abstract：:ASXL1 and SRSF2 mutations in AML are frequently found in patients with preexisting myeloid malignancies and are individually associated with poor outcomes. In this multi-institutional retrospective analysis, we assessed the genetic features and clinical outcomes of 43 patients with ASXL1mut SRSF2mut AML and compared o...

journal_title：American journal of hematology

authors： Richardson DR,Swoboda DM,Moore DT,Johnson SM,Chan O,Galeotti J,Esparza S,Hussaini MO,Van Deventer H,Foster MC,Coombs CC,Montgomery ND,Sallman DA,Zeidner JF

更新日期：2021-01-27 00:00:00

abstract：:Thrombotic complications occur at high rates in hospitalized patients with COVID-19, yet the impact of intensive antithrombotic therapy on mortality is uncertain. We examined in-hospital mortality with intermediate- compared to prophylactic-dose anticoagulation, and separately with in-hospital aspirin compared to no a...

journal_title：American journal of hematology

authors： Meizlish ML,Goshua G,Liu Y,Fine R,Amin K,Chang E,DeFilippo N,Keating C,Liu Y,Mankbadi M,McManus D,Wang SY,Price C,Bona RD,Ochoa Chaar CI,Chun HJ,Pine AB,Rinder HM,Siner JM,Neuberg DS,Owusu KA,Lee AI

更新日期：2021-01-21 00:00:00

abstract：:Karyotypic analysis at time of diagnosis has an important value in determining initial response to treatment, remission duration and overall survival (OS) in acute myeloid leukemia (AML). Less is known about its value before allogeneic hematopoietic cell transplantation (allo-HCT) in patients transplanted with active ...

journal_title：American journal of hematology

authors： Poiani M,Labopin M,Battipaglia G,Beelen DW,Tischer J,Finke J,Brecht A,Forcade E,Ganser A,Passweg JR,Labussiere-Wallet H,Yakoub-Agha I,Schäfer-Eckart K,Kroeger N,Guffroy B,Ruggeri A,Esteve J,Nagler A,Mohty M

更新日期：2021-01-01 00:00:00

abstract：:Therapies engineered to prolong clotting factor protein circulation time, manipulate the balance of pro-coagulant and anti-coagulant proteins, or introduce new genetic material to enable endogenous factor protein production dominate the clinical trial landscape of hemophilia. The availability of clotting factor concen...

journal_title：American journal of hematology

authors： Croteau SE,Wang M,Wheeler AP

更新日期：2021-01-01 00:00:00

abstract：:Autologous blood doping refers to the illegal re-transfusion of any quantities of blood or blood components with blood donor and recipient being the same person. The re-transfusion of stored erythrocyte concentrates is particularly attractive to high-performance athletes as this practice improves their oxygen capacity...

journal_title：American journal of hematology

authors： Mussack V,Wittmann G,Pfaffl MW

更新日期：2020-12-16 00:00:00

abstract：:FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare disease: robust epidemiological data are lacking and reported issues are scarce, of low sample-size and limited follow-up. Imatinib mesylate (IM) is highly efficient but no predictive factor of relapse after discontinuation has yet been i...

journal_title：American journal of hematology

authors： Rohmer J,Couteau-Chardon A,Trichereau J,Panel K,Gesquiere C,Ben Abdelali R,Bidet A,Bladé JS,Cayuela JM,Cony-Makhoul P,Cottin V,Delabesse E,Ebbo M,Fain O,Flandrin P,Galicier L,Godon C,Grardel N,Guffroy A,Hamidou M,

更新日期：2020-11-01 00:00:00

abstract：:We aimed to determine the survival benefits of chemotherapy (CT) added to radiotherapy (RT) in different risk groups of patients with early-stage extranodal nasal-type NK/T-cell lymphoma (ENKTCL), and to investigate the risk of postponing RT based on induction CT responses. A total of 1360 patients who received RT wit...

journal_title：American journal of hematology

authors： Qi SN,Yang Y,Zhang YJ,Huang HQ,Wang Y,He X,Zhang LL,Wu G,Qu BL,Qian LT,Hou XR,Zhang FQ,Qiao XY,Wang H,Li GF,Zhu Y,Cao JZ,Wu JX,Wu T,Zhu SY,Shi M,Xu LM,Yuan ZY,Su H,Song YQ,Zhu J,Hu C,Li YX

更新日期：2020-09-01 00:00:00

abstract：:Thalassemia is one of the most prevalent monogenic diseases usually caused by quantitative defects in the production of β-globin leading to severe anemia. Technological advances in genome sequencing, stem cell selection, viral vector development, transduction and gene editing strategies now allow for efficient exvivo ...

journal_title：American journal of hematology

authors： Soni S

更新日期：2020-09-01 00:00:00

abstract：DISEASE OVERVIEW:Approximately one-fourth of primary cutaneous lymphomas are B-cell derived and are generally classified into three distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCD...

journal_title：American journal of hematology

authors： Hristov AC,Tejasvi T,Wilcox RA

更新日期：2020-08-20 00:00:00

abstract：:Withdrawal: Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective. The above article, published online on 20 August 2020 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article, has been withdrawn by agreement between the authors, t...

journal_title：American journal of hematology

authors： Cordeiro Mitchell CN,Pradhan A,Singh B,Naik RP,Baker VL,Lanzkron SM,Christianson MS,Pecker LH

更新日期：2020-08-20 00:00:00

abstract：:Relapsed or refractory acute myeloid leukemia (R/R AML) has a poor prognosis and is best treated with salvage chemotherapy as a bridge to allogeneic stem cell transplant (alloSCT). However, the optimal salvage therapy remains unknown. Here we compared two salvage regimens; mitoxantrone, etoposide, and cytarabine (MEC)...

journal_title：American journal of hematology

authors： Christian S,Arain S,Patel P,Khan I,Calip GS,Agrawal V,Sweiss K,Griffin S,Cahill K,Konig H,Esen A,Shergill A,Odenike O,Stock W,Quigley JG

更新日期：2020-08-01 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) has a wide range of presentations after hematopoietic stem-cell transplantation (HSCT). We retrospectively studied the risk factors and outcomes of patients with early (≤day 100) and late (>day 100) TA-TMA. Among the 1451 HSCT recipients, early TA-TMA occurred ...

journal_title：American journal of hematology

authors： Heybeli C,Sridharan M,Alkhateeb HB,Villasboas Bisneto JC,Buadi FK,Chen D,Dingli D,Dispenzieri A,Gertz MA,Go RS,Hashmi SK,Hayman SR,Hogan WJ,Inwards DJ,Kenderian SS,Kumar SK,Litzow MR,Porrata LF,Lacy MQ,Micallef IN,

更新日期：2020-07-02 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) is feasible and effective in selected older patients with Multiple Myeloma, but specific criteria for evaluating ASCT eligibility in elderly patients are lacking. We evaluated 131 patients aged 65-75 considered for ASCT at our center: The Charlson Comorbidity Index (CCI), He...

journal_title：American journal of hematology

authors： Belotti A,Ribolla R,Cancelli V,Crippa C,Bianchetti N,Ferrari S,Bottelli C,Cattaneo C,Tucci A,De La Fuente Barrigon C,Rossi G

更新日期：2020-07-01 00:00:00

abstract：DISEASE OVERVIEW:Immunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy chain are deposited in tissues. Clinical features depend on organs involved but can include heart failure with preserved ejection fraction, nephrotic syndrome, h...

journal_title：American journal of hematology

authors： Gertz MA

更新日期：2020-07-01 00:00:00

abstract：:While evidence for measurable residual disease (MRD) is a harbinger of inferior outcome in acute myeloid leukemia (AML) patients referred for allogeneic stem cell transplantation (allo-SCT), the exact clinical trajectory of specific patient subsets in this clinical setting is undefined. Using a recently published prog...

journal_title：American journal of hematology

authors： Nagler A,Labopin M,Canaani J,Niittyvuopio R,Socié G,Kröger N,Itäla-Remes M,Yakoub-Agha I,Labussière-Wallet H,Gallego-Hernanz MP,Deconinck E,Chevallier P,Finke J,Esteve J,Mohty M

更新日期：2020-06-12 00:00:00

abstract：:New treatments have transformed multiple myeloma into a chronic disease. Hence, optimal management of treatment and disease-related complications remains a critical component of survivorship care. Survivorship care model in cancers requiring a fixed-duration therapy may not be applicable to myeloma, since patients are...

journal_title：American journal of hematology

authors： Chakraborty R,Majhail NS

更新日期：2020-06-01 00:00:00

abstract：:Acute leukemias of ambiguous lineage (ALAL) comprise acute undifferentiated leukemias (AUL) and mixed-phenotype acute leukemias (MPAL). In the revised fourth edition of the World Health Organization (WHO) classification provided further refinements to the diagnostic criteria for ALAL. Molecular characterization of MPA...

journal_title：American journal of hematology

authors： Patel SS,Weinberg OK

更新日期：2020-06-01 00:00:00

abstract：:The diagnosis of primary plasma cell leukemia (pPCL) has been made by quantifying circulating plasma cells (cPCs) morphologically on a peripheral blood (PB) smear. However, this technique is not sufficiently sensitive. Multiparametric flow cytometry (MFC) provides a readily available and highly sensitive method to ide...

journal_title：American journal of hematology

authors： Evans LA,Jevremovic D,Nandakumar B,Dispenzieri A,Buadi FK,Dingli D,Lacy MQ,Hayman SR,Kapoor P,Leung N,Fonder A,Hobbs M,Hwa YL,Muchtar E,Warsame R,Kourelis TV,Go R,Russell S,Lust JA,Lin Y,Siddiqui M,Kyle RA,Ger

更新日期：2020-06-01 00:00:00

abstract：:Micro-transplantation (MST) by chemotherapy, combined with granulocyte colony-stimulating factor-mobilized peripheral blood stem cell (GPBSC) infusion, from an HLA partial matched related donor has shown some encouraging effective therapy for acute myeloid leukemia (AML). However, the outcome of human leukocyte antige...

journal_title：American journal of hematology

authors： Hu KX,Du X,Guo M,Yu CL,Qiao JH,Sun QY,Zuo HL,Cai B,Huang YJ,Ai HS,Dong Z,Wang Y

更新日期：2020-06-01 00:00:00

abstract：:Reduced ferrochelatase activity in erythropoietic protoporphyria (EPP) causes the accumulation of protoporphyrin IX (PPIX) leading to acute cutaneous photosensitivity and liver injury. Many EPP patients also have a mild hypochromic, microcytic anemia and iron deficiency. Iron deficiency can lead to decreased PPIX accu...

journal_title：American journal of hematology

authors： Schmidt PJ,Hollowell ML,Fitzgerald K,Butler JS,Fleming MD

更新日期：2020-05-01 00:00:00

abstract：DISEASE OVERVIEW:Chronic neutrophilic leukemia (CNL) is a rare, often aggressive myeloproliferative neoplasm (MPN) defined by persistent mature neutrophilic leukocytosis, bone marrow granulocyte hyperplasia, and frequent hepatosplenomegaly. The seminal discovery of oncogenic driver mutations in colony-stimulating facto...

journal_title：American journal of hematology

authors： Szuber N,Elliott M,Tefferi A

更新日期：2020-02-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a common cause of morbidity and mortality among patients with multiple myeloma (MM). The International Myeloma Working Group (IMWG) developed guidelines recommending primary thromboprophylaxis, in those identified at high-risk of VTE by the presence of risk factors. The National Compreh...

journal_title：American journal of hematology

authors： Sanfilippo KM,Luo S,Wang TF,Fiala M,Schoen M,Wildes TM,Mikhael J,Kuderer NM,Calverley DC,Keller J,Thomas T,Carson KR,Gage BF

更新日期：2019-11-01 00:00:00

abstract：:Acute myeloid leukemia (AML) with mutated NPM1 is a newly recognized separate entity in the revised 2016 WHO classification, and is associated with a favorable prognosis. While previous studies have evaluated NPM1 in a binary fashion, we recently demonstrated a significant independent negative prognostic effect of hig...

journal_title：American journal of hematology

authors： Patel SS,Pinkus GS,Ritterhouse LL,Segal JP,Dal Cin P,Restrepo T,Harris MH,Stone RM,Hasserjian RP,Weinberg OK

更新日期：2019-08-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with isolated thrombocytopenia and hemorrhagic risk. While many children with ITP can be safely observed, treatments are often needed for various reasons, including to decrease bleeding, or to improve health related quality of life (HRQoL). There are a n...

journal_title：American journal of hematology

authors： Grace RF,Shimano KA,Bhat R,Neunert C,Bussel JB,Klaassen RJ,Lambert MP,Rothman JA,Breakey VR,Hege K,Bennett CM,Rose MJ,Haley KM,Buchanan GR,Geddis A,Lorenzana A,Jeng M,Pastore YD,Crary SE,Neier M,Neufeld EJ,Neu N

更新日期：2019-07-01 00:00:00

abstract：:Achievement of a complete response has been associated with improved outcomes in patients with multiple myeloma. Recently, increasing application of minimal residual disease (MRD) assessment has shown that MRD negativity is a powerful prognostic factor for survival outcomes. We wanted to examine the impact of the poly...

journal_title：American journal of hematology

authors： Tschautscher MA,Jevremovic D,Rajkumar V,Dispenzieri A,Lacy MQ,Gertz MA,Buadi FK,Dingli D,Hwa YL,Fonder AL,Hobbs MA,Hayman SR,Zeldenrust SR,Lust JA,Russell SJ,Leung N,Kapoor P,Go RS,Lin Y,Gonsalves WI,Kourelis T,

更新日期：2019-07-01 00:00:00

abstract：:Compared to age-matched controls, cancer patients have increased risk of bleeding when treated with anticoagulation. However, there are little data regarding bleeding as it relates to anticoagulant choice and other risk factors. We evaluated the six-month incidence of bleeding among patients treated with anticoagulati...

journal_title：American journal of hematology

authors： Angelini DE,Radivoyevitch T,McCrae KR,Khorana AA

更新日期：2019-07-01 00:00:00

abstract：:Single agents have demonstrated activity in relapsed and refractory (R/R) peripheral T-cell lymphoma (PTCL). Their benefit relative to combination chemotherapy remains undefined. Patients with histologically confirmed PTCL were enrolled in the Comprehensive Oncology Measures for Peripheral T-cell Lymphoma Treatment (C...

journal_title：American journal of hematology

authors： Stuver RN,Khan N,Schwartz M,Acosta M,Federico M,Gisselbrecht C,Horwitz SM,Lansigan F,Pinter-Brown LC,Pro B,Shustov AR,Foss FM,Jain S

更新日期：2019-06-01 00:00:00

abstract：:Unprecedented advances in our understanding of the pathobiology, prognostication, and therapeutic options in mantle cell lymphoma (MCL) have taken place in the last few years. Heterogeneity in the clinical course of MCL-indolent vs aggressive-is further delineated by a correlation with the mutational status of the var...

journal_title：American journal of hematology

authors： Jain P,Wang M

更新日期：2019-06-01 00:00:00

abstract：:Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR T cells are then expanded for clinical use and infused back into the patie...

journal_title：American journal of hematology

authors： Feins S,Kong W,Williams EF,Milone MC,Fraietta JA

更新日期：2019-05-01 00:00:00

abstract：:Therapy-related acute myeloid leukemia (t-AML) arises as a late complication following antecedent solid tumors or hematologic diseases and their associated treatments. There are limited data regarding risk factors and outcomes following allogeneic hematopoietic cell transplantation (HCT) for t-AML following a prior so...

journal_title：American journal of hematology

authors： Lee CJ,Labopin M,Beelen D,Finke J,Blaise D,Ganser A,Itälä-Remes M,Chevallier P,Labussière-Wallet H,Maertens J,Yakoub-Agha I,Bourhis JH,Mailhol A,Mohty M,Savani BN,Nagler A

更新日期：2019-04-01 00:00:00

abstract：:Karyotype is frequently used to predict response and outcome in leukemia. This post hoc exploratory analysis evaluated the relationship between baseline cytogenetics and outcome in patients with relapsed/refractory acute lymphoblastic leukemia (R/R ALL) treated with inotuzumab ozogamicin (InO), a humanized CD22 antibo...

journal_title：American journal of hematology

authors： Jabbour E,Advani AS,Stelljes M,Stock W,Liedtke M,Gökbuget N,Martinelli G,O'Brien S,White JL,Wang T,Luisa Paccagnella M,Sleight B,Vandendries E,DeAngelo DJ,Kantarjian HM

更新日期：2019-04-01 00:00:00

abstract：:Identification of genetic causes of neutropenia informs precision medicine approaches to medical management and treatment. Accurate diagnosis of genetic neutropenia disorders informs treatment options, enables risk stratification, cancer surveillance, and attention to associated medical complications. The rapidly expa...

journal_title：American journal of hematology

authors： Furutani E,Newburger PE,Shimamura A

更新日期：2019-03-01 00:00:00

abstract：:This study demonstrates the quantitative characteristics of the first patient-reported outcome (PRO) tool developed for patients with nontransfusion-dependent β-thalassemia (NTDT), the NTDT-PRO© . A multicenter validation study was performed over 24 weeks, involving 48 patients from Italy, Lebanon, Greece, and Thailan...

journal_title：American journal of hematology

authors： Taher A,Cappellini MD,Viprakasit V,Sutcharitchan P,Mahmoud D,Laadem A,Khan A,Gwaltney C,Harding G,Attie K,Zhang X,Zou J,Pariseau J,Henry Hu X,Kattamis A

更新日期：2019-02-01 00:00:00

abstract：DISEASE OVERVIEW:Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell-derived clonal myeloproliferation that is often but not always accompanied by JAK2, CALR, or MPL mutations; additional disease features include bone marrow stromal reaction including reticulin fibrosis, abnorm...

journal_title：American journal of hematology

authors： Tefferi A

更新日期：2018-12-01 00:00:00

abstract：:Sickle cell disease (SCD) nephropathy and lower estimated glomerular filtration rate (eGFR) are risk factors for early mortality. Furthermore, rate of eGFR decline predicts progression to end-stage renal disease in many clinical settings. However, factors predicting renal function decline in SCD are poorly documented....

journal_title：American journal of hematology

authors： Xu JZ,Garrett ME,Soldano KL,Chen ST,Clish CB,Ashley-Koch AE,Telen MJ

更新日期：2018-12-01 00:00:00

abstract：:Positron emission tomography-computed tomography (PET-CT) can identify bony lesions, assess disease burden, and detect extramedullary disease (EMD) in patients with multiple myeloma. We retrospectively reviewed records of patients who underwent PET-CT within 60 days of a new diagnosis (before therapy commenced) to ide...

journal_title：American journal of hematology

authors： Aljama MA,Sidiqi MH,Buadi FK,Lacy MQ,Gertz MA,Dispenzieri A,Dingli D,Muchtar E,Fonder AL,Hayman SR,Hobbs MA,Gonsalves WI,Warsame RM,Kourelis T,Hwa YL,Kapoor P,Kyle RA,Leung N,Go RS,Rajkumar SV,Kumar SK

更新日期：2018-12-01 00:00:00

abstract：:Duvelisib (IPI-145), an oral, dual inhibitor of phosphoinositide-3-kinase (PI3K)-δ and -γ, was evaluated in a Phase 1 study in advanced hematologic malignancies, which included expansion cohorts in relapsed/refractory (RR) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and treatment-naïve (TN) CLL...

journal_title：American journal of hematology

authors： O'Brien S,Patel M,Kahl BS,Horwitz SM,Foss FM,Porcu P,Jones J,Burger J,Jain N,Allen K,Faia K,Douglas M,Stern HM,Sweeney J,Kelly P,Kelly V,Flinn I

更新日期：2018-11-01 00:00:00

abstract：:In this study, we investigated the incidence and prognostic impact of monosomal karyotype (MK) in 405 higher-risk Myelodysplastic Syndromes (MDS) patients treated with 5-AZA. The MK was present in 66 out of 405 (16.3%) patients, most of whom had complex karyotype (CK). MK was strongly associated with CK and the cytoge...

journal_title：American journal of hematology

authors： Papageorgiou SG,Vasilatou D,Kontos CK,Kotsianidis I,Symeonidis A,Galanopoulos AG,Hatzimichael E,Megalakaki A,Poulakidas E,Diamantopoulos P,Vassilakopoulos TP,Zikos P,Papadaki H,Mparmparousi D,Bouronikou E,Panayiotidis P,V

更新日期：2018-07-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common malignancy among children. The trial Chinese Children Leukemia Group (CCLG)-ALL 2008 was a prospective clinical trial designed to improve treatment outcome of childhood ALL through the first nation-wide collaborative study in China. Totally 2231 patients were recru...

journal_title：American journal of hematology

authors： Cui L,Li ZG,Chai YH,Yu J,Gao J,Zhu XF,Jin RM,Shi XD,Zhang LP,Gao YJ,Zhang RD,Zheng HY,Hu SY,Cui YH,Zhu YP,Zou Y,Ng MHL,Xiao Y,Li JH,Zhang YH,He HL,Xian Y,Wang TY,Li CK,Wu MY,Chinese Children Leukemia Gro

更新日期：2018-07-01 00:00:00

abstract：:Secondary acute myeloid leukemia (sAML) traditionally has inferior outcomes compared to de novo AML. Allogeneic hematopoietic cell transplantation (HCT) is the sole potentially curative therapy. This study analyzes the outcomes for unmanipulated haploidentical HCT (haploHCT) for sAML using the Acute Leukemia Working P...

journal_title：American journal of hematology

authors： Li Z,Labopin M,Ciceri F,Blaise D,Tischer J,Ehninger G,Van Lint MT,Koc Y,Santarone S,Forcade E,Castagna L,Polge E,Mailhol A,Ruggeri A,Mohty M,Savani BN,Nagler A

更新日期：2018-06-01 00:00:00