Abstract：
:The aim of the study is to compare the prevalence of suicidal ideation and attempts in the United States in 1991-1992 and 2001-2002, and identify sociodemographic groups at increased risk for suicidal ideation and attempts. Data were drawn from the National Institute on Alcohol Abuse and Alcoholism 1991-1992 National Longitudinal Alcohol Epidemiologic Survey (n=42,862) and the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (n=43,093), two nationally representative household surveys of non-institutionalized civilians aged 18 years and older, residing in the United States. The lifetime prevalence of suicide attempts remained unchanged in the United States between 1991-1992 and 2001-2002. Specific groups, namely 18- to 24-year-old white and black women, 25- to 44-year-old white women and 45- to 64-year-old Native American men were identified as being at high risk for suicide attempts. Despite prevention and treatment efforts, the lifetime prevalence of suicide attempts remains unchanged. Given the morbidity and mortality associated with suicide attempts, urgent action is needed to decrease the prevalence of suicide attempts in the United States.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Baca-Garcia E,Perez-Rodriguez MM,Keyes KM,Oquendo MA,Hasin DS,Grant BF,Blanco Cdoi
10.1038/mp.2008.98subject
Has Abstractpub_date
2010-03-01 00:00:00pages
250-9issue
3eissn
1359-4184issn
1476-5578pii
mp200898journal_volume
15pub_type
杂志文章abstract：:We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. Expression of LIM was decreased in the lymphoblastoid cells derived from patients with bipolar disorders and schizophrenia. LI...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001719
更新日期：2005-11-01 00:00:00
abstract：:The 102-T/C polymorphism of the 5-HT(2A) receptor gene was analysed in 159 patients with major depression and 164 unrelated and healthy controls using a case-control design. Allele and genotype frequencies did not differ between cases and controls. No differences according to sex, age of onset, melancholia, suicidal b...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000818
更新日期：2001-03-01 00:00:00
abstract：:Current antidepressants act principally by blocking monoamine reuptake by high-affinity transporters in the brain. However, these antidepressants show important shortcomings such as slow action onset and limited efficacy in nearly a third of patients with major depression disorder. Here, we report the development of a...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-019-0548-4
更新日期：2020-06-01 00:00:00
abstract：:The different serotonin (5-HT) receptors, including the serotonin transporter (5-HTT), are excellent candidate genes for suicide and suicidal behavior, and thus, they have been investigated in a large number of allelic association studies. The individual results of these studies have been inconsistent and definite con...
journal_title：Molecular psychiatry
pub_type： 杂志文章,meta分析,评审
doi：10.1038/sj.mp.4001336
更新日期：2003-07-01 00:00:00
abstract：:Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale c...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-019-0559-1
更新日期：2020-12-01 00:00:00
abstract：:Biological characterization of genetic variants identified in genome-wide association studies (GWAS) remains a substantial challenge. Here we used human-induced pluripotent stem cells (iPSC) and their neural derivatives to characterize common variants on chromosome 3p22 that have been associated by GWAS with major men...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0207-1
更新日期：2019-04-01 00:00:00
abstract：:Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification of predisposing genes has remained a challenge. Utilizing a large family-based schizophrenia study...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4002047
更新日期：2008-07-01 00:00:00
abstract：:(+) 3,4-Methylenedioxymethamphetamine (MDMA) is a psychedelic drug of abuse that causes selective degeneration of serotonergic fibers of dorsal raphe neurons that project throughout the forebrain. Previous studies using pharmacological and behavioral approaches suggested that MDMA treatment leads to desensitization of...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000574
更新日期：1999-11-01 00:00:00
abstract：:Although schizophrenia is considered a brain disorder, the role of brain organization for symptomatic improvement remains inadequately defined. We investigated the relationship between baseline brain morphology, resting-state network connectivity and clinical response after 24-weeks of antipsychotic treatment in patie...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0269-0
更新日期：2020-04-01 00:00:00
abstract：:A genetic predisposition to the development of neuroleptic malignant syndrome (NMS) has been suggested by clinical studies. Although the molecular basis of NMS is unclear, a dopaminergic blockade mechanism has been considered the main cause. We therefore investigated the association between NMS and three functional po...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001422
更新日期：2004-03-01 00:00:00
abstract：:Many antidepressants stimulate adult hippocampal neurogenesis, but the mechanisms by which they increase neurogenesis and modulate behavior are incompletely understood. Here we show that hippocampal bone morphogenetic protein (BMP) signaling is modulated by antidepressant treatment, and that the changes in BMP signali...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2016.160
更新日期：2017-06-01 00:00:00
abstract：:Latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDACi), are being investigated as a strategy to eliminate latency in HIV-infected patients on suppressive antiretroviral therapy. The effectiveness of LRAs in activating latent infection in HIV strains derived from the central nervous system (C...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2015.111
更新日期：2016-04-01 00:00:00
abstract：:Mental disorders cause more disability than any other class of medical illness in Americans between ages 15 and 44 years. The suicide rate is higher than the annual mortality from homicide, AIDS, and most forms of cancer. In contrast to nearly all communicable and most non-communicable diseases, there is little eviden...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/sj.mp.4001777
更新日期：2006-01-01 00:00:00
abstract：:The molecular genetic research on panic disorder (PD) has grown tremendously in the past decade. Although the data from twin and family studies suggest an involvement of genetic factors in the familial transmission of PD with the heritability estimate near 40%, the genetic substrate underlying panicogenesis is not yet...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/mp.2009.145
更新日期：2010-07-01 00:00:00
abstract：:Depression is a heritable disorder that is often precipitated by stress. Abnormalities of the stress-reactive hypothalamic-pituitary-adrenal (HPA) axis are also common in depressed patients. In animal models, the forced swim test (FST) is the most frequently used test of depressive-like behavior. We have used a propos...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001255
更新日期：2003-04-01 00:00:00
abstract：:Myo-inositol exerts behavioral effects in animal models of psychiatric disorders and is effective in clinical trials in psychiatric patients. Interestingly, epi-inositol exerts behavioral effects similar to myo-inositol, even though epi-inositol is not a substrate for synthesis of phosphatidylinositol. We postulated t...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000965
更新日期：2002-01-01 00:00:00
abstract：:Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each transmitter in the regulatio...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2015.104
更新日期：2015-11-01 00:00:00
abstract：:Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype-phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) constitute a potentially informative target for genetic studies of intermediate phenotypes as their genetic underp...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2012.183
更新日期：2014-02-01 00:00:00
abstract：:Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other members of the neurotrophin family, are central mediators of the activity-dependent plasticity through which environmental experiences, such as sensory information are translated into the structure and function of neuronal networks. ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.61
更新日期：2017-08-01 00:00:00
abstract：:Psychotic symptoms occur in ~40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. We undertook a combined analysi...
journal_title：Molecular psychiatry
pub_type： 杂志文章,meta分析,多中心研究
doi：10.1038/mp.2011.125
更新日期：2012-12-01 00:00:00
abstract：:Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association is presently unknown. Both diseases are considered protein misfolding disorders associated with...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2016.230
更新日期：2017-09-01 00:00:00
abstract：:The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challenges of obtaining such l...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2012.81
更新日期：2013-05-01 00:00:00
abstract：:Previous studies have shown inconsistent results regarding the actions of antidepressants on glucocorticoid receptor (GR) signalling. To resolve these inconsistencies, we used a lentiviral-based reporter system to directly monitor rat hippocampal GR activity during stress adaptation. Temporal GR activation was induced...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2014.137
更新日期：2016-02-01 00:00:00
abstract：:Although few studies dispute that there are gender differences in depression, the etiology is still unknown. In this review, we cover a number of proposed factors and the evidences for and against these factors that may account for gender differences in depression. These include the possible role of estrogens at puber...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/mp.2009.94
更新日期：2010-01-01 00:00:00
abstract：:Bipolar disorder is a major medical, social and economic burden worldwide. However, the mechanisms of action of effective antibipolar disorder drugs remain elusive. In this paper, we review studies using a neuropharmacological approach in unanesthetized rats, combined with kinetic, biochemical and molecular biology te...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/mp.2008.31
更新日期：2008-06-01 00:00:00
abstract：:In our genome scan for schizophrenia genes in 265 Irish pedigrees, marker D5S818 in 5q22 produced the second best result of the first 223 markers tested (P = 0.002). We then tested an additional 13 markers and the evidence suggests the presence of a vulnerability locus for schizophrenia in region 5q22-31. This region ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000258
更新日期：1997-03-01 00:00:00
abstract：:Several reports have suggested the presence of anticipation in bipolar affective disorder (BPAD). In addition, independent studies using the RED (repeat expansion detection) have shown association between BPAD and longer CAG/CTG repeats. Therefore loci with large CAG/CTG repeats are plausible candidates in the inherit...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000898
更新日期：2001-09-01 00:00:00
abstract：:Genetic factors do not fully account for the relatively high heritability of neurodevelopmental conditions, suggesting that non-genetic heritable factors contribute to their etiology. To evaluate the potential contribution of aberrant thyroid hormone status to the epigenetic inheritance of neurological phenotypes, we ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0281-4
更新日期：2020-05-01 00:00:00
abstract：:Circulating adiponectin (APN) levels decrease with age and obesity. On the other hand, a reduction in APN levels is associated with neurodegeneration and neuroinflammation. We previously showed that aged adiponectin knockout (APN-/-) mice developed Alzheimer's like pathologies, cerebral insulin resistance, and cogniti...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-020-0701-0
更新日期：2020-03-04 00:00:00
abstract：:Circulating inflammatory mediators can signal neurons through a pathway in which cytokine activation of the cells of the blood-brain barrier causes the induction of the nuclear factor kappa B (NF-kappaB), leading to the transcription of target genes, such as the one encoding cyclooxygenase 2 (COX-2), the enzyme that i...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
