Specific induction of a 72-kDa heat shock protein protects esophageal mucosa from reflux esophagitis.

Abstract:

AIMS:The aim of this study is to investigate the expression and cytoprotective function of a 72-kDa heat shock protein (HSP72) using a reflux esophagitis model in rats. MAIN METHODS:Expression of HSP60, HSP72, and HSP90 in rat esophageal mucosa was evaluated by Western blot analysis before and after hyperthermia (42.5 degrees C, 20 min). Rats received the operation to produce reflux esophagitis with or without pretreatment with hyperthermia to induce HSPs. The esophageal mucosal damage was evaluated 12 h after the operation. KEY FINDINGS:Expression of HSP72 was significantly increased by hyperthermia in rat esophageal mucosa. Reflux esophagitis was dramatically prevented when HSP72 was preinduced by hyperthermia. Furthermore, activation of TNF-alpha and IL-1beta in esophageal mucosa was also suppressed. SIGNIFICANCE:These results suggested that hyperthermia protects the esophageal mucosa in reflux esophagitis model by inducing HSP72 and suppressing proinflammatory cytokine activation. These findings might suggest that HSP-inducing therapy could be a novel and unique therapy for reflux esophagitis.

journal_name

Life Sci

journal_title

Life sciences

authors

Izumi Y,Otaka M,Takahashi T,Takada M,Shimada Y,Asaoka D,Nagahara A,Itoh H,Watanabe S

doi

10.1016/j.lfs.2009.01.016

subject

Has Abstract

pub_date

2009-04-10 00:00:00

pages

517-22

issue

15-16

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(09)00042-3

journal_volume

84

pub_type

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