Abstract：
:Responses of atrial mRNA, atrial peptide and plasma peptide of atrial natriuretic factor (ANF) to treatments to alter fluid volume were studied in rats using RNA dot hybridization assay and radioimmunoassay. Specific changes in the level of ANF mRNA relative to total atrial RNA were observed in atria from sodium restricted rats and water deprived then sodium loaded rats, demonstrating an association of change in water-sodium balance with the expression of ANF gene. The levels of mRNA and the immunoreactive ANF in plasma decreased to 30% and 15% of controls, respectively, on water-deprivation and then increased again to control levels after administering 1.8% NaCl solution, whereas atrial immunoreactive ANF increased to about twice the control on water-deprivation and decreased again after supplying NaCl solution, in parallel with the level of the hematocrit. These findings suggest that atrial ANF content is dependent more on ANF release than on biosynthesis.
journal_name
Life Scijournal_title
Life sciencesauthors
Takayanagi R,Tanaka I,Maki M,Inagami Tdoi
10.1016/0024-3205(85)90157-2subject
Has Abstractpub_date
1985-05-13 00:00:00pages
1843-8issue
19eissn
0024-3205issn
1879-0631pii
0024-3205(85)90157-2journal_volume
36pub_type
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