Sex, trauma, stress hormones and depression.

abstract：:Chromosome 1q has been implicated in the etiology of schizophrenia in several independent studies. However, the peak linkage findings have been dispersed over a large chromosomal region, with negative findings in this region also being reported. Our group has previously observed linkage on chromosome 1q42, maximizing ...

journal_title：Molecular psychiatry

authors： Ekelund J,Hennah W,Hiekkalinna T,Parker A,Meyer J,Lönnqvist J,Peltonen L

更新日期：2004-11-01 00:00:00

abstract：:Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale c...

journal_title：Molecular psychiatry

authors： Purves KL,Coleman JRI,Meier SM,Rayner C,Davis KAS,Cheesman R,Bækvad-Hansen M,Børglum AD,Wan Cho S,Jürgen Deckert J,Gaspar HA,Bybjerg-Grauholm J,Hettema JM,Hotopf M,Hougaard D,Hübel C,Kan C,McIntosh AM,Mors O,Bo Mort

更新日期：2020-12-01 00:00:00

abstract：:Anxiety disorders constitute a major disease and social burden worldwide; however, many questions concerning the underlying molecular mechanisms still remain open. Besides the involvement of the major excitatory (glutamate) and inhibitory (gamma aminobutyric acid (GABA)) neurotransmitter circuits in anxiety disorders,...

journal_title：Molecular psychiatry

authors： Hartmann J,Dedic N,Pöhlmann ML,Häusl A,Karst H,Engelhardt C,Westerholz S,Wagner KV,Labermaier C,Hoeijmakers L,Kertokarijo M,Chen A,Joëls M,Deussing JM,Schmidt MV

更新日期：2017-03-01 00:00:00

abstract：:Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-inv...

journal_title：Molecular psychiatry

authors： Hadar R,Winter R,Edemann-Callesen H,Wieske F,Habelt B,Khadka N,Felgel-Farnholz V,Barroeta-Hlusicka E,Reis J,Tatarau CA,Funke K,Fritsch B,Bernhardt N,Bikson M,Nitsche MA,Winter C

更新日期：2020-04-01 00:00:00

abstract：:Family studies have demonstrated genetic influences on environmental exposure: the phenomenon of gene-environment correlation (rGE). A few molecular genetic studies have confirmed the results, but the identification of rGE in studies that measure genes and environments faces several challenges. Using examples from stu...

journal_title：Molecular psychiatry

authors： Jaffee SR,Price TS

更新日期：2007-05-01 00:00:00

abstract：:Social deficits are common in many psychiatric disorders. However, due to inadequate tools for manipulating circuit activity in humans and unspecific paradigms for modeling social behaviors in rodents, our understanding of the molecular and circuit mechanisms mediating social behaviors remains relatively limited. Usin...

journal_title：Molecular psychiatry

authors： Li A,Jing D,Dellarco DV,Hall BS,Yang R,Heilberg RT,Huang C,Liston C,Casey BJ,Lee FS

更新日期：2019-04-16 00:00:00

abstract：:Circular RNAs (circRNAs), highly expressed in the central nervous system, are involved in various regulatory processes and implicated in some pathophysiology. However, the potential role of circRNAs in psychiatric diseases, particularly major depressive disorder (MDD), remains largely unknown. Here, we demonstrated th...

journal_title：Molecular psychiatry

authors： Zhang Y,Du L,Bai Y,Han B,He C,Gong L,Huang R,Shen L,Chao J,Liu P,Zhang H,Zhang H,Gu L,Li J,Hu G,Xie C,Zhang Z,Yao H

更新日期：2020-06-01 00:00:00

abstract：:A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0.03) and with low cerebrospinal fluid levels of cholesterol (P=0.005). This polymorphism of SOAT1 is a...

journal_title：Molecular psychiatry

authors： Wollmer MA,Streffer JR,Tsolaki M,Grimaldi LM,Lütjohann D,Thal D,von Bergmann K,Nitsch RM,Hock C,Papassotiropoulos A

更新日期：2003-06-01 00:00:00

abstract：:The 102-T/C polymorphism of the 5-HT(2A) receptor gene was analysed in 159 patients with major depression and 164 unrelated and healthy controls using a case-control design. Allele and genotype frequencies did not differ between cases and controls. No differences according to sex, age of onset, melancholia, suicidal b...

journal_title：Molecular psychiatry

authors： Arias B,Gutiérrez B,Pintor L,Gastó C,Fañanás L

更新日期：2001-03-01 00:00:00

abstract：:The goal of this study is to investigate the familial transmission of the spectrum of bipolar disorder in a nonclinical sample of probands with a broad range of manifestations of mood disorders. The sample included a total of 447 probands recruited from a clinically enriched community screening and their 2082 adult li...

journal_title：Molecular psychiatry

authors： Merikangas KR,Cui L,Heaton L,Nakamura E,Roca C,Ding J,Qin H,Guo W,Shugart YY,Zarate C,Angst J

更新日期：2014-02-01 00:00:00

abstract：:Circulating triglycerides (TGs) normally increase after a meal but are altered in pathophysiological conditions, such as obesity. Although TG metabolism in the brain remains poorly understood, several brain structures express enzymes that process TG-enriched particles, including mesolimbic structures. For this reason,...

journal_title：Molecular psychiatry

authors： Cansell C,Castel J,Denis RG,Rouch C,Delbes AS,Martinez S,Mestivier D,Finan B,Maldonado-Aviles JG,Rijnsburger M,Tschöp MH,DiLeone RJ,Eckel RH,la Fleur SE,Magnan C,Hnasko TS,Luquet S

更新日期：2014-10-01 00:00:00

abstract：:A whole genome association study was performed in a phase 3 clinical trial conducted to evaluate a novel antipsychotic, iloperidone, administered to treat patients with schizophrenia. Genotypes of 407 patients were analyzed for 334,563 single nucleotide polymorphisms (SNPs). SNPs associated with iloperidone efficacy w...

journal_title：Molecular psychiatry

authors： Lavedan C,Licamele L,Volpi S,Hamilton J,Heaton C,Mack K,Lannan R,Thompson A,Wolfgang CD,Polymeropoulos MH

更新日期：2009-08-01 00:00:00

abstract：:The GRIA1 locus, encoding the GluA1 (also known as GluRA or GluR1) AMPA glutamate receptor subunit, shows genome-wide association to schizophrenia. As well as extending the evidence that glutamatergic abnormalities have a key role in the disorder, this finding draws attention to the behavioural phenotype of Gria1 knoc...

journal_title：Molecular psychiatry

authors： Barkus C,Sanderson DJ,Rawlins JN,Walton ME,Harrison PJ,Bannerman DM

更新日期：2014-10-01 00:00:00

abstract：:Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation, making them highly useful adjuncts to animal models. Here, we ex...

journal_title：Molecular psychiatry

authors： Konopka G,Wexler E,Rosen E,Mukamel Z,Osborn GE,Chen L,Lu D,Gao F,Gao K,Lowe JK,Geschwind DH

更新日期：2012-02-01 00:00:00

abstract：:While localizing sensory and motor deficits is one of the cornerstones of clinical neurology, behavioral and cognitive deficits in psychiatry remain impervious to this approach. In psychiatry, major challenges include the relative subtlety by which neural circuits are perturbed, and the limited understanding of how ba...

journal_title：Molecular psychiatry

authors： Schmitt LI,Halassa MM

更新日期：2017-02-01 00:00:00

abstract：:Schizophrenia is a chronic, severe and highly complex mental illness. Current treatments manage the positive symptoms, yet have minimal effects on the negative and cognitive symptoms, two prominent features of the disease with critical impact on the long-term morbidity. In addition, antipsychotic treatments trigger se...

journal_title：Molecular psychiatry

authors： Revel FG,Moreau JL,Pouzet B,Mory R,Bradaia A,Buchy D,Metzler V,Chaboz S,Groebke Zbinden K,Galley G,Norcross RD,Tuerck D,Bruns A,Morairty SR,Kilduff TS,Wallace TL,Risterucci C,Wettstein JG,Hoener MC

更新日期：2013-05-01 00:00:00

abstract：:People who experience childhood abuse are at increased risk of mental illness. Twin studies suggest that inherited genetic risk for mental illness may account for some of these associations. Yet, the hypothesis that individuals who have experienced childhood abuse may carry genetic loading for mental illness has never...

journal_title：Molecular psychiatry

authors： Ratanatharathorn A,Koenen KC,Chibnik LB,Weisskopf MG,Rich-Edwards JW,Roberts AL

更新日期：2021-01-22 00:00:00

abstract：:Obscure work on the inheritance of two peculiar genetic traits in yeast has recently collided with work on infectious, neurodegenerative diseases in mammals. The impact illuminates both fields. The yeast work reveals a new mechanism of genetic variation that is based on differences in protein conformation rather than ...

journal_title：Molecular psychiatry

authors： Lindquist S

更新日期：1996-11-01 00:00:00

abstract：:Diverse studies have investigated the impact of prenatal exposure to vitamin D levels on brain development; however, evidence in humans has never been systematically reviewed. This article summarized evidence of the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or newborn bloo...

journal_title：Molecular psychiatry

authors： García-Serna AM,Morales E

更新日期：2020-10-01 00:00:00

abstract：:We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increased perception of p...

journal_title：Molecular psychiatry

authors： Niculescu AB,Le-Niculescu H,Levey DF,Roseberry K,Soe KC,Rogers J,Khan F,Jones T,Judd S,McCormick MA,Wessel AR,Williams A,Kurian SM,White FA

更新日期：2019-04-01 00:00:00

abstract：:The endogenous opioid system, which alleviates physical pain, is also known to regulate social distress and reward in animal models. To test this hypothesis in humans (n=18), we used an μ-opioid receptor (MOR) radiotracer to measure changes in MOR availability in vivo with positron emission tomography during social re...

journal_title：Molecular psychiatry

authors： Hsu DT,Sanford BJ,Meyers KK,Love TM,Hazlett KE,Wang H,Ni L,Walker SJ,Mickey BJ,Korycinski ST,Koeppe RA,Crocker JK,Langenecker SA,Zubieta JK

更新日期：2013-11-01 00:00:00

abstract：:The Raf kinases Raf-1 and B-Raf are upstream activators of the extracellular signal-regulated kinase (ERK)-signaling pathway and therefore participates in many physiological functions in brain, including neuronal survival and synaptic plasticity. Previously, we observed that activation of ERK-1/2, the downstream compo...

journal_title：Molecular psychiatry

authors： Dwivedi Y,Rizavi HS,Conley RR,Pandey GN

更新日期：2006-01-01 00:00:00

abstract：:In mammals, most adult neural stem cells (NSCs) are located in the ventricular-subventricular zone (V-SVZ) along the wall of the lateral ventricles and they are the source of olfactory bulb interneurons. Adult NSCs exhibit an apico-basal polarity; they harbor a short apical process and a long basal process, reminiscen...

journal_title：Molecular psychiatry

authors： García-González D,Dumitru I,Zuccotti A,Yen TY,Herranz-Pérez V,Tan LL,Neitz A,García-Verdugo JM,Kuner R,Alfonso J,Monyer H

更新日期：2020-07-01 00:00:00

abstract：:Educational attainment has been associated with drinking behaviors in observation studies. We performed Mendelian randomization analysis to determine whether educational attainment causally affected drinking behaviors, including amount of alcohol intakes (in total and various types), drinking frequency, and drinking w...

journal_title：Molecular psychiatry

authors： Zhou T,Sun D,Li X,Ma H,Heianza Y,Qi L

更新日期：2019-11-25 00:00:00

abstract：:Psychotic symptoms occur in ~40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. We undertook a combined analysi...

journal_title：Molecular psychiatry

authors： Hollingworth P,Sweet R,Sims R,Harold D,Russo G,Abraham R,Stretton A,Jones N,Gerrish A,Chapman J,Ivanov D,Moskvina V,Lovestone S,Priotsi P,Lupton M,Brayne C,Gill M,Lawlor B,Lynch A,Craig D,McGuinness B,Johnston J

更新日期：2012-12-01 00:00:00

abstract：:Positron emission tomography (PET) studies suggest opioidergic system dysfunction in morbid obesity, while evidence for the role of the dopaminergic system is less consistent. Whether opioid dysfunction represents a state or trait in obesity remains unresolved, but could be assessed in obese subjects undergoing weight...

journal_title：Molecular psychiatry

authors： Karlsson HK,Tuulari JJ,Tuominen L,Hirvonen J,Honka H,Parkkola R,Helin S,Salminen P,Nuutila P,Nummenmaa L

更新日期：2016-08-01 00:00:00

abstract：:The serotonergic neurons of the dorsal raphe (DR) nucleus in the CNS are involved in fear, anxiety and depression. Depression and anxiety occur quite frequently in postmenopausal women, but estrogen replacement to correct these CNS disorders is at present not favored because estrogen carries with it an increased risk ...

journal_title：Molecular psychiatry

authors： Suzuki H,Barros RP,Sugiyama N,Krishnan V,Yaden BC,Kim HJ,Warner M,Gustafsson JÅ

更新日期：2013-06-01 00:00:00

abstract：:This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...

journal_title：Molecular psychiatry

authors： Haure-Mirande JV,Wang M,Audrain M,Fanutza T,Kim SH,Heja S,Readhead B,Dudley JT,Blitzer RD,Schadt EE,Zhang B,Gandy S,Ehrlich ME

更新日期：2019-03-01 00:00:00

abstract：:A 3-day Nobel Conference entitled 'The role of genetics in promoting suicide prevention and the mental health of the population' was held at the Nobel Forum, Karolinska Institute (KI) in Stockholm, Sweden, during 8-10 June 2009. The conference was sponsored by the Nobel Assembly for Physiology or Medicine and organize...

journal_title：Molecular psychiatry

authors： Wasserman D,Terenius L,Wasserman J,Sokolowski M

更新日期：2010-01-01 00:00:00

abstract：:Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate, and, thus, are reasonable candidate susceptibility genes for these conditions. In this study, we examined th...

journal_title：Molecular psychiatry

authors： Hettema JM,An SS,Neale MC,Bukszar J,van den Oord EJ,Kendler KS,Chen X

更新日期：2006-08-01 00:00:00