A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior.

abstract：:The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. A meta-analysis was performed on 15 studies including data of 1435 subjects. We tested three phenotypes: remission rate,...

journal_title：Molecular psychiatry

authors： Serretti A,Kato M,De Ronchi D,Kinoshita T

更新日期：2007-03-01 00:00:00

abstract：:Adults with psychotic disorders have dysconnectivity in critical brain networks, including the default mode (DM) and the cingulo-opercular (CO) networks. However, it is unknown whether such deficits are present in youth with less severe symptoms. We conducted a multivariate connectome-wide association study examining ...

journal_title：Molecular psychiatry

authors： Satterthwaite TD,Vandekar SN,Wolf DH,Bassett DS,Ruparel K,Shehzad Z,Craddock RC,Shinohara RT,Moore TM,Gennatas ED,Jackson C,Roalf DR,Milham MP,Calkins ME,Hakonarson H,Gur RC,Gur RE

更新日期：2015-12-01 00:00:00

abstract：:Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in the pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the dynamic plasticity of dendritic spines of pyramidal neurons (PNs) and "en passant" axonal bouton of parvalbumin-expressing interneurons (PVI...

journal_title：Molecular psychiatry

authors： Huang Y,Jiang H,Zheng Q,Fok AHK,Li X,Lau CG,Lai CSW

更新日期：2021-01-20 00:00:00

abstract：:It is believed that genetic factors play a large role in the development of many cognitive and neurological processes; however, epidemiological evidence for the genetic basis of childhood neurodevelopment is very limited. Identification of the genetic polymorphisms associated with early-stage neurodevelopment will hel...

journal_title：Molecular psychiatry

authors： Sun R,Wang Z,Claus Henn B,Su L,Lu Q,Lin X,Wright RO,Bellinger DC,Kile M,Mazumdar M,Tellez-Rojo MM,Schnaas L,Christiani DC

更新日期：2020-11-01 00:00:00

abstract：:Several lines of evidence implicate dopa decarboxylase (DDC) with schizophrenia. By analysis of two putative functional DDC variants in 173 schizophrenic patients and 204 controls we tested the hypotheses that DDC is involved in: (1) predisposition to schizophrenia; and (2) modulation of age at disease onset. No assoc...

journal_title：Molecular psychiatry

authors： Børglum AD,Hampson M,Kjeldsen TE,Muir W,Murray V,Ewald H,Mors O,Blackwood D,Kruse TA

更新日期：2001-11-01 00:00:00

abstract：:This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...

journal_title：Molecular psychiatry

authors： Haure-Mirande JV,Wang M,Audrain M,Fanutza T,Kim SH,Heja S,Readhead B,Dudley JT,Blitzer RD,Schadt EE,Zhang B,Gandy S,Ehrlich ME

更新日期：2019-03-01 00:00:00

abstract：:Amyloid-β peptide (Aβ) accumulation in the brain is a hallmark of Alzheimer's Disease. An important mechanism of Aβ clearance in the brain is uptake and degradation by microglia. Presenilin 1 (PS1) is the catalytic subunit of γ-secretase, an enzyme complex responsible for the maturation of multiple substrates, such as...

journal_title：Molecular psychiatry

authors： Ledo JH,Liebmann T,Zhang R,Chang JC,Azevedo EP,Wong E,Silva HM,Troyanskaya OG,Bustos V,Greengard P

更新日期：2020-08-13 00:00:00

abstract：:How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA-assessed from SA in s...

journal_title：Molecular psychiatry

authors： Kendler KS,Ohlsson H,Keefe RSE,Sundquist K,Sundquist J

更新日期：2018-04-01 00:00:00

abstract：:Cariprazine (CAR) is a strong inhibitor of the Dhcr7 enzyme, the last enzyme in the cholesterol biosynthesis pathway. We assessed the effects of CAR on maternally exposed Dhcr7+/- and wild-type mouse offspring, and tested the biochemical effects of CAR in human serum samples. Dhcr7+/- and wild-type time-pregnant mice ...

journal_title：Molecular psychiatry

authors： Genaro-Mattos TC,Anderson A,Allen LB,Tallman KA,Porter NA,Korade Z,Mirnics K

更新日期：2020-11-01 00:00:00

abstract：:Disruption of persistent, stress-associated memories is relevant for treating posttraumatic stress disorder (PTSD) and related syndromes, which develop in a subset of individuals following a traumatic event. We previously developed a stress-enhanced fear learning (SEFL) paradigm in inbred mice that produces PTSD-like ...

journal_title：Molecular psychiatry

authors： Sillivan SE,Jamieson S,de Nijs L,Jones M,Snijders C,Klengel T,Joseph NF,Krauskopf J,Kleinjans J,Vinkers CH,Boks MPM,Geuze E,Vermetten E,Berretta S,Ressler KJ,Rutten BPF,Rumbaugh G,Miller CA

更新日期：2020-05-01 00:00:00

abstract：:Intellectual disability (ID) is a measurable phenotypic consequence of genetic and environmental factors. In this study, we prospectively assessed the diagnostic yield of genomic tools (molecular karyotyping, multi-gene panel and exome sequencing) in a cohort of 337 ID subjects as a first-tier test and compared it wit...

journal_title：Molecular psychiatry

authors： Anazi S,Maddirevula S,Faqeih E,Alsedairy H,Alzahrani F,Shamseldin HE,Patel N,Hashem M,Ibrahim N,Abdulwahab F,Ewida N,Alsaif HS,Al Sharif H,Alamoudi W,Kentab A,Bashiri FA,Alnaser M,AlWadei AH,Alfadhel M,Eyaid W,Has

更新日期：2017-04-01 00:00:00

abstract：:Previous studies have shown inconsistent results regarding the actions of antidepressants on glucocorticoid receptor (GR) signalling. To resolve these inconsistencies, we used a lentiviral-based reporter system to directly monitor rat hippocampal GR activity during stress adaptation. Temporal GR activation was induced...

journal_title：Molecular psychiatry

authors： Lee MS,Kim YH,Park WS,Park OK,Kwon SH,Hong KS,Rhim H,Shim I,Morita K,Wong DL,Patel PD,Lyons DM,Schatzberg AF,Her S

更新日期：2016-02-01 00:00:00

abstract：:Many antidepressants stimulate adult hippocampal neurogenesis, but the mechanisms by which they increase neurogenesis and modulate behavior are incompletely understood. Here we show that hippocampal bone morphogenetic protein (BMP) signaling is modulated by antidepressant treatment, and that the changes in BMP signali...

journal_title：Molecular psychiatry

authors： Brooker SM,Gobeske KT,Chen J,Peng CY,Kessler JA

更新日期：2017-06-01 00:00:00

abstract：:Depression often accompanies the perimenopausal transition and it often precedes overt symptomology in common neurodegenerative diseases (NDDs, such as Alzheimer's, Parkinson's, Huntington, amyotrophic lateral sclerosis). Serotonin dysfunction is frequently found in the different etiologies of depression. We have show...

journal_title：Molecular psychiatry

authors： Bethea CL,Reddy AP

更新日期：2015-12-01 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and sex using a 51-plex cyto...

journal_title：Molecular psychiatry

authors： Hornig M,Gottschalk G,Peterson DL,Knox KK,Schultz AF,Eddy ML,Che X,Lipkin WI

更新日期：2016-02-01 00:00:00

abstract：:This Article was originally published under Nature Research's License to Publish, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the Article have been modified accordingly. ...

journal_title：Molecular psychiatry

authors： Perry A,Roberts G,Mitchell PB,Breakspear M

更新日期：2019-09-01 00:00:00

abstract：:With the advent of technologies that allow simultaneous genotyping of thousands of single-nucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex diseases can be explored at an unprecedented detail. This study is among the first to apply the genome-wide association study (GWAS) approach...

journal_title：Molecular psychiatry

authors： Feulner TM,Laws SM,Friedrich P,Wagenpfeil S,Wurst SH,Riehle C,Kuhn KA,Krawczak M,Schreiber S,Nikolaus S,Förstl H,Kurz A,Riemenschneider M

更新日期：2010-07-01 00:00:00

abstract：:In mammals, most adult neural stem cells (NSCs) are located in the ventricular-subventricular zone (V-SVZ) along the wall of the lateral ventricles and they are the source of olfactory bulb interneurons. Adult NSCs exhibit an apico-basal polarity; they harbor a short apical process and a long basal process, reminiscen...

journal_title：Molecular psychiatry

authors： García-González D,Dumitru I,Zuccotti A,Yen TY,Herranz-Pérez V,Tan LL,Neitz A,García-Verdugo JM,Kuner R,Alfonso J,Monyer H

更新日期：2020-07-01 00:00:00

abstract：:The effect of endogenous dopamine (DA) on neostriatal DA D(1) and D(2) receptor binding potentials (D(1)RBP and D(2)RBP, respectively) in vivo was evaluated with positron emission tomography (PET) and the radiotracers [(11)C]SCH23390 and [(11)C]raclopride, respectively, by comparing the D(1)RBP and D(2)RBP before and ...

journal_title：Molecular psychiatry

authors： Verhoeff NP,Hussey D,Lee M,Tauscher J,Papatheodorou G,Wilson AA,Houle S,Kapur S

更新日期：2002-01-01 00:00:00

abstract：:Whilst cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers for amyloid-β (Aβ) and tau pathologies are accurate for the diagnosis of Alzheimer's disease (AD), their broad implementation in clinical and trial settings are restricted by high cost and limited accessibility. Plasma phosphorylated-ta...

journal_title：Molecular psychiatry

authors： Karikari TK,Benedet AL,Ashton NJ,Lantero Rodriguez J,Snellman A,Suárez-Calvet M,Saha-Chaudhuri P,Lussier F,Kvartsberg H,Rial AM,Pascoal TA,Andreasson U,Schöll M,Weiner MW,Rosa-Neto P,Trojanowski JQ,Shaw LM,Blennow K,Z

更新日期：2020-10-26 00:00:00

abstract：:We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25-q26 that had been typed in a genome-wide association study (GWAS) of schi...

journal_title：Molecular psychiatry

authors： O'Donovan MC,Norton N,Williams H,Peirce T,Moskvina V,Nikolov I,Hamshere M,Carroll L,Georgieva L,Dwyer S,Holmans P,Marchini JL,Spencer CC,Howie B,Leung HT,Giegling I,Hartmann AM,Möller HJ,Morris DW,Shi Y,Feng G,H

更新日期：2009-01-01 00:00:00

abstract：:Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages spanning 100 years, as well as 67 adult individuals diagnosed with autism (ASD), schizophrenia (SZ), and Down synd...

journal_title：Molecular psychiatry

authors： Yu Q,He Z,Zubkov D,Huang S,Kurochkin I,Yang X,Halene T,Willmitzer L,Giavalisco P,Akbarian S,Khaitovich P

更新日期：2020-11-01 00:00:00

abstract：:The dorsolateral prefrontal cortex (dlpfc) is strongly implicated in the pathogenesis of schizophrenia (SCZ) and bipolar disorder (BPD) and, within this region, abnormalities in glutamatergic neurotransmission and synaptic function have been described. Proteins associated with these functions are enriched in membrane ...

journal_title：Molecular psychiatry

authors： Behan AT,Byrne C,Dunn MJ,Cagney G,Cotter DR

更新日期：2009-06-01 00:00:00

abstract：:In our genome scan for schizophrenia genes in 265 Irish pedigrees, marker D5S818 in 5q22 produced the second best result of the first 223 markers tested (P = 0.002). We then tested an additional 13 markers and the evidence suggests the presence of a vulnerability locus for schizophrenia in region 5q22-31. This region ...

journal_title：Molecular psychiatry

authors： Straub RE,MacLean CJ,O'Neill FA,Walsh D,Kendler KS

更新日期：1997-03-01 00:00:00

abstract：:Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification of predisposing genes has remained a challenge. Utilizing a large family-based schizophrenia study...

journal_title：Molecular psychiatry

authors： Wedenoja J,Loukola A,Tuulio-Henriksson A,Paunio T,Ekelund J,Silander K,Varilo T,Heikkilä K,Suvisaari J,Partonen T,Lönnqvist J,Peltonen L

更新日期：2008-07-01 00:00:00

abstract：:In developing his mature concept of hebephrenic dementia praecox (DP) in his 4th (1893) through 6th textbook editions (1899), Kraepelin worked from the hebephrenic syndrome first described by Hecker (1871) and then carefully studied by his student Daraszkiewicz (1892). Working under Kraepelin's supervision, Daraszkiew...

journal_title：Molecular psychiatry

authors： Kendler KS

更新日期：2020-01-01 00:00:00

abstract：:Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate, and, thus, are reasonable candidate susceptibility genes for these conditions. In this study, we examined th...

journal_title：Molecular psychiatry

authors： Hettema JM,An SS,Neale MC,Bukszar J,van den Oord EJ,Kendler KS,Chen X

更新日期：2006-08-01 00:00:00

abstract：:Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) ...

journal_title：Molecular psychiatry

authors： Papassotiropoulos A,Stefanova E,Vogler C,Gschwind L,Ackermann S,Spalek K,Rasch B,Heck A,Aerni A,Hanser E,Demougin P,Huynh KD,Luechinger R,Klarhöfer M,Novakovic I,Kostic V,Boesiger P,Scheffler K,de Quervain DJ

更新日期：2013-02-01 00:00:00

abstract：:Polyglutamine expansion (PGE) encoded by a CAG repeat underlies eight inherited neurodegenerative diseases, among which is Huntington's disease. CAG expansion has also been reported in schizophrenia, suggesting a role for PGE. To investigate the potential role of PGE as a candidate for schizophrenia, we searched for P...

journal_title：Molecular psychiatry

authors： Moriniere S,Saada C,Holbert S,Sidransky E,Galat A,Ginns E,Rapoport JL,Neri C

更新日期：1999-01-01 00:00:00

abstract：:Among the most consistent results of studies of post-mortem brain tissue from schizophrenia patients (SZP) is the finding that in this disease, several genes expressed by GABAergic neurons are downregulated. This downregulation may be caused by hypermethylation of the relevant promoters in affected neurons. Indeed, in...

journal_title：Molecular psychiatry

authors： Ruzicka WB,Zhubi A,Veldic M,Grayson DR,Costa E,Guidotti A

更新日期：2007-04-01 00:00:00