In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy.

abstract：:Although schizophrenia is generally considered to occur as a consequence of multiple genes that interact with one another, very few methods have been developed to model epistasis. Phenotype definition has also been a major challenge for research on the genetics of schizophrenia. In this report, we use novel statistica...

journal_title：Molecular psychiatry

authors： Andreasen NC,Wilcox MA,Ho BC,Epping E,Ziebell S,Zeien E,Weiss B,Wassink T

更新日期：2012-11-01 00:00:00

abstract：:How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA-assessed from SA in s...

journal_title：Molecular psychiatry

authors： Kendler KS,Ohlsson H,Keefe RSE,Sundquist K,Sundquist J

更新日期：2018-04-01 00:00:00

abstract：:Accumulating evidence from both genetic and clinico-pharmacological studies suggests that D-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ). Although an association of genes for D-serine degradation, such as D-amino acid oxidase and G72, has been reported...

journal_title：Molecular psychiatry

authors： Fujii K,Maeda K,Hikida T,Mustafa AK,Balkissoon R,Xia J,Yamada T,Ozeki Y,Kawahara R,Okawa M,Huganir RL,Ujike H,Snyder SH,Sawa A

更新日期：2006-02-01 00:00:00

abstract：:Medical treatment with various cytokines can provoke psychiatric symptoms. Conversely, psychiatric patients can display abnormalities in cytokine and neurotrophic factor expression. Such observations have pointed to the potential contribution of cytokines and growth factors to schizophrenic pathology and/or etiology. ...

journal_title：Molecular psychiatry

authors： Nawa H,Takahashi M,Patterson PH

更新日期：2000-11-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not ju...

journal_title：Molecular psychiatry

authors： Dean KR,Hammamieh R,Mellon SH,Abu-Amara D,Flory JD,Guffanti G,Wang K,Daigle BJ Jr,Gautam A,Lee I,Yang R,Almli LM,Bersani FS,Chakraborty N,Donohue D,Kerley K,Kim TK,Laska E,Young Lee M,Lindqvist D,Lori A,Lu L,M

更新日期：2020-12-01 00:00:00

abstract：:Large numbers of single nucleotide polymorphisms (SNPs) are being identified by several laboratories for the purpose of developing dense genetic maps. Single-strand conformation polymorphism (SSCP) analysis has been widely used as a method for detecting novel sequence variations in PCR products. Differences in migrati...

journal_title：Molecular psychiatry

authors： Gonen D,Veenstra-VanderWeele J,Yang Z,Leventhal B,Cook EH Jr

更新日期：1999-07-01 00:00:00

abstract：:Depression is a common debilitating human disease whose etiology has defied decades of research. A critical bottleneck is the difficulty in modeling depressive episodes in animals. Here, we show that a transgenic mouse with chronic forebrain expression of a dominant negative mutant of Polg1, a mitochondrial DNA (mtDNA...

journal_title：Molecular psychiatry

authors： Kasahara T,Takata A,Kato TM,Kubota-Sakashita M,Sawada T,Kakita A,Mizukami H,Kaneda D,Ozawa K,Kato T

更新日期：2016-01-01 00:00:00

abstract：:The core nature of nicotine dependence is evident in wide variations in how individuals become and remain smokers. Individuals with pre-existing behavioral traits are more likely to develop nicotine dependence and experience difficulty when attempting to quit. Many molecular factors likely contribute to individual var...

journal_title：Molecular psychiatry

authors： Hiroi N,Scott D

更新日期：2009-07-01 00:00:00

abstract：:A polymorphism in the serotonin (5-HT) transporter gene regulatory region (5-HTTLPR) is associated with measures of 5-HT transporter (5-HTT) expression and 5-HT-mediated behaviors in humans. An analogous length variation of the 5-HTTLPR has been reported in rhesus monkeys (rh5-HTTLPR). A retrospective association stud...

journal_title：Molecular psychiatry

authors： Champoux M,Bennett A,Shannon C,Higley JD,Lesch KP,Suomi SJ

更新日期：2002-01-01 00:00:00

abstract：:Chronic stress contributes to the development of psychiatric disorders including anxiety and depression. Several inflammatory-related effects of stress are associated with increased interleukin-1 (IL-1) signaling within the central nervous system and are mediated by IL-1 receptor 1 (IL-1R1) on several distinct cell ty...

journal_title：Molecular psychiatry

authors： DiSabato DJ,Nemeth DP,Liu X,Witcher KG,O'Neil SM,Oliver B,Bray CE,Sheridan JF,Godbout JP,Quan N

更新日期：2020-05-22 00:00:00

abstract：:Schizophrenia is a highly heritable disorder for which anatomical brain alterations have been repeatedly reported in clinical samples. Unaffected at-risk groups have also been studied in an attempt to identify brain changes that do not reflect reverse causation or treatment effects. However, no robust associations hav...

journal_title：Molecular psychiatry

authors： Warland A,Kendall KM,Rees E,Kirov G,Caseras X

更新日期：2020-04-01 00:00:00

abstract：:The s allele variant of the serotonin transporter gene (5-HTT) has recently been observed to moderate the relationship of stress to depression and anxiety. To date no study has considered interactive effects of 5-HTT genotype, stress and hypothalamic-pituitary-adrenal (HPA) function on cognition in healthy, older adul...

journal_title：Molecular psychiatry

authors： O'Hara R,Schröder CM,Mahadevan R,Schatzberg AF,Lindley S,Fox S,Weiner M,Kraemer HC,Noda A,Lin X,Gray HL,Hallmayer JF

更新日期：2007-06-01 00:00:00

abstract：:Schizophrenia and bipolar disorder have both been linked to structural abnormalities of the hippocampus, which is consistent with a neurodevelopmental anomaly. One isoform of the neural cell adhesion molecule (N-CAM) protein, cytosolic N-CAM 105-115 kDa, was previously shown to be increased in schizophrenia in the hip...

journal_title：Molecular psychiatry

authors： Vawter MP,Howard AL,Hyde TM,Kleinman JE,Freed WJ

更新日期：1999-09-01 00:00:00

abstract：:Identifying biomarkers in schizophrenia during the first episode without the confounding effects of treatment has been challenging. Leveraging these biomarkers to establish diagnosis and make individualized predictions of future treatment responses to antipsychotics would be of great value, but there has been limited ...

journal_title：Molecular psychiatry

authors： Cao B,Cho RY,Chen D,Xiu M,Wang L,Soares JC,Zhang XY

更新日期：2020-04-01 00:00:00

abstract：:The dorsolateral prefrontal cortex (dlpfc) is strongly implicated in the pathogenesis of schizophrenia (SCZ) and bipolar disorder (BPD) and, within this region, abnormalities in glutamatergic neurotransmission and synaptic function have been described. Proteins associated with these functions are enriched in membrane ...

journal_title：Molecular psychiatry

authors： Behan AT,Byrne C,Dunn MJ,Cagney G,Cotter DR

更新日期：2009-06-01 00:00:00

abstract：:Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patie...

journal_title：Molecular psychiatry

authors： Albrecht DS,Kim M,Akeju O,Torrado-Carvajal A,Edwards RR,Zhang Y,Bergan C,Protsenko E,Kucyi A,Wasan AD,Hooker JM,Napadow V,Loggia ML

更新日期：2019-05-28 00:00:00

abstract：:This Article was originally published under Nature Research's License to Publish, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the Article have been modified accordingly. ...

journal_title：Molecular psychiatry

authors： Perry A,Roberts G,Mitchell PB,Breakspear M

更新日期：2019-09-01 00:00:00

abstract：:The catechol-O-methyl transferase (COMT) gene is considered a leading schizophrenia candidate gene. Although its role in increasing schizophrenia susceptibility has been conflicting, recent studies suggest the valine allele may contribute to poor cognitive function in schizophrenia. V(158)M COMT genotype was obtained ...

journal_title：Molecular psychiatry

authors： Ho BC,Wassink TH,O'Leary DS,Sheffield VC,Andreasen NC

更新日期：2005-03-01 00:00:00

abstract：:The molecular genetic research on panic disorder (PD) has grown tremendously in the past decade. Although the data from twin and family studies suggest an involvement of genetic factors in the familial transmission of PD with the heritability estimate near 40%, the genetic substrate underlying panicogenesis is not yet...

journal_title：Molecular psychiatry

authors： Maron E,Hettema JM,Shlik J

更新日期：2010-07-01 00:00:00

abstract：:Several microbes have been suspected as pathogenetic factors in schizophrenia. We have previously observed increased frequencies of chlamydial infections and of human lymphocyte antigen (HLA)-A10 in independent studies of schizophrenia. Our aim here was to analyze frequencies of three types of Chlamydiaceae in schizop...

journal_title：Molecular psychiatry

authors： Fellerhoff B,Laumbacher B,Mueller N,Gu S,Wank R

更新日期：2007-03-01 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and sex using a 51-plex cyto...

journal_title：Molecular psychiatry

authors： Hornig M,Gottschalk G,Peterson DL,Knox KK,Schultz AF,Eddy ML,Che X,Lipkin WI

更新日期：2016-02-01 00:00:00

abstract：:Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-inv...

journal_title：Molecular psychiatry

authors： Hadar R,Winter R,Edemann-Callesen H,Wieske F,Habelt B,Khadka N,Felgel-Farnholz V,Barroeta-Hlusicka E,Reis J,Tatarau CA,Funke K,Fritsch B,Bernhardt N,Bikson M,Nitsche MA,Winter C

更新日期：2020-04-01 00:00:00

abstract：:Autistic individuals experience significantly elevated rates of childhood trauma, self-harm and suicidal behaviour and ideation (SSBI). Is this purely the result of negative environmental experiences, or does this interact with genetic predisposition? In this study we investigated if a genetic predisposition for autis...

journal_title：Molecular psychiatry

authors： Warrier V,Baron-Cohen S

更新日期：2019-10-29 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Molecular psychiatry

authors： Haarsma J,Fletcher PC,Griffin JD,Taverne HJ,Ziauddeen H,Spencer TJ,Miller C,Katthagen T,Goodyer I,Diederen KMJ,Murray GK

更新日期：2020-10-14 00:00:00

abstract：:Epidermal growth factor (EGF) comprises a structurally related family of proteins containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that regulates the development of dopaminergic neurons as well as monoamine metabolism. We assessed the contribution of EGF to sch...

journal_title：Molecular psychiatry

authors： Futamura T,Toyooka K,Iritani S,Niizato K,Nakamura R,Tsuchiya K,Someya T,Kakita A,Takahashi H,Nawa H

更新日期：2002-01-01 00:00:00

abstract：:Corticotropin-releasing hormone (CRH) is the principal regulator of the hypothalamic-pituitary-adrenal (HPA) axis and an activator of the sympathoadrenal (SA) and systemic sympathetic (SS) systems. Mental disorders, including major depression and, more recently, Alzheimer's disease have been associated with dysregulat...

journal_title：Molecular psychiatry

authors： Willenberg HS,Bornstein SR,Hiroi N,Päth G,Goretzki PE,Scherbaum WA,Chrousos GP

更新日期：2000-03-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/mp.2017.5. ...

journal_title：Molecular psychiatry

authors： Deary V,Hagenaars SP,Harris SE,Hill WD,Davies G,Liewald DCM,International Consortium for Blood Pressure GWAS.,CHARGE consortium Aging and Longevity Group.,CHARGE consortium Inflammation Group.,McIntosh AM,Gale CR,Deary IJ

更新日期：2018-03-01 00:00:00

abstract：:The search for genetic factors predisposing to Attention Deficit Hyperactivity Disorder (ADHD) has focused on genes that regulate dopaminergic pathways such as dopamine receptors and enzymes that regulate levels of dopamine in the synapse. There have been several reports of association between ADHD and polymorphic var...

journal_title：Molecular psychiatry

authors： Tahir E,Yazgan Y,Cirakoglu B,Ozbay F,Waldman I,Asherson PJ

更新日期：2000-07-01 00:00:00

abstract：:The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challenges of obtaining such l...

journal_title：Molecular psychiatry

authors： Vélez JI,Chandrasekharappa SC,Henao E,Martinez AF,Harper U,Jones M,Solomon BD,Lopez L,Garcia G,Aguirre-Acevedo DC,Acosta-Baena N,Correa JC,Lopera-Gómez CM,Jaramillo-Elorza MC,Rivera D,Kosik KS,Schork NJ,Swanson JM,Lop

更新日期：2013-05-01 00:00:00

abstract：:Bipolar affective disorder is one of the most common mental illnesses with a population prevalence of approximately 1%. The disorder is genetically complex, with an increasing number of loci being implicated through genetic linkage studies. However, the specific genetic variations and molecules involved in bipolar sus...

journal_title：Molecular psychiatry

authors： Blair IP,Adams LJ,Badenhop RF,Moses MJ,Scimone A,Morris JA,Ma L,Austin CP,Donald JA,Mitchell PB,Schofield PR

更新日期：2002-01-01 00:00:00