Abstract:
:Circulating inflammatory mediators can signal neurons through a pathway in which cytokine activation of the cells of the blood-brain barrier causes the induction of the nuclear factor kappa B (NF-kappaB), leading to the transcription of target genes, such as the one encoding cyclooxygenase 2 (COX-2), the enzyme that initiates prostaglandin formation. These active products of the arachidonate metabolism produced by the cerebral microvasculature have critical roles in initiating the neuronal responses and the neurophysiological outcomes that take place during immunogenic stimuli, including sickness behaviors, fever and increase in the hypothalamic-pituitary adrenal axis. Whether there is more than a single cell type in the blood-brain barrier responsible for the synthesis of prostanoids in the presence of circulating proinflammatory cytokines is an interesting debate that will be summarized here.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Rivest Ssubject
Has Abstractpub_date
1999-11-01 00:00:00pages
500-7issue
6eissn
1359-4184issn
1476-5578journal_volume
4pub_type
杂志文章,评审abstract::Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other members of the neurotrophin family, are central mediators of the activity-dependent plasticity through which environmental experiences, such as sensory information are translated into the structure and function of neuronal networks. ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2017.61
更新日期:2017-08-01 00:00:00
abstract::Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate, and, thus, are reasonable candidate susceptibility genes for these conditions. In this study, we examined th...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001845
更新日期:2006-08-01 00:00:00
abstract::Microdeletions of chromosomal region 2q23.1 that disrupt MBD5 (methyl-CpG-binding domain protein 5) contribute to a spectrum of neurodevelopmental phenotypes; however, the impact of this locus on human psychopathology has not been fully explored. To characterize the structural variation landscape of MBD5 disruptions a...
journal_title:Molecular psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1038/mp.2013.42
更新日期:2014-03-01 00:00:00
abstract::The human 16p11.2 gene locus is a hot spot for copy number variations, which predispose carriers to a range of neuropsychiatric phenotypes. Microduplications of 16p11.2 are associated with autism spectrum disorder (ASD), intellectual disability (ID), and schizophrenia (SZ). Despite the debilitating nature of 16p11.2 d...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-0693-9
更新日期:2020-02-25 00:00:00
abstract::Exercise has a variety of beneficial effects on brain structure and function, such as hippocampal neurogenesis, mood and memory. Previous studies have shown that exercise enhances hippocampal neurogenesis, induces antidepressant effects and improves learning behavior. Brain serotonin (5-hydroxytryptamine, 5-HT) levels...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.153
更新日期:2015-11-01 00:00:00
abstract::Post-traumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-related diseases and neurodegeneration. In this paper, we review evidence relevant to the hypothesis that chronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and accelerates cellula...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2014.111
更新日期:2014-11-01 00:00:00
abstract::Depression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There are data to support several different theories of causation, including the mono...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/s41380-020-00930-0
更新日期:2021-01-01 00:00:00
abstract::Diverse studies have investigated the impact of prenatal exposure to vitamin D levels on brain development; however, evidence in humans has never been systematically reviewed. This article summarized evidence of the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or newborn bloo...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0357-9
更新日期:2020-10-01 00:00:00
abstract::Bipolar affective disorder (BPAD) is a common psychiatric disorder with complex genetic aetiology. We have undertaken a genome-wide scan in one of the largest samples of bipolar affected sibling pairs (ASPs) using a two-stage approach combining sample splitting and marker grid tightening. In this second stage analysis...
journal_title:Molecular psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.mp.4001684
更新日期:2005-09-01 00:00:00
abstract::Nitric oxide (NO) is a widespread and multifunctional biological messenger molecule. It mediates vasodilation of blood vessels, host defence against infectious agents and tumors, and neurotransmission of the central and peripheral nervous systems. In the nervous system, NO is generated by three nitric oxide synthase (...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/sj.mp.4000272
更新日期:1997-07-01 00:00:00
abstract::Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encod...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/s41380-018-0036-2
更新日期:2019-01-01 00:00:00
abstract::Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification of predisposing genes has remained a challenge. Utilizing a large family-based schizophrenia study...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4002047
更新日期:2008-07-01 00:00:00
abstract::Folate receptor alpha (FRα) autoantibodies have been associated with fetal abnormalities and cerebral folate deficiency-related developmental disorders. Over 70% of the children with autism spectrum disorders (ASD) are positive for these autoantibodies and high-dose folinic acid is beneficial in treating these childre...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.153
更新日期:2017-09-01 00:00:00
abstract::In developing his mature concept of hebephrenic dementia praecox (DP) in his 4th (1893) through 6th textbook editions (1899), Kraepelin worked from the hebephrenic syndrome first described by Hecker (1871) and then carefully studied by his student Daraszkiewicz (1892). Working under Kraepelin's supervision, Daraszkiew...
journal_title:Molecular psychiatry
pub_type: 历史文章,杂志文章,评审
doi:10.1038/s41380-019-0411-7
更新日期:2020-01-01 00:00:00
abstract::Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental syndrome characterized by hyperactivity, inattention and increased impulsivity. To detect micro-deletions and micro-duplications that may have a role in the pathogenesis of ADHD, we carried out a genome-wide screen for cop...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.29
更新日期:2011-05-01 00:00:00
abstract::The G-protein coupled metabotropic glutamate receptors (GRMs/mGluRs) have been implicated in the aetiology of schizophrenia as they modulate the NMDA response and that of other neurotransmitters including dopamine and GABA.(1-3) Electrophysiological studies in GRM subtype 5 knockout mice reveal, in one study, a sensor...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000848
更新日期:2001-05-01 00:00:00
abstract::Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patie...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0433-1
更新日期:2019-05-28 00:00:00
abstract::Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. From the Enhanci...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-01002-z
更新日期:2021-01-17 00:00:00
abstract::Chromosome 1q has been implicated in the etiology of schizophrenia in several independent studies. However, the peak linkage findings have been dispersed over a large chromosomal region, with negative findings in this region also being reported. Our group has previously observed linkage on chromosome 1q42, maximizing ...
journal_title:Molecular psychiatry
pub_type: 临床试验,杂志文章
doi:10.1038/sj.mp.4001536
更新日期:2004-11-01 00:00:00
abstract::The prefrontal cortex, a part of the limbic-thalamic-cortical network, participates in regulation of mood, cognition and behavior and has been implicated in the pathophysiology of major depressive disorder (MDD). Many neuropsychological studies demonstrate impairment of working memory in patients with MDD. However, th...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001894
更新日期:2007-02-01 00:00:00
abstract::Epidermal growth factor (EGF) comprises a structurally related family of proteins containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that regulates the development of dopaminergic neurons as well as monoamine metabolism. We assessed the contribution of EGF to sch...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001081
更新日期:2002-01-01 00:00:00
abstract::Major depressive disorder (MDD) is associated with reduced concentrations of γ-aminobutyric acid (GABA) that are normalized by antidepressant therapies. Moreover, depressive-like phenotypes of GABAA receptor mutant mice can be reversed by treatment with conventional antidepressants drugs, as well as by subanesthetic d...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.188
更新日期:2017-06-01 00:00:00
abstract::The glutamate hypothesis of schizophrenia derived from evidence that phencyclidine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, produces schizophrenia-like symptoms in healthy humans. Sensorimotor gating, measured by prepulse inhibition (PPI), is a fundamental form of information processing that is defici...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001404
更新日期:2004-01-01 00:00:00
abstract::The GABAB receptor (GABABR) agonist baclofen has been used to treat alcohol and several other substance use disorders (AUD/SUD), yet its underlying neural mechanism remains unclear. The present study aimed to investigate cortical GABABR dynamics following chronic alcohol exposure. Ex vivo brain slice recordings from m...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-01009-6
更新日期:2021-01-11 00:00:00
abstract::The methionine-folate cycle-dependent one-carbon metabolism is implicated in the pathophysiology of schizophrenia. Since schizophrenia is a developmental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestation has on mice progeny. Pregnant mice were administered methionine equ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2017.164
更新日期:2018-02-01 00:00:00
abstract::Although schizophrenia is considered a brain disorder, the role of brain organization for symptomatic improvement remains inadequately defined. We investigated the relationship between baseline brain morphology, resting-state network connectivity and clinical response after 24-weeks of antipsychotic treatment in patie...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0269-0
更新日期:2020-04-01 00:00:00
abstract::A recent report showed significant associations between several SNPs in a previously unknown EST cluster with schizophrenia. (1). The cluster was identified as the human dystrobrevin binding protein 1 gene (DTNBP1) by sequence database comparisons and homology with mouse DTNBP1. (2). However, the linkage disequilibriu...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001263
更新日期:2003-05-01 00:00:00
abstract::Serum antibodies against amyloid-β peptide (Aβ) in humans with or without diagnosis of Alzheimer's disease (AD) indicate the possibility of immune responses against brain antigens. In an unbiased screening for antibodies directed against brain proteins, we found in AD patients high serum levels of antibodies against t...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.70
更新日期:2013-03-01 00:00:00
abstract::APAF1, encoding the protein apoptosis protease activating factor 1 (Apaf-1), has recently been established as a chromosome 12 gene conferring predisposition to major depression in humans. The molecular phenotypes of Apaf-1 variants were determined by in vitro reconstruction of the apoptosome complex in which Apaf-1 ac...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001755
更新日期:2006-01-01 00:00:00
abstract::This Article was originally published under Nature Research's License to Publish, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the Article have been modified accordingly. ...
journal_title:Molecular psychiatry
pub_type: 已发布勘误
doi:10.1038/s41380-018-0327-7
更新日期:2019-09-01 00:00:00