Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor.

abstract：:Several epidemiological studies confirmed that Anxiety Disorders as a group are the most prevalent psychiatric conditions in the United States. The importance of these conditions is underlined by the fact that they cause significant disability, poor quality of life, alcohol and drug abuse. Anxiety disorders are treata...

journal_title：Molecular psychiatry

authors： Bystritsky A

更新日期：2006-09-01 00:00:00

abstract：:Significant evidence for linkage between bipolar affective disorder and markers on chromosome 4p16 has been reported in Scottish families. Linkage analyses using 16 DNA markers covering more than 50 cM from chromosome 4pter-4p12, including candidate genes encoding the dopamine D5 receptor and an adrenergic receptor (2...

journal_title：Molecular psychiatry

authors： Ewald H,Degn B,Mors O,Kruse TA

更新日期：1998-09-01 00:00:00

abstract：:The methionine-folate cycle-dependent one-carbon metabolism is implicated in the pathophysiology of schizophrenia. Since schizophrenia is a developmental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestation has on mice progeny. Pregnant mice were administered methionine equ...

journal_title：Molecular psychiatry

authors： Alachkar A,Wang L,Yoshimura R,Hamzeh AR,Wang Z,Sanathara N,Lee SM,Xu X,Abbott GW,Civelli O

更新日期：2018-02-01 00:00:00

abstract：:Although few studies dispute that there are gender differences in depression, the etiology is still unknown. In this review, we cover a number of proposed factors and the evidences for and against these factors that may account for gender differences in depression. These include the possible role of estrogens at puber...

journal_title：Molecular psychiatry

authors： Young E,Korszun A

更新日期：2010-01-01 00:00:00

abstract：:Autism is a neurodevelopmental disorder manifesting early in childhood. Some symptoms of autism are alleviated by treatment with selective serotonin reuptake inhibitors, which are known to interact with the serotonin transporter. Moreover, variation in the gene that encodes the transporter (SLC6A4), especially the HTT...

journal_title：Molecular psychiatry

authors： Devlin B,Cook EH Jr,Coon H,Dawson G,Grigorenko EL,McMahon W,Minshew N,Pauls D,Smith M,Spence MA,Rodier PM,Stodgell C,Schellenberg GD,CPEA Genetics Network.

更新日期：2005-12-01 00:00:00

abstract：:Gonadal hormones influence neuronal organization and plasticity. Yet the consequences of altering their concentrations by administering contraceptive agents, which are used by most reproductive-age women in the United States, are unclear. Cross-sectional studies have found both larger and smaller cortical regions alon...

journal_title：Molecular psychiatry

authors： Petersen N,Kearley NW,Ghahremani DG,Pochon JB,Fry ME,Rapkin AJ,London ED

更新日期：2021-01-08 00:00:00

abstract：:Episodic memory, a fundamental component of human cognition, is significantly impaired in autism. We believe we report the first evidence for this problem in the Fmr1-knockout (KO) mouse model of Fragile X syndrome and describe potentially treatable underlying causes. The hippocampus is critical for the formation and ...

journal_title：Molecular psychiatry

authors： Wang W,Cox BM,Jia Y,Le AA,Cox CD,Jung KM,Hou B,Piomelli D,Gall CM,Lynch G

更新日期：2018-08-01 00:00:00

abstract：:Several reports have suggested the presence of anticipation in bipolar affective disorder (BPAD). In addition, independent studies using the RED (repeat expansion detection) have shown association between BPAD and longer CAG/CTG repeats. Therefore loci with large CAG/CTG repeats are plausible candidates in the inherit...

journal_title：Molecular psychiatry

authors： Meira-Lima IV,Zhao J,Sham P,Pereira AC,Krieger JE,Vallada H

更新日期：2001-09-01 00:00:00

abstract：:Psychotropic medications target glycogen synthase kinase 3β (GSK3β), but the functional integration with other factors relevant for drug efficacy is poorly understood. We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3β at serine 9 (pGSK3β(S9))....

journal_title：Molecular psychiatry

authors： Gassen NC,Hartmann J,Zannas AS,Kretzschmar A,Zschocke J,Maccarrone G,Hafner K,Zellner A,Kollmannsberger LK,Wagner KV,Mehta D,Kloiber S,Turck CW,Lucae S,Chrousos GP,Holsboer F,Binder EB,Ising M,Schmidt MV,Rein T

更新日期：2016-02-01 00:00:00

abstract：:Abnormalities in the density of neuroreceptors that regulate norepinephrine and serotonin release have been repeatedly reported in brains of suicide victims with mood disorders. Recently, the modulation of the [(35)S]GTPgammaS binding to G-proteins has been introduced as a suitable measure of receptor activity in post...

journal_title：Molecular psychiatry

authors： González-Maeso J,Rodríguez-Puertas R,Meana JJ,García-Sevilla JA,Guimón J

更新日期：2002-01-01 00:00:00

abstract：:The 102-T/C polymorphism of the 5-HT(2A) receptor gene was analysed in 159 patients with major depression and 164 unrelated and healthy controls using a case-control design. Allele and genotype frequencies did not differ between cases and controls. No differences according to sex, age of onset, melancholia, suicidal b...

journal_title：Molecular psychiatry

authors： Arias B,Gutiérrez B,Pintor L,Gastó C,Fañanás L

更新日期：2001-03-01 00:00:00

abstract：:Given the manifold ways that depression impairs Darwinian fitness, the persistence in the human genome of risk alleles for the disorder remains a much debated mystery. Evolutionary theories that view depressive symptoms as adaptive fail to provide parsimonious explanations for why even mild depressive symptoms impair ...

journal_title：Molecular psychiatry

authors： Raison CL,Miller AH

更新日期：2013-01-01 00:00:00

abstract：:The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. A meta-analysis was performed on 15 studies including data of 1435 subjects. We tested three phenotypes: remission rate,...

journal_title：Molecular psychiatry

authors： Serretti A,Kato M,De Ronchi D,Kinoshita T

更新日期：2007-03-01 00:00:00

abstract：:Dysthymia is characterized by long-lasting periods of lowered mood. Epidemiological studies in the USA and Europe have demonstrated that the prevalence of dysthymia is at least 3% of the general population. Its pervasive occurrence makes dysthymia a public health problem worldwide. One feature of this disorder is its ...

journal_title：Molecular psychiatry

authors： Akiskal HS,Bolis CL,Cazzullo C,Costa e Silva JA,Gentil V,Lecrubier Y,Licinio J,Linden M,Lopez-Ibor JJ,Ndiaye IP,Pani L,Prilipko L,Robertson MM,Robinson RG,Starkstein SE,Thomas P,Wang Y,Wong ML

更新日期：1996-12-01 00:00:00

abstract：:Chronic methamphetamine use poses potentially devastating consequences for directly affected individuals and for society. Lower dopamine D2-type receptor availability has been observed in striata of methamphetamine users as compared with controls, but an analogous comparison of D1-type receptors has been conducted onl...

journal_title：Molecular psychiatry

authors： Okita K,Morales AM,Dean AC,Johnson MC,Lu V,Farahi J,Mandelkern MA,London ED

更新日期：2018-05-01 00:00:00

abstract：:The search for genetic factors predisposing to Attention Deficit Hyperactivity Disorder (ADHD) has focused on genes that regulate dopaminergic pathways such as dopamine receptors and enzymes that regulate levels of dopamine in the synapse. There have been several reports of association between ADHD and polymorphic var...

journal_title：Molecular psychiatry

authors： Tahir E,Yazgan Y,Cirakoglu B,Ozbay F,Waldman I,Asherson PJ

更新日期：2000-07-01 00:00:00

abstract：:Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test the hypothesis that rare variants in many different genes, including de novo variants, could predispose to these conditions i...

journal_title：Molecular psychiatry

authors： Piton A,Gauthier J,Hamdan FF,Lafrenière RG,Yang Y,Henrion E,Laurent S,Noreau A,Thibodeau P,Karemera L,Spiegelman D,Kuku F,Duguay J,Destroismaisons L,Jolivet P,Côté M,Lachapelle K,Diallo O,Raymond A,Marineau C,Cham

更新日期：2011-08-01 00:00:00

abstract：:Activation of the inflammatory response system has been related to the pathophysiology of schizophrenia by several recent studies. Schizophrenic patients have varied levels of proinflammatory cytokines, such as interleukin (IL)-1, -6, and tumor necrosis factor (TNF)alpha in their peripheral blood or cerebrospinal flui...

journal_title：Molecular psychiatry

authors： Katila H,Hänninen K,Hurme M

更新日期：1999-03-01 00:00:00

abstract：:Microvascular pathology and ischemic lesions contribute substantially to neuronal dysfunction and loss that lead to Alzheimer disease (AD). To facilitate recovery, the brain stimulates neovascularization of damaged tissue via sprouting angiogenesis, a process regulated by endothelial cell (EC) sprouting and the EphB4/...

journal_title：Molecular psychiatry

authors： Yoon Y,Voloudakis G,Doran N,Zhang E,Dimovasili C,Chen L,Shao Z,Darmanis S,Tang C,Tang J,Wang VX,Hof PR,Robakis NK,Georgakopoulos A

更新日期：2020-06-15 00:00:00

abstract：:Exercise has a variety of beneficial effects on brain structure and function, such as hippocampal neurogenesis, mood and memory. Previous studies have shown that exercise enhances hippocampal neurogenesis, induces antidepressant effects and improves learning behavior. Brain serotonin (5-hydroxytryptamine, 5-HT) levels...

journal_title：Molecular psychiatry

authors： Kondo M,Nakamura Y,Ishida Y,Shimada S

更新日期：2015-11-01 00:00:00

abstract：:Population-based linkage analysis is a new method for analysing genomewide single nucleotide polymorphism (SNP) genotype data in case-control samples, which does not assume a common disease, common variant model. The genome is scanned for extended segments that show increased identity-by-descent sharing within case-ca...

journal_title：Molecular psychiatry

authors： Francks C,Tozzi F,Farmer A,Vincent JB,Rujescu D,St Clair D,Muglia P

更新日期：2010-03-01 00:00:00

abstract：:Although schizophrenia is considered a brain disorder, the role of brain organization for symptomatic improvement remains inadequately defined. We investigated the relationship between baseline brain morphology, resting-state network connectivity and clinical response after 24-weeks of antipsychotic treatment in patie...

journal_title：Molecular psychiatry

authors： Doucet GE,Moser DA,Luber MJ,Leibu E,Frangou S

更新日期：2020-04-01 00:00:00

abstract：:Many human hereditary neurodegenerative diseases are caused by expanded CAG repeats, and anonymous CAG expansions have also been described in schizophrenia and bipolar disorder. We have isolated and sequenced a novel human cDNA encoding a neuronal, small conductance calcium-activated potassium channel (hSKCa3) that co...

journal_title：Molecular psychiatry

authors： Chandy KG,Fantino E,Wittekindt O,Kalman K,Tong LL,Ho TH,Gutman GA,Crocq MA,Ganguli R,Nimgaonkar V,Morris-Rosendahl DJ,Gargus JJ

更新日期：1998-01-01 00:00:00

abstract：:Volume reduction and shape abnormality of the hippocampus have been associated with mood disorders. However, the hippocampus is not a uniform structure and consists of several subfields, such as the cornu ammonis (CA) subfields CA1-4, the dentate gyrus (DG) including a granule cell layer (GCL) and a molecular layer (M...

journal_title：Molecular psychiatry

authors： Cao B,Passos IC,Mwangi B,Amaral-Silva H,Tannous J,Wu MJ,Zunta-Soares GB,Soares JC

更新日期：2017-09-01 00:00:00

abstract：:Epidermal growth factor (EGF) comprises a structurally related family of proteins containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that regulates the development of dopaminergic neurons as well as monoamine metabolism. We assessed the contribution of EGF to sch...

journal_title：Molecular psychiatry

authors： Futamura T,Toyooka K,Iritani S,Niizato K,Nakamura R,Tsuchiya K,Someya T,Kakita A,Takahashi H,Nawa H

更新日期：2002-01-01 00:00:00

abstract：:Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The disease specificity of this risk has not been addressed and the possibility of confounding has not been excluded. Children with ASD or attention-deficit hypera...

journal_title：Molecular psychiatry

authors： Clements CC,Castro VM,Blumenthal SR,Rosenfield HR,Murphy SN,Fava M,Erb JL,Churchill SE,Kaimal AJ,Doyle AE,Robinson EB,Smoller JW,Kohane IS,Perlis RH

更新日期：2015-06-01 00:00:00

abstract：:Although inherited DNA sequences have a well-demonstrated role in psychiatric disease risk, for even the most heritable mental disorders, monozygotic twins are discordant at a significant rate. The genetic variation associated with mental disorders has heretofore been based on the search for rare or common variation i...

journal_title：Molecular psychiatry

authors： Insel TR

更新日期：2014-02-01 00:00:00

abstract：:Higher scores on the personality trait of neuroticism, the tendency to experience negative emotions, are associated with worse mental and physical health. Studies examining links between neuroticism and health typically operationalize neuroticism by summing the items from a neuroticism scale. However, neuroticism is m...

journal_title：Molecular psychiatry

authors： Hill WD,Weiss A,Liewald DC,Davies G,Porteous DJ,Hayward C,McIntosh AM,Gale CR,Deary IJ

更新日期：2020-11-01 00:00:00

abstract：:Neurotrophins promote neuronal survival and synaptic plasticity via activating the tropomyosin receptor kinases. BDNF and its high-affinity receptor TrkB are reduced in Alzheimer's disease (AD), contributing to progressive cognitive decline. However, how the signaling mediates AD pathologies remains incompletely under...

journal_title：Molecular psychiatry

authors： Xia Y,Wang ZH,Liu P,Edgington-Mitchell L,Liu X,Wang XC,Ye K

更新日期：2020-08-11 00:00:00

abstract：:Niemann-Pick disease type A (NPA) is a rare lysosomal storage disorder characterized by severe neurological alterations that leads to death in childhood. Loss-of-function mutations in the acid sphingomyelinase (ASM) gene cause NPA, and result in the accumulation of sphingomyelin (SM) in lysosomes and plasma membrane o...

journal_title：Molecular psychiatry

authors： Pérez-Cañamás A,Benvegnù S,Rueda CB,Rábano A,Satrústegui J,Ledesma MD

更新日期：2017-05-01 00:00:00