Abstract：
:Significant evidence for linkage between bipolar affective disorder and markers on chromosome 4p16 has been reported in Scottish families. Linkage analyses using 16 DNA markers covering more than 50 cM from chromosome 4pter-4p12, including candidate genes encoding the dopamine D5 receptor and an adrenergic receptor (2C), were performed in two Danish families with bipolar affective disorder. Assuming homogeneity in the two families, the highest lod score found in the two-point linkage analyses was 2.00 at 0.03 recombination fraction for D4S394, i.e. the marker which also was most significant in the original Scottish study. Simulation showed that such a lod score would only occur six out of 10,000 times with an unlinked marker. Though the present study thus replicates the Scottish findings according to the criteria suggested by Lander and Kruglyak, caution is warranted as the mode of inheritance which yielded the highest lod score in the two studies was different. Final proof of a disease locus in the Scottish and our study has to await the identification of a DNA sequence of functional significance for bipolar disorder.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Ewald H,Degn B,Mors O,Kruse TAdoi
10.1038/sj.mp.4000420subject
Has Abstractpub_date
1998-09-01 00:00:00pages
442-8issue
5eissn
1359-4184issn
1476-5578journal_volume
3pub_type
杂志文章abstract：:The serotonergic neurotransmitter system has been widely implicated in the pathophysiology of mood-related disorders such as anxiety and major depressive disorder (MDD). The onset of therapeutic efficacy of traditional antidepressants is delayed by several weeks. The 5-HT4 receptor has emerged as a new therapeutic tar...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.240
更新日期：2018-04-01 00:00:00
abstract：:Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and the concomitant impact on plasticity and critical periods, is hypothesized to be disrupted in neurodevelopmen...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-019-0635-6
更新日期：2020-01-03 00:00:00
abstract：:Several lines of evidence have suggested altered functions of the brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). In the search for polymorphisms in the 5'-flanking and 5'-noncoding regions of the BDNF gene, we found a novel nucleotide subs...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000792
更新日期：2001-01-01 00:00:00
abstract：:The hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the etiology of major depressive disorder (MDD). Although meta-analyses do confirm associations between depression and these biological systems, effect sizes vary greatl...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2012.144
更新日期：2013-06-01 00:00:00
abstract：:Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with ...
journal_title：Molecular psychiatry
pub_type： 杂志文章,meta分析
doi：10.1038/s41380-018-0040-6
更新日期：2019-02-01 00:00:00
abstract：:Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ~1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated association of genetic variants in expert-curated synaptic gene groups with schizophrenia in 4673 ca...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2011.117
更新日期：2012-10-01 00:00:00
abstract：:Post-traumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-related diseases and neurodegeneration. In this paper, we review evidence relevant to the hypothesis that chronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and accelerates cellula...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/mp.2014.111
更新日期：2014-11-01 00:00:00
abstract：:This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...
journal_title：Molecular psychiatry
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41380-018-0301-4
更新日期：2019-03-01 00:00:00
abstract：:Acetylcholinesterase (AChE), the enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, has been implicated in non-cholinergic actions which may play a role in neurodegenerative diseases such as Alzheimer's disease. To study the potential cytotoxicity of brain AChE, the effects of affinity purified A...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000383
更新日期：1998-05-01 00:00:00
abstract：:Delivery of drugs into the brain is poor due to the blood brain barrier (BBB). This study describes the development of a novel liposome-based brain-targeting drug delivery system. The liposomes incorporate a diacylglycerol moiety coupled through a linker to a peptide of 5 amino acids selected from amyloid precursor pr...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-020-0742-4
更新日期：2020-05-05 00:00:00
abstract：:Two recent association studies have implicated the neuregulin-1 gene (NRG1) at chromosome 8p21-22 as a susceptibility gene for schizophrenia. Stefansson et al identified three 'at-risk' haplotypes (HapA, B and C) which spanned the NRG1 locus and shared a common core haplotype. Subsequently, they demonstrated evidence ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001412
更新日期：2004-02-01 00:00:00
abstract：:Adults with psychotic disorders have dysconnectivity in critical brain networks, including the default mode (DM) and the cingulo-opercular (CO) networks. However, it is unknown whether such deficits are present in youth with less severe symptoms. We conducted a multivariate connectome-wide association study examining ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2015.66
更新日期：2015-12-01 00:00:00
abstract：:To examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-matched controls in the Japanese population. Allelic and genotypic distributions of ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001029
更新日期：2002-01-01 00:00:00
abstract：:High impulsive and aggressive traits associate with poor behavioural self-control. Despite their importance in predicting behavioural negative outcomes including suicide, the molecular mechanisms underlying the expression of impulsive and aggressive traits remain poorly understood. Here, we identified and characterize...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-019-0637-4
更新日期：2020-01-06 00:00:00
abstract：:The term 'mood stabilizer' has been applied to a number of medications for the treatment of patients with bipolar disorder. The operational definition of the properties of a mood-stabilizing medication has varied according to the properties of specific medications and the clinical characteristics of the illness. Rando...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/sj.mp.4001013
更新日期：2002-01-01 00:00:00
abstract：:We previously found that ovarian steroids promote neuroprotection in serotonin neurons by decreasing the expression of pro-apoptotic genes and proteins in the dorsal raphe nucleus of rhesus macaques, even in the absence of overt injury. In this study, we questioned whether these actions would lead to a reduction in DN...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2009.97
更新日期：2010-06-01 00:00:00
abstract：:To identify loci associated with Alzheimer disease, we conducted a three-stage analysis using existing genome-wide association studies (GWAS) and genotyping in a new sample. In Stage I, all suggestive single-nucleotide polymorphisms (at P<0.001) in a previously reported GWAS of seven independent studies (8082 Alzheime...
journal_title：Molecular psychiatry
pub_type： 杂志文章,meta分析
doi：10.1038/mp.2013.86
更新日期：2014-06-01 00:00:00
abstract：:The prefrontal cortex, a part of the limbic-thalamic-cortical network, participates in regulation of mood, cognition and behavior and has been implicated in the pathophysiology of major depressive disorder (MDD). Many neuropsychological studies demonstrate impairment of working memory in patients with MDD. However, th...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001894
更新日期：2007-02-01 00:00:00
abstract：:The human serotonin transporter gene (5-HTT) demonstrates two polymorphisms with possible functional impact: a 44-bp insertion/deletion polymorphism of the promoter region and a 17-bp variable number of tandem repeat polymorphism (VNTR) in intron 2 (STin2). Such genetic polymorphisms in the serotoninergic system may i...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000821
更新日期：2001-03-01 00:00:00
abstract：:Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test the hypothesis that rare variants in many different genes, including de novo variants, could predispose to these conditions i...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2010.54
更新日期：2011-08-01 00:00:00
abstract：:A recent report showed significant associations between several SNPs in a previously unknown EST cluster with schizophrenia. (1). The cluster was identified as the human dystrobrevin binding protein 1 gene (DTNBP1) by sequence database comparisons and homology with mouse DTNBP1. (2). However, the linkage disequilibriu...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001263
更新日期：2003-05-01 00:00:00
abstract：:Although inherited DNA sequences have a well-demonstrated role in psychiatric disease risk, for even the most heritable mental disorders, monozygotic twins are discordant at a significant rate. The genetic variation associated with mental disorders has heretofore been based on the search for rare or common variation i...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2013.168
更新日期：2014-02-01 00:00:00
abstract：:Induction of neuroprotective heat-shock proteins via pharmacological Hsp90 inhibitors is currently being investigated as a potential treatment for neurodegenerative diseases. Two major hurdles for therapeutic use of Hsp90 inhibitors are systemic toxicity and limited central nervous system permeability. We demonstrate ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2016.104
更新日期：2017-07-01 00:00:00
abstract：:Previous work has demonstrated associations between lower cognitive ability and childhood and adult non-psychotic psychopathology. As both cognitive ability (CA) and child psychopathology (CP) are influenced by genetic factors, one explanation for the association is that they are the pleiotropic manifestations of the ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000971
更新日期：2002-01-01 00:00:00
abstract：:Microvascular pathology and ischemic lesions contribute substantially to neuronal dysfunction and loss that lead to Alzheimer disease (AD). To facilitate recovery, the brain stimulates neovascularization of damaged tissue via sprouting angiogenesis, a process regulated by endothelial cell (EC) sprouting and the EphB4/...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-020-0812-7
更新日期：2020-06-15 00:00:00
abstract：:Several studies suggest that decreased expression of presynaptic proteins may be characteristic of schizophrenia. We examined one such protein, synapsin, in schizophrenia and bipolar disorder. Samples of hippocampal tissue from controls (n = 13), patients with schizophrenia (n = 16), or bipolar disorder (n = 6), and s...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001158
更新日期：2002-01-01 00:00:00
abstract：:It is believed that genetic factors play a large role in the development of many cognitive and neurological processes; however, epidemiological evidence for the genetic basis of childhood neurodevelopment is very limited. Identification of the genetic polymorphisms associated with early-stage neurodevelopment will hel...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0205-3
更新日期：2020-11-01 00:00:00
abstract：:In developing his mature concept of hebephrenic dementia praecox (DP) in his 4th (1893) through 6th textbook editions (1899), Kraepelin worked from the hebephrenic syndrome first described by Hecker (1871) and then carefully studied by his student Daraszkiewicz (1892). Working under Kraepelin's supervision, Daraszkiew...
journal_title：Molecular psychiatry
pub_type： 历史文章,杂志文章,评审
doi：10.1038/s41380-019-0411-7
更新日期：2020-01-01 00:00:00
abstract：:The GRIA1 locus, encoding the GluA1 (also known as GluRA or GluR1) AMPA glutamate receptor subunit, shows genome-wide association to schizophrenia. As well as extending the evidence that glutamatergic abnormalities have a key role in the disorder, this finding draws attention to the behavioural phenotype of Gria1 knoc...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/mp.2014.91
更新日期：2014-10-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/mp.2016.107. ...
journal_title：Molecular psychiatry
pub_type： 杂志文章,已发布勘误
doi：10.1038/mp.2017.203
更新日期：2018-01-01 00:00:00
