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Serine racemase binds to PICK1: potential relevance to schizophrenia.

Abstract：

:Accumulating evidence from both genetic and clinico-pharmacological studies suggests that D-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ). Although an association of genes for D-serine degradation, such as D-amino acid oxidase and G72, has been reported, a role for D-serine in SZ has been unclear. In this study, we identify and characterize protein interacting with C-kinase (PICK1) as a protein interactor of the D-serine synthesizing enzyme, serine racemase (SR). The binding of endogenous PICK1 and SR requires the PDZ domain of PICK1. The gene coding for PICK1 is located at chromosome 22q13, a region frequently linked to SZ. In a case-control association study using well-characterized Japanese subjects, we observe an association of the PICK1 gene with SZ, which is more prominent in disorganized SZ. Our findings implicating PICK1 as a susceptibility gene for SZ are consistent with a role for D-serine in the disease.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Fujii K,Maeda K,Hikida T,Mustafa AK,Balkissoon R,Xia J,Yamada T,Ozeki Y,Kawahara R,Okawa M,Huganir RL,Ujike H,Snyder SH,Sawa A

doi

10.1038/sj.mp.4001776

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

150-7

issue

2

eissn

1359-4184

issn

1476-5578

pii

4001776

journal_volume

11

pub_type

杂志文章

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