Dopamine depletion results in increased neostriatal D(2), but not D(1), receptor binding in humans.

abstract：:Volume reduction and shape abnormality of the hippocampus have been associated with mood disorders. However, the hippocampus is not a uniform structure and consists of several subfields, such as the cornu ammonis (CA) subfields CA1-4, the dentate gyrus (DG) including a granule cell layer (GCL) and a molecular layer (M...

journal_title：Molecular psychiatry

authors： Cao B,Passos IC,Mwangi B,Amaral-Silva H,Tannous J,Wu MJ,Zunta-Soares GB,Soares JC

更新日期：2017-09-01 00:00:00

abstract：:Epidermal growth factor (EGF) comprises a structurally related family of proteins containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that regulates the development of dopaminergic neurons as well as monoamine metabolism. We assessed the contribution of EGF to sch...

journal_title：Molecular psychiatry

authors： Futamura T,Toyooka K,Iritani S,Niizato K,Nakamura R,Tsuchiya K,Someya T,Kakita A,Takahashi H,Nawa H

更新日期：2002-01-01 00:00:00

abstract：:Patients with psychotic disorders are at high risk for type 2 diabetes mellitus, and there is increasing evidence that patients display glucose metabolism abnormalities before significant antipsychotic medication exposure. In the present study, we examined insulin action by quantifying insulin sensitivity in first-epi...

journal_title：Molecular psychiatry

authors： Chouinard VA,Henderson DC,Dalla Man C,Valeri L,Gray BE,Ryan KP,Cypess AM,Cobelli C,Cohen BM,Öngür D

更新日期：2019-10-01 00:00:00

abstract：:Use of substances such as cannabis, alcohol, and tobacco, has been associated with increased risk of suicide attempt in several observational studies. However, establishing whether these associations are causal is challenging when using observational designs. To evaluate the potential causal contributions of cannabis ...

journal_title：Molecular psychiatry

authors： Orri M,Séguin JR,Castellanos-Ryan N,Tremblay RE,Côté SM,Turecki G,Geoffroy MC

更新日期：2020-06-08 00:00:00

abstract：:Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown. We found that widely used antidepressants such as amitriptyline and fluoxetine induce autoph...

journal_title：Molecular psychiatry

authors： Gulbins A,Schumacher F,Becker KA,Wilker B,Soddemann M,Boldrin F,Müller CP,Edwards MJ,Goodman M,Caldwell CC,Kleuser B,Kornhuber J,Szabo I,Gulbins E

更新日期：2018-12-01 00:00:00

abstract：:A recent report showed significant associations between several SNPs in a previously unknown EST cluster with schizophrenia. (1). The cluster was identified as the human dystrobrevin binding protein 1 gene (DTNBP1) by sequence database comparisons and homology with mouse DTNBP1. (2). However, the linkage disequilibriu...

journal_title：Molecular psychiatry

authors： van den Oord EJ,Sullivan PF,Jiang Y,Walsh D,O'Neill FA,Kendler KS,Riley BP

更新日期：2003-05-01 00:00:00

abstract：:This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...

journal_title：Molecular psychiatry

authors： Haure-Mirande JV,Wang M,Audrain M,Fanutza T,Kim SH,Heja S,Readhead B,Dudley JT,Blitzer RD,Schadt EE,Zhang B,Gandy S,Ehrlich ME

更新日期：2019-03-01 00:00:00

abstract：:The 'neurodegeneration with brain iron accumulation' (NBIA) disease family entails movement or cognitive impairment, often with psychiatric features. To understand how iron loading affects the brain, we studied mice with disruption of two iron regulatory genes, hemochromatosis (Hfe) and transferrin receptor 2 (Tfr2). ...

journal_title：Molecular psychiatry

authors： Heidari M,Johnstone DM,Bassett B,Graham RM,Chua AC,House MJ,Collingwood JF,Bettencourt C,Houlden H,Ryten M,Olynyk JK,Trinder D,Milward EA

更新日期：2016-11-01 00:00:00

abstract：:Semi-starvation induced hyperactivity (SIH) occurs in rodents upon caloric restriction. We hypothesized that SIH is triggered by the decline in leptin secretion associated with food restriction. To test this hypothesis, rats, which had established a stable level of activity, were treated with leptin or vehicle via imp...

journal_title：Molecular psychiatry

authors： Exner C,Hebebrand J,Remschmidt H,Wewetzer C,Ziegler A,Herpertz S,Schweiger U,Blum WF,Preibisch G,Heldmaier G,Klingenspor M

更新日期：2000-09-01 00:00:00

abstract：:Psychopathy is strongly associated with serious criminal behaviour (for example, rape and murder) and recidivism. However, the biological basis of psychopathy remains poorly understood. Earlier studies suggested that dysfunction of the amygdala and/or orbitofrontal cortex (OFC) may underpin psychopathy. Nobody, howeve...

journal_title：Molecular psychiatry

authors： Craig MC,Catani M,Deeley Q,Latham R,Daly E,Kanaan R,Picchioni M,McGuire PK,Fahy T,Murphy DG

更新日期：2009-10-01 00:00:00

abstract：:The core nature of nicotine dependence is evident in wide variations in how individuals become and remain smokers. Individuals with pre-existing behavioral traits are more likely to develop nicotine dependence and experience difficulty when attempting to quit. Many molecular factors likely contribute to individual var...

journal_title：Molecular psychiatry

authors： Hiroi N,Scott D

更新日期：2009-07-01 00:00:00

abstract：:Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype-phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) constitute a potentially informative target for genetic studies of intermediate phenotypes as their genetic underp...

journal_title：Molecular psychiatry

authors： Luykx JJ,Bakker SC,Lentjes E,Neeleman M,Strengman E,Mentink L,DeYoung J,de Jong S,Sul JH,Eskin E,van Eijk K,van Setten J,Buizer-Voskamp JE,Cantor RM,Lu A,van Amerongen M,van Dongen EP,Keijzers P,Kappen T,Borgdorff P

更新日期：2014-02-01 00:00:00

abstract：:We assessed the ability of lithium to reduce neurodegeneration and to stimulate cell proliferation in a rat model of Huntington's disease in which quinolinic acid (QA) was unilaterally infused into the striatum. LiCl (0.5-3.0 mEq/kg) was injected subcutaneously 24 h before and 1 h after QA infusion. At 7 days after QA...

journal_title：Molecular psychiatry

authors： Senatorov VV,Ren M,Kanai H,Wei H,Chuang DM

更新日期：2004-04-01 00:00:00

abstract：:Depression often accompanies the perimenopausal transition and it often precedes overt symptomology in common neurodegenerative diseases (NDDs, such as Alzheimer's, Parkinson's, Huntington, amyotrophic lateral sclerosis). Serotonin dysfunction is frequently found in the different etiologies of depression. We have show...

journal_title：Molecular psychiatry

authors： Bethea CL,Reddy AP

更新日期：2015-12-01 00:00:00

abstract：:Many antidepressants stimulate adult hippocampal neurogenesis, but the mechanisms by which they increase neurogenesis and modulate behavior are incompletely understood. Here we show that hippocampal bone morphogenetic protein (BMP) signaling is modulated by antidepressant treatment, and that the changes in BMP signali...

journal_title：Molecular psychiatry

authors： Brooker SM,Gobeske KT,Chen J,Peng CY,Kessler JA

更新日期：2017-06-01 00:00:00

abstract：:Endocannabinoids and their attending cannabinoid type 1 (CB1) receptor have been implicated in animal models of post-traumatic stress disorder (PTSD). However, their specific role has not been studied in people with PTSD. Herein, we present an in vivo imaging study using positron emission tomography (PET) and the CB1-...

journal_title：Molecular psychiatry

authors： Neumeister A,Normandin MD,Pietrzak RH,Piomelli D,Zheng MQ,Gujarro-Anton A,Potenza MN,Bailey CR,Lin SF,Najafzadeh S,Ropchan J,Henry S,Corsi-Travali S,Carson RE,Huang Y

更新日期：2013-09-01 00:00:00

abstract：:The human serotonin transporter gene (5-HTT) demonstrates two polymorphisms with possible functional impact: a 44-bp insertion/deletion polymorphism of the promoter region and a 17-bp variable number of tandem repeat polymorphism (VNTR) in intron 2 (STin2). Such genetic polymorphisms in the serotoninergic system may i...

journal_title：Molecular psychiatry

authors： Kaiser R,Tremblay PB,Schmider J,Henneken M,Dettling M,Müller-Oerlinghausen B,Uebelhack R,Roots I,Brockmöller J

更新日期：2001-03-01 00:00:00

abstract：:Environmental enrichment (EE) is known to have an anxiolytic effect in several animal models; however, the molecular mechanisms underlying these behavioral changes are not understood. In this study, we have shown that the anxiolytic effect of EE is associated with alterations in the corticotropin-releasing factor rece...

journal_title：Molecular psychiatry

authors： Sztainberg Y,Kuperman Y,Tsoory M,Lebow M,Chen A

更新日期：2010-09-01 00:00:00

abstract：:Mol Psychiatry 2000; 5: 77-84 ...

journal_title：Molecular psychiatry

authors： Li T,Ball D,Zhao J,Murray RM,Liu X,Sham PC,Collier DA

更新日期：2000-07-01 00:00:00

abstract：:Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D-serine/NMDA receptor hypofunction have both been implicated in the pathophysiology of schizophrenia and other psychiatric disorders. In the present study, we demonstrate that these two pathways intersect with behavioral consequences. DISC1 binds to and stabili...

journal_title：Molecular psychiatry

authors： Ma TM,Abazyan S,Abazyan B,Nomura J,Yang C,Seshadri S,Sawa A,Snyder SH,Pletnikov MV

更新日期：2013-05-01 00:00:00

abstract：:Converging advances in the fields of molecular biology, molecular genetics, cellular biology and embryology have given researchers the tools for the targeted delivery and stable germline transmission of foreign genes (transgenes) in the mouse. In the realm of neuropsychiatry, this so-named transgenic technology has be...

journal_title：Molecular psychiatry

authors： Campbell IL,Gold LH

更新日期：1996-05-01 00:00:00

abstract：:Critical periods are temporary windows of heightened neural plasticity early in development. For example, fear memories in juvenile rodents are subject to erasure following extinction training, while after closure of this critical period, extinction training only temporarily and weakly suppresses fear memories. Persis...

journal_title：Molecular psychiatry

authors： Bhagat SM,Butler SS,Taylor JR,McEwen BS,Strittmatter SM

更新日期：2016-09-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated HPA axis overactivity in major depression, a relationship of HPA axis activity to cognitive performance and a potential role of HPA axis geneti...

journal_title：Molecular psychiatry

authors： Keller J,Gomez R,Williams G,Lembke A,Lazzeroni L,Murphy GM Jr,Schatzberg AF

更新日期：2017-04-01 00:00:00

abstract：:A recent study using a 'partial' rodent model of schizophrenia has employed amygdalar activation to induce reported changes in the expression of hippocampal genes associated with metabolic and signaling pathways in response to amygdalar activation. The amygdalo-hippocampal pathway plays a central role in the regulatio...

journal_title：Molecular psychiatry

authors： Burke RE,Walsh J,Matzilevich D,Benes FM

更新日期：2006-02-01 00:00:00

abstract：:Although inherited DNA sequences have a well-demonstrated role in psychiatric disease risk, for even the most heritable mental disorders, monozygotic twins are discordant at a significant rate. The genetic variation associated with mental disorders has heretofore been based on the search for rare or common variation i...

journal_title：Molecular psychiatry

authors： Insel TR

更新日期：2014-02-01 00:00:00

abstract：:The serotonergic neurotransmitter system has been widely implicated in the pathophysiology of mood-related disorders such as anxiety and major depressive disorder (MDD). The onset of therapeutic efficacy of traditional antidepressants is delayed by several weeks. The 5-HT4 receptor has emerged as a new therapeutic tar...

journal_title：Molecular psychiatry

authors： Castello J,LeFrancois B,Flajolet M,Greengard P,Friedman E,Rebholz H

更新日期：2018-04-01 00:00:00

abstract：:Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of CNTN5 and CNTN6 have previously been reported in individuals with autism spectrum disorders (ASDs), but very little is known on their prevalence and clinical impact....

journal_title：Molecular psychiatry

authors： Mercati O,Huguet G,Danckaert A,André-Leroux G,Maruani A,Bellinzoni M,Rolland T,Gouder L,Mathieu A,Buratti J,Amsellem F,Benabou M,Van-Gils J,Beggiato A,Konyukh M,Bourgeois JP,Gazzellone MJ,Yuen RK,Walker S,Delépine M

更新日期：2017-04-01 00:00:00

abstract：:Several lines of evidence implicate dopa decarboxylase (DDC) with schizophrenia. By analysis of two putative functional DDC variants in 173 schizophrenic patients and 204 controls we tested the hypotheses that DDC is involved in: (1) predisposition to schizophrenia; and (2) modulation of age at disease onset. No assoc...

journal_title：Molecular psychiatry

authors： Børglum AD,Hampson M,Kjeldsen TE,Muir W,Murray V,Ewald H,Mors O,Blackwood D,Kruse TA

更新日期：2001-11-01 00:00:00

abstract：:It is believed that genetic factors play a large role in the development of many cognitive and neurological processes; however, epidemiological evidence for the genetic basis of childhood neurodevelopment is very limited. Identification of the genetic polymorphisms associated with early-stage neurodevelopment will hel...

journal_title：Molecular psychiatry

authors： Sun R,Wang Z,Claus Henn B,Su L,Lu Q,Lin X,Wright RO,Bellinger DC,Kile M,Mazumdar M,Tellez-Rojo MM,Schnaas L,Christiani DC

更新日期：2020-11-01 00:00:00

abstract：:A whole genome association study was performed in a phase 3 clinical trial conducted to evaluate a novel antipsychotic, iloperidone, administered to treat patients with schizophrenia. Genotypes of 407 patients were analyzed for 334,563 single nucleotide polymorphisms (SNPs). SNPs associated with iloperidone efficacy w...

journal_title：Molecular psychiatry

authors： Lavedan C,Licamele L,Volpi S,Hamilton J,Heaton C,Mack K,Lannan R,Thompson A,Wolfgang CD,Polymeropoulos MH

更新日期：2009-08-01 00:00:00