听力与言语-语言病理学

行为科学

医学伦理学

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  • Polygenic risk for autism, attention-deficit hyperactivity disorder, schizophrenia, major depressive disorder, and neuroticism is associated with the experience of childhood abuse.

    abstract::People who experience childhood abuse are at increased risk of mental illness. Twin studies suggest that inherited genetic risk for mental illness may account for some of these associations. Yet, the hypothesis that individuals who have experienced childhood abuse may carry genetic loading for mental illness has never...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00996-w

    authors: Ratanatharathorn A,Koenen KC,Chibnik LB,Weisskopf MG,Rich-Edwards JW,Roberts AL

    更新日期:2021-01-22 00:00:00

  • Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescence.

    abstract::Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in the pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the dynamic plasticity of dendritic spines of pyramidal neurons (PNs) and "en passant" axonal bouton of parvalbumin-expressing interneurons (PVI...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-01005-w

    authors: Huang Y,Jiang H,Zheng Q,Fok AHK,Li X,Lau CG,Lai CSW

    更新日期:2021-01-20 00:00:00

  • Altered temporal, but intact spatial, features of transient network dynamics in psychosis.

    abstract::Contemporary models of psychosis suggest that a continuum of severity of psychotic symptoms exists, with subthreshold psychotic experiences (PEs) potentially reflecting some genetic and environmental risk factors shared with clinical psychosis. Thus, identifying abnormalities in brain activity that manifest across thi...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00983-1

    authors: Wang D,Peng X,Pelletier-Baldelli A,Orlov N,Farabaugh A,Nasr S,Eryilmaz H,Fava M,Holmes AJ,Roffman JL,Liu H,Holt DJ

    更新日期:2021-01-18 00:00:00

  • Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders.

    abstract::Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. From the Enhanci...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-01002-z

    authors: Radonjić NV,Hess JL,Rovira P,Andreassen O,Buitelaar JK,Ching CRK,Franke B,Hoogman M,Jahanshad N,McDonald C,Schmaal L,Sisodiya SM,Stein DJ,van den Heuvel OA,van Erp TGM,van Rooij D,Veltman DJ,Thompson P,Faraone SV

    更新日期:2021-01-17 00:00:00

  • Reduced motor cortex GABABR function following chronic alcohol exposure.

    abstract::The GABAB receptor (GABABR) agonist baclofen has been used to treat alcohol and several other substance use disorders (AUD/SUD), yet its underlying neural mechanism remains unclear. The present study aimed to investigate cortical GABABR dynamics following chronic alcohol exposure. Ex vivo brain slice recordings from m...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-01009-6

    authors: Peng SY,Shi Z,Zhou DS,Wang XY,Li XX,Liu XL,Wang WD,Lin GN,Pan BX,Voon V,Grace AA,Heilig M,Wong ML,Yuan TF

    更新日期:2021-01-11 00:00:00

  • Effects of oral contraceptive pills on mood and magnetic resonance imaging measures of prefrontal cortical thickness.

    abstract::Gonadal hormones influence neuronal organization and plasticity. Yet the consequences of altering their concentrations by administering contraceptive agents, which are used by most reproductive-age women in the United States, are unclear. Cross-sectional studies have found both larger and smaller cortical regions alon...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00990-2

    authors: Petersen N,Kearley NW,Ghahremani DG,Pochon JB,Fry ME,Rapkin AJ,London ED

    更新日期:2021-01-08 00:00:00

  • Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation.

    abstract::Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations betwee...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00976-0

    authors: Sammallahti S,Cortes Hidalgo AP,Tuominen S,Malmberg A,Mulder RH,Brunst KJ,Alemany S,McBride NS,Yousefi P,Heiss JA,McRae N,Page CM,Jin J,Pesce G,Caramaschi D,Rifas-Shiman SL,Koen N,Adams CD,Magnus MC,Baïz N,Ratanat

    更新日期:2021-01-07 00:00:00

  • Oligodendrocyte lineage cells and depression.

    abstract::Depression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There are data to support several different theories of causation, including the mono...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审

    doi:10.1038/s41380-020-00930-0

    authors: Zhou B,Zhu Z,Ransom BR,Tong X

    更新日期:2021-01-01 00:00:00

  • Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder.

    abstract::Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not ju...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-019-0496-z

    authors: Dean KR,Hammamieh R,Mellon SH,Abu-Amara D,Flory JD,Guffanti G,Wang K,Daigle BJ Jr,Gautam A,Lee I,Yang R,Almli LM,Bersani FS,Chakraborty N,Donohue D,Kerley K,Kim TK,Laska E,Young Lee M,Lindqvist D,Lori A,Lu L,M

    更新日期:2020-12-01 00:00:00

  • Glycobiology and schizophrenia: a biological hypothesis emerging from genomic research.

    abstract::Advances in genomics are opening new windows into the biology of schizophrenia. Though common variants individually have small effects on disease risk, GWAS provide a powerful opportunity to explore pathways and mechanisms contributing to pathophysiology. Here, we highlight an underappreciated biological theme emergin...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审

    doi:10.1038/s41380-020-0753-1

    authors: Mealer RG,Williams SE,Daly MJ,Scolnick EM,Cummings RD,Smoller JW

    更新日期:2020-12-01 00:00:00

  • Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core.

    abstract::Poorly regulated reward seeking is a central feature of substance use disorder. Recent research shows that rewarding drug-related experiences induce synchronous activation of a discrete number of neurons in the nucleus accumbens that are causally linked to reward-related contexts. Here we comprehensively characterize ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00888-z

    authors: Bobadilla AC,Dereschewitz E,Vaccaro L,Heinsbroek JA,Scofield MD,Kalivas PW

    更新日期:2020-12-01 00:00:00

  • A major role for common genetic variation in anxiety disorders.

    abstract::Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale c...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-019-0559-1

    authors: Purves KL,Coleman JRI,Meier SM,Rayner C,Davis KAS,Cheesman R,Bækvad-Hansen M,Børglum AD,Wan Cho S,Jürgen Deckert J,Gaspar HA,Bybjerg-Grauholm J,Hettema JM,Hotopf M,Hougaard D,Hübel C,Kan C,McIntosh AM,Mors O,Bo Mort

    更新日期:2020-12-01 00:00:00

  • A hidden menace? Cytomegalovirus infection is associated with reduced cortical gray matter volume in major depressive disorder.

    abstract::Human cytomegalovirus (HCMV) infection is associated with neuropathology in patients with impaired immunity and/or inflammatory diseases. However, the association between gray matter volume (GMV) and HCMV has never been examined in major depressive disorder (MDD) despite the presence of inflammation and impaired viral...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00932-y

    authors: Zheng H,Ford BN,Bergamino M,Kuplicki R,Tulsa 1000 Investigators.,Hunt PW,Bodurka J,Teague TK,Irwin MR,Yolken RH,Paulus MP,Savitz J

    更新日期:2020-11-22 00:00:00

  • Mood stabilizers and/or antipsychotics for bipolar disorder in the maintenance phase: a systematic review and network meta-analysis of randomized controlled trials.

    abstract::We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which th...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00946-6

    authors: Kishi T,Ikuta T,Matsuda Y,Sakuma K,Okuya M,Mishima K,Iwata N

    更新日期:2020-11-11 00:00:00

  • Identification of novel loci associated with infant cognitive ability.

    abstract::It is believed that genetic factors play a large role in the development of many cognitive and neurological processes; however, epidemiological evidence for the genetic basis of childhood neurodevelopment is very limited. Identification of the genetic polymorphisms associated with early-stage neurodevelopment will hel...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-018-0205-3

    authors: Sun R,Wang Z,Claus Henn B,Su L,Lu Q,Lin X,Wright RO,Bellinger DC,Kile M,Mazumdar M,Tellez-Rojo MM,Schnaas L,Christiani DC

    更新日期:2020-11-01 00:00:00

  • Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life.

    abstract::Higher scores on the personality trait of neuroticism, the tendency to experience negative emotions, are associated with worse mental and physical health. Studies examining links between neuroticism and health typically operationalize neuroticism by summing the items from a neuroticism scale. However, neuroticism is m...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-019-0387-3

    authors: Hill WD,Weiss A,Liewald DC,Davies G,Porteous DJ,Hayward C,McIntosh AM,Gale CR,Deary IJ

    更新日期:2020-11-01 00:00:00

  • Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders.

    abstract::Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages spanning 100 years, as well as 67 adult individuals diagnosed with autism (ASD), schizophrenia (SZ), and Down synd...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-018-0200-8

    authors: Yu Q,He Z,Zubkov D,Huang S,Kurochkin I,Yang X,Halene T,Willmitzer L,Giavalisco P,Akbarian S,Khaitovich P

    更新日期:2020-11-01 00:00:00

  • Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS.

    abstract::Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis spectrum. However, there is a lack of studies investigating longitudinal hippocampal development and its relationship with psychotic symptoms. The 22q11.2 deletion syndrome (22q11DS) has proven to be a remarkable model for the pro...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-019-0443-z

    authors: Mancini V,Sandini C,Padula MC,Zöller D,Schneider M,Schaer M,Eliez S

    更新日期:2020-11-01 00:00:00

  • Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis.

    abstract::Cariprazine (CAR) is a strong inhibitor of the Dhcr7 enzyme, the last enzyme in the cholesterol biosynthesis pathway. We assessed the effects of CAR on maternally exposed Dhcr7+/- and wild-type mouse offspring, and tested the biochemical effects of CAR in human serum samples. Dhcr7+/- and wild-type time-pregnant mice ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-0801-x

    authors: Genaro-Mattos TC,Anderson A,Allen LB,Tallman KA,Porter NA,Korade Z,Mirnics K

    更新日期:2020-11-01 00:00:00

  • Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.

    abstract::Categorizing people with late-onset Alzheimer's disease into biologically coherent subgroups is important for personalized medicine. We evaluated data from five studies (total n = 4050, of whom 2431 had genome-wide single-nucleotide polymorphism (SNP) data). We assigned people to cognitively defined subgroups on the b...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-018-0298-8

    authors: Mukherjee S,Mez J,Trittschuh EH,Saykin AJ,Gibbons LE,Fardo DW,Wessels M,Bauman J,Moore M,Choi SE,Gross AL,Rich J,Louden DKN,Sanders RE,Grabowski TJ,Bird TD,McCurry SM,Snitz BE,Kamboh MI,Lopez OL,De Jager PL,Benn

    更新日期:2020-11-01 00:00:00

  • Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative.

    abstract::Whilst cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers for amyloid-β (Aβ) and tau pathologies are accurate for the diagnosis of Alzheimer's disease (AD), their broad implementation in clinical and trial settings are restricted by high cost and limited accessibility. Plasma phosphorylated-ta...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00923-z

    authors: Karikari TK,Benedet AL,Ashton NJ,Lantero Rodriguez J,Snellman A,Suárez-Calvet M,Saha-Chaudhuri P,Lussier F,Kvartsberg H,Rial AM,Pascoal TA,Andreasson U,Schöll M,Weiner MW,Rosa-Neto P,Trojanowski JQ,Shaw LM,Blennow K,Z

    更新日期:2020-10-26 00:00:00

  • ADORA1-driven brain-sympathetic neuro-adipose connections control body weight and adipose lipid metabolism.

    abstract::It is essential to elucidate brain-adipocyte interactions in order to tackle obesity and its comorbidities, as the precise control of brain-adipose tissue cross-talk is crucial for energy and glucose homeostasis. Recent studies show that in the peripheral adipose tissue, adenosine induces adipogenesis through peripher...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00908-y

    authors: Zhang J,Hou Y,Du XL,Chen D,Sui G,Qi Y,Licinio J,Wong ML,Yang Y

    更新日期:2020-10-16 00:00:00

  • Correction: Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Molecular psychiatry

    pub_type: 已发布勘误

    doi:10.1038/s41380-020-00919-9

    authors: Haarsma J,Fletcher PC,Griffin JD,Taverne HJ,Ziauddeen H,Spencer TJ,Miller C,Katthagen T,Goodyer I,Diederen KMJ,Murray GK

    更新日期:2020-10-14 00:00:00

  • Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis.

    abstract::Diverse studies have investigated the impact of prenatal exposure to vitamin D levels on brain development; however, evidence in humans has never been systematically reviewed. This article summarized evidence of the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or newborn bloo...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-019-0357-9

    authors: García-Serna AM,Morales E

    更新日期:2020-10-01 00:00:00

  • Nuclear receptor corepressors in intellectual disability and autism.

    abstract::Autism spectrum disorder (ASD) is characterized by neurocognitive dysfunctions, such as impaired social interaction and language learning. Gene-environment interactions have a pivotal role in ASD pathogenesis. Nuclear receptor corepressors (NCORs) are transcription co-regulators physically associated with histone deac...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审

    doi:10.1038/s41380-020-0667-y

    authors: Kong Y,Zhou W,Sun Z

    更新日期:2020-10-01 00:00:00

  • Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder.

    abstract::Cannabis is one of the most commonly and widely used psychoactive drugs. The rates of cannabis misuse have been increasing. Therefore, understanding the effects of cannabis use on the brain is important. Adolescent and adult rodents exposed to repeated administration of cannabinoids show persistent microstructural cha...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00891-4

    authors: D'Souza DC,Radhakrishnan R,Naganawa M,Ganesh S,Nabulsi N,Najafzadeh S,Ropchan J,Ranganathan M,Cortes-Briones J,Huang Y,Carson RE,Skosnik P

    更新日期:2020-09-24 00:00:00

  • Literature review and methodological considerations for understanding circulating risk biomarkers following trauma exposure.

    abstract::Exposure to traumatic events is common. While many individuals recover following trauma exposure, a substantial subset develop adverse posttraumatic neuropsychiatric sequelae (APNS) such as posttraumatic stress, major depression, and regional or widespread chronic musculoskeletal pain. APNS cause substantial burden to...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章,评审

    doi:10.1038/s41380-019-0636-5

    authors: Linnstaedt SD,Zannas AS,McLean SA,Koenen KC,Ressler KJ

    更新日期:2020-09-01 00:00:00

  • Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma.

    abstract::Psychiatric diseases have a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance alone but to also involve epigenetic factors in germ cells. Initial evidence suggested that sperm RNA is causally linked to the transmission of symptoms induced by traumatic experiences. Here, we...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-018-0271-6

    authors: Gapp K,van Steenwyk G,Germain PL,Matsushima W,Rudolph KLM,Manuella F,Roszkowski M,Vernaz G,Ghosh T,Pelczar P,Mansuy IM,Miska EA

    更新日期:2020-09-01 00:00:00

  • Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia.

    abstract::Amyloid-β peptide (Aβ) accumulation in the brain is a hallmark of Alzheimer's Disease. An important mechanism of Aβ clearance in the brain is uptake and degradation by microglia. Presenilin 1 (PS1) is the catalytic subunit of γ-secretase, an enzyme complex responsible for the maturation of multiple substrates, such as...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-0856-8

    authors: Ledo JH,Liebmann T,Zhang R,Chang JC,Azevedo EP,Wong E,Silva HM,Troyanskaya OG,Bustos V,Greengard P

    更新日期:2020-08-13 00:00:00

  • TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies.

    abstract::Neurotrophins promote neuronal survival and synaptic plasticity via activating the tropomyosin receptor kinases. BDNF and its high-affinity receptor TrkB are reduced in Alzheimer's disease (AD), contributing to progressive cognitive decline. However, how the signaling mediates AD pathologies remains incompletely under...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-00863-8

    authors: Xia Y,Wang ZH,Liu P,Edgington-Mitchell L,Liu X,Wang XC,Ye K

    更新日期:2020-08-11 00:00:00

  • Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

    abstract::A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Molecular psychiatry

    pub_type: 已发布勘误

    doi:10.1038/s41380-019-0529-7

    authors: Bis JC,Jian X,Kunkle BW,Chen Y,Hamilton-Nelson KL,Bush WS,Salerno WJ,Lancour D,Ma Y,Renton AE,Marcora E,Farrell JJ,Zhao Y,Qu L,Ahmad S,Amin N,Amouyel P,Beecham GW,Below JE,Campion D,Cantwell L,Charbonnier C,Ch

    更新日期:2020-08-01 00:00:00

  • The neuropathology of bipolar disorder: systematic review and meta-analysis.

    abstract::Various neuropathological findings have been reported in bipolar disorder (BD). However, it is unclear which findings are well established. To address this gap, we carried out a systematic review of the literature. We searched over 5000 publications, identifying 103 data papers, of which 81 were eligible for inclusion...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-018-0213-3

    authors: Harrison PJ,Colbourne L,Harrison CH

    更新日期:2020-08-01 00:00:00

  • The symptom network structure of depressive symptoms in late-life: Results from a European population study.

    abstract::The network theory conceptualizes mental disorders as complex networks of symptoms influencing each other by creating feedback loops, leading to a self-sustained syndromic constellation. Symptoms central to the network have the greatest impact in sustaining the rest of symptoms. This analysis focused on the network st...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-018-0232-0

    authors: Belvederi Murri M,Amore M,Respino M,Alexopoulos GS

    更新日期:2020-07-01 00:00:00

  • Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain.

    abstract::In mammals, most adult neural stem cells (NSCs) are located in the ventricular-subventricular zone (V-SVZ) along the wall of the lateral ventricles and they are the source of olfactory bulb interneurons. Adult NSCs exhibit an apico-basal polarity; they harbor a short apical process and a long basal process, reminiscen...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-0823-4

    authors: García-González D,Dumitru I,Zuccotti A,Yen TY,Herranz-Pérez V,Tan LL,Neitz A,García-Verdugo JM,Kuner R,Alfonso J,Monyer H

    更新日期:2020-07-01 00:00:00

  • PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival.

    abstract::Microvascular pathology and ischemic lesions contribute substantially to neuronal dysfunction and loss that lead to Alzheimer disease (AD). To facilitate recovery, the brain stimulates neovascularization of damaged tissue via sprouting angiogenesis, a process regulated by endothelial cell (EC) sprouting and the EphB4/...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-0812-7

    authors: Yoon Y,Voloudakis G,Doran N,Zhang E,Dimovasili C,Chen L,Shao Z,Darmanis S,Tang C,Tang J,Wang VX,Hof PR,Robakis NK,Georgakopoulos A

    更新日期:2020-06-15 00:00:00

  • A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt.

    abstract::Use of substances such as cannabis, alcohol, and tobacco, has been associated with increased risk of suicide attempt in several observational studies. However, establishing whether these associations are causal is challenging when using observational designs. To evaluate the potential causal contributions of cannabis ...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-0785-6

    authors: Orri M,Séguin JR,Castellanos-Ryan N,Tremblay RE,Côté SM,Turecki G,Geoffroy MC

    更新日期:2020-06-08 00:00:00

  • Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression.

    abstract::Current antidepressants act principally by blocking monoamine reuptake by high-affinity transporters in the brain. However, these antidepressants show important shortcomings such as slow action onset and limited efficacy in nearly a third of patients with major depression disorder. Here, we report the development of a...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-019-0548-4

    authors: Orrico-Sanchez A,Chausset-Boissarie L,Alves de Sousa R,Coutens B,Rezai Amin S,Vialou V,Louis F,Hessani A,Dansette PM,Zornoza T,Gruszczynski C,Giros B,Guiard BP,Acher F,Pietrancosta N,Gautron S

    更新日期:2020-06-01 00:00:00

  • CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination.

    abstract::Circular RNAs (circRNAs), highly expressed in the central nervous system, are involved in various regulatory processes and implicated in some pathophysiology. However, the potential role of circRNAs in psychiatric diseases, particularly major depressive disorder (MDD), remains largely unknown. Here, we demonstrated th...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-018-0285-0

    authors: Zhang Y,Du L,Bai Y,Han B,He C,Gong L,Huang R,Shen L,Chao J,Liu P,Zhang H,Zhang H,Gu L,Li J,Hu G,Xie C,Zhang Z,Yao H

    更新日期:2020-06-01 00:00:00

  • Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress.

    abstract::Chronic stress contributes to the development of psychiatric disorders including anxiety and depression. Several inflammatory-related effects of stress are associated with increased interleukin-1 (IL-1) signaling within the central nervous system and are mediated by IL-1 receptor 1 (IL-1R1) on several distinct cell ty...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-0788-3

    authors: DiSabato DJ,Nemeth DP,Liu X,Witcher KG,O'Neil SM,Oliver B,Bray CE,Sheridan JF,Godbout JP,Quan N

    更新日期:2020-05-22 00:00:00

  • Neuropsychosocial markers of binge drinking in young adults.

    abstract::Binge drinking is associated with disease and death, and developing tools to identify risky drinkers could mitigate its damage. Brain processes underlie risky drinking, so we examined whether neural and psychosocial markers could identify binge drinkers. Reward is the most widely studied neural process in addiction, b...

    journal_title:Molecular psychiatry

    pub_type: 杂志文章

    doi:10.1038/s41380-020-0771-z

    authors: Gowin JL,Manza P,Ramchandani VA,Volkow ND

    更新日期:2020-05-12 00:00:00

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