当前位置： SCI文献检索 > MOLECULAR PSYCHIATRY期刊下所有文献 > Connectome imaging for mapping human brain pathways.

Connectome imaging for mapping human brain pathways.

Abstract：

:With the fast advance of connectome imaging techniques, we have the opportunity of mapping the human brain pathways in vivo at unprecedented resolution. In this article we review the current developments of diffusion magnetic resonance imaging (MRI) for the reconstruction of anatomical pathways in connectome studies. We first introduce the background of diffusion MRI with an emphasis on the technical advances and challenges in state-of-the-art multi-shell acquisition schemes used in the Human Connectome Project. Characterization of the microstructural environment in the human brain is discussed from the tensor model to the general fiber orientation distribution (FOD) models that can resolve crossing fibers in each voxel of the image. Using FOD-based tractography, we describe novel methods for fiber bundle reconstruction and graph-based connectivity analysis. Building upon these novel developments, there have already been successful applications of connectome imaging techniques in reconstructing challenging brain pathways. Examples including retinofugal and brainstem pathways will be reviewed. Finally, we discuss future directions in connectome imaging and its interaction with other aspects of brain imaging research.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Shi Y,Toga AW

doi

10.1038/mp.2017.92

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

1230-1240

issue

9

eissn

1359-4184

issn

1476-5578

pii

mp201792

journal_volume

22

pub_type

杂志文章

相关文献

MOLECULAR PSYCHIATRY文献大全
  • Genetic contributions to self-reported tiredness.

    abstract：:This corrects the article DOI: 10.1038/mp.2017.5. ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/mp.2017.70

    authors： Deary V,Hagenaars SP,Harris SE,Hill WD,Davies G,Liewald DCM,International Consortium for Blood Pressure GWAS.,CHARGE consortium Aging and Longevity Group.,CHARGE consortium Inflammation Group.,McIntosh AM,Gale CR,Deary IJ

    更新日期：2018-03-01 00:00:00

  • Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder.

    abstract：:Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder. Genetic loci have not yet been identified by genome-wide association studies. Rare copy number variations (CNVs), such as chromosomal deletions or duplications, have been implicated in ADHD and other neurodevelop...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2012.161

    authors： Jarick I,Volckmar AL,Pütter C,Pechlivanis S,Nguyen TT,Dauvermann MR,Beck S,Albayrak Ö,Scherag S,Gilsbach S,Cichon S,Hoffmann P,Degenhardt F,Nöthen MM,Schreiber S,Wichmann HE,Jöckel KH,Heinrich J,Tiesler CM,Faraone S

    更新日期：2014-01-01 00:00:00

  • Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs.

    abstract：:We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increased perception of p...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-018-0345-5

    authors： Niculescu AB,Le-Niculescu H,Levey DF,Roseberry K,Soe KC,Rogers J,Khan F,Jones T,Judd S,McCormick MA,Wessel AR,Williams A,Kurian SM,White FA

    更新日期：2019-04-01 00:00:00

  • Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder.

    abstract：:Cannabis is one of the most commonly and widely used psychoactive drugs. The rates of cannabis misuse have been increasing. Therefore, understanding the effects of cannabis use on the brain is important. Adolescent and adult rodents exposed to repeated administration of cannabinoids show persistent microstructural cha...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-00891-4

    authors： D'Souza DC,Radhakrishnan R,Naganawa M,Ganesh S,Nabulsi N,Najafzadeh S,Ropchan J,Ranganathan M,Cortes-Briones J,Huang Y,Carson RE,Skosnik P

    更新日期：2020-09-24 00:00:00

  • Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS.

    abstract：:Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis spectrum. However, there is a lack of studies investigating longitudinal hippocampal development and its relationship with psychotic symptoms. The 22q11.2 deletion syndrome (22q11DS) has proven to be a remarkable model for the pro...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0443-z

    authors： Mancini V,Sandini C,Padula MC,Zöller D,Schneider M,Schaer M,Eliez S

    更新日期：2020-11-01 00:00:00

  • Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression.

    abstract：:Current antidepressants act principally by blocking monoamine reuptake by high-affinity transporters in the brain. However, these antidepressants show important shortcomings such as slow action onset and limited efficacy in nearly a third of patients with major depression disorder. Here, we report the development of a...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0548-4

    authors： Orrico-Sanchez A,Chausset-Boissarie L,Alves de Sousa R,Coutens B,Rezai Amin S,Vialou V,Louis F,Hessani A,Dansette PM,Zornoza T,Gruszczynski C,Giros B,Guiard BP,Acher F,Pietrancosta N,Gautron S

    更新日期：2020-06-01 00:00:00

  • Associations between Chlamydophila infections, schizophrenia and risk of HLA-A10.

    abstract：:Several microbes have been suspected as pathogenetic factors in schizophrenia. We have previously observed increased frequencies of chlamydial infections and of human lymphocyte antigen (HLA)-A10 in independent studies of schizophrenia. Our aim here was to analyze frequencies of three types of Chlamydiaceae in schizop...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001925

    authors： Fellerhoff B,Laumbacher B,Mueller N,Gu S,Wank R

    更新日期：2007-03-01 00:00:00

  • Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22.

    abstract：:Linkage disequilibrium (LD) mapping was used to follow up reports of linkage between reading disability (RD) and an 18 cM region of chromosome 6p21.3-22. Using a two-stage approach, we tested for association between RD and 22 microsatellite markers in two independent samples of 101 (Stage 1) and 77 (Stage 2) parent/pr...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001216

    authors： Turic D,Robinson L,Duke M,Morris DW,Webb V,Hamshere M,Milham C,Hopkin E,Pound K,Fernando S,Grierson A,Easton M,Williams N,Van Den Bree M,Chowdhury R,Gruen J,Stevenson J,Krawczak M,Owen MJ,O'Donovan MC,Williams J

    更新日期：2003-02-01 00:00:00

  • Hippocampal bone morphogenetic protein signaling mediates behavioral effects of antidepressant treatment.

    abstract：:Many antidepressants stimulate adult hippocampal neurogenesis, but the mechanisms by which they increase neurogenesis and modulate behavior are incompletely understood. Here we show that hippocampal bone morphogenetic protein (BMP) signaling is modulated by antidepressant treatment, and that the changes in BMP signali...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.160

    authors： Brooker SM,Gobeske KT,Chen J,Peng CY,Kessler JA

    更新日期：2017-06-01 00:00:00

  • Treatment-resistant anxiety disorders.

    abstract：:Several epidemiological studies confirmed that Anxiety Disorders as a group are the most prevalent psychiatric conditions in the United States. The importance of these conditions is underlined by the fact that they cause significant disability, poor quality of life, alcohol and drug abuse. Anxiety disorders are treata...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/sj.mp.4001852

    authors： Bystritsky A

    更新日期：2006-09-01 00:00:00

  • The tumor suppressor adenomatous polyposis coli gene is associated with susceptibility to schizophrenia.

    abstract：:The etiology of schizophrenia is unclear, although family, twin, and linkage studies implicate genetic factors. Here, we identified adenomatous polyposis coli (APC), a tumor suppressor gene, as a risk factor for schizophrenia. We compared leukocytic gene expression patterns of six pairs of patients with schizophrenia ...

    journal_title：Molecular psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.mp.4001653

    authors： Cui DH,Jiang KD,Jiang SD,Xu YF,Yao H

    更新日期：2005-07-01 00:00:00

  • Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree.

    abstract：:Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental syndrome characterized by hyperactivity, inattention and increased impulsivity. To detect micro-deletions and micro-duplications that may have a role in the pathogenesis of ADHD, we carried out a genome-wide screen for cop...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2010.29

    authors： Lesch KP,Selch S,Renner TJ,Jacob C,Nguyen TT,Hahn T,Romanos M,Walitza S,Shoichet S,Dempfle A,Heine M,Boreatti-Hümmer A,Romanos J,Gross-Lesch S,Zerlaut H,Wultsch T,Heinzel S,Fassnacht M,Fallgatter A,Allolio B,Schäf

    更新日期：2011-05-01 00:00:00

  • Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population.

    abstract：:Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people with ASD compared with controls, but consistent evidence is lacking. Few s...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2015.12

    authors： Clarke TK,Lupton MK,Fernandez-Pujals AM,Starr J,Davies G,Cox S,Pattie A,Liewald DC,Hall LS,MacIntyre DJ,Smith BH,Hocking LJ,Padmanabhan S,Thomson PA,Hayward C,Hansell NK,Montgomery GW,Medland SE,Martin NG,Wright MJ

    更新日期：2016-03-01 00:00:00

  • Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors.

    abstract：:Abnormalities in the density of neuroreceptors that regulate norepinephrine and serotonin release have been repeatedly reported in brains of suicide victims with mood disorders. Recently, the modulation of the [(35)S]GTPgammaS binding to G-proteins has been introduced as a suitable measure of receptor activity in post...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001067

    authors： González-Maeso J,Rodríguez-Puertas R,Meana JJ,García-Sevilla JA,Guimón J

    更新日期：2002-01-01 00:00:00

  • Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection.

    abstract：:Among the most consistent results of studies of post-mortem brain tissue from schizophrenia patients (SZP) is the finding that in this disease, several genes expressed by GABAergic neurons are downregulated. This downregulation may be caused by hypermethylation of the relevant promoters in affected neurons. Indeed, in...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001954

    authors： Ruzicka WB,Zhubi A,Veldic M,Grayson DR,Costa E,Guidotti A

    更新日期：2007-04-01 00:00:00

  • Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes.

    abstract：:An increase in corticotropin-releasing factor (CRF) is a putative factor in the pathophysiology of stress-related disorders. As CRF expression in the central nucleus of the amygdala (CeA) is important in adaptation to chronic stress, we hypothesized that unrestrained synthesis of CRF in CeA would mimic the consequence...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2008.91

    authors： Keen-Rhinehart E,Michopoulos V,Toufexis DJ,Martin EI,Nair H,Ressler KJ,Davis M,Owens MJ,Nemeroff CB,Wilson ME

    更新日期：2009-01-01 00:00:00

  • An epigenetic mechanism links socioeconomic status to changes in depression-related brain function in high-risk adolescents.

    abstract：:Identifying biological mechanisms through which the experience of adversity emerges as individual risk for mental illness is an important step toward developing strategies for personalized treatment and, ultimately, prevention. Preclinical studies have identified epigenetic modification of gene expression as one such ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.82

    authors： Swartz JR,Hariri AR,Williamson DE

    更新日期：2017-02-01 00:00:00

  • The neuropathology of bipolar disorder: systematic review and meta-analysis.

    abstract：:Various neuropathological findings have been reported in bipolar disorder (BD). However, it is unclear which findings are well established. To address this gap, we carried out a systematic review of the literature. We searched over 5000 publications, identifying 103 data papers, of which 81 were eligible for inclusion...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-018-0213-3

    authors： Harrison PJ,Colbourne L,Harrison CH

    更新日期：2020-08-01 00:00:00

  • The 2009 Nobel conference on the role of genetics in promoting suicide prevention and the mental health of the population.

    abstract：:A 3-day Nobel Conference entitled 'The role of genetics in promoting suicide prevention and the mental health of the population' was held at the Nobel Forum, Karolinska Institute (KI) in Stockholm, Sweden, during 8-10 June 2009. The conference was sponsored by the Nobel Assembly for Physiology or Medicine and organize...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2009.113

    authors： Wasserman D,Terenius L,Wasserman J,Sokolowski M

    更新日期：2010-01-01 00:00:00

  • A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.

    abstract：:Dietary intake of methyl donors, such as folic acid and methionine, shows considerable intra-individual variation in human populations. While it is recognized that maternal departures from the optimum of dietary methyl donor intake can increase the risk for mental health issues and neurological disorders in offspring,...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2017.53

    authors： Ryan DP,Henzel KS,Pearson BL,Siwek ME,Papazoglou A,Guo L,Paesler K,Yu M,Müller R,Xie K,Schröder S,Becker L,Garrett L,Hölter SM,Neff F,Rácz I,Rathkolb B,Rozman J,Ehninger G,Klingenspor M,Klopstock T,Wolf E,Wurs

    更新日期：2018-05-01 00:00:00

  • Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative.

    abstract：:Whilst cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers for amyloid-β (Aβ) and tau pathologies are accurate for the diagnosis of Alzheimer's disease (AD), their broad implementation in clinical and trial settings are restricted by high cost and limited accessibility. Plasma phosphorylated-ta...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-00923-z

    authors： Karikari TK,Benedet AL,Ashton NJ,Lantero Rodriguez J,Snellman A,Suárez-Calvet M,Saha-Chaudhuri P,Lussier F,Kvartsberg H,Rial AM,Pascoal TA,Andreasson U,Schöll M,Weiner MW,Rosa-Neto P,Trojanowski JQ,Shaw LM,Blennow K,Z

    更新日期：2020-10-26 00:00:00

  • Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis.

    abstract：:Post-traumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-related diseases and neurodegeneration. In this paper, we review evidence relevant to the hypothesis that chronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and accelerates cellula...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/mp.2014.111

    authors： Miller MW,Sadeh N

    更新日期：2014-11-01 00:00:00

  • Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11

    abstract：:Mol Psychiatry 2000; 5: 77-84 ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000752

    authors： Li T,Ball D,Zhao J,Murray RM,Liu X,Sham PC,Collier DA

    更新日期：2000-07-01 00:00:00

  • Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system.

    abstract：:Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The disease specificity of this risk has not been addressed and the possibility of confounding has not been excluded. Children with ASD or attention-deficit hypera...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2014.90

    authors： Clements CC,Castro VM,Blumenthal SR,Rosenfield HR,Murphy SN,Fava M,Erb JL,Churchill SE,Kaimal AJ,Doyle AE,Robinson EB,Smoller JW,Kohane IS,Perlis RH

    更新日期：2015-06-01 00:00:00

  • Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders.

    abstract：:Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. From the Enhanci...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-01002-z

    authors： Radonjić NV,Hess JL,Rovira P,Andreassen O,Buitelaar JK,Ching CRK,Franke B,Hoogman M,Jahanshad N,McDonald C,Schmaal L,Sisodiya SM,Stein DJ,van den Heuvel OA,van Erp TGM,van Rooij D,Veltman DJ,Thompson P,Faraone SV

    更新日期：2021-01-17 00:00:00

  • Predicting educational achievement from DNA.

    abstract：:This corrects the article DOI: 10.1038/mp.2016.107. ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/mp.2017.203

    authors： Selzam S,Krapohl E,von Stumm S,O'Reilly PF,Rimfeld K,Kovas Y,Dale PS,Lee JJ,Plomin R

    更新日期：2018-01-01 00:00:00

  • CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia.

    abstract：:To examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-matched controls in the Japanese population. Allelic and genotypic distributions of ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001029

    authors： Ujike H,Takaki M,Nakata K,Tanaka Y,Takeda T,Kodama M,Fujiwara Y,Sakai A,Kuroda S

    更新日期：2002-01-01 00:00:00

  • Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIalpha gene (PIP5K2A) with schizophrenia.

    abstract：:Linkage studies in schizophrenia have identified a candidate region on chromosome 10p14-11 as reported for several independent samples. We investigated association of DNA sequence variants in a plausible candidate gene located in this region, the gene for phosphatidylinositol-4-phosphate 5-kinase IIalpha (PIP5K2A), in...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,多中心研究

    doi：10.1038/sj.mp.4001864

    authors： Schwab SG,Knapp M,Sklar P,Eckstein GN,Sewekow C,Borrmann-Hassenbach M,Albus M,Becker T,Hallmayer JF,Lerer B,Maier W,Wildenauer DB

    更新日期：2006-09-01 00:00:00

  • Histone deacetylase 4 (HDAC4): a new player in anorexia nervosa?

    abstract：:Anorexia nervosa (AN) and other eating disorders continue to constitute significant challenges for individual and public health. AN is thought to develop as a result of complex interactions between environmental triggers, psychological risk factors, sociocultural influences, and genetic vulnerability. Recent research ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/s41380-019-0366-8

    authors： Sild M,Booij L

    更新日期：2019-10-01 00:00:00

  • Educational attainment and drinking behaviors: Mendelian randomization study in UK Biobank.

    abstract：:Educational attainment has been associated with drinking behaviors in observation studies. We performed Mendelian randomization analysis to determine whether educational attainment causally affected drinking behaviors, including amount of alcohol intakes (in total and various types), drinking frequency, and drinking w...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0596-9

    authors： Zhou T,Sun D,Li X,Ma H,Heianza Y,Qi L

    更新日期：2019-11-25 00:00:00