Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life.

abstract：:We posit in this article that hierarchical temporal processing deficit is the underlying basis of reality distortion and psychoses. Schizophrenia is a prototypical reality distortion disorder in which the patient manifests with auditory hallucinations, delusions, disorganized speech and thinking, cognitive impairment,...

journal_title：Molecular psychiatry

authors： Krishnan RR,Fivaz M,Kraus MS,Keefe RS

更新日期：2011-02-01 00:00:00

abstract：:Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in the pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the dynamic plasticity of dendritic spines of pyramidal neurons (PNs) and "en passant" axonal bouton of parvalbumin-expressing interneurons (PVI...

journal_title：Molecular psychiatry

authors： Huang Y,Jiang H,Zheng Q,Fok AHK,Li X,Lau CG,Lai CSW

更新日期：2021-01-20 00:00:00

abstract：:Although disrupted in schizophrenia 1 (DISC1) has been implicated in many psychiatric disorders, including schizophrenia, bipolar disorder, schizoaffective disorder and major depression, its biological role in these disorders is unclear. To better understand this gene and its role in psychiatric disease, we conducted ...

journal_title：Molecular psychiatry

authors： Carless MA,Glahn DC,Johnson MP,Curran JE,Bozaoglu K,Dyer TD,Winkler AM,Cole SA,Almasy L,MacCluer JW,Duggirala R,Moses EK,Göring HH,Blangero J

更新日期：2011-11-01 00:00:00

abstract：:Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose the effects of (partially) recessive deleterious mutations. Even among outbred populations, auto...

journal_title：Molecular psychiatry

authors： Howrigan DP,Simonson MA,Davies G,Harris SE,Tenesa A,Starr JM,Liewald DC,Deary IJ,McRae A,Wright MJ,Montgomery GW,Hansell N,Martin NG,Payton A,Horan M,Ollier WE,Abdellaoui A,Boomsma DI,DeRosse P,Knowles EE,Glahn DC

更新日期：2016-06-01 00:00:00

abstract：:Circulating inflammatory mediators can signal neurons through a pathway in which cytokine activation of the cells of the blood-brain barrier causes the induction of the nuclear factor kappa B (NF-kappaB), leading to the transcription of target genes, such as the one encoding cyclooxygenase 2 (COX-2), the enzyme that i...

journal_title：Molecular psychiatry

authors： Rivest S

更新日期：1999-11-01 00:00:00

abstract：:The G-protein coupled metabotropic glutamate receptors (GRMs/mGluRs) have been implicated in the aetiology of schizophrenia as they modulate the NMDA response and that of other neurotransmitters including dopamine and GABA.(1-3) Electrophysiological studies in GRM subtype 5 knockout mice reveal, in one study, a sensor...

journal_title：Molecular psychiatry

authors： Devon RS,Anderson S,Teague PW,Muir WJ,Murray V,Pelosi AJ,Blackwood DH,Porteous DJ

更新日期：2001-05-01 00:00:00

abstract：:There is evidence that obesity-related disorders are increased among people with depression. Variation in the FTO (fat mass and obesity associated) gene has been shown to contribute to common forms of human obesity. This study aimed to investigate the genetic influence of polymorphisms in FTO in relation to body mass ...

journal_title：Molecular psychiatry

authors： Rivera M,Cohen-Woods S,Kapur K,Breen G,Ng MY,Butler AW,Craddock N,Gill M,Korszun A,Maier W,Mors O,Owen MJ,Preisig M,Bergmann S,Tozzi F,Rice J,Rietschel M,Rucker J,Schosser A,Aitchison KJ,Uher R,Craig IW,Lewis

更新日期：2012-06-01 00:00:00

abstract：:Translin-associated protein X (TRAX) is a scaffold protein with various functions and has been associated with mental illnesses, including schizophrenia. We have previously demonstrated that TRAX interacts with a Gsα protein-coupled receptor, the A2A adenosine receptor (A2AR), and mediates the function of this recepto...

journal_title：Molecular psychiatry

authors： Chien T,Weng YT,Chang SY,Lai HL,Chiu FL,Kuo HC,Chuang DM,Chern Y

更新日期：2018-12-01 00:00:00

abstract：:It is essential to elucidate brain-adipocyte interactions in order to tackle obesity and its comorbidities, as the precise control of brain-adipose tissue cross-talk is crucial for energy and glucose homeostasis. Recent studies show that in the peripheral adipose tissue, adenosine induces adipogenesis through peripher...

journal_title：Molecular psychiatry

authors： Zhang J,Hou Y,Du XL,Chen D,Sui G,Qi Y,Licinio J,Wong ML,Yang Y

更新日期：2020-10-16 00:00:00

abstract：:Recent in vivo studies have shown low dopamine D2 receptor and dopamine transporter densities among late onset (type 1) alcoholics. We have now studied 6-[18F]-FDOPA (FDOPA) uptake in 10 type 1 alcoholics and eight matched controls to test the hypothesis that striatal presynaptic dopamine function is lower among alcoh...

journal_title：Molecular psychiatry

authors： Tiihonen J,Vilkman H,Räsänen P,Ryynänen OP,Hakko H,Bergman J,Hämäläinen T,Laakso A,Haaparanta-Solin M,Solin O,Kuoppamäki M,Syvälahti E,Hietala J

更新日期：1998-03-01 00:00:00

abstract：:Familial and twin studies have suggested that anorexia nervosa (AN) is a multifactorial disorder with a substantial genetic contribution. The hSKCa3 potassium channel gene, which contains polymorphic CAG repeats in the coding region and is involved in the regulation of neuronal activity, may be a candidate gene for AN...

journal_title：Molecular psychiatry

authors： Koronyo-Hamaoui M,Danziger Y,Frisch A,Stein D,Leor S,Laufer N,Carel C,Fennig S,Minoumi M,Apter A,Goldman B,Barkai G,Weizman A,Gak E

更新日期：2002-01-01 00:00:00

abstract：:Environmental enrichment (EE) is known to have an anxiolytic effect in several animal models; however, the molecular mechanisms underlying these behavioral changes are not understood. In this study, we have shown that the anxiolytic effect of EE is associated with alterations in the corticotropin-releasing factor rece...

journal_title：Molecular psychiatry

authors： Sztainberg Y,Kuperman Y,Tsoory M,Lebow M,Chen A

更新日期：2010-09-01 00:00:00

abstract：:To identify loci associated with Alzheimer disease, we conducted a three-stage analysis using existing genome-wide association studies (GWAS) and genotyping in a new sample. In Stage I, all suggestive single-nucleotide polymorphisms (at P<0.001) in a previously reported GWAS of seven independent studies (8082 Alzheime...

journal_title：Molecular psychiatry

authors： Boada M,Antúnez C,Ramírez-Lorca R,DeStefano AL,González-Pérez A,Gayán J,López-Arrieta J,Ikram MA,Hernández I,Marín J,Galán JJ,Bis JC,Mauleón A,Rosende-Roca M,Moreno-Rey C,Gudnasson V,Morón FJ,Velasco J,Carrasco JM,A

更新日期：2014-06-01 00:00:00

abstract：:Suicide is a major public health concern and a leading cause of death in most societies. Suicidal behaviour is complex and heterogeneous, likely resulting from several causes. It associates with multiple factors, including psychopathology, personality traits, early-life adversity and stressful life events, among other...

journal_title：Molecular psychiatry

authors： Lutz PE,Mechawar N,Turecki G

更新日期：2017-10-01 00:00:00

abstract：:Posttranscriptional regulation of gene expression plays an important role in the maturation, transport, stability and translation of coding and noncoding RNAs. RNA-binding protein (RBP) is a key factor of the regulation. Regulator of calcineurin 1 (RCAN1) is a multifunctional protein involved in neurodegeneration, mit...

journal_title：Molecular psychiatry

authors： Yun Y,Zhang Y,Zhang C,Huang L,Tan S,Wang P,Vilariño-Gúell C,Song W,Sun X

更新日期：2019-08-27 00:00:00

abstract：:This corrects the article DOI: 10.1038/mp.2016.107. ...

journal_title：Molecular psychiatry

authors： Selzam S,Krapohl E,von Stumm S,O'Reilly PF,Rimfeld K,Kovas Y,Dale PS,Lee JJ,Plomin R

更新日期：2018-01-01 00:00:00

abstract：:We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which th...

journal_title：Molecular psychiatry

authors： Kishi T,Ikuta T,Matsuda Y,Sakuma K,Okuya M,Mishima K,Iwata N

更新日期：2020-11-11 00:00:00

abstract：:Latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDACi), are being investigated as a strategy to eliminate latency in HIV-infected patients on suppressive antiretroviral therapy. The effectiveness of LRAs in activating latent infection in HIV strains derived from the central nervous system (C...

journal_title：Molecular psychiatry

authors： Gray LR,Cowley D,Welsh C,Lu HK,Brew BJ,Lewin SR,Wesselingh SL,Gorry PR,Churchill MJ

更新日期：2016-04-01 00:00:00

abstract：:Linkage disequilibrium (LD) mapping was used to follow up reports of linkage between reading disability (RD) and an 18 cM region of chromosome 6p21.3-22. Using a two-stage approach, we tested for association between RD and 22 microsatellite markers in two independent samples of 101 (Stage 1) and 77 (Stage 2) parent/pr...

journal_title：Molecular psychiatry

authors： Turic D,Robinson L,Duke M,Morris DW,Webb V,Hamshere M,Milham C,Hopkin E,Pound K,Fernando S,Grierson A,Easton M,Williams N,Van Den Bree M,Chowdhury R,Gruen J,Stevenson J,Krawczak M,Owen MJ,O'Donovan MC,Williams J

更新日期：2003-02-01 00:00:00

abstract：:The long alleles (> or =6 repeats) of the dopamine D4 dopamine receptor exon III polymorphism have been linked in some, but not all, studies to Novelty Seeking (NS), one of four personality traits defined by Cloninger's tridimensional personality questionnarie (TPQ). In order to further examine the robustness of our o...

journal_title：Molecular psychiatry

authors： Ebstein RP,Nemanov L,Klotz I,Gritsenko I,Belmaker RH

更新日期：1997-10-01 00:00:00

abstract：:Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations betwee...

journal_title：Molecular psychiatry

authors： Sammallahti S,Cortes Hidalgo AP,Tuominen S,Malmberg A,Mulder RH,Brunst KJ,Alemany S,McBride NS,Yousefi P,Heiss JA,McRae N,Page CM,Jin J,Pesce G,Caramaschi D,Rifas-Shiman SL,Koen N,Adams CD,Magnus MC,Baïz N,Ratanat

更新日期：2021-01-07 00:00:00

abstract：:Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes. Here, we present data from independent large-scale clinical data sets (including 29 557 cases and 32 056 controls) rev...

journal_title：Molecular psychiatry

authors： Chang H,Hoshina N,Zhang C,Ma Y,Cao H,Wang Y,Wu DD,Bergen SE,Landén M,Hultman CM,Preisig M,Kutalik Z,Castelao E,Grigoroiu-Serbanescu M,Forstner AJ,Strohmaier J,Hecker J,Schulze TG,Müller-Myhsok B,Reif A,Mitchell PB

更新日期：2018-02-01 00:00:00

abstract：:(+) 3,4-Methylenedioxymethamphetamine (MDMA) is a psychedelic drug of abuse that causes selective degeneration of serotonergic fibers of dorsal raphe neurons that project throughout the forebrain. Previous studies using pharmacological and behavioral approaches suggested that MDMA treatment leads to desensitization of...

journal_title：Molecular psychiatry

authors： Sexton TJ,McEvoy C,Neumaier JF

更新日期：1999-11-01 00:00:00

abstract：:Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown. We found that widely used antidepressants such as amitriptyline and fluoxetine induce autoph...

journal_title：Molecular psychiatry

authors： Gulbins A,Schumacher F,Becker KA,Wilker B,Soddemann M,Boldrin F,Müller CP,Edwards MJ,Goodman M,Caldwell CC,Kleuser B,Kornhuber J,Szabo I,Gulbins E

更新日期：2018-12-01 00:00:00

abstract：:Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental syndrome characterized by hyperactivity, inattention and increased impulsivity. To detect micro-deletions and micro-duplications that may have a role in the pathogenesis of ADHD, we carried out a genome-wide screen for cop...

journal_title：Molecular psychiatry

authors： Lesch KP,Selch S,Renner TJ,Jacob C,Nguyen TT,Hahn T,Romanos M,Walitza S,Shoichet S,Dempfle A,Heine M,Boreatti-Hümmer A,Romanos J,Gross-Lesch S,Zerlaut H,Wultsch T,Heinzel S,Fassnacht M,Fallgatter A,Allolio B,Schäf

更新日期：2011-05-01 00:00:00

abstract：:Folate receptor alpha (FRα) autoantibodies have been associated with fetal abnormalities and cerebral folate deficiency-related developmental disorders. Over 70% of the children with autism spectrum disorders (ASD) are positive for these autoantibodies and high-dose folinic acid is beneficial in treating these childre...

journal_title：Molecular psychiatry

authors： Desai A,Sequeira JM,Quadros EV

更新日期：2017-09-01 00:00:00

abstract：:Bipolar disorder (BD) is a progressive psychiatric disorder with more than 3% prevalence worldwide. Affected individuals experience recurrent episodes of depression and mania, disrupting normal life and increasing the risk of suicide greatly. The complexity and genetic heterogeneity of psychiatric disorders have chall...

journal_title：Molecular psychiatry

authors： Stern S,Santos R,Marchetto MC,Mendes APD,Rouleau GA,Biesmans S,Wang QW,Yao J,Charnay P,Bang AG,Alda M,Gage FH

更新日期：2018-06-01 00:00:00

abstract：:Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation, making them highly useful adjuncts to animal models. Here, we ex...

journal_title：Molecular psychiatry

authors： Konopka G,Wexler E,Rosen E,Mukamel Z,Osborn GE,Chen L,Lu D,Gao F,Gao K,Lowe JK,Geschwind DH

更新日期：2012-02-01 00:00:00

abstract：:Recent studies have revealed that the gut microbiota modulates brain development and behavior, but the underlying mechanisms are still poorly understood. Here, we show that bacterial peptidoglycan (PGN) derived from the commensal gut microbiota can be translocated into the brain and sensed by specific pattern-recognit...

journal_title：Molecular psychiatry

authors： Arentsen T,Qian Y,Gkotzis S,Femenia T,Wang T,Udekwu K,Forssberg H,Diaz Heijtz R

更新日期：2017-02-01 00:00:00

abstract：:Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A receptors (GABAARs), GABA-gated chloride/bicarbonate channels, which are the key mediators of transmission at inhibitory synapses in the brain. This activity underpins potent anxiolytic, anticonvulsant and hypnotic effec...

journal_title：Molecular psychiatry

authors： Nicholson MW,Sweeney A,Pekle E,Alam S,Ali AB,Duchen M,Jovanovic JN

更新日期：2018-09-01 00:00:00