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A close correlation between the amount of met-enkephalin-immunoreactivity and epinephrine in adrenal pheochromocytoma tissue from patients with Sipple's syndrome.

Abstract：

:The concentration of epinephrine, norepinephrine, dopamine, met-enkephalin-, ACTH-, calcitonin- and somatostatin-like immunoreactivity (IR) were determined in the extracts of 9 adrenal pheochromocytomas from 7 patients. Six of these patients had Sipple's syndrome. There was a close correlation between the amounts of met-enkephalin-IR and of epinephrine present in the tumor tissue (p less than 0.01). Such a correlation was not found between catecholamines and the other polypeptide hormones investigated. The relevance of the close parallel in the occurrence of met-enkephalin-IR and epinephrine in human adrenal pheochromocytoma tissue is unknown, but it underlines earlier observations in the normal bovine and rat adrenal medulla on a co-storage and co-release of these substances in normal circumstances.

journal_name

Life Sci

journal_title

Life sciences

authors

Lamberts SW,Bons E,Oosterom R,Bruining H,de Greef WJ,Hackeng WH

doi

10.1016/0024-3205(84)90652-0

subject

Has Abstract

pub_date

1984-07-23 00:00:00

pages

417-21

issue

4

eissn

0024-3205

issn

1879-0631

pii

0024-3205(84)90652-0

journal_volume

35

pub_type

杂志文章

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