Abstract:
:This corrects the article DOI: 10.1038/mp.2017.5.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Deary V,Hagenaars SP,Harris SE,Hill WD,Davies G,Liewald DCM,International Consortium for Blood Pressure GWAS.,CHARGE consortium Aging and Longevity Group.,CHARGE consortium Inflammation Group.,McIntosh AM,Gale CR,Deary IJdoi
10.1038/mp.2017.70subject
Has Abstractpub_date
2018-03-01 00:00:00pages
789-790issue
3eissn
1359-4184issn
1476-5578pii
mp201770journal_volume
23pub_type
杂志文章,已发布勘误abstract::A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstrea...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001496
更新日期:2004-09-01 00:00:00
abstract::The prefrontal cortex, a part of the limbic-thalamic-cortical network, participates in regulation of mood, cognition and behavior and has been implicated in the pathophysiology of major depressive disorder (MDD). Many neuropsychological studies demonstrate impairment of working memory in patients with MDD. However, th...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001894
更新日期:2007-02-01 00:00:00
abstract::Environmental enrichment (EE) is known to have an anxiolytic effect in several animal models; however, the molecular mechanisms underlying these behavioral changes are not understood. In this study, we have shown that the anxiolytic effect of EE is associated with alterations in the corticotropin-releasing factor rece...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.151
更新日期:2010-09-01 00:00:00
abstract::Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each transmitter in the regulatio...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.104
更新日期:2015-11-01 00:00:00
abstract::Folate receptor alpha (FRα) autoantibodies have been associated with fetal abnormalities and cerebral folate deficiency-related developmental disorders. Over 70% of the children with autism spectrum disorders (ASD) are positive for these autoantibodies and high-dose folinic acid is beneficial in treating these childre...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.153
更新日期:2017-09-01 00:00:00
abstract::Several studies suggest that decreased expression of presynaptic proteins may be characteristic of schizophrenia. We examined one such protein, synapsin, in schizophrenia and bipolar disorder. Samples of hippocampal tissue from controls (n = 13), patients with schizophrenia (n = 16), or bipolar disorder (n = 6), and s...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001158
更新日期:2002-01-01 00:00:00
abstract::The search for susceptibility genes for bipolar disorder (BD) depends on appropriate definitions of the phenotype. In this paper, we review data on diagnosis and clinical features of BD that could be used in genetic studies to better characterize patients or to define homogeneous subgroups. Clinical symptoms, long-ter...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/sj.mp.4001701
更新日期:2005-09-01 00:00:00
abstract::The glutamate hypothesis of schizophrenia derived from evidence that phencyclidine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, produces schizophrenia-like symptoms in healthy humans. Sensorimotor gating, measured by prepulse inhibition (PPI), is a fundamental form of information processing that is defici...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001404
更新日期:2004-01-01 00:00:00
abstract::Volume reduction and shape abnormality of the hippocampus have been associated with mood disorders. However, the hippocampus is not a uniform structure and consists of several subfields, such as the cornu ammonis (CA) subfields CA1-4, the dentate gyrus (DG) including a granule cell layer (GCL) and a molecular layer (M...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.262
更新日期:2017-09-01 00:00:00
abstract::Educational attainment has been associated with drinking behaviors in observation studies. We performed Mendelian randomization analysis to determine whether educational attainment causally affected drinking behaviors, including amount of alcohol intakes (in total and various types), drinking frequency, and drinking w...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0596-9
更新日期:2019-11-25 00:00:00
abstract::Bipolar disorder is a major medical, social and economic burden worldwide. However, the mechanisms of action of effective antibipolar disorder drugs remain elusive. In this paper, we review studies using a neuropharmacological approach in unanesthetized rats, combined with kinetic, biochemical and molecular biology te...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2008.31
更新日期:2008-06-01 00:00:00
abstract::Neurotrophins promote neuronal survival and synaptic plasticity via activating the tropomyosin receptor kinases. BDNF and its high-affinity receptor TrkB are reduced in Alzheimer's disease (AD), contributing to progressive cognitive decline. However, how the signaling mediates AD pathologies remains incompletely under...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-00863-8
更新日期:2020-08-11 00:00:00
abstract::This corrects the article DOI: 10.1038/mp.2016.107. ...
journal_title:Molecular psychiatry
pub_type: 杂志文章,已发布勘误
doi:10.1038/mp.2017.203
更新日期:2018-01-01 00:00:00
abstract::Whilst cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers for amyloid-β (Aβ) and tau pathologies are accurate for the diagnosis of Alzheimer's disease (AD), their broad implementation in clinical and trial settings are restricted by high cost and limited accessibility. Plasma phosphorylated-ta...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-00923-z
更新日期:2020-10-26 00:00:00
abstract::The human serotonin transporter gene (5-HTT) demonstrates two polymorphisms with possible functional impact: a 44-bp insertion/deletion polymorphism of the promoter region and a 17-bp variable number of tandem repeat polymorphism (VNTR) in intron 2 (STin2). Such genetic polymorphisms in the serotoninergic system may i...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4000821
更新日期:2001-03-01 00:00:00
abstract::Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation, making them highly useful adjuncts to animal models. Here, we ex...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.60
更新日期:2012-02-01 00:00:00
abstract::We conducted a 10 centimorgan (cM) linkage genome scan in a set of American extended pedigrees ascertained through probands with panic disorder. Several anxiety disorders segregate in these families. In this article, we describe results for simple phobia from 14 of these families (including 129 subjects of whom 57 are...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/sj.mp.4001224
更新日期:2003-01-01 00:00:00
abstract::Here, we report a novel target of the drug memantine, ATP-sensitive K+ (KATP) channels, potentially relevant to memory improvement. We confirmed that memantine antagonizes memory impairment in Alzheimer's model APP23 mice. Memantine increased CaMKII activity in the APP23 mouse hippocampus, and memantine-induced enhanc...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.187
更新日期:2018-02-01 00:00:00
abstract::The serotonergic neurons of the dorsal raphe (DR) nucleus in the CNS are involved in fear, anxiety and depression. Depression and anxiety occur quite frequently in postmenopausal women, but estrogen replacement to correct these CNS disorders is at present not favored because estrogen carries with it an increased risk ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.62
更新日期:2013-06-01 00:00:00
abstract::We earlier reported a genome-wide significant linkage to schizophrenia at chromosome 17 that was identified in a single pedigree (C702) consisting of six affected, male siblings with DSM-IV schizophrenia and prominent mood symptoms. In this study, we adopted several approaches in an attempt to map the putative disease...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.96
更新日期:2010-11-01 00:00:00
abstract::Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis spectrum. However, there is a lack of studies investigating longitudinal hippocampal development and its relationship with psychotic symptoms. The 22q11.2 deletion syndrome (22q11DS) has proven to be a remarkable model for the pro...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0443-z
更新日期:2020-11-01 00:00:00
abstract::We previously found that ovarian steroids promote neuroprotection in serotonin neurons by decreasing the expression of pro-apoptotic genes and proteins in the dorsal raphe nucleus of rhesus macaques, even in the absence of overt injury. In this study, we questioned whether these actions would lead to a reduction in DN...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.97
更新日期:2010-06-01 00:00:00
abstract::Circulating triglycerides (TGs) normally increase after a meal but are altered in pathophysiological conditions, such as obesity. Although TG metabolism in the brain remains poorly understood, several brain structures express enzymes that process TG-enriched particles, including mesolimbic structures. For this reason,...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.31
更新日期:2014-10-01 00:00:00
abstract::Gonadal hormones influence neuronal organization and plasticity. Yet the consequences of altering their concentrations by administering contraceptive agents, which are used by most reproductive-age women in the United States, are unclear. Cross-sectional studies have found both larger and smaller cortical regions alon...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-00990-2
更新日期:2021-01-08 00:00:00
abstract::Autism spectrum disorder (ASD) is characterized by neurocognitive dysfunctions, such as impaired social interaction and language learning. Gene-environment interactions have a pivotal role in ASD pathogenesis. Nuclear receptor corepressors (NCORs) are transcription co-regulators physically associated with histone deac...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/s41380-020-0667-y
更新日期:2020-10-01 00:00:00
abstract::Latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDACi), are being investigated as a strategy to eliminate latency in HIV-infected patients on suppressive antiretroviral therapy. The effectiveness of LRAs in activating latent infection in HIV strains derived from the central nervous system (C...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.111
更新日期:2016-04-01 00:00:00
abstract::Panic disorder (PD) has a lifetime prevalence of 2-4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide geno...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-019-0590-2
更新日期:2019-11-11 00:00:00
abstract::Eating disorders are complex heritable conditions influenced by both genetic and environmental factors. Given the progress of genomic discovery in anorexia nervosa, with the identification of the first genome-wide significant locus, as well as animated discussion of epigenetic mechanisms in linking environmental facto...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-018-0254-7
更新日期:2019-06-01 00:00:00
abstract::Although few studies dispute that there are gender differences in depression, the etiology is still unknown. In this review, we cover a number of proposed factors and the evidences for and against these factors that may account for gender differences in depression. These include the possible role of estrogens at puber...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2009.94
更新日期:2010-01-01 00:00:00
abstract::We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which th...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/s41380-020-00946-6
更新日期:2020-11-11 00:00:00