Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders.

abstract：:The current study provides a novel in-depth assessment of the extent of antipsychotic drugs transport across the blood-brain barrier (BBB) into various brain regions, as well as across the blood-spinal cord barrier (BSCB) and the blood-cerebrospinal fluid barrier (BCSFB). This is combined with an estimation of cellula...

journal_title：Molecular psychiatry

authors： Loryan I,Melander E,Svensson M,Payan M,König F,Jansson B,Hammarlund-Udenaes M

更新日期：2016-11-01 00:00:00

abstract：:Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia. This study comprises genome-wide association (GWA) and follow-up analyses of all individuals born in Denmark since 1...

journal_title：Molecular psychiatry

authors： Børglum AD,Demontis D,Grove J,Pallesen J,Hollegaard MV,Pedersen CB,Hedemand A,Mattheisen M,GROUP investigators10.,Uitterlinden A,Nyegaard M,Ørntoft T,Wiuf C,Didriksen M,Nordentoft M,Nöthen MM,Rietschel M,Ophoff RA,Cic

更新日期：2014-03-01 00:00:00

abstract：:Schizophrenia is a highly heritable disorder for which anatomical brain alterations have been repeatedly reported in clinical samples. Unaffected at-risk groups have also been studied in an attempt to identify brain changes that do not reflect reverse causation or treatment effects. However, no robust associations hav...

journal_title：Molecular psychiatry

authors： Warland A,Kendall KM,Rees E,Kirov G,Caseras X

更新日期：2020-04-01 00:00:00

abstract：:Genomic risk profile scores (GRPSs) have been shown to predict case-control status of schizophrenia (SCZ), albeit with varying sensitivity and specificity. The extent to which this variability in prediction accuracy is related to differences in sampling strategies is unknown. Danish population-based registers and Neon...

journal_title：Molecular psychiatry

authors： Meier SM,Agerbo E,Maier R,Pedersen CB,Lang M,Grove J,Hollegaard MV,Demontis D,Trabjerg BB,Hjorthøj C,Ripke S,Degenhardt F,Nöthen MM,Rujescu D,Maier W,MooDS SCZ Consortium.,Werge T,Mors O,Hougaard DM,Børglum AD,Wra

更新日期：2016-07-01 00:00:00

abstract：:Disruption of persistent, stress-associated memories is relevant for treating posttraumatic stress disorder (PTSD) and related syndromes, which develop in a subset of individuals following a traumatic event. We previously developed a stress-enhanced fear learning (SEFL) paradigm in inbred mice that produces PTSD-like ...

journal_title：Molecular psychiatry

authors： Sillivan SE,Jamieson S,de Nijs L,Jones M,Snijders C,Klengel T,Joseph NF,Krauskopf J,Kleinjans J,Vinkers CH,Boks MPM,Geuze E,Vermetten E,Berretta S,Ressler KJ,Rutten BPF,Rumbaugh G,Miller CA

更新日期：2020-05-01 00:00:00

abstract：:Folate receptor alpha (FRα) autoantibodies have been associated with fetal abnormalities and cerebral folate deficiency-related developmental disorders. Over 70% of the children with autism spectrum disorders (ASD) are positive for these autoantibodies and high-dose folinic acid is beneficial in treating these childre...

journal_title：Molecular psychiatry

authors： Desai A,Sequeira JM,Quadros EV

更新日期：2017-09-01 00:00:00

abstract：:The GABAB receptor (GABABR) agonist baclofen has been used to treat alcohol and several other substance use disorders (AUD/SUD), yet its underlying neural mechanism remains unclear. The present study aimed to investigate cortical GABABR dynamics following chronic alcohol exposure. Ex vivo brain slice recordings from m...

journal_title：Molecular psychiatry

authors： Peng SY,Shi Z,Zhou DS,Wang XY,Li XX,Liu XL,Wang WD,Lin GN,Pan BX,Voon V,Grace AA,Heilig M,Wong ML,Yuan TF

更新日期：2021-01-11 00:00:00

abstract：:Patients with psychotic disorders are at high risk for type 2 diabetes mellitus, and there is increasing evidence that patients display glucose metabolism abnormalities before significant antipsychotic medication exposure. In the present study, we examined insulin action by quantifying insulin sensitivity in first-epi...

journal_title：Molecular psychiatry

authors： Chouinard VA,Henderson DC,Dalla Man C,Valeri L,Gray BE,Ryan KP,Cypess AM,Cobelli C,Cohen BM,Öngür D

更新日期：2019-10-01 00:00:00

abstract：:Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) ...

journal_title：Molecular psychiatry

authors： Papassotiropoulos A,Stefanova E,Vogler C,Gschwind L,Ackermann S,Spalek K,Rasch B,Heck A,Aerni A,Hanser E,Demougin P,Huynh KD,Luechinger R,Klarhöfer M,Novakovic I,Kostic V,Boesiger P,Scheffler K,de Quervain DJ

更新日期：2013-02-01 00:00:00

abstract：:Serotonergic (5HT) neurons exert diverse and widespread functions in the brain. Dysfunction of the serotonergic system gives rise to a variety of mental illnesses including depression, anxiety, obsessive compulsive disorder, autism and eating disorders. Here we show that human primary fibroblasts were directly convert...

journal_title：Molecular psychiatry

authors： Xu Z,Jiang H,Zhong P,Yan Z,Chen S,Feng J

更新日期：2016-01-01 00:00:00

abstract：:Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A receptors (GABAARs), GABA-gated chloride/bicarbonate channels, which are the key mediators of transmission at inhibitory synapses in the brain. This activity underpins potent anxiolytic, anticonvulsant and hypnotic effec...

journal_title：Molecular psychiatry

authors： Nicholson MW,Sweeney A,Pekle E,Alam S,Ali AB,Duchen M,Jovanovic JN

更新日期：2018-09-01 00:00:00

abstract：:Environmental enrichment (EE) is known to have an anxiolytic effect in several animal models; however, the molecular mechanisms underlying these behavioral changes are not understood. In this study, we have shown that the anxiolytic effect of EE is associated with alterations in the corticotropin-releasing factor rece...

journal_title：Molecular psychiatry

authors： Sztainberg Y,Kuperman Y,Tsoory M,Lebow M,Chen A

更新日期：2010-09-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not ju...

journal_title：Molecular psychiatry

authors： Dean KR,Hammamieh R,Mellon SH,Abu-Amara D,Flory JD,Guffanti G,Wang K,Daigle BJ Jr,Gautam A,Lee I,Yang R,Almli LM,Bersani FS,Chakraborty N,Donohue D,Kerley K,Kim TK,Laska E,Young Lee M,Lindqvist D,Lori A,Lu L,M

更新日期：2020-12-01 00:00:00

abstract：:There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety. We studied the association of CR...

journal_title：Molecular psychiatry

authors： Licinio J,O'Kirwan F,Irizarry K,Merriman B,Thakur S,Jepson R,Lake S,Tantisira KG,Weiss ST,Wong ML

更新日期：2004-12-01 00:00:00

abstract：:Bipolar affective disorder (BPAD) is a common psychiatric disorder with complex genetic aetiology. We have undertaken a genome-wide scan in one of the largest samples of bipolar affected sibling pairs (ASPs) using a two-stage approach combining sample splitting and marker grid tightening. In this second stage analysis...

journal_title：Molecular psychiatry

authors： Lambert D,Middle F,Hamshere ML,Segurado R,Raybould R,Corvin A,Green E,O'Mahony E,Nikolov I,Mulcahy T,Haque S,Bort S,Bennett P,Norton N,Owen MJ,Kirov G,Lendon C,Jones L,Jones I,Holmans P,Gill M,Craddock N

更新日期：2005-09-01 00:00:00

abstract：:A recent study has suggested a possible association of a polymorphism near the dopamine D5 receptor gene (DRD5) and attention-deficit hyperactivity disorder. The polymorphism studied was a (CA)n repeat located in the cosmid containing the D5 receptor gene2 and the allele that was reported to be associated with attenti...

journal_title：Molecular psychiatry

authors： Barr CL,Wigg KG,Feng Y,Zai G,Malone M,Roberts W,Schachar R,Tannock R,Kennedy JL

更新日期：2000-09-01 00:00:00

abstract：:Induction of neuroprotective heat-shock proteins via pharmacological Hsp90 inhibitors is currently being investigated as a potential treatment for neurodegenerative diseases. Two major hurdles for therapeutic use of Hsp90 inhibitors are systemic toxicity and limited central nervous system permeability. We demonstrate ...

journal_title：Molecular psychiatry

authors： Wang B,Liu Y,Huang L,Chen J,Li JJ,Wang R,Kim E,Chen Y,Justicia C,Sakata K,Chen H,Planas A,Ostrom RS,Li W,Yang G,McDonald MP,Chen R,Heck DH,Liao FF

更新日期：2017-07-01 00:00:00

abstract：:Accumulating evidence from both genetic and clinico-pharmacological studies suggests that D-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ). Although an association of genes for D-serine degradation, such as D-amino acid oxidase and G72, has been reported...

journal_title：Molecular psychiatry

authors： Fujii K,Maeda K,Hikida T,Mustafa AK,Balkissoon R,Xia J,Yamada T,Ozeki Y,Kawahara R,Okawa M,Huganir RL,Ujike H,Snyder SH,Sawa A

更新日期：2006-02-01 00:00:00

abstract：:Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder. Genetic loci have not yet been identified by genome-wide association studies. Rare copy number variations (CNVs), such as chromosomal deletions or duplications, have been implicated in ADHD and other neurodevelop...

journal_title：Molecular psychiatry

authors： Jarick I,Volckmar AL,Pütter C,Pechlivanis S,Nguyen TT,Dauvermann MR,Beck S,Albayrak Ö,Scherag S,Gilsbach S,Cichon S,Hoffmann P,Degenhardt F,Nöthen MM,Schreiber S,Wichmann HE,Jöckel KH,Heinrich J,Tiesler CM,Faraone S

更新日期：2014-01-01 00:00:00

abstract：:This study explores whether inflammatory biomarkers act as moderators of clinical response to omega-3 (n-3) fatty acids in subjects with major depressive disorder (MDD). One hundred fifty-five subjects with Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) MDD, a baseline 17-item Hamilton Dep...

journal_title：Molecular psychiatry

authors： Rapaport MH,Nierenberg AA,Schettler PJ,Kinkead B,Cardoos A,Walker R,Mischoulon D

更新日期：2016-01-01 00:00:00

abstract：:Hyperactivation of the amygdala following chronic stress is believed to be one of the primary mechanisms underlying the increased propensity for anxiety-like behaviors and pathological states; however, the mechanisms by which chronic stress modulates amygdalar function are not well characterized. The aim of the curren...

journal_title：Molecular psychiatry

authors： Hill MN,Kumar SA,Filipski SB,Iverson M,Stuhr KL,Keith JM,Cravatt BF,Hillard CJ,Chattarji S,McEwen BS

更新日期：2013-10-01 00:00:00

abstract：:Cariprazine (CAR) is a strong inhibitor of the Dhcr7 enzyme, the last enzyme in the cholesterol biosynthesis pathway. We assessed the effects of CAR on maternally exposed Dhcr7+/- and wild-type mouse offspring, and tested the biochemical effects of CAR in human serum samples. Dhcr7+/- and wild-type time-pregnant mice ...

journal_title：Molecular psychiatry

authors： Genaro-Mattos TC,Anderson A,Allen LB,Tallman KA,Porter NA,Korade Z,Mirnics K

更新日期：2020-11-01 00:00:00

abstract：:Bipolar affective disorder is one of the most common mental illnesses with a population prevalence of approximately 1%. The disorder is genetically complex, with an increasing number of loci being implicated through genetic linkage studies. However, the specific genetic variations and molecules involved in bipolar sus...

journal_title：Molecular psychiatry

authors： Blair IP,Adams LJ,Badenhop RF,Moses MJ,Scimone A,Morris JA,Ma L,Austin CP,Donald JA,Mitchell PB,Schofield PR

更新日期：2002-01-01 00:00:00

abstract：:It is essential to elucidate brain-adipocyte interactions in order to tackle obesity and its comorbidities, as the precise control of brain-adipose tissue cross-talk is crucial for energy and glucose homeostasis. Recent studies show that in the peripheral adipose tissue, adenosine induces adipogenesis through peripher...

journal_title：Molecular psychiatry

authors： Zhang J,Hou Y,Du XL,Chen D,Sui G,Qi Y,Licinio J,Wong ML,Yang Y

更新日期：2020-10-16 00:00:00

abstract：:Schizophrenia and bipolar disorder have both been linked to structural abnormalities of the hippocampus, which is consistent with a neurodevelopmental anomaly. One isoform of the neural cell adhesion molecule (N-CAM) protein, cytosolic N-CAM 105-115 kDa, was previously shown to be increased in schizophrenia in the hip...

journal_title：Molecular psychiatry

authors： Vawter MP,Howard AL,Hyde TM,Kleinman JE,Freed WJ

更新日期：1999-09-01 00:00:00

abstract：:Depression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There are data to support several different theories of causation, including the mono...

journal_title：Molecular psychiatry

authors： Zhou B,Zhu Z,Ransom BR,Tong X

更新日期：2021-01-01 00:00:00

abstract：:The search for genetic factors predisposing to Attention Deficit Hyperactivity Disorder (ADHD) has focused on genes that regulate dopaminergic pathways such as dopamine receptors and enzymes that regulate levels of dopamine in the synapse. There have been several reports of association between ADHD and polymorphic var...

journal_title：Molecular psychiatry

authors： Tahir E,Yazgan Y,Cirakoglu B,Ozbay F,Waldman I,Asherson PJ

更新日期：2000-07-01 00:00:00

abstract：:To quantify aging- and disease-associated alterations in the integrative and interactive components of a pulsatile neuroendocrine axis, novel biomathematical strategies are required. Here, I illustrate as an investigative paradigm otherwise subtle aging-dependent disturbances of the gonadotropin-releasing-hormone (GnR...

journal_title：Molecular psychiatry

authors： Veldhuis JD

更新日期：1997-01-01 00:00:00

abstract：:Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and the concomitant impact on plasticity and critical periods, is hypothesized to be disrupted in neurodevelopmen...

journal_title：Molecular psychiatry

authors： Chen K,Ma X,Nehme A,Wei J,Cui Y,Cui Y,Yao D,Wu J,Anderson T,Ferguson D,Levitt P,Qiu S

更新日期：2020-01-03 00:00:00

abstract：:Neurobiological disorders have diverse manifestations and symptomology. Neurodegenerative disorders, such as Alzheimer's disease, manifest late in life and are characterized by, among other symptoms, progressive loss of synaptic markers. Developmental disorders, such as autism spectrum, appear in childhood. Neuropsych...

journal_title：Molecular psychiatry

authors： Lahiri DK,Maloney B,Zawia NH

更新日期：2009-11-01 00:00:00