Abstract:
:Depression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There are data to support several different theories of causation, including the monoamine hypothesis, hypothalamic-pituitary-adrenal axis changes, inflammation and immune system alterations, abnormalities of neurogenesis and a conducive environmental milieu. Research in these areas and others has greatly advanced the current understanding of depression; however, there are other, less widely known theories of pathogenesis. Oligodendrocyte lineage cells, including oligodendrocyte progenitor cells and mature oligodendrocytes, have numerous important functions, which include forming myelin sheaths that enwrap central nervous system axons, supporting axons metabolically, and mediating certain forms of neuroplasticity. These specialized glial cells have been implicated in psychiatric disorders such as depression. In this review, we summarize recent findings that shed light on how oligodendrocyte lineage cells might participate in the pathogenesis of depression, and we discuss new approaches for targeting these cells as a novel strategy to treat depression.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Zhou B,Zhu Z,Ransom BR,Tong Xdoi
10.1038/s41380-020-00930-0subject
Has Abstractpub_date
2021-01-01 00:00:00pages
103-117issue
1eissn
1359-4184issn
1476-5578pii
10.1038/s41380-020-00930-0journal_volume
26pub_type
杂志文章,评审abstract::Abnormalities in prefrontal gamma aminobutyric acid (GABA)ergic transmission, particularly in fast-spiking interneurons that express parvalbumin (PV), are hypothesized to contribute to the pathophysiology of multiple psychiatric disorders, including schizophrenia, bipolar disorder, anxiety disorders and depression. Wh...
journal_title:Molecular psychiatry
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1038/s41380-019-0635-6
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pub_type: 杂志文章
doi:10.1038/s41380-019-0590-2
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pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/s41380-018-0254-7
更新日期:2019-06-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.63
更新日期:2011-02-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001296
更新日期:2003-06-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001978
更新日期:2007-06-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0443-z
更新日期:2020-11-01 00:00:00
abstract::Low dietary folate intake has been implicated as a risk factor for depression. However, observational epidemiological studies are plagued by problems of confounding, reverse causality and measurement error. A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and ...
journal_title:Molecular psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1038/sj.mp.4001790
更新日期:2006-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/s41380-018-0269-0
更新日期:2020-04-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000563
更新日期:2000-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.144
更新日期:2013-06-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000405
更新日期:1998-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/s41380-019-0357-9
更新日期:2020-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/mp.2009.115
更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.mp.4000744
更新日期:2000-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.mp.4001845
更新日期:2006-08-01 00:00:00
abstract::This Article was originally published under Nature Research's License to Publish, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the Article have been modified accordingly. ...
journal_title:Molecular psychiatry
pub_type: 已发布勘误
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更新日期:2019-09-01 00:00:00
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