Cytogenetic risk score maintains its prognostic significance in AML patients with detectable measurable residual disease undergoing transplantation in remission: On behalf of the acute leukemia working party of the European society for blood and marrow tr

Abstract:

:While evidence for measurable residual disease (MRD) is a harbinger of inferior outcome in acute myeloid leukemia (AML) patients referred for allogeneic stem cell transplantation (allo-SCT), the exact clinical trajectory of specific patient subsets in this clinical setting is undefined. Using a recently published prognostic cytogenetic model (Canaani et al. Leukemia 2019) we evaluated whether this model applied also to studies of patients with positive MRD. The analysis comprised MRD+ patients in first complete remission undergoing allo-SCT from a matched sibling donor or unrelated donor. Seven hundred and seventy-five patients were evaluated with a median follow-up duration of 22 months. Cytogenetic risk score was favorable, intermediate/FLT3wt intermediate/FLT3-ITD3, and adverse in 15%, 28.3%, 37% and 19.7% of the patients, respectively. Favorable and intermediate/FLT3wt risk patients had 2-year leukemia-free survival rates of 78% and 61%, respectively, compared with only 50% and 37% for intermediate/FLT3-ITD3 and adverse risk patients, respectively (P < .001). In multivariate analysis adverse and intermediate/FLT3-ITD3 risk patients were more likely to experience disease relapse compared with favorable risk patients [hazard ratio (HR) = 3.9, 95% confidence interval (CI), 2.1-7.3; P < .001, and HR = 4.4, CI 95%, 2.4-7.8; P < .001, respectively]. The European society for blood and marrow transplantation cytogenetic risk score is a valuable adjunct for risk stratification of MRD+ AML patients.

journal_name

Am J Hematol

authors

Nagler A,Labopin M,Canaani J,Niittyvuopio R,Socié G,Kröger N,Itäla-Remes M,Yakoub-Agha I,Labussière-Wallet H,Gallego-Hernanz MP,Deconinck E,Chevallier P,Finke J,Esteve J,Mohty M

doi

10.1002/ajh.25905

subject

Has Abstract

pub_date

2020-06-12 00:00:00

eissn

0361-8609

issn

1096-8652

pub_type

杂志文章
  • Comparable long-term outcomes after reduced-intensity conditioning versus myeloablative conditioning allogeneic stem cell transplantation for adult high-risk acute lymphoblastic leukemia in complete remission.

    abstract::The role of reduced-intensity conditioning (RIC) in adult acute lymphoblastic leukemia (ALL) remains unclear because of the small sample size, short follow-up duration, various regimens for conditioning and graft-versus-host disease (GVHD) prophylaxis, and the heterogeneity of selection criteria for transplantation. W...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ajh.23465

    authors: Eom KS,Shin SH,Yoon JH,Yahng SA,Lee SE,Cho BS,Kim YJ,Kim HJ,Min CK,Kim DW,Lee JW,Min WS,Park CW,Lee S

    更新日期:2013-08-01 00:00:00

  • Durable molecular remissions with a single cycle of timed sequential consolidation chemotherapy in acute promyelocytic leukemia.

    abstract::In a pilot study to reduce the duration of treatment and potential long-term toxicities, 39 patients with acute promyelocytic leukemia in remission received a single cycle of intensive consolidation therapy, followed by intermittent ATRA maintenance. Consolidation therapy required prolonged hospitalization and was ass...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20354

    authors: Gore SD,Smith BD,Gojo I,Grever M,Kaufmann SH,Letendre L,Leonard DG,Marcucci G,Miller CB,Morris L,Piantadosi S,Prior T,Stock W,Karp JE

    更新日期:2005-06-01 00:00:00

  • Developing human erythroid cells grown in transferrin-free medium utilize iron originating from extracellular ferritin.

    abstract::In addition to transferrin, ferritin can also function as a source of iron for heme synthesis (Gelvin D, et al. Blood 1996;88:3200-3207; Meyron-Holtz EG, et al. Blood 1999;94:3205-3211). In the present study we investigate the effect of external ferritin on the proliferation and hemoglobinization of human erythroid pr...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.10355

    authors: Leimberg JM,Konijn AM,Fibach E

    更新日期:2003-07-01 00:00:00

  • Modified APC-resistance test: variable ratios with respect to source of factor V-deficient plasma.

    abstract::A single point mutation of the factor V (FV) gene, leading to the substitution Arg506Gln in the FV molecule (FV-Leiden) and hence resistance to its breakdown by activated protein C (APC), is the most prevalent risk factor for venous thrombosis in the Caucasians. A ratio determined by activated partial thromboplastin t...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199703)54:3<214::aid-ajh7>

    authors: Ts'ao C,Neofotistos D,Oropeza M,Vahabinejad S,Finn WG

    更新日期:1997-03-01 00:00:00

  • High serum lactate dehydrogenase level predicts short survival after vincristine-doxorubicin-dexamethasone (VAD) salvage for refractory multiple myeloma.

    abstract::We evaluated possible prognostic factors just before salvage therapy with vincristine, doxorubicin, and dexamethasone (VAD) for 36 patients with refractory multiple myeloma. The median duration from diagnosis to the first VAD salvage was 14 months (range 2-76 months). Among parameters that have been shown to be associ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/1096-8652(200010)65:2<132::aid-ajh7>3.0.co

    authors: Suguro M,Kanda Y,Yamamoto R,Chizuka A,Hamaki T,Matsuyama T,Takezako N,Miwa A,Togawa A

    更新日期:2000-10-01 00:00:00

  • Acquired hypoprothrombinemia: effects of danazol treatment.

    abstract::The lupus anticoagulant may be accompanied by an acquired factor II deficiency and bleeding. We report on a patient with a lupus anticoagulant and factor II (Fll) deficiency responsive to Danazol. Acquired hypoprothrombinemia (FII) with the lupus anticoagulant (LA) may be accompanied by a hemorrhagic diathesis. A 64-y...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-8652(199612)53:4<272::AID-AJH14

    authors: Williams S,Linardic C,Wilson O,Comp P,Gralnick HR

    更新日期:1996-12-01 00:00:00

  • History and implications of the neutrophil glycoprotein deficiencies.

    abstract::This review focuses on the initial clinical descriptions and subsequent investigation of the syndrome of recurrent infections associated with neutrophil membrane glycoprotein deficiencies. Characterization of the missing group of three glycoprotein heterodimers and their role in adhesion-related neutrophil function is...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1002/ajh.2830310416

    authors: Styrt B

    更新日期:1989-08-01 00:00:00

  • Autoimmune hemolytic anemia in patients infected with human immunodeficiency virus-1.

    abstract::Four men were diagnosed with human immunodeficiency virus infection (AIDS) and autoimmune hemolytic anemia (HIV-AIHA) during the years 1997-2000 at Cook County Hospital, Chicago. All patients presented with the acute onset of severe hemolytic anemia, fever, and splenomegaly. The direct and indirect antiglobulin tests ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.10096

    authors: Koduri PR,Singa P,Nikolinakos P

    更新日期:2002-06-01 00:00:00

  • Inhibitory effect of short-chain aliphatic acids on deoxythymidine incorporation into DNA in mitogen-stimulated and leukemic lymphocytes.

    abstract::The effect of short-chain aliphatic acids on [3H]deoxythymidine incorporation into DNA was studied in human mitogen-stimulated lymphocytes. Butyric acid at 1-2 mM level was strongly inhibitory; however, its hydroxy or amino derivatives were ineffective. Valeric and propionic acids were less inhibitory. Formic, acetic,...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830130203

    authors: Stolc V

    更新日期:1982-09-01 00:00:00

  • Addition of cladribine to the standard induction treatment improves outcomes in a subset of elderly acute myeloid leukemia patients. Results of a randomized Polish Adult Leukemia Group (PALG) phase II trial.

    abstract::Intensive induction chemotherapy using anthracycline and cytarabine backbone is considered the most effective upfront therapy in physically fit older patients with acute myeloid leukemia (AML). However, outcomes of the standard induction in elderly AML are inferior to those observed in younger patients, and they are s...

    journal_title:American journal of hematology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ajh.24654

    authors: Pluta A,Robak T,Wrzesien-Kus A,Katarzyna Budziszewska B,Sulek K,Wawrzyniak E,Czemerska M,Zwolinska M,Golos A,Holowiecka-Goral A,Kyrcz-Krzemien S,Piszcz J,Kloczko J,Mordak-Domagala M,Lange A,Razny M,Madry K,Wiktor-Jedrze

    更新日期:2017-04-01 00:00:00

  • Aspirin increases the bleeding side effects in essential thrombocythemia independent of the cyclooxygenase pathway: role of the lipoxygenase pathway.

    abstract::Acetylsalicylic acid (ASA) is currently recommended as an antithrombotic for patients with essential thrombocythemia (ET) who are at an increased risk of thrombotic events. However, ASA is also associated with an increased risk of bleeding in these patients as compared to the risk of bleeding in other patients treated...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199804)57:4<277::aid-ajh2>

    authors: Cortelazzo S,Marchetti M,Orlando E,Falanga A,Barbui T,Buchanan MR

    更新日期:1998-04-01 00:00:00

  • Annual Clinical Updates in Hematological Malignancies: a continuing medical education series: polycythemia vera and essential thrombocythemia: 2011 update on diagnosis, risk-stratification, and management.

    abstract:DISEASE OVERVIEW:Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms primarily characterized by erythrocytosis and thrombocytosis, respectively. Other disease features include leukocytosis, splenomegaly, thrombohemorrhagic complications, vasomotor disturbances, pruritus, and a sma...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1002/ajh.21946

    authors: Tefferi A

    更新日期:2011-03-01 00:00:00

  • Effect of interleukin-1, tumor necrosis factor-alpha, and interferon-alpha on the blast cells of acute myeloblastic leukemia.

    abstract::In this study, we further established the role of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta, tumor necrosis factor-alpha (TNF-alpha), and interferon-alpha (IFN-alpha) as regulators of proliferation of acute myeloid leukemia (AML) cells. AML cells from 8 of 15 patients incorporated high levels of 3H-thymidin...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830400402

    authors: Carter A,Silvian-Draxler I,Tatarsky I

    更新日期:1992-08-01 00:00:00

  • Protein-bound cobalamin absorption declines in the elderly.

    abstract::A modified protein-bound cobalamin absorption test was used to study dietary cobalamin absorption in healthy adults of different age groups and patients with isolated low serum concentrations of cobalamin. Dietary cobalamin absorption was significantly reduced in healthy adults aged 55-75 years compared with young adu...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830390202

    authors: Scarlett JD,Read H,O'Dea K

    更新日期:1992-02-01 00:00:00

  • Cytogenetic findings in 21 cases of peripheral T-cell lymphoma.

    abstract::Although numerous publications have described the chromosome abnormalities in B-cell non-Hodgkin lymphoma and their significance, sparse literature exists pertaining to the chromosome abnormalities in T-cell lymphoma. We did cytogenetic analyses in 21 cases of peripheral T-cell lymphoma (PTCL). Chromosomally abnormal ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830350205

    authors: Inwards DJ,Habermann TM,Banks PM,Colgan JP,Dewald GW

    更新日期:1990-10-01 00:00:00

  • Plasminogen activator inhibitor (PAI-1) antigen levels in primary TTP and secondary TTP post-bone marrow transplantation.

    abstract::Our objectives were to measure and compare plasminogen activator inhibitor levels (PAI-1) in primary adult thrombotic thrombocytopenic purpura (TTP) and in secondary TTP associated with bone marrow transplantation (BMT)-TTP. PAI-1 antigen levels were measured by an enzyme linked immunosorbent assay on platelet poor pl...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/(sici)1096-8652(199809)59:1<9::aid-ajh3>3.

    authors: Anthony MT,Zeigler ZR,Lister J,Raymond JM,Shadduck RK,Kramer RE,Gryn JF,Rintels PB,Besa EC,George JN,Silver B,Joyce R,Bodensteiner D

    更新日期:1998-09-01 00:00:00

  • Clinical course and molecular characterization of a compound heterozygote for sickle hemoglobin and hemoglobin Kenya.

    abstract::We describe a 25-year-old black woman who presented with a long history of anemia requiring transfusions during childhood and adolescence. Molecular analysis revealed her to be a compound heterozygote for the sickle mutation and the approximately 22.7 kb deletion associated with hemoglobin Kenya. This patient's clinic...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830410413

    authors: Waye JS,Cai SP,Eng B,Chui DH,Francombe WH

    更新日期:1992-12-01 00:00:00

  • PCR-based diagnosis of the Filipino (--(FIL)) and Thai (--(THAI)) alpha-thalassemia-1 deletions.

    abstract::In southeast Asia, the carrier frequency of two-gene alpha-thalassemia deletions is quite high, ranging from 4% to 14% depending on the population. The most common alpha-thalassemia-1 deletion is the so-called southeast Asian deletion (--(SEA)). In addition, a significant proportion of cases involve two other deletion...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(200001)63:1<54::aid-ajh12>

    authors: Eng B,Patterson M,Borys S,Chui DH,Waye JS

    更新日期:2000-01-01 00:00:00

  • HTLV-1 unrelated adult T-cell leukemia/lymphoma with unique phenotype and karyotype.

    abstract::We describe a unique case of adult T-cell leukemia/lymphoma (ATL). The patient had typical clinicohematological features as ATL, but showed a lack of antibody to human T-cell leukemia virus type-1 (HTLV-1) and was negative for HTLV-1 proviral DNA in the peripheral mononuclear cells by means of polymerase chain reactio...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(200005)64:1<64::aid-ajh11>

    authors: Nakase K,Hasegawa M,Tsuji K,Ikeda T,Tamaki S,Tanigawa M,Miyanishi E,Shiku H

    更新日期:2000-05-01 00:00:00

  • Transplant eligibility in elderly multiple myeloma patients: Prospective external validation of the international myeloma working group frailty score and comparison with clinical judgment and other comorbidity scores in unselected patients aged 65-75 year

    abstract::Autologous stem cell transplantation (ASCT) is feasible and effective in selected older patients with Multiple Myeloma, but specific criteria for evaluating ASCT eligibility in elderly patients are lacking. We evaluated 131 patients aged 65-75 considered for ASCT at our center: The Charlson Comorbidity Index (CCI), He...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ajh.25797

    authors: Belotti A,Ribolla R,Cancelli V,Crippa C,Bianchetti N,Ferrari S,Bottelli C,Cattaneo C,Tucci A,De La Fuente Barrigon C,Rossi G

    更新日期:2020-07-01 00:00:00

  • all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia.

    abstract::all-trans-Retinoic acid (ATRA) induces complete remission in majority of patients with acute promyelocytic leukemia (APL). However, accelerated metabolism of ATRA that is induced by chronic daily administration of oral ATRA has been implicated as one of the mechanisms leading to a reduced sensitivity or resistance to ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.10099

    authors: Ozpolat B,Mehta K,Tari AM,Lopez-Berestein G

    更新日期:2002-05-01 00:00:00

  • NK-cell repertoire is feasible for diagnosing Epstein-Barr virus-infected NK-cell lymphoproliferative disease and evaluating the treatment effect.

    abstract::Epstein-Barr virus (EBV) occasionally infects T and NK cells and causes EBV-infected T/NK-cell lymphoproliferative disease (LPD), which comprises chronic active EBV infection, EBV-associated hemophagocytic syndrome, mosquito allergy, hydroa vacciniforme, aggressive NK-cell leukemia, and NK/T-cell lymphoma. The diagnos...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20659

    authors: Sawada A,Sato E,Koyama M,Higuchi B,Kusuki S,Kim JY,Takeshita Y,Sakata A,Sakata N,Okamura T,Yasui M,Inoue M,Kawa K

    更新日期:2006-08-01 00:00:00

  • Outcomes and management strategies for graft failure after umbilical cord blood transplantation.

    abstract::Graft failure is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT). Graft failure is more prevalent after umbilical cord blood transplantation (UCBT) compared with conventional adult stem cell sources. We identified 21 consecutive patients who experienced graft failure aft...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.23845

    authors: Singh H,Nikiforow S,Li S,Ballen KK,Spitzer TR,Soiffer R,Antin JH,Cutler C,Chen YB

    更新日期:2014-12-01 00:00:00

  • Immunoglobulin light chain amyloidosis: 2020 update on diagnosis, prognosis, and treatment.

    abstract:DISEASE OVERVIEW:Immunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy chain are deposited in tissues. Clinical features depend on organs involved but can include heart failure with preserved ejection fraction, nephrotic syndrome, h...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1002/ajh.25819

    authors: Gertz MA

    更新日期:2020-07-01 00:00:00

  • CD5 positive immunoregulatory B cells in spleen populations from multiple myeloma patients.

    abstract::CD19+CD5+ lymphocytes constitute a minority of peripheral blood B cells. In view of the importance of these cells in the pathogenesis of the immunoregulation of myeloma, their incidence in another lymphoid organ was determined. CD5+ B cells were studied in 9 spleens from patients with multiple myeloma and in 10 spleen...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830370306

    authors: MacKenzie MR,Paglieroni T,Caggiano V

    更新日期:1991-07-01 00:00:00

  • Up-regulation of amphotrophic retroviral receptor expression in human peripheral blood CD34+ cells.

    abstract::Retroviral-mediated gene transfer into hematopoietic stem cells provides the only means of stable transduction of these cells and their progeny for use with a variety of potentially therapeutic genes. Expression of the Moloney amphotropic retroviral receptor-pit-2 or GLVR-2-is critical to the recognition and entry of ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199908)61:4<243::aid-ajh4>

    authors: Kaubisch A,Ward M,Schoetz S,Hesdorffer C,Bank A

    更新日期:1999-08-01 00:00:00

  • Hepcidin, iron status, and renal function in chronic renal failure, kidney transplantation, and hemodialysis.

    abstract::Hepcidin is a small defensin-like peptide whose production by hepatocytes is modulated in response to anemia, hypoxia, or inflammation. Hepcidin could also act as an indicator of functional iron deficiency in these patients. Cross-sectional study was performed to assess hepcidin correlations with renal function, iron ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20657

    authors: Malyszko J,Malyszko JS,Pawlak K,Mysliwiec M

    更新日期:2006-11-01 00:00:00

  • Persistency with zoledronic acid is associated with clinical benefit in patients with multiple myeloma.

    abstract::Zoledronic acid (ZOL), an intravenous bisphosphonate, has been shown to reduce and delay the incidence of skeletal-related events (SREs) in multiple myeloma (MM) patients with bone disease. A retrospective claims-based analysis was conducted that used two distinct US managed care databases to examine the relationship ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.23164

    authors: Henk HJ,Teitelbaum A,Perez JR,Kaura S

    更新日期:2012-05-01 00:00:00

  • Systemic AL amyloidosis with acquired factor X deficiency: A study of perioperative bleeding risk and treatment outcomes in 60 patients.

    abstract::Systemic light-chain (AL) amyloidosis may be associated with acquired factor X (FX) deficiency and optimal management of this coagulopathy is unknown. We reviewed our experience with 60 patients with isolated FX deficiency (< or =50%) due to AL amyloidosis that underwent an invasive procedure between 1975 and 2007. Th...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.21603

    authors: Thompson CA,Kyle R,Gertz M,Heit J,Pruthi R,Pardanani A

    更新日期:2010-03-01 00:00:00

  • Simple method for differentiating between HLA and platelet-specific antibodies by flow cytometry.

    abstract::Since platelets express both platelet-specific and class I HLA antigens, serum antiplatelet reactivity assessed by most platelet antibody techniques could be due to antibodies with either or both specificities. Flow cytometric analysis of sera for detection of antiplatelet antibody commonly employs a purified platelet...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830380411

    authors: Freedman J,Hornstein A

    更新日期:1991-12-01 00:00:00