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Induction of inducible nitric oxide synthase by ginsenosides in cultured porcine endothelial cells.

Abstract：

:Mechanism of Nitric oxide (NO) production by ginsenosides was investigated in cultured porcine endothelial cells. Beta-nicotinamide adenine dinucleotide phosphate (beta-NADPH) staining showed that the NO production was significantly enhanced by the presence of 40 microg/ml ginsenosides with 10 microM L-arginine after 12 h incubation. NO production was suppressed by addition of 0.5 microM Nomega-Nitro-L-arginine (L-NNA), an inhibitor of NO synthases (NOSs), to the incubation medium. In addition, the immunoreactive signals of inducible NOS (iNOS) were appeared in endothelial cells after 12-h incubation of ginsenosides, whereas the signals were not observed in non-treated cells. Our findings suggest that ginsenosides can enhance NO production by induction of iNOS in addition to its direct effect on endothelial cells by increasing intracellular Ca2+ concentration.

journal_name

Life Sci

journal_title

Life sciences

authors

Li Z,Niwa Y,Sakamoto S,Shono M,Chen X,Nakaya Y

doi

10.1016/s0024-3205(00)00880-8

subject

Has Abstract

pub_date

2000-11-03 00:00:00

pages

2983-9

issue

24

eissn

0024-3205

issn

1879-0631

pii

S0024320500008808

journal_volume

67

pub_type

杂志文章

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