当前位置： SCI文献检索 > MOLECULAR PSYCHIATRY期刊下所有文献 > Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits.

Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits.

Abstract：

:The urocortin (Ucn) family of neuropeptides is suggested to be involved in homeostatic coping mechanisms of the central stress response through the activation of corticotropin-releasing factor receptor type 2 (CRFR2). The neuropeptides, Ucn1 and Ucn2, serve as endogenous ligands for the CRFR2, which is highly expressed by the dorsal raphe serotonergic neurons and is suggested to be involved in regulating major component of the central stress response. Here, we describe genetically modified mice in which both Ucn1 and Ucn2 are developmentally deleted. The double knockout mice showed a robust anxiolytic phenotype and altered hypothalamic-pituitary-adrenal axis activity compared with wild-type mice. The significant reduction in anxiety-like behavior observed in these mice was further enhanced after exposure to acute stress, and was correlated with the levels of serotonin and 5-hydroxyindoleacetic acid measured in brain regions associated with anxiety circuits. Thus, we propose that the Ucn/CRFR2 serotonergic system has an important role in regulating homeostatic equilibrium under challenge conditions.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Neufeld-Cohen A,Evans AK,Getselter D,Spyroglou A,Hill A,Gil S,Tsoory M,Beuschlein F,Lowry CA,Vale W,Chen A

doi

10.1038/mp.2009.115

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

426-41, 339

issue

4

eissn

1359-4184

issn

1476-5578

pii

mp2009115

journal_volume

15

pub_type

杂志文章

相关文献

MOLECULAR PSYCHIATRY文献大全
  • Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

    abstract：:A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Molecular psychiatry

    pub_type： 已发布勘误

    doi：10.1038/s41380-019-0529-7

    authors： Bis JC,Jian X,Kunkle BW,Chen Y,Hamilton-Nelson KL,Bush WS,Salerno WJ,Lancour D,Ma Y,Renton AE,Marcora E,Farrell JJ,Zhao Y,Qu L,Ahmad S,Amin N,Amouyel P,Beecham GW,Below JE,Campion D,Cantwell L,Charbonnier C,Ch

    更新日期：2020-08-01 00:00:00

  • Modeling the functional genomics of autism using human neurons.

    abstract：:Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation, making them highly useful adjuncts to animal models. Here, we ex...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2011.60

    authors： Konopka G,Wexler E,Rosen E,Mukamel Z,Osborn GE,Chen L,Lu D,Gao F,Gao K,Lowe JK,Geschwind DH

    更新日期：2012-02-01 00:00:00

  • Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.

    abstract：:Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype-phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) constitute a potentially informative target for genetic studies of intermediate phenotypes as their genetic underp...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2012.183

    authors： Luykx JJ,Bakker SC,Lentjes E,Neeleman M,Strengman E,Mentink L,DeYoung J,de Jong S,Sul JH,Eskin E,van Eijk K,van Setten J,Buizer-Voskamp JE,Cantor RM,Lu A,van Amerongen M,van Dongen EP,Keijzers P,Kappen T,Borgdorff P

    更新日期：2014-02-01 00:00:00

  • The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.

    abstract：:Exercise has a variety of beneficial effects on brain structure and function, such as hippocampal neurogenesis, mood and memory. Previous studies have shown that exercise enhances hippocampal neurogenesis, induces antidepressant effects and improves learning behavior. Brain serotonin (5-hydroxytryptamine, 5-HT) levels...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2014.153

    authors： Kondo M,Nakamura Y,Ishida Y,Shimada S

    更新日期：2015-11-01 00:00:00

  • Altered connections on the road to psychopathy.

    abstract：:Psychopathy is strongly associated with serious criminal behaviour (for example, rape and murder) and recidivism. However, the biological basis of psychopathy remains poorly understood. Earlier studies suggested that dysfunction of the amygdala and/or orbitofrontal cortex (OFC) may underpin psychopathy. Nobody, howeve...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2009.40

    authors： Craig MC,Catani M,Deeley Q,Latham R,Daly E,Kanaan R,Picchioni M,McGuire PK,Fahy T,Murphy DG

    更新日期：2009-10-01 00:00:00

  • Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder.

    abstract：:Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder. Genetic loci have not yet been identified by genome-wide association studies. Rare copy number variations (CNVs), such as chromosomal deletions or duplications, have been implicated in ADHD and other neurodevelop...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2012.161

    authors： Jarick I,Volckmar AL,Pütter C,Pechlivanis S,Nguyen TT,Dauvermann MR,Beck S,Albayrak Ö,Scherag S,Gilsbach S,Cichon S,Hoffmann P,Degenhardt F,Nöthen MM,Schreiber S,Wichmann HE,Jöckel KH,Heinrich J,Tiesler CM,Faraone S

    更新日期：2014-01-01 00:00:00

  • Reduced motor cortex GABABR function following chronic alcohol exposure.

    abstract：:The GABAB receptor (GABABR) agonist baclofen has been used to treat alcohol and several other substance use disorders (AUD/SUD), yet its underlying neural mechanism remains unclear. The present study aimed to investigate cortical GABABR dynamics following chronic alcohol exposure. Ex vivo brain slice recordings from m...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-01009-6

    authors： Peng SY,Shi Z,Zhou DS,Wang XY,Li XX,Liu XL,Wang WD,Lin GN,Pan BX,Voon V,Grace AA,Heilig M,Wong ML,Yuan TF

    更新日期：2021-01-11 00:00:00

  • Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.

    abstract：:Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia. This study comprises genome-wide association (GWA) and follow-up analyses of all individuals born in Denmark since 1...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2013.2

    authors： Børglum AD,Demontis D,Grove J,Pallesen J,Hollegaard MV,Pedersen CB,Hedemand A,Mattheisen M,GROUP investigators10.,Uitterlinden A,Nyegaard M,Ørntoft T,Wiuf C,Didriksen M,Nordentoft M,Nöthen MM,Rietschel M,Ophoff RA,Cic

    更新日期：2014-03-01 00:00:00

  • Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.

    abstract：:This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41380-018-0301-4

    authors： Haure-Mirande JV,Wang M,Audrain M,Fanutza T,Kim SH,Heja S,Readhead B,Dudley JT,Blitzer RD,Schadt EE,Zhang B,Gandy S,Ehrlich ME

    更新日期：2019-03-01 00:00:00

  • Treatment response prediction and individualized identification of first-episode drug-naïve schizophrenia using brain functional connectivity.

    abstract：:Identifying biomarkers in schizophrenia during the first episode without the confounding effects of treatment has been challenging. Leveraging these biomarkers to establish diagnosis and make individualized predictions of future treatment responses to antipsychotics would be of great value, but there has been limited ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-018-0106-5

    authors： Cao B,Cho RY,Chen D,Xiu M,Wang L,Soares JC,Zhang XY

    更新日期：2020-04-01 00:00:00

  • Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescence.

    abstract：:Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in the pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the dynamic plasticity of dendritic spines of pyramidal neurons (PNs) and "en passant" axonal bouton of parvalbumin-expressing interneurons (PVI...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-01005-w

    authors： Huang Y,Jiang H,Zheng Q,Fok AHK,Li X,Lau CG,Lai CSW

    更新日期：2021-01-20 00:00:00

  • Educational attainment and drinking behaviors: Mendelian randomization study in UK Biobank.

    abstract：:Educational attainment has been associated with drinking behaviors in observation studies. We performed Mendelian randomization analysis to determine whether educational attainment causally affected drinking behaviors, including amount of alcohol intakes (in total and various types), drinking frequency, and drinking w...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0596-9

    authors： Zhou T,Sun D,Li X,Ma H,Heianza Y,Qi L

    更新日期：2019-11-25 00:00:00

  • Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice.

    abstract：:TET3 is a member of the ten-eleven translocation (TET) family of enzymes which oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Tet3 is highly expressed in the brain, where 5hmC levels are most abundant. In adult mice, we observed that TET3 is present in mature neurons and oligodendrocytes but is ab...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-0695-7

    authors： Antunes C,Da Silva JD,Guerra-Gomes S,Alves ND,Ferreira F,Loureiro-Campos E,Branco MR,Sousa N,Reik W,Pinto L,Marques CJ

    更新日期：2020-02-26 00:00:00

  • RNA editing of the 5-HT(2C) receptor is reduced in schizophrenia.

    abstract：:5-HT(2C) receptor (5HT(2C)R, serotonin-2C) RNA undergoes editing to produce several receptor variants, some with pharmacological differences. This investigation comprised two parts: the characterisation of 5-HT(2C)R RNA editing in a larger human control sample than previously examined, and a comparative study in subje...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000920

    authors： Sodhi MS,Burnet PW,Makoff AJ,Kerwin RW,Harrison PJ

    更新日期：2001-07-01 00:00:00

  • Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative.

    abstract：:Whilst cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers for amyloid-β (Aβ) and tau pathologies are accurate for the diagnosis of Alzheimer's disease (AD), their broad implementation in clinical and trial settings are restricted by high cost and limited accessibility. Plasma phosphorylated-ta...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-00923-z

    authors： Karikari TK,Benedet AL,Ashton NJ,Lantero Rodriguez J,Snellman A,Suárez-Calvet M,Saha-Chaudhuri P,Lussier F,Kvartsberg H,Rial AM,Pascoal TA,Andreasson U,Schöll M,Weiner MW,Rosa-Neto P,Trojanowski JQ,Shaw LM,Blennow K,Z

    更新日期：2020-10-26 00:00:00

  • Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine.

    abstract：:A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memory reconsolidation represents a potential therapeutic strategy,...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2015.157

    authors： Boury-Jamot B,Carrard A,Martin JL,Halfon O,Magistretti PJ,Boutrel B

    更新日期：2016-08-01 00:00:00

  • Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide.

    abstract：:Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown. We found that widely used antidepressants such as amitriptyline and fluoxetine induce autoph...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-018-0090-9

    authors： Gulbins A,Schumacher F,Becker KA,Wilker B,Soddemann M,Boldrin F,Müller CP,Edwards MJ,Goodman M,Caldwell CC,Kleuser B,Kornhuber J,Szabo I,Gulbins E

    更新日期：2018-12-01 00:00:00

  • Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter.

    abstract：:The astrocytic cystine/glutamate antiporter system xc- represents an important source of extracellular glutamate in the central nervous system, with potential impact on excitatory neurotransmission. Yet, its function and importance in brain physiology remain incompletely understood. Employing slice electrophysiology a...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-0751-3

    authors： Bentea E,Villers A,Moore C,Funk AJ,O'Donovan SM,Verbruggen L,Lara O,Janssen P,De Pauw L,Declerck NB,DePasquale EAK,Churchill MJ,Sato H,Hermans E,Arckens L,Meshul CK,Ris L,McCullumsmith RE,Massie A

    更新日期：2020-05-04 00:00:00

  • Disruption of MBD5 contributes to a spectrum of psychopathology and neurodevelopmental abnormalities.

    abstract：:Microdeletions of chromosomal region 2q23.1 that disrupt MBD5 (methyl-CpG-binding domain protein 5) contribute to a spectrum of neurodevelopmental phenotypes; however, the impact of this locus on human psychopathology has not been fully explored. To characterize the structural variation landscape of MBD5 disruptions a...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,多中心研究

    doi：10.1038/mp.2013.42

    authors： Hodge JC,Mitchell E,Pillalamarri V,Toler TL,Bartel F,Kearney HM,Zou YS,Tan WH,Hanscom C,Kirmani S,Hanson RR,Skinner SA,Rogers RC,Everman DB,Boyd E,Tapp C,Mullegama SV,Keelean-Fuller D,Powell CM,Elsea SH,Morton CC

    更新日期：2014-03-01 00:00:00

  • Dissecting bipolar disorder complexity through epigenomic approach.

    abstract：:In recent years, numerous studies of gene regulation mechanisms have emerged in neuroscience. Epigenetic modifications, described as heritable but reversible changes, include DNA methylation, DNA hydroxymethylation, histone modifications and noncoding RNAs. The pathogenesis of psychiatric disorders, such as bipolar di...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/mp.2016.123

    authors： Ludwig B,Dwivedi Y

    更新日期：2016-11-01 00:00:00

  • Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy.

    abstract：:Here, we report a novel target of the drug memantine, ATP-sensitive K+ (KATP) channels, potentially relevant to memory improvement. We confirmed that memantine antagonizes memory impairment in Alzheimer's model APP23 mice. Memantine increased CaMKII activity in the APP23 mouse hippocampus, and memantine-induced enhanc...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.187

    authors： Moriguchi S,Ishizuka T,Yabuki Y,Shioda N,Sasaki Y,Tagashira H,Yawo H,Yeh JZ,Sakagami H,Narahashi T,Fukunaga K

    更新日期：2018-02-01 00:00:00

  • Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis.

    abstract：:Diverse studies have investigated the impact of prenatal exposure to vitamin D levels on brain development; however, evidence in humans has never been systematically reviewed. This article summarized evidence of the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or newborn bloo...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0357-9

    authors： García-Serna AM,Morales E

    更新日期：2020-10-01 00:00:00

  • Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro.

    abstract：:Acetylcholinesterase (AChE), the enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, has been implicated in non-cholinergic actions which may play a role in neurodegenerative diseases such as Alzheimer's disease. To study the potential cytotoxicity of brain AChE, the effects of affinity purified A...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000383

    authors： Calderón FH,von Bernhardi R,De Ferrari G,Luza S,Aldunate R,Inestrosa NC

    更新日期：1998-05-01 00:00:00

  • Liposome-based targeting of dopamine to the brain: a novel approach for the treatment of Parkinson's disease.

    abstract：:Delivery of drugs into the brain is poor due to the blood brain barrier (BBB). This study describes the development of a novel liposome-based brain-targeting drug delivery system. The liposomes incorporate a diacylglycerol moiety coupled through a linker to a peptide of 5 amino acids selected from amyloid precursor pr...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-0742-4

    authors： Kahana M,Weizman A,Gabay M,Loboda Y,Segal-Gavish H,Gavish A,Barhum Y,Offen D,Finberg J,Allon N,Gavish M

    更新日期：2020-05-05 00:00:00

  • Variants in Apaf-1 segregating with major depression promote apoptosome function.

    abstract：:APAF1, encoding the protein apoptosis protease activating factor 1 (Apaf-1), has recently been established as a chromosome 12 gene conferring predisposition to major depression in humans. The molecular phenotypes of Apaf-1 variants were determined by in vitro reconstruction of the apoptosome complex in which Apaf-1 ac...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001755

    authors： Harlan J,Chen Y,Gubbins E,Mueller R,Roch JM,Walter K,Lake M,Olsen T,Metzger P,Dorwin S,Ladror U,Egan DA,Severin J,Johnson RW,Holzman TF,Voelp K,Davenport C,Beck A,Potter J,Gopalakrishnan M,Hahn A,Spear BB,Halb

    更新日期：2006-01-01 00:00:00

  • Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core.

    abstract：:Poorly regulated reward seeking is a central feature of substance use disorder. Recent research shows that rewarding drug-related experiences induce synchronous activation of a discrete number of neurons in the nucleus accumbens that are causally linked to reward-related contexts. Here we comprehensively characterize ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-00888-z

    authors： Bobadilla AC,Dereschewitz E,Vaccaro L,Heinsbroek JA,Scofield MD,Kalivas PW

    更新日期：2020-12-01 00:00:00

  • COMT haplotypes suggest P2 promoter region relevance for schizophrenia.

    abstract：:A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstrea...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001496

    authors： Palmatier MA,Pakstis AJ,Speed W,Paschou P,Goldman D,Odunsi A,Okonofua F,Kajuna S,Karoma N,Kungulilo S,Grigorenko E,Zhukova OV,Bonne-Tamir B,Lu RB,Parnas J,Kidd JR,DeMille MM,Kidd KK

    更新日期：2004-09-01 00:00:00

  • Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor.

    abstract：:We tested the hypothesis that, compared with subjects with no history of psychiatric illness (controls), changes in gene expression in the dorsolateral prefrontal cortex from two subgroups of subjects with schizophrenia, one with a marked deficit in muscarinic M1 receptors (muscarinic receptor-deficit schizophrenia (M...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.195

    authors： Scarr E,Udawela M,Thomas EA,Dean B

    更新日期：2018-02-01 00:00:00

  • Population-based linkage analysis of schizophrenia and bipolar case-control cohorts identifies a potential susceptibility locus on 19q13.

    abstract：:Population-based linkage analysis is a new method for analysing genomewide single nucleotide polymorphism (SNP) genotype data in case-control samples, which does not assume a common disease, common variant model. The genome is scanned for extended segments that show increased identity-by-descent sharing within case-ca...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,meta分析

    doi：10.1038/mp.2008.100

    authors： Francks C,Tozzi F,Farmer A,Vincent JB,Rujescu D,St Clair D,Muglia P

    更新日期：2010-03-01 00:00:00

  • Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample.

    abstract：:Association between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of the dopamine transporter gene (DAT1) has been reported in independent clinical samples using a categorical clinical definition of ADHD. The present study adopts a quantitative trait loci (QTL) approach to examine the associ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001641

    authors： Cornish KM,Manly T,Savage R,Swanson J,Morisano D,Butler N,Grant C,Cross G,Bentley L,Hollis CP

    更新日期：2005-07-01 00:00:00