当前位置： SCI文献检索 > MOLECULAR PSYCHIATRY期刊下所有文献 > Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder.

Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder.

Abstract：

:The prefrontal cortex, a part of the limbic-thalamic-cortical network, participates in regulation of mood, cognition and behavior and has been implicated in the pathophysiology of major depressive disorder (MDD). Many neuropsychological studies demonstrate impairment of working memory in patients with MDD. However, there are few functional neuroimaging studies of MDD patients during working memory processing, and most of the available ones included medicated patients or patients with both MDD and bipolar disorder. We used functional magnetic resonance imaging (fMRI) to measure prefrontal cortex function during working memory processing in untreated depressed patients with MDD. Fifteen untreated individuals with Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition recurrent MDD (mean age+/-s.d.=34.3+/-11.5 years) and 15 healthy comparison subjects (37.7+/-12.1 years) matched for age, sex and race were studied using a GE/Elscint 2T MR system. An echo-planar MRI sequence was used to acquire 24 axial slices. The n-back task (0-back, 1-back and 2-back) was used to elicit frontal cortex activation. Data were analyzed with a multiple regression analysis using the FSL-FEAT software. MDD patients showed significantly greater left dorsolateral cortex activation during the n-back task compared to the healthy controls (P<0.01), although task performance was similar in the two groups. Furthermore, the patients showed significant anterior cingulate cortex activation during the task, but the comparison subjects did not (P<0.01). This study provides in vivo imaging evidence of abnormal frontolimbic circuit function during working memory processing in individuals with MDD.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Matsuo K,Glahn DC,Peluso MA,Hatch JP,Monkul ES,Najt P,Sanches M,Zamarripa F,Li J,Lancaster JL,Fox PT,Gao JH,Soares JC

doi

10.1038/sj.mp.4001894

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

158-66

issue

2

eissn

1359-4184

issn

1476-5578

pii

4001894

journal_volume

12

pub_type

杂志文章

相关文献

MOLECULAR PSYCHIATRY文献大全
  • Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.

    abstract：:This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41380-018-0301-4

    authors： Haure-Mirande JV,Wang M,Audrain M,Fanutza T,Kim SH,Heja S,Readhead B,Dudley JT,Blitzer RD,Schadt EE,Zhang B,Gandy S,Ehrlich ME

    更新日期：2019-03-01 00:00:00

  • Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide.

    abstract：:Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown. We found that widely used antidepressants such as amitriptyline and fluoxetine induce autoph...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-018-0090-9

    authors： Gulbins A,Schumacher F,Becker KA,Wilker B,Soddemann M,Boldrin F,Müller CP,Edwards MJ,Goodman M,Caldwell CC,Kleuser B,Kornhuber J,Szabo I,Gulbins E

    更新日期：2018-12-01 00:00:00

  • Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families.

    abstract：:A recent report showed significant associations between several SNPs in a previously unknown EST cluster with schizophrenia. (1). The cluster was identified as the human dystrobrevin binding protein 1 gene (DTNBP1) by sequence database comparisons and homology with mouse DTNBP1. (2). However, the linkage disequilibriu...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001263

    authors： van den Oord EJ,Sullivan PF,Jiang Y,Walsh D,O'Neill FA,Kendler KS,Riley BP

    更新日期：2003-05-01 00:00:00

  • The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders.

    abstract：:Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes. Here, we present data from independent large-scale clinical data sets (including 29 557 cases and 32 056 controls) rev...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,meta分析

    doi：10.1038/mp.2016.231

    authors： Chang H,Hoshina N,Zhang C,Ma Y,Cao H,Wang Y,Wu DD,Bergen SE,Landén M,Hultman CM,Preisig M,Kutalik Z,Castelao E,Grigoroiu-Serbanescu M,Forstner AJ,Strohmaier J,Hecker J,Schulze TG,Müller-Myhsok B,Reif A,Mitchell PB

    更新日期：2018-02-01 00:00:00

  • Time-delimited signaling of MET receptor tyrosine kinase regulates cortical circuit development and critical period plasticity.

    abstract：:Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and the concomitant impact on plasticity and critical periods, is hypothesized to be disrupted in neurodevelopmen...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0635-6

    authors： Chen K,Ma X,Nehme A,Wei J,Cui Y,Cui Y,Yao D,Wu J,Anderson T,Ferguson D,Levitt P,Qiu S

    更新日期：2020-01-03 00:00:00

  • Educational attainment and drinking behaviors: Mendelian randomization study in UK Biobank.

    abstract：:Educational attainment has been associated with drinking behaviors in observation studies. We performed Mendelian randomization analysis to determine whether educational attainment causally affected drinking behaviors, including amount of alcohol intakes (in total and various types), drinking frequency, and drinking w...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0596-9

    authors： Zhou T,Sun D,Li X,Ma H,Heianza Y,Qi L

    更新日期：2019-11-25 00:00:00

  • Baseline brain structural and functional predictors of clinical outcome in the early course of schizophrenia.

    abstract：:Although schizophrenia is considered a brain disorder, the role of brain organization for symptomatic improvement remains inadequately defined. We investigated the relationship between baseline brain morphology, resting-state network connectivity and clinical response after 24-weeks of antipsychotic treatment in patie...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-018-0269-0

    authors： Doucet GE,Moser DA,Luber MJ,Leibu E,Frangou S

    更新日期：2020-04-01 00:00:00

  • Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis.

    abstract：:Patients with psychotic disorders are at high risk for type 2 diabetes mellitus, and there is increasing evidence that patients display glucose metabolism abnormalities before significant antipsychotic medication exposure. In the present study, we examined insulin action by quantifying insulin sensitivity in first-epi...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-018-0045-1

    authors： Chouinard VA,Henderson DC,Dalla Man C,Valeri L,Gray BE,Ryan KP,Cypess AM,Cobelli C,Cohen BM,Öngür D

    更新日期：2019-10-01 00:00:00

  • Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca2+/calcineurin signalling downstream of GABAA receptors.

    abstract：:Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A receptors (GABAARs), GABA-gated chloride/bicarbonate channels, which are the key mediators of transmission at inhibitory synapses in the brain. This activity underpins potent anxiolytic, anticonvulsant and hypnotic effec...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-018-0100-y

    authors： Nicholson MW,Sweeney A,Pekle E,Alam S,Ali AB,Duchen M,Jovanovic JN

    更新日期：2018-09-01 00:00:00

  • A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease.

    abstract：:Several lines of evidence have suggested altered functions of the brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). In the search for polymorphisms in the 5'-flanking and 5'-noncoding regions of the BDNF gene, we found a novel nucleotide subs...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000792

    authors： Kunugi H,Ueki A,Otsuka M,Isse K,Hirasawa H,Kato N,Nabika T,Kobayashi S,Nanko S

    更新日期：2001-01-01 00:00:00

  • Mad cows meet mad yeast: the prion hypothesis.

    abstract：:Obscure work on the inheritance of two peculiar genetic traits in yeast has recently collided with work on infectious, neurodegenerative diseases in mammals. The impact illuminates both fields. The yeast work reveals a new mechanism of genetic variation that is based on differences in protein conformation rather than ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：

    authors： Lindquist S

    更新日期：1996-11-01 00:00:00

  • Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects.

    abstract：:Only in the past decade has a role of heredity in substance abuse been established as a result of extensive twin and family studies. More recently, several candidate genes have been investigated for their possible role in alcoholism and cocaine abuse. Specific genetic factors in opioid substance abuse have not been in...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000248

    authors： Kotler M,Cohen H,Segman R,Gritsenko I,Nemanov L,Lerer B,Kramer I,Zer-Zion M,Kletz I,Ebstein RP

    更新日期：1997-05-01 00:00:00

  • Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits.

    abstract：:The urocortin (Ucn) family of neuropeptides is suggested to be involved in homeostatic coping mechanisms of the central stress response through the activation of corticotropin-releasing factor receptor type 2 (CRFR2). The neuropeptides, Ucn1 and Ucn2, serve as endogenous ligands for the CRFR2, which is highly expresse...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2009.115

    authors： Neufeld-Cohen A,Evans AK,Getselter D,Spyroglou A,Hill A,Gil S,Tsoory M,Beuschlein F,Lowry CA,Vale W,Chen A

    更新日期：2010-04-01 00:00:00

  • MicroRNA regulation of persistent stress-enhanced memory.

    abstract：:Disruption of persistent, stress-associated memories is relevant for treating posttraumatic stress disorder (PTSD) and related syndromes, which develop in a subset of individuals following a traumatic event. We previously developed a stress-enhanced fear learning (SEFL) paradigm in inbred mice that produces PTSD-like ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0432-2

    authors： Sillivan SE,Jamieson S,de Nijs L,Jones M,Snijders C,Klengel T,Joseph NF,Krauskopf J,Kleinjans J,Vinkers CH,Boks MPM,Geuze E,Vermetten E,Berretta S,Ressler KJ,Rutten BPF,Rumbaugh G,Miller CA

    更新日期：2020-05-01 00:00:00

  • Differential effects on T-cell function following exposure to serum from schizophrenia smokers.

    abstract：:Cigarette smoking is more prevalent in subjects with schizophrenia compared to those with other psychiatric disorders or the general population and could therefore affect molecular pathways that impact the pathophysiology of this disorder. As smoking is also known to suppress immune responses, we investigated the effe...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2008.120

    authors： Herberth M,Krzyszton DN,Koethe D,Craddock MR,Bulger E,Schwarz E,Guest P,Leweke FM,Bahn S

    更新日期：2010-04-01 00:00:00

  • Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques.

    abstract：:Depression often accompanies the perimenopausal transition and it often precedes overt symptomology in common neurodegenerative diseases (NDDs, such as Alzheimer's, Parkinson's, Huntington, amyotrophic lateral sclerosis). Serotonin dysfunction is frequently found in the different etiologies of depression. We have show...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2014.178

    authors： Bethea CL,Reddy AP

    更新日期：2015-12-01 00:00:00

  • Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.

    abstract：:Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ~1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated association of genetic variants in expert-curated synaptic gene groups with schizophrenia in 4673 ca...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2011.117

    authors： Lips ES,Cornelisse LN,Toonen RF,Min JL,Hultman CM,International Schizophrenia Consortium.,Holmans PA,O'Donovan MC,Purcell SM,Smit AB,Verhage M,Sullivan PF,Visscher PM,Posthuma D

    更新日期：2012-10-01 00:00:00

  • Response of the μ-opioid system to social rejection and acceptance.

    abstract：:The endogenous opioid system, which alleviates physical pain, is also known to regulate social distress and reward in animal models. To test this hypothesis in humans (n=18), we used an μ-opioid receptor (MOR) radiotracer to measure changes in MOR availability in vivo with positron emission tomography during social re...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2013.96

    authors： Hsu DT,Sanford BJ,Meyers KK,Love TM,Hazlett KE,Wang H,Ni L,Walker SJ,Mickey BJ,Korycinski ST,Koeppe RA,Crocker JK,Langenecker SA,Zubieta JK

    更新日期：2013-11-01 00:00:00

  • Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington's disease.

    abstract：:We assessed the ability of lithium to reduce neurodegeneration and to stimulate cell proliferation in a rat model of Huntington's disease in which quinolinic acid (QA) was unilaterally infused into the striatum. LiCl (0.5-3.0 mEq/kg) was injected subcutaneously 24 h before and 1 h after QA infusion. At 7 days after QA...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001463

    authors： Senatorov VV,Ren M,Kanai H,Wei H,Chuang DM

    更新日期：2004-04-01 00:00:00

  • Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS.

    abstract：:Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis spectrum. However, there is a lack of studies investigating longitudinal hippocampal development and its relationship with psychotic symptoms. The 22q11.2 deletion syndrome (22q11DS) has proven to be a remarkable model for the pro...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0443-z

    authors： Mancini V,Sandini C,Padula MC,Zöller D,Schneider M,Schaer M,Eliez S

    更新日期：2020-11-01 00:00:00

  • Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state.

    abstract：:Major depressive disorder (MDD) is associated with reduced concentrations of γ-aminobutyric acid (GABA) that are normalized by antidepressant therapies. Moreover, depressive-like phenotypes of GABAA receptor mutant mice can be reversed by treatment with conventional antidepressants drugs, as well as by subanesthetic d...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.188

    authors： Fuchs T,Jefferson SJ,Hooper A,Yee PH,Maguire J,Luscher B

    更新日期：2017-06-01 00:00:00

  • Variants in Apaf-1 segregating with major depression promote apoptosome function.

    abstract：:APAF1, encoding the protein apoptosis protease activating factor 1 (Apaf-1), has recently been established as a chromosome 12 gene conferring predisposition to major depression in humans. The molecular phenotypes of Apaf-1 variants were determined by in vitro reconstruction of the apoptosome complex in which Apaf-1 ac...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001755

    authors： Harlan J,Chen Y,Gubbins E,Mueller R,Roch JM,Walter K,Lake M,Olsen T,Metzger P,Dorwin S,Ladror U,Egan DA,Severin J,Johnson RW,Holzman TF,Voelp K,Davenport C,Beck A,Potter J,Gopalakrishnan M,Hahn A,Spear BB,Halb

    更新日期：2006-01-01 00:00:00

  • The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm.

    abstract：:Research on avoidance conditioning began in the late 1930s as a way to use laboratory experiments to better understand uncontrollable fear and anxiety. Avoidance was initially conceived of as a two-factor learning process in which fear is first acquired through Pavlovian aversive conditioning (so-called fear condition...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/mp.2016.166

    authors： LeDoux JE,Moscarello J,Sears R,Campese V

    更新日期：2017-01-01 00:00:00

  • Downregulation of autophagy by 12/15Lipoxygenase worsens the phenotype of an Alzheimer's disease mouse model with plaques, tangles, and memory impairments.

    abstract：:Among the different initiating events in Alzheimer's disease (AD) pathogenesis, oxidative stress and neuroinflammation are some of the most iimportant. In the central nervous system, the 12/15Lipoxygenase (12/15LO) enzyme is the source of potent pro-oxidants and inflammatory lipid mediators. Previous works showed that...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-018-0268-1

    authors： Li JG,Chu J,Praticò D

    更新日期：2018-10-02 00:00:00

  • Replication of 1q42 linkage in Finnish schizophrenia pedigrees.

    abstract：:Chromosome 1q has been implicated in the etiology of schizophrenia in several independent studies. However, the peak linkage findings have been dispersed over a large chromosomal region, with negative findings in this region also being reported. Our group has previously observed linkage on chromosome 1q42, maximizing ...

    journal_title：Molecular psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.mp.4001536

    authors： Ekelund J,Hennah W,Hiekkalinna T,Parker A,Meyer J,Lönnqvist J,Peltonen L

    更新日期：2004-11-01 00:00:00

  • Serotonin transporter gene variation impacts innate fear processing: Acoustic startle response and emotional startle.

    abstract：:Anxiety-related behaviors are closely linked to neural circuits relaying fear-specific information to the amygdala. Many of these circuits, like those underlying processing of innate fear, are remarkably well understood. Recent imaging studies have contributed to this knowledge by discriminating more detailed corticoa...

    journal_title：Molecular psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.mp.4001908

    authors： Brocke B,Armbruster D,Muller J,Hensch T,Jacob CP,Lesch KP,Kirschbaum C,Strobel A

    更新日期：2006-12-01 00:00:00

  • Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes.

    abstract：:Although disrupted in schizophrenia 1 (DISC1) has been implicated in many psychiatric disorders, including schizophrenia, bipolar disorder, schizoaffective disorder and major depression, its biological role in these disorders is unclear. To better understand this gene and its role in psychiatric disease, we conducted ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2011.37

    authors： Carless MA,Glahn DC,Johnson MP,Curran JE,Bozaoglu K,Dyer TD,Winkler AM,Cole SA,Almasy L,MacCluer JW,Duggirala R,Moses EK,Göring HH,Blangero J

    更新日期：2011-11-01 00:00:00

  • Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway.

    abstract：:Attention-deficit hyperactivity disorder (ADHD) is typically characterized as a disorder of inattention and hyperactivity/impulsivity but there is increasing evidence of deficits in motivation. Using positron emission tomography (PET), we showed decreased function in the brain dopamine reward pathway in adults with AD...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2010.97

    authors： Volkow ND,Wang GJ,Newcorn JH,Kollins SH,Wigal TL,Telang F,Fowler JS,Goldstein RZ,Klein N,Logan J,Wong C,Swanson JM

    更新日期：2011-11-01 00:00:00

  • Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.

    abstract：:The lack of strong association between brain beta-amyloid deposition and cognitive impairment has been a challenge for the Alzheimer's disease (AD) field. Although beta-amyloid is necessary for the pathologic diagnosis of AD, it is not sufficient to make the pathologic diagnosis or cause dementia. We sought to identif...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.35

    authors： Roostaei T,Nazeri A,Felsky D,De Jager PL,Schneider JA,Pollock BG,Bennett DA,Voineskos AN,Alzheimer’s Disease Neuroimaging Initiative (ADNI).

    更新日期：2017-02-01 00:00:00

  • Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach.

    abstract：:Identifying genes for bipolar mood disorders through classic genetics has proven difficult. Here, we present a comprehensive convergent approach that translationally integrates brain gene expression data from a relevant pharmacogenomic mouse model (involving treatments with a stimulant--methamphetamine, and a mood sta...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001547

    authors： Ogden CA,Rich ME,Schork NJ,Paulus MP,Geyer MA,Lohr JB,Kuczenski R,Niculescu AB

    更新日期：2004-11-01 00:00:00