Abstract：
:A recent study using a 'partial' rodent model of schizophrenia has employed amygdalar activation to induce reported changes in the expression of hippocampal genes associated with metabolic and signaling pathways in response to amygdalar activation. The amygdalo-hippocampal pathway plays a central role in the regulation of the stress response and emotional learning. In the current study, we have performed a chromosome mapping analysis to determine whether genes showing changes in response to environmental stress may form clusters and, if so, whether they might show a topographical association with linkage sites for schizophrenia. When the hippocampal genes showing changes in expression were topographically mapped on specific rat chromosomes, significant clustering was observed on chromosomes 1, 4 and 8, although chromosome 1 showed the largest amount of clustering. When these same rodent genes were mapped to human chromosomes, most of the genes found on chromosome 1 in rat mapped to chromosome 11 in human. The vast majority of the genes showing changes in regulation were excluded from known linkage sites for schizophrenia. Based on these findings, we postulate that environmental factors may contribute to the endophenotype for schizophrenia through the activation and/or deactivation of specific genetic clusters, ones that do not appear to be directly associated with susceptibility genes for this disorder.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Burke RE,Walsh J,Matzilevich D,Benes FMdoi
10.1038/sj.mp.4001769subject
Has Abstractpub_date
2006-02-01 00:00:00pages
158-71issue
2eissn
1359-4184issn
1476-5578pii
4001769journal_volume
11pub_type
杂志文章abstract：:Anxiety-related behaviors are closely linked to neural circuits relaying fear-specific information to the amygdala. Many of these circuits, like those underlying processing of innate fear, are remarkably well understood. Recent imaging studies have contributed to this knowledge by discriminating more detailed corticoa...
journal_title：Molecular psychiatry
pub_type： 临床试验,杂志文章
doi：10.1038/sj.mp.4001908
更新日期：2006-12-01 00:00:00
abstract：:The aim of the study is to compare the prevalence of suicidal ideation and attempts in the United States in 1991-1992 and 2001-2002, and identify sociodemographic groups at increased risk for suicidal ideation and attempts. Data were drawn from the National Institute on Alcohol Abuse and Alcoholism 1991-1992 National ...
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abstract：:Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions regarding how the m...
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pub_type： 杂志文章,评审
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更新日期：2020-02-01 00:00:00
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pub_type： 杂志文章,已发布勘误
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更新日期：2018-03-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 临床试验,杂志文章
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更新日期：2005-12-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001496
更新日期：2004-09-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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更新日期：2002-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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更新日期：2019-08-14 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001641
更新日期：2005-07-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章,meta分析
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更新日期：2010-03-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/sj.mp.4000926
更新日期：2001-11-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-020-01009-6
更新日期：2021-01-11 00:00:00
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pub_type： 杂志文章,评审
doi：10.1038/mp.2009.145
更新日期：2010-07-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 临床试验,杂志文章
doi：10.1038/sj.mp.4001536
更新日期：2004-11-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000931
更新日期：2002-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
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更新日期：1996-09-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001719
更新日期：2005-11-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000564
更新日期：1999-07-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2008.120
更新日期：2010-04-01 00:00:00
abstract：:Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy number variations (CNVs) in SCZ cases and identified multiple rare recurrent CNVs that increase risk of SCZ although with incomplete penetranc...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2014.40
更新日期：2014-07-01 00:00:00
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journal_title：Molecular psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/mp.2015.22
更新日期：2016-01-01 00:00:00
