Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.

abstract：:Several studies have indicated that patients with bipolar disorder (BD) who respond well to lithium prophylaxis constitute a biologically distinct subgroup. Lithium is thought to stabilize mood by acting at the phosphoinositide cycle. We have investigated a polymorphism located in the gene (PLCG1) that codes for a gam...

journal_title：Molecular psychiatry

authors： Turecki G,Grof P,Cavazzoni P,Duffy A,Grof E,Ahrens B,Berghöfer A,Müller-Oerlinghausen B,Dvoráková M,Libigerová E,Vojtechovský M,Zvolský P,Joober R,Nilsson A,Prochazka H,Licht RW,Rasmussen NA,Schou M,Vestergaard P,Ho

更新日期：1998-11-01 00:00:00

abstract：:Research on avoidance conditioning began in the late 1930s as a way to use laboratory experiments to better understand uncontrollable fear and anxiety. Avoidance was initially conceived of as a two-factor learning process in which fear is first acquired through Pavlovian aversive conditioning (so-called fear condition...

journal_title：Molecular psychiatry

authors： LeDoux JE,Moscarello J,Sears R,Campese V

更新日期：2017-01-01 00:00:00

abstract：:Psychotic symptoms occur in ~40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. We undertook a combined analysi...

journal_title：Molecular psychiatry

authors： Hollingworth P,Sweet R,Sims R,Harold D,Russo G,Abraham R,Stretton A,Jones N,Gerrish A,Chapman J,Ivanov D,Moskvina V,Lovestone S,Priotsi P,Lupton M,Brayne C,Gill M,Lawlor B,Lynch A,Craig D,McGuinness B,Johnston J

更新日期：2012-12-01 00:00:00

abstract：:Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate, and, thus, are reasonable candidate susceptibility genes for these conditions. In this study, we examined th...

journal_title：Molecular psychiatry

authors： Hettema JM,An SS,Neale MC,Bukszar J,van den Oord EJ,Kendler KS,Chen X

更新日期：2006-08-01 00:00:00

abstract：:Polymorphic variants of the dopamine D(4) receptor have been consistently associated with attention-deficit hyperactivity disorder (ADHD). However, the functional significance of the risk polymorphism (variable number of tandem repeats in exon 3) is still unclear. Here, we show that whereas the most frequent 4-repeat ...

journal_title：Molecular psychiatry

authors： González S,Rangel-Barajas C,Peper M,Lorenzo R,Moreno E,Ciruela F,Borycz J,Ortiz J,Lluís C,Franco R,McCormick PJ,Volkow ND,Rubinstein M,Floran B,Ferré S

更新日期：2012-06-01 00:00:00

abstract：:Myo-inositol exerts behavioral effects in animal models of psychiatric disorders and is effective in clinical trials in psychiatric patients. Interestingly, epi-inositol exerts behavioral effects similar to myo-inositol, even though epi-inositol is not a substrate for synthesis of phosphatidylinositol. We postulated t...

journal_title：Molecular psychiatry

authors： Shaldubina A,Ju S,Vaden DL,Ding D,Belmaker RH,Greenberg ML

更新日期：2002-01-01 00:00:00

abstract：:The epigenome is associated with biological factors, such as disease status, and environmental factors, such as smoking, alcohol consumption and body mass index. Although there is a widespread perception that environmental influences on the epigenome are pervasive and profound, there has been little evidence to date i...

journal_title：Molecular psychiatry

authors： Karlsson Linnér R,Marioni RE,Rietveld CA,Simpkin AJ,Davies NM,Watanabe K,Armstrong NJ,Auro K,Baumbach C,Bonder MJ,Buchwald J,Fiorito G,Ismail K,Iurato S,Joensuu A,Karell P,Kasela S,Lahti J,McRae AF,Mandaviya PR,Se

更新日期：2017-12-01 00:00:00

abstract：:Although schizophrenia is generally considered to occur as a consequence of multiple genes that interact with one another, very few methods have been developed to model epistasis. Phenotype definition has also been a major challenge for research on the genetics of schizophrenia. In this report, we use novel statistica...

journal_title：Molecular psychiatry

authors： Andreasen NC,Wilcox MA,Ho BC,Epping E,Ziebell S,Zeien E,Weiss B,Wassink T

更新日期：2012-11-01 00:00:00

abstract：:How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA-assessed from SA in s...

journal_title：Molecular psychiatry

authors： Kendler KS,Ohlsson H,Keefe RSE,Sundquist K,Sundquist J

更新日期：2018-04-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the etiology of major depressive disorder (MDD). Although meta-analyses do confirm associations between depression and these biological systems, effect sizes vary greatl...

journal_title：Molecular psychiatry

authors： Lamers F,Vogelzangs N,Merikangas KR,de Jonge P,Beekman AT,Penninx BW

更新日期：2013-06-01 00:00:00

abstract：:Dysthymia is characterized by long-lasting periods of lowered mood. Epidemiological studies in the USA and Europe have demonstrated that the prevalence of dysthymia is at least 3% of the general population. Its pervasive occurrence makes dysthymia a public health problem worldwide. One feature of this disorder is its ...

journal_title：Molecular psychiatry

authors： Akiskal HS,Bolis CL,Cazzullo C,Costa e Silva JA,Gentil V,Lecrubier Y,Licinio J,Linden M,Lopez-Ibor JJ,Ndiaye IP,Pani L,Prilipko L,Robertson MM,Robinson RG,Starkstein SE,Thomas P,Wang Y,Wong ML

更新日期：1996-12-01 00:00:00

abstract：:Bipolar affective disorder (BPAD) is a common psychiatric disorder with complex genetic aetiology. We have undertaken a genome-wide scan in one of the largest samples of bipolar affected sibling pairs (ASPs) using a two-stage approach combining sample splitting and marker grid tightening. In this second stage analysis...

journal_title：Molecular psychiatry

authors： Lambert D,Middle F,Hamshere ML,Segurado R,Raybould R,Corvin A,Green E,O'Mahony E,Nikolov I,Mulcahy T,Haque S,Bort S,Bennett P,Norton N,Owen MJ,Kirov G,Lendon C,Jones L,Jones I,Holmans P,Gill M,Craddock N

更新日期：2005-09-01 00:00:00

abstract：:The development of the cerebral cortex is a tightly regulated process that relies on exquisitely coordinated actions of intrinsic and extrinsic cues. Here, we show that the communication between forebrain meninges and apical neural progenitor cells (aNPC) is essential to cortical development, and that the basal compar...

journal_title：Molecular psychiatry

authors： Boucherie C,Boutin C,Jossin Y,Schakman O,Goffinet AM,Ris L,Gailly P,Tissir F

更新日期：2018-03-01 00:00:00

abstract：:A recent study using a 'partial' rodent model of schizophrenia has employed amygdalar activation to induce reported changes in the expression of hippocampal genes associated with metabolic and signaling pathways in response to amygdalar activation. The amygdalo-hippocampal pathway plays a central role in the regulatio...

journal_title：Molecular psychiatry

authors： Burke RE,Walsh J,Matzilevich D,Benes FM

更新日期：2006-02-01 00:00:00

abstract：:The catechol-O-methyl transferase (COMT) gene is considered a leading schizophrenia candidate gene. Although its role in increasing schizophrenia susceptibility has been conflicting, recent studies suggest the valine allele may contribute to poor cognitive function in schizophrenia. V(158)M COMT genotype was obtained ...

journal_title：Molecular psychiatry

authors： Ho BC,Wassink TH,O'Leary DS,Sheffield VC,Andreasen NC

更新日期：2005-03-01 00:00:00

abstract：:Accumulating research demonstrates the potential of intranasal delivery of psychopharmacological agents to treat a range of psychiatric disorders and symptoms. It is believed that intranasal administration offers both direct and indirect pathways to deliver psychopharmacological agents to the central nervous system. T...

journal_title：Molecular psychiatry

authors： Quintana DS,Guastella AJ,Westlye LT,Andreassen OA

更新日期：2016-01-01 00:00:00

abstract：:Low dietary folate intake has been implicated as a risk factor for depression. However, observational epidemiological studies are plagued by problems of confounding, reverse causality and measurement error. A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and ...

journal_title：Molecular psychiatry

authors： Lewis SJ,Lawlor DA,Davey Smith G,Araya R,Timpson N,Day IN,Ebrahim S

更新日期：2006-04-01 00:00:00

abstract：:The 'neurodegeneration with brain iron accumulation' (NBIA) disease family entails movement or cognitive impairment, often with psychiatric features. To understand how iron loading affects the brain, we studied mice with disruption of two iron regulatory genes, hemochromatosis (Hfe) and transferrin receptor 2 (Tfr2). ...

journal_title：Molecular psychiatry

authors： Heidari M,Johnstone DM,Bassett B,Graham RM,Chua AC,House MJ,Collingwood JF,Bettencourt C,Houlden H,Ryten M,Olynyk JK,Trinder D,Milward EA

更新日期：2016-11-01 00:00:00

abstract：:We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. Expression of LIM was decreased in the lymphoblastoid cells derived from patients with bipolar disorders and schizophrenia. LI...

journal_title：Molecular psychiatry

authors： Kato T,Iwayama Y,Kakiuchi C,Iwamoto K,Yamada K,Minabe Y,Nakamura K,Mori N,Fujii K,Nanko S,Yoshikawa T

更新日期：2005-11-01 00:00:00

abstract：:The s allele variant of the serotonin transporter gene (5-HTT) has recently been observed to moderate the relationship of stress to depression and anxiety. To date no study has considered interactive effects of 5-HTT genotype, stress and hypothalamic-pituitary-adrenal (HPA) function on cognition in healthy, older adul...

journal_title：Molecular psychiatry

authors： O'Hara R,Schröder CM,Mahadevan R,Schatzberg AF,Lindley S,Fox S,Weiner M,Kraemer HC,Noda A,Lin X,Gray HL,Hallmayer JF

更新日期：2007-06-01 00:00:00

abstract：:The different serotonin (5-HT) receptors, including the serotonin transporter (5-HTT), are excellent candidate genes for suicide and suicidal behavior, and thus, they have been investigated in a large number of allelic association studies. The individual results of these studies have been inconsistent and definite con...

journal_title：Molecular psychiatry

authors： Anguelova M,Benkelfat C,Turecki G

更新日期：2003-07-01 00:00:00

abstract：:Exposure to traumatic events is common. While many individuals recover following trauma exposure, a substantial subset develop adverse posttraumatic neuropsychiatric sequelae (APNS) such as posttraumatic stress, major depression, and regional or widespread chronic musculoskeletal pain. APNS cause substantial burden to...

journal_title：Molecular psychiatry

authors： Linnstaedt SD,Zannas AS,McLean SA,Koenen KC,Ressler KJ

更新日期：2020-09-01 00:00:00

abstract：:We assessed the ability of lithium to reduce neurodegeneration and to stimulate cell proliferation in a rat model of Huntington's disease in which quinolinic acid (QA) was unilaterally infused into the striatum. LiCl (0.5-3.0 mEq/kg) was injected subcutaneously 24 h before and 1 h after QA infusion. At 7 days after QA...

journal_title：Molecular psychiatry

authors： Senatorov VV,Ren M,Kanai H,Wei H,Chuang DM

更新日期：2004-04-01 00:00:00

abstract：:Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ~1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated association of genetic variants in expert-curated synaptic gene groups with schizophrenia in 4673 ca...

journal_title：Molecular psychiatry

authors： Lips ES,Cornelisse LN,Toonen RF,Min JL,Hultman CM,International Schizophrenia Consortium.,Holmans PA,O'Donovan MC,Purcell SM,Smit AB,Verhage M,Sullivan PF,Visscher PM,Posthuma D

更新日期：2012-10-01 00:00:00

abstract：:Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patie...

journal_title：Molecular psychiatry

authors： Albrecht DS,Kim M,Akeju O,Torrado-Carvajal A,Edwards RR,Zhang Y,Bergan C,Protsenko E,Kucyi A,Wasan AD,Hooker JM,Napadow V,Loggia ML

更新日期：2019-05-28 00:00:00

abstract：:Among the different initiating events in Alzheimer's disease (AD) pathogenesis, oxidative stress and neuroinflammation are some of the most iimportant. In the central nervous system, the 12/15Lipoxygenase (12/15LO) enzyme is the source of potent pro-oxidants and inflammatory lipid mediators. Previous works showed that...

journal_title：Molecular psychiatry

authors： Li JG,Chu J,Praticò D

更新日期：2018-10-02 00:00:00

abstract：:Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental syndrome characterized by hyperactivity, inattention and increased impulsivity. To detect micro-deletions and micro-duplications that may have a role in the pathogenesis of ADHD, we carried out a genome-wide screen for cop...

journal_title：Molecular psychiatry

authors： Lesch KP,Selch S,Renner TJ,Jacob C,Nguyen TT,Hahn T,Romanos M,Walitza S,Shoichet S,Dempfle A,Heine M,Boreatti-Hümmer A,Romanos J,Gross-Lesch S,Zerlaut H,Wultsch T,Heinzel S,Fassnacht M,Fallgatter A,Allolio B,Schäf

更新日期：2011-05-01 00:00:00

abstract：:Genomic risk profile scores (GRPSs) have been shown to predict case-control status of schizophrenia (SCZ), albeit with varying sensitivity and specificity. The extent to which this variability in prediction accuracy is related to differences in sampling strategies is unknown. Danish population-based registers and Neon...

journal_title：Molecular psychiatry

authors： Meier SM,Agerbo E,Maier R,Pedersen CB,Lang M,Grove J,Hollegaard MV,Demontis D,Trabjerg BB,Hjorthøj C,Ripke S,Degenhardt F,Nöthen MM,Rujescu D,Maier W,MooDS SCZ Consortium.,Werge T,Mors O,Hougaard DM,Børglum AD,Wra

更新日期：2016-07-01 00:00:00

abstract：:Two recent association studies have implicated the neuregulin-1 gene (NRG1) at chromosome 8p21-22 as a susceptibility gene for schizophrenia. Stefansson et al identified three 'at-risk' haplotypes (HapA, B and C) which spanned the NRG1 locus and shared a common core haplotype. Subsequently, they demonstrated evidence ...

journal_title：Molecular psychiatry

authors： Corvin AP,Morris DW,McGhee K,Schwaiger S,Scully P,Quinn J,Meagher D,Clair DS,Waddington JL,Gill M

更新日期：2004-02-01 00:00:00

abstract：:Peripheral blood brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in bipolar disorder, speculated to mirror alterations in brain expression of BDNF. The research area is rapidly evolving; however, recent investigations have yielded con...

journal_title：Molecular psychiatry

authors： Munkholm K,Vinberg M,Kessing LV

更新日期：2016-02-01 00:00:00