Abstract:
:Only in the past decade has a role of heredity in substance abuse been established as a result of extensive twin and family studies. More recently, several candidate genes have been investigated for their possible role in alcoholism and cocaine abuse. Specific genetic factors in opioid substance abuse have not been investigated in man, although animal studies suggest that quantitative trait loci (QTLs) can be identified that predispose mice both to morphine and alcohol preference. Central dopaminergic pathways figure prominently in drug-mediated reinforcement suggesting that dopamine receptors are likely candiadates for association with substance abuse in man. In addition, we recently reported an association between a human personality trait, Novelty Seeking and the long alleles (represented chiefly by the 7-repeat) of the D4 dopamine receptor (D4DR) exon III polymorphism. The personality trait of Novelty Seeking is also more pronounced in substance abusers, who score higher in this dimension than control subjects. The twin role of dopamine receptors in mediating Novelty Seeking and drugreinforcement prompted us to examine a group of Israeli heroin addicts for prevalence of the D4DR repeat polymorphism. We now show that the 7-repeat allele is significantly over-represented in the opioid-dependent cohort and confers a relative risk of 2.46. To our knowledge this is the first report of an association between a specific genetic polymorphism and opioid addiction.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Kotler M,Cohen H,Segman R,Gritsenko I,Nemanov L,Lerer B,Kramer I,Zer-Zion M,Kletz I,Ebstein RPdoi
10.1038/sj.mp.4000248subject
Has Abstractpub_date
1997-05-01 00:00:00pages
251-4issue
3eissn
1359-4184issn
1476-5578journal_volume
2pub_type
杂志文章abstract::Several reports have suggested the presence of anticipation in bipolar affective disorder (BPAD). In addition, independent studies using the RED (repeat expansion detection) have shown association between BPAD and longer CAG/CTG repeats. Therefore loci with large CAG/CTG repeats are plausible candidates in the inherit...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000898
更新日期:2001-09-01 00:00:00
abstract::Abnormalities in the density of neuroreceptors that regulate norepinephrine and serotonin release have been repeatedly reported in brains of suicide victims with mood disorders. Recently, the modulation of the [(35)S]GTPgammaS binding to G-proteins has been introduced as a suitable measure of receptor activity in post...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001067
更新日期:2002-01-01 00:00:00
abstract::Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate, and, thus, are reasonable candidate susceptibility genes for these conditions. In this study, we examined th...
journal_title:Molecular psychiatry
pub_type: 杂志文章
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.70
更新日期:2013-03-01 00:00:00
abstract::Various neuropathological findings have been reported in bipolar disorder (BD). However, it is unclear which findings are well established. To address this gap, we carried out a systematic review of the literature. We searched over 5000 publications, identifying 103 data papers, of which 81 were eligible for inclusion...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0213-3
更新日期:2020-08-01 00:00:00
abstract::It is believed that genetic factors play a large role in the development of many cognitive and neurological processes; however, epidemiological evidence for the genetic basis of childhood neurodevelopment is very limited. Identification of the genetic polymorphisms associated with early-stage neurodevelopment will hel...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0205-3
更新日期:2020-11-01 00:00:00
abstract::Biological characterization of genetic variants identified in genome-wide association studies (GWAS) remains a substantial challenge. Here we used human-induced pluripotent stem cells (iPSC) and their neural derivatives to characterize common variants on chromosome 3p22 that have been associated by GWAS with major men...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0207-1
更新日期:2019-04-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0200-8
更新日期:2020-11-01 00:00:00
abstract::This paper summarizes recent research on mitochondrial DNA (mtDNA)--which might be described as the "other, forgotten genome". Recent studies suggest the possible pathophysiological significance of mtDNA in schizophrenia and neurodegenerative and mood disorders. Decreased activity of the mitochondrial electron transpo...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/sj.mp.4000926
更新日期:2001-11-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0432-2
更新日期:2020-05-01 00:00:00
abstract::Among the different initiating events in Alzheimer's disease (AD) pathogenesis, oxidative stress and neuroinflammation are some of the most iimportant. In the central nervous system, the 12/15Lipoxygenase (12/15LO) enzyme is the source of potent pro-oxidants and inflammatory lipid mediators. Previous works showed that...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0268-1
更新日期:2018-10-02 00:00:00
abstract::A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstrea...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001496
更新日期:2004-09-01 00:00:00
abstract::Long-term weight-restored patients with anorexia nervosa (AN) have lower norepinephrine levels than controls. Since this may reflect altered reuptake by the norepinephrine transporter (NET), we hypothesised that the NET gene was involved in the genetic component of AN. PCR-amplification of an AAGG repeat island (AAGG1...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001080
更新日期:2002-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0553-7
更新日期:2020-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/s41380-019-0356-x
更新日期:2020-04-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2017.141
更新日期:2017-10-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0254-7
更新日期:2019-06-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2009.16
更新日期:2009-07-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.229
更新日期:2016-11-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-01002-z
更新日期:2021-01-17 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001999
更新日期:2007-09-01 00:00:00
abstract::Neuregulin and the neuregulin receptor ERBB4 have been genetically and functionally implicated in schizophrenia. In this study, we used the yeast two-hybrid system to identify proteins that interact with ERBB4, to identify genes and pathways that might contribute to schizophrenia susceptibility. We identified the MAGI...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001991
更新日期:2008-02-01 00:00:00
abstract::The network theory conceptualizes mental disorders as complex networks of symptoms influencing each other by creating feedback loops, leading to a self-sustained syndromic constellation. Symptoms central to the network have the greatest impact in sustaining the rest of symptoms. This analysis focused on the network st...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0232-0
更新日期:2020-07-01 00:00:00
abstract::Circulating adiponectin (APN) levels decrease with age and obesity. On the other hand, a reduction in APN levels is associated with neurodegeneration and neuroinflammation. We previously showed that aged adiponectin knockout (APN-/-) mice developed Alzheimer's like pathologies, cerebral insulin resistance, and cogniti...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-0701-0
更新日期:2020-03-04 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-0823-4
更新日期:2020-07-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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journal_title:Molecular psychiatry
pub_type: 杂志文章,meta分析
doi:10.1038/mp.2013.86
更新日期:2014-06-01 00:00:00