Abstract：
AIMS:The aim of this study is to investigate the expression and cytoprotective function of a 72-kDa heat shock protein (HSP72) using a reflux esophagitis model in rats. MAIN METHODS:Expression of HSP60, HSP72, and HSP90 in rat esophageal mucosa was evaluated by Western blot analysis before and after hyperthermia (42.5 degrees C, 20 min). Rats received the operation to produce reflux esophagitis with or without pretreatment with hyperthermia to induce HSPs. The esophageal mucosal damage was evaluated 12 h after the operation. KEY FINDINGS:Expression of HSP72 was significantly increased by hyperthermia in rat esophageal mucosa. Reflux esophagitis was dramatically prevented when HSP72 was preinduced by hyperthermia. Furthermore, activation of TNF-alpha and IL-1beta in esophageal mucosa was also suppressed. SIGNIFICANCE:These results suggested that hyperthermia protects the esophageal mucosa in reflux esophagitis model by inducing HSP72 and suppressing proinflammatory cytokine activation. These findings might suggest that HSP-inducing therapy could be a novel and unique therapy for reflux esophagitis.
journal_name
Life Scijournal_title
Life sciencesauthors
Izumi Y,Otaka M,Takahashi T,Takada M,Shimada Y,Asaoka D,Nagahara A,Itoh H,Watanabe Sdoi
10.1016/j.lfs.2009.01.016subject
Has Abstractpub_date
2009-04-10 00:00:00pages
517-22issue
15-16eissn
0024-3205issn
1879-0631pii
S0024-3205(09)00042-3journal_volume
84pub_type
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