Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis.

abstract：:Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and mGluR5 signaling. We examined agonist-induced mGluR5 signaling in the postmortem dorsolateral ...

journal_title：Molecular psychiatry

authors： Wang HY,MacDonald ML,Borgmann-Winter KE,Banerjee A,Sleiman P,Tom A,Khan A,Lee KC,Roussos P,Siegel SJ,Hemby SE,Bilker WB,Gur RE,Hahn CG

更新日期：2020-04-01 00:00:00

abstract：:We assessed the ability of lithium to reduce neurodegeneration and to stimulate cell proliferation in a rat model of Huntington's disease in which quinolinic acid (QA) was unilaterally infused into the striatum. LiCl (0.5-3.0 mEq/kg) was injected subcutaneously 24 h before and 1 h after QA infusion. At 7 days after QA...

journal_title：Molecular psychiatry

authors： Senatorov VV,Ren M,Kanai H,Wei H,Chuang DM

更新日期：2004-04-01 00:00:00

abstract：:The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with 'Western' diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched 'Western' ...

journal_title：Molecular psychiatry

authors： Cinquina V,Calvigioni D,Farlik M,Halbritter F,Fife-Gernedl V,Shirran SL,Fuszard MA,Botting CH,Poullet P,Piscitelli F,Máté Z,Szabó G,Yanagawa Y,Kasper S,Di Marzo V,Mackie K,McBain CJ,Bock C,Keimpema E,Harkany T

更新日期：2020-01-01 00:00:00

abstract：:Obscure work on the inheritance of two peculiar genetic traits in yeast has recently collided with work on infectious, neurodegenerative diseases in mammals. The impact illuminates both fields. The yeast work reveals a new mechanism of genetic variation that is based on differences in protein conformation rather than ...

journal_title：Molecular psychiatry

authors： Lindquist S

更新日期：1996-11-01 00:00:00

abstract：:Neuregulin and the neuregulin receptor ERBB4 have been genetically and functionally implicated in schizophrenia. In this study, we used the yeast two-hybrid system to identify proteins that interact with ERBB4, to identify genes and pathways that might contribute to schizophrenia susceptibility. We identified the MAGI...

journal_title：Molecular psychiatry

authors： Buxbaum JD,Georgieva L,Young JJ,Plescia C,Kajiwara Y,Jiang Y,Moskvina V,Norton N,Peirce T,Williams H,Craddock NJ,Carroll L,Corfas G,Davis KL,Owen MJ,Harroch S,Sakurai T,O'Donovan MC

更新日期：2008-02-01 00:00:00

abstract：:Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification of predisposing genes has remained a challenge. Utilizing a large family-based schizophrenia study...

journal_title：Molecular psychiatry

authors： Wedenoja J,Loukola A,Tuulio-Henriksson A,Paunio T,Ekelund J,Silander K,Varilo T,Heikkilä K,Suvisaari J,Partonen T,Lönnqvist J,Peltonen L

更新日期：2008-07-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the etiology of major depressive disorder (MDD). Although meta-analyses do confirm associations between depression and these biological systems, effect sizes vary greatl...

journal_title：Molecular psychiatry

authors： Lamers F,Vogelzangs N,Merikangas KR,de Jonge P,Beekman AT,Penninx BW

更新日期：2013-06-01 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and sex using a 51-plex cyto...

journal_title：Molecular psychiatry

authors： Hornig M,Gottschalk G,Peterson DL,Knox KK,Schultz AF,Eddy ML,Che X,Lipkin WI

更新日期：2016-02-01 00:00:00

abstract：:Circulating triglycerides (TGs) normally increase after a meal but are altered in pathophysiological conditions, such as obesity. Although TG metabolism in the brain remains poorly understood, several brain structures express enzymes that process TG-enriched particles, including mesolimbic structures. For this reason,...

journal_title：Molecular psychiatry

authors： Cansell C,Castel J,Denis RG,Rouch C,Delbes AS,Martinez S,Mestivier D,Finan B,Maldonado-Aviles JG,Rijnsburger M,Tschöp MH,DiLeone RJ,Eckel RH,la Fleur SE,Magnan C,Hnasko TS,Luquet S

更新日期：2014-10-01 00:00:00

abstract：:Mol Psychiatry 2000; 5: 77-84 ...

journal_title：Molecular psychiatry

authors： Li T,Ball D,Zhao J,Murray RM,Liu X,Sham PC,Collier DA

更新日期：2000-07-01 00:00:00

abstract：:Identifying biological mechanisms through which the experience of adversity emerges as individual risk for mental illness is an important step toward developing strategies for personalized treatment and, ultimately, prevention. Preclinical studies have identified epigenetic modification of gene expression as one such ...

journal_title：Molecular psychiatry

authors： Swartz JR,Hariri AR,Williamson DE

更新日期：2017-02-01 00:00:00

abstract：:Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patie...

journal_title：Molecular psychiatry

authors： Albrecht DS,Kim M,Akeju O,Torrado-Carvajal A,Edwards RR,Zhang Y,Bergan C,Protsenko E,Kucyi A,Wasan AD,Hooker JM,Napadow V,Loggia ML

更新日期：2019-05-28 00:00:00

abstract：:Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype-phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) constitute a potentially informative target for genetic studies of intermediate phenotypes as their genetic underp...

journal_title：Molecular psychiatry

authors： Luykx JJ,Bakker SC,Lentjes E,Neeleman M,Strengman E,Mentink L,DeYoung J,de Jong S,Sul JH,Eskin E,van Eijk K,van Setten J,Buizer-Voskamp JE,Cantor RM,Lu A,van Amerongen M,van Dongen EP,Keijzers P,Kappen T,Borgdorff P

更新日期：2014-02-01 00:00:00

abstract：:Chronic methamphetamine use poses potentially devastating consequences for directly affected individuals and for society. Lower dopamine D2-type receptor availability has been observed in striata of methamphetamine users as compared with controls, but an analogous comparison of D1-type receptors has been conducted onl...

journal_title：Molecular psychiatry

authors： Okita K,Morales AM,Dean AC,Johnson MC,Lu V,Farahi J,Mandelkern MA,London ED

更新日期：2018-05-01 00:00:00

abstract：:In mammals, most adult neural stem cells (NSCs) are located in the ventricular-subventricular zone (V-SVZ) along the wall of the lateral ventricles and they are the source of olfactory bulb interneurons. Adult NSCs exhibit an apico-basal polarity; they harbor a short apical process and a long basal process, reminiscen...

journal_title：Molecular psychiatry

authors： García-González D,Dumitru I,Zuccotti A,Yen TY,Herranz-Pérez V,Tan LL,Neitz A,García-Verdugo JM,Kuner R,Alfonso J,Monyer H

更新日期：2020-07-01 00:00:00

abstract：:Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown. We found that widely used antidepressants such as amitriptyline and fluoxetine induce autoph...

journal_title：Molecular psychiatry

authors： Gulbins A,Schumacher F,Becker KA,Wilker B,Soddemann M,Boldrin F,Müller CP,Edwards MJ,Goodman M,Caldwell CC,Kleuser B,Kornhuber J,Szabo I,Gulbins E

更新日期：2018-12-01 00:00:00

abstract：:A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memory reconsolidation represents a potential therapeutic strategy,...

journal_title：Molecular psychiatry

authors： Boury-Jamot B,Carrard A,Martin JL,Halfon O,Magistretti PJ,Boutrel B

更新日期：2016-08-01 00:00:00

abstract：:Among the most consistent results of studies of post-mortem brain tissue from schizophrenia patients (SZP) is the finding that in this disease, several genes expressed by GABAergic neurons are downregulated. This downregulation may be caused by hypermethylation of the relevant promoters in affected neurons. Indeed, in...

journal_title：Molecular psychiatry

authors： Ruzicka WB,Zhubi A,Veldic M,Grayson DR,Costa E,Guidotti A

更新日期：2007-04-01 00:00:00

abstract：:Identifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group performed a large-scale meta-analysis and reported widespread white matter microstructural alterations in schizophr...

journal_title：Molecular psychiatry

authors： Koshiyama D,Fukunaga M,Okada N,Morita K,Nemoto K,Usui K,Yamamori H,Yasuda Y,Fujimoto M,Kudo N,Azechi H,Watanabe Y,Hashimoto N,Narita H,Kusumi I,Ohi K,Shimada T,Kataoka Y,Yamamoto M,Ozaki N,Okada G,Okamoto Y,Ha

更新日期：2020-04-01 00:00:00

abstract：:(+) 3,4-Methylenedioxymethamphetamine (MDMA) is a psychedelic drug of abuse that causes selective degeneration of serotonergic fibers of dorsal raphe neurons that project throughout the forebrain. Previous studies using pharmacological and behavioral approaches suggested that MDMA treatment leads to desensitization of...

journal_title：Molecular psychiatry

authors： Sexton TJ,McEvoy C,Neumaier JF

更新日期：1999-11-01 00:00:00

abstract：:Several lines of evidence implicate dopa decarboxylase (DDC) with schizophrenia. By analysis of two putative functional DDC variants in 173 schizophrenic patients and 204 controls we tested the hypotheses that DDC is involved in: (1) predisposition to schizophrenia; and (2) modulation of age at disease onset. No assoc...

journal_title：Molecular psychiatry

authors： Børglum AD,Hampson M,Kjeldsen TE,Muir W,Murray V,Ewald H,Mors O,Blackwood D,Kruse TA

更新日期：2001-11-01 00:00:00

abstract：:Previous studies have implicated DTNBP1 as a schizophrenia susceptibility gene and its encoded protein, dysbindin, as a potential regulator of synaptic vesicle physiology. In this study, we found that endogenous levels of the dysbindin protein in the mouse brain are developmentally regulated, with higher levels observ...

journal_title：Molecular psychiatry

authors： Ghiani CA,Starcevic M,Rodriguez-Fernandez IA,Nazarian R,Cheli VT,Chan LN,Malvar JS,de Vellis J,Sabatti C,Dell'Angelica EC

更新日期：2010-02-01 00:00:00

abstract：:5-HT(2C) receptor (5HT(2C)R, serotonin-2C) RNA undergoes editing to produce several receptor variants, some with pharmacological differences. This investigation comprised two parts: the characterisation of 5-HT(2C)R RNA editing in a larger human control sample than previously examined, and a comparative study in subje...

journal_title：Molecular psychiatry

authors： Sodhi MS,Burnet PW,Makoff AJ,Kerwin RW,Harrison PJ

更新日期：2001-07-01 00:00:00

abstract：:There is evidence that obesity-related disorders are increased among people with depression. Variation in the FTO (fat mass and obesity associated) gene has been shown to contribute to common forms of human obesity. This study aimed to investigate the genetic influence of polymorphisms in FTO in relation to body mass ...

journal_title：Molecular psychiatry

authors： Rivera M,Cohen-Woods S,Kapur K,Breen G,Ng MY,Butler AW,Craddock N,Gill M,Korszun A,Maier W,Mors O,Owen MJ,Preisig M,Bergmann S,Tozzi F,Rice J,Rietschel M,Rucker J,Schosser A,Aitchison KJ,Uher R,Craig IW,Lewis

更新日期：2012-06-01 00:00:00

abstract：:Autistic individuals experience significantly elevated rates of childhood trauma, self-harm and suicidal behaviour and ideation (SSBI). Is this purely the result of negative environmental experiences, or does this interact with genetic predisposition? In this study we investigated if a genetic predisposition for autis...

journal_title：Molecular psychiatry

authors： Warrier V,Baron-Cohen S

更新日期：2019-10-29 00:00:00

abstract：:The dorsolateral prefrontal cortex (dlpfc) is strongly implicated in the pathogenesis of schizophrenia (SCZ) and bipolar disorder (BPD) and, within this region, abnormalities in glutamatergic neurotransmission and synaptic function have been described. Proteins associated with these functions are enriched in membrane ...

journal_title：Molecular psychiatry

authors： Behan AT,Byrne C,Dunn MJ,Cagney G,Cotter DR

更新日期：2009-06-01 00:00:00

abstract：:With the fast advance of connectome imaging techniques, we have the opportunity of mapping the human brain pathways in vivo at unprecedented resolution. In this article we review the current developments of diffusion magnetic resonance imaging (MRI) for the reconstruction of anatomical pathways in connectome studies. ...

journal_title：Molecular psychiatry

authors： Shi Y,Toga AW

更新日期：2017-09-01 00:00:00

abstract：:Accumulating research demonstrates the potential of intranasal delivery of psychopharmacological agents to treat a range of psychiatric disorders and symptoms. It is believed that intranasal administration offers both direct and indirect pathways to deliver psychopharmacological agents to the central nervous system. T...

journal_title：Molecular psychiatry

authors： Quintana DS,Guastella AJ,Westlye LT,Andreassen OA

更新日期：2016-01-01 00:00:00

abstract：:Stress and exposure to glucocorticoids (GC) during early life render individuals vulnerable to brain disorders by inducing structural and chemical alterations in specific neural substrates. Here we show that adult rats that had been exposed to in utero GCs (iuGC) display increased preference for opiates and ethanol, a...

journal_title：Molecular psychiatry

authors： Rodrigues AJ,Leão P,Pêgo JM,Cardona D,Carvalho MM,Oliveira M,Costa BM,Carvalho AF,Morgado P,Araújo D,Palha JA,Almeida OF,Sousa N

更新日期：2012-12-01 00:00:00

abstract：:Gonadal hormones influence neuronal organization and plasticity. Yet the consequences of altering their concentrations by administering contraceptive agents, which are used by most reproductive-age women in the United States, are unclear. Cross-sectional studies have found both larger and smaller cortical regions alon...

journal_title：Molecular psychiatry

authors： Petersen N,Kearley NW,Ghahremani DG,Pochon JB,Fry ME,Rapkin AJ,London ED

更新日期：2021-01-08 00:00:00