload and in overtraining. The influence of intense exercise on plasma hormones and glutamine concentration may contribute to this effect. However, the effect of such exercise-induced changes upon lymphocyte and...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2006.10.015

    authors: Santos RV,Caperuto EC,Costa Rosa LF

    更新日期:2007-01-16 00:00:00

  • Over expression of bone morphogenetic protein-3b (BMP-3b) using an adenoviral vector promote the osteoblastic differentiation in C2C12 cells and augment the bone formation induced by bone morphogenetic protein-2 (BMP-2) in rats.

    abstract::BMP-3b is a novel BMP-3-related protein and its biological functions are unknown. In order to investigate the biological actions of BMP-3b, we constructed a BMP-3b-expressing recombinant adenoviral vector (AxCAKBMP-3b). We show that over expression of BMP-3b stimulated the induction of differentiation and the osteoind...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(02)02477-3

    authors: Kaihara S,Bessho K,Okubo Y,Sonobe J,Komatsu Y,Miura M,Miyatake S,Nakao K,Iizuka T

    更新日期:2003-02-28 00:00:00

  • Neutralizing IL-6 reduces heart injury by decreasing nerve growth factor precursor in the heart and hypothalamus during rat cardiopulmonary bypass.

    abstract:AIMS:To investigate whether the expression of nerve growth factor precursor (proNGF) changes during cardiopulmonary bypass (CPB) and whether neutralizing interleukin-6 (IL-6) during CPB has cardiac benefits. MAIN METHODS:Thirty patients undergoing CPB were recruited and their serum proNGF and troponin-I (TNI) were det...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2017.04.007

    authors: Cheng C,Xu JM,Yu T

    更新日期:2017-06-01 00:00:00

  • Puerarin attenuates palmitate-induced mitochondrial dysfunction, impaired mitophagy and inflammation in L6 myotubes.

    abstract:AIMS:High level of saturated fatty acids leads to mitochondrial dysfunction and inflammation in the development of insulin resistance in skeletal muscle. We recently found that puerarin improved impaired insulin signaling in skeletal muscle in diabetic animals and in myotubes in vitro. However, whether puerarin can act...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2018.05.041

    authors: Chen X,Yi L,Song S,Wang L,Liang Q,Wang Y,Wu Y,Gao Q

    更新日期:2018-08-01 00:00:00

  • MiR-27b suppresses epithelial-mesenchymal transition and chemoresistance in lung cancer by targeting Snail1.

    abstract:HEADING AIMS:MicroRNA-27b (miR-27b) has been shown to play a role in the progression of many different forms of cancer, but its specific relevance in the context of non-small cell lung cancer (NSCLC) remains uncertain. As such, this study sought to explore the role of miR-27b in NSCLC and the mechanisms whereby it func...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2019.117238

    authors: Zhang J,Hua X,Qi N,Han G,Yu J,Yu Y,Wei X,Li H,Chen X,Leng C,Liu Q,Lu Y,Li Y

    更新日期:2020-08-01 00:00:00

  • Routes of administration and effect of carbidopa pretreatment on 6-[18F]fluoro-L-dopa/PET scans in non-human primates.

    abstract::In 6-[18F]fluoro-L-dopa (Fdopa)/positron emission tomography (PET) studies, carbidopa pretreatment increases the Fdopa bioavailability to the brain and enhances the intensity of striatal PET images. Different PET research teams have used various carbidopa doses and routes of administration in non-human primate studies...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(95)00147-x

    authors: Chan GL,Doudet DJ,Dobko T,Hewitt KA,Schofield P,Pate BD,Ruth TJ

    更新日期:1995-01-01 00:00:00

  • Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression.

    abstract:AIMS:Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. MAIN METHODS:Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assay...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2013.01.031

    authors: Sogawa N,Hirai K,Sogawa C,Ohyama K,Miyazaki I,Tsukamoto G,Asanuma M,Sasaki A,Kitayama S

    更新日期:2013-04-09 00:00:00

  • Serum type III, IV collagens and TIMP in patients with type II diabetes mellitus.

    abstract::We investigated serum levels of type III procollagen aminopeptide (CIII), 7S type IV collagen (CIV), and tissue inhibitor of metalloproteinase (TIMP) in 33 patients with type II diabetes mellitus (DM) without uremia (serum creatinine less than 1.5 mg/dl). The patients were divided into three groups based on measuremen...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(96)00099-9

    authors: Ishimura E,Nishizawa Y,Shoji S,Mori H

    更新日期:1996-01-01 00:00:00

  • Immunopathogenesis of HTLV-1-assoaciated myelopathy/tropical spastic paraparesis (HAM/TSP).

    abstract::Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic, and HAM/TSP...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2014.03.025

    authors: Fuzii HT,da Silva Dias GA,de Barros RJ,Falcão LF,Quaresma JA

    更新日期:2014-05-28 00:00:00

  • The importance of estrogen for bone protection in experimental hyperthyroidism in human osteoblasts.

    abstract::Triiodothyronine (T3) and estrogen (E2) play important roles in the bone remodeling process and signaling of receptor activator of the nuclear factor-kappa β (RANKL) and osteoprotegerin (OPG) expressed by osteoblasts. However, little is known of the molecular action of these hormones in conditions of hyperthyroidism a...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2019.116556

    authors: Olímpio RMC,Moretto FCF,De Sibio MT,de Oliveira M,Mathias LS,Gonçalves BM,Deprá IC,Tilli HP,Rodrigues BM,Saraiva PP,Maria DA,Nogueira CR

    更新日期:2019-08-15 00:00:00

  • Insulin analogs: Glimpse on contemporary facts and future prospective.

    abstract::Insulin remains a predominant life-saving medication for type 1 and type 2 Diabetes Mellites. Natural insulin secretion limits the fluctuation of the narrow and high surge of blood glucose levels. However, imitating the same by external insulin remains a challenge as a variety of insulin analogs (rapid acting, short a...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2019.01.011

    authors: Sharma AK,Taneja G,Kumar A,Sahu M,Sharma G,Kumar A,Sardana S,Deep A

    更新日期:2019-02-15 00:00:00

  • TNF-α and cancer cachexia: Molecular insights and clinical implications.

    abstract::Cancer cachexia characterized by a chronic wasting syndrome, involves skeletal muscle loss and adipose tissue loss and resistance to conventional nutritional support. Cachexia is responsible for the reduction in quality and length of life of cancer patients. It also decreases the muscle strength of the patients. The p...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2016.11.033

    authors: Patel HJ,Patel BM

    更新日期:2017-02-01 00:00:00

  • Schisantherin A causes endothelium-dependent and -independent vasorelaxation in isolated rat thoracic aorta.

    abstract:AIMS:Schisandra is a good choice in Traditional Chinese Medicine for the therapy of cardiovascular diseases, but whether it contains a or some specific component (s) responsible these effects are still unclear. In the present study, we explored whether Schisantherin A (SCA) causes vasorelaxation in isolated rat thoraci...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.117357

    authors: Yang S,Xu Z,Lin C,Li H,Sun J,Chen J,Wang C

    更新日期:2020-03-15 00:00:00

  • Stimulation of the Na+,K(+)-ATPase activity of K562 human erythroleukemia cells by triiodothyronine.

    abstract::The effect of triiodothyronine (T3) on Na+,K(+)-ATPase activity of K562 human erythroleukemic cell was studied to understand why the erythrocyte sodium pump activity is decreased in hyperthyroidism. Na+,K(+)-ATPase activity of K562 cell lysates was assayed by measuring the release of inorganic phosphate (Pi) from ATP....

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(92)90107-z

    authors: Arumanayagam M,Swaminathan R

    更新日期:1992-01-01 00:00:00

  • Ajulemic acid, a synthetic cannabinoid acid, induces an antiinflammatory profile of eicosanoids in human synovial cells.

    abstract:AIMS:To better understand mechanisms whereby Ajulemic acid (AjA), a synthetic antiinflammatory cannabinoid, promotes resolution of acute and chronic inflammation in animal models, we investigated its influence on cyclooxygenase 2 (COX2) expression and eicosanoid production in human fibroblast-like synovial cells (FLS)....

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2008.09.004

    authors: Stebulis JA,Johnson DR,Rossetti RG,Burstein SH,Zurier RB

    更新日期:2008-11-07 00:00:00

  • Tetrandrine, a calcium antagonist of Chinese herbal origin, interacts with vascular muscle alpha 1-adrenoceptor.

    abstract::The effects of tetrandrine (TET) on the contractile responses of rat aortic rings and perfused rat mesenteric arteries to phenylephrine (PE) were investigated. TET inhibited the maximal contraction to PE in a concentration-dependent manner. TET significantly inhibited the transient contraction in Ca(2+)-free medium pr...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(96)00552-8

    authors: Kwan CY,Chen YY,Ma MF,Daniel EE,Hui SC

    更新日期:1996-01-01 00:00:00

  • Metformin promotes autophagy in ischemia/reperfusion myocardium via cytoplasmic AMPKα1 and nuclear AMPKα2 pathways.

    abstract:AIMS:In myocardial ischemia-reperfusion (MI/R) injury, impaired autophagy function worsens cardiomyocyte death. AMP-activated protein kinase (AMPK) is a heterotrimeric protein that plays an important role in cardioprotection and myocardial autophagic function. AMPKα1 and α2 are localized primarily in the cytoplasm and ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2019.04.002

    authors: Wang Y,Yang Z,Zheng G,Yu L,Yin Y,Mu N,Ma H

    更新日期:2019-05-15 00:00:00

  • Development of vacuous chewing movements in rats: role of housing environment.

    abstract::The influence of stressful experiences on the development of vacuous chewing movements (VCM) was investigated in non-medicated rats. After an initial baseline period one group of rats was housed in a noisy environment while another group was housed in quiet surroundings. The development of VCM was recorded during a 16...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(91)90146-3

    authors: Glenthøj B,Hemmingsen R

    更新日期:1991-01-01 00:00:00

  • Effect of transient receptor potential vanilloid-1 on cough hypersensitivity induced by particulate matter 2.5.

    abstract:AIMS:The mechanism of cough hypersensitivity induced by particulate matter 2.5 (PM2.5) remains elusive. The current study was designed to explore the effect of transient receptor potential vanilloid-1 (TRPV1) on cough hypersensitivity in airway and central nervous system. MAIN METHODS:The PM2.5-induced chronic cough m...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2016.02.064

    authors: Lv H,Yue J,Chen Z,Chai S,Cao X,Zhan J,Ji Z,Zhang H,Dong R,Lai K

    更新日期:2016-04-15 00:00:00

  • Effect of age on contractile response to angiotensin II in rat aorta.

    abstract::The effects of aging on contractile response to angiotensin II and tachyphylaxis to it were investigated using aortic strips from rats aged 1.5, 4 and 22 months. Whether the endothelium was present or not, the contractile response to angiotensin II was greater and tachyphylaxis to it was less in 1.5-month-old rats tha...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(90)90549-7

    authors: Wakabayashi I,Sakamoto K,Hatake K,Yoshimoto S,Kurahashi M

    更新日期:1990-01-01 00:00:00

  • Cod liver oil ameliorates sodium nitrite-induced insulin resistance and degradation of rat hepatic glycogen through inhibition of cAMP/PKA pathway.

    abstract:AIMS:Sodium nitrite is used to inhibit the growth of microorganisms and is responsible for the desirable red color of meat; however, it can be toxic in high quantities for humans and other animals. Moreover, glycogen, a branched polysaccharide, efficiently stores and releases glucose monosaccharides to be accessible fo...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2014.11.002

    authors: Al-Gayyar MM,Alyoussef A,Hamdan AM,Abbas A,Darweish MM,El-Hawwary AA

    更新日期:2015-01-01 00:00:00