Abstract：
:Obscure work on the inheritance of two peculiar genetic traits in yeast has recently collided with work on infectious, neurodegenerative diseases in mammals. The impact illuminates both fields. The yeast work reveals a new mechanism of genetic variation that is based on differences in protein conformation rather than differences in nucleic acid. In the light of this work the prion hypothesis for transmissible neurodegenerative disease no longer seems so bizarre. Indeed, the mammalian prion hypothesis is now placed within a larger framework that is likely to be of universal importance in biology. Yeast prions, as the genetic elements are called, can be cured, offering new insights into the molecular processes involved in protein-based inheritance and new hope for the treatment of neurodegenerative diseases in man.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Lindquist Ssubject
Has Abstractpub_date
1996-11-01 00:00:00pages
376-9issue
5eissn
1359-4184issn
1476-5578journal_volume
1pub_type
杂志文章,评审abstract：:Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with ...
journal_title：Molecular psychiatry
pub_type： 杂志文章,meta分析
doi：10.1038/s41380-018-0040-6
更新日期：2019-02-01 00:00:00
abstract：:We posit in this article that hierarchical temporal processing deficit is the underlying basis of reality distortion and psychoses. Schizophrenia is a prototypical reality distortion disorder in which the patient manifests with auditory hallucinations, delusions, disorganized speech and thinking, cognitive impairment,...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2010.63
更新日期：2011-02-01 00:00:00
abstract：:Long-term weight-restored patients with anorexia nervosa (AN) have lower norepinephrine levels than controls. Since this may reflect altered reuptake by the norepinephrine transporter (NET), we hypothesised that the NET gene was involved in the genetic component of AN. PCR-amplification of an AAGG repeat island (AAGG1...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001080
更新日期：2002-01-01 00:00:00
abstract：:Episodic memory, a fundamental component of human cognition, is significantly impaired in autism. We believe we report the first evidence for this problem in the Fmr1-knockout (KO) mouse model of Fragile X syndrome and describe potentially treatable underlying causes. The hippocampus is critical for the formation and ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.221
更新日期：2018-08-01 00:00:00
abstract：:Several microbes have been suspected as pathogenetic factors in schizophrenia. We have previously observed increased frequencies of chlamydial infections and of human lymphocyte antigen (HLA)-A10 in independent studies of schizophrenia. Our aim here was to analyze frequencies of three types of Chlamydiaceae in schizop...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001925
更新日期：2007-03-01 00:00:00
abstract：:High impulsive and aggressive traits associate with poor behavioural self-control. Despite their importance in predicting behavioural negative outcomes including suicide, the molecular mechanisms underlying the expression of impulsive and aggressive traits remain poorly understood. Here, we identified and characterize...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-019-0637-4
更新日期：2020-01-06 00:00:00
abstract：:The different serotonin (5-HT) receptors, including the serotonin transporter (5-HTT), are excellent candidate genes for suicide and suicidal behavior, and thus, they have been investigated in a large number of allelic association studies. The individual results of these studies have been inconsistent and definite con...
journal_title：Molecular psychiatry
pub_type： 杂志文章,meta分析,评审
doi：10.1038/sj.mp.4001336
更新日期：2003-07-01 00:00:00
abstract：:Abnormalities in prefrontal gamma aminobutyric acid (GABA)ergic transmission, particularly in fast-spiking interneurons that express parvalbumin (PV), are hypothesized to contribute to the pathophysiology of multiple psychiatric disorders, including schizophrenia, bipolar disorder, anxiety disorders and depression. Wh...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2015.222
更新日期：2016-07-01 00:00:00
abstract：:After psychological trauma, recurrent intrusive visual memories may be distressing and disruptive. Preventive interventions post trauma are lacking. Here we test a behavioural intervention after real-life trauma derived from cognitive neuroscience. We hypothesized that intrusive memories would be significantly reduced...
journal_title：Molecular psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1038/mp.2017.23
更新日期：2018-03-01 00:00:00
abstract：:Many antidepressants stimulate adult hippocampal neurogenesis, but the mechanisms by which they increase neurogenesis and modulate behavior are incompletely understood. Here we show that hippocampal bone morphogenetic protein (BMP) signaling is modulated by antidepressant treatment, and that the changes in BMP signali...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2016.160
更新日期：2017-06-01 00:00:00
abstract：:The core nature of nicotine dependence is evident in wide variations in how individuals become and remain smokers. Individuals with pre-existing behavioral traits are more likely to develop nicotine dependence and experience difficulty when attempting to quit. Many molecular factors likely contribute to individual var...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/mp.2009.16
更新日期：2009-07-01 00:00:00
abstract：:Anxiety and depression are devastating mental illnesses that are a significant public health concern. Selective serotonin-reuptake inhibitors are the first-line treatment strategy for these disorders, which despite being a significant advantage over older treatments, are hampered by a limited efficacy in a significant...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/mp.2011.162
更新日期：2012-04-01 00:00:00
abstract：:The long alleles (> or =6 repeats) of the dopamine D4 dopamine receptor exon III polymorphism have been linked in some, but not all, studies to Novelty Seeking (NS), one of four personality traits defined by Cloninger's tridimensional personality questionnarie (TPQ). In order to further examine the robustness of our o...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4000333
更新日期：1997-10-01 00:00:00
abstract：:Genetic factors do not fully account for the relatively high heritability of neurodevelopmental conditions, suggesting that non-genetic heritable factors contribute to their etiology. To evaluate the potential contribution of aberrant thyroid hormone status to the epigenetic inheritance of neurological phenotypes, we ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0281-4
更新日期：2020-05-01 00:00:00
abstract：:The network theory conceptualizes mental disorders as complex networks of symptoms influencing each other by creating feedback loops, leading to a self-sustained syndromic constellation. Symptoms central to the network have the greatest impact in sustaining the rest of symptoms. This analysis focused on the network st...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0232-0
更新日期：2020-07-01 00:00:00
abstract：:Serotonin (5-HT) neurons project from the raphe nuclei throughout the brain where they act to maintain homeostasis. Here, we study 5-HT inputs into the bed nucleus of the stria terminalis (BNST), a major subdivision of the extended amygdala that has been proposed to regulate responses to anxiogenic environments in hum...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.165
更新日期：2018-10-01 00:00:00
abstract：:The amygdala is a key brain region that is critically involved in the processing and expression of anxiety and fear-related signals. In parallel, a growing number of preclinical and human studies have implicated the microbiome-gut-brain in regulating anxiety and stress-related responses. However, the role of the micro...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.100
更新日期：2018-05-01 00:00:00
abstract：:Folic acid supplementation confers modest benefit in schizophrenia, but its effectiveness is influenced by common genetic variants in the folate pathway that hinder conversion to its active form. We examined physiological and clinical effects of l-methylfolate, the fully reduced and bioactive form of folate, in schizo...
journal_title：Molecular psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1038/mp.2017.41
更新日期：2018-02-01 00:00:00
abstract：:Older patients with severe physical trauma are at high risk of developing neuropsychiatric syndromes with global impairment of cognition, attention, and consciousness. We employed a thoracic trauma (TxT) mouse model and thoroughly analyzed age-dependent spatial and temporal posttraumatic alterations in the central ner...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-020-0659-y
更新日期：2020-02-12 00:00:00
abstract：:The goal of this study is to investigate the familial transmission of the spectrum of bipolar disorder in a nonclinical sample of probands with a broad range of manifestations of mood disorders. The sample included a total of 447 probands recruited from a clinically enriched community screening and their 2082 adult li...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2013.116
更新日期：2014-02-01 00:00:00
abstract：:Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other members of the neurotrophin family, are central mediators of the activity-dependent plasticity through which environmental experiences, such as sensory information are translated into the structure and function of neuronal networks. ...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2017.61
更新日期：2017-08-01 00:00:00
abstract：:Psychiatric diseases have a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance alone but to also involve epigenetic factors in germ cells. Initial evidence suggested that sperm RNA is causally linked to the transmission of symptoms induced by traumatic experiences. Here, we...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0271-6
更新日期：2020-09-01 00:00:00
abstract：:Volume reduction and shape abnormality of the hippocampus have been associated with mood disorders. However, the hippocampus is not a uniform structure and consists of several subfields, such as the cornu ammonis (CA) subfields CA1-4, the dentate gyrus (DG) including a granule cell layer (GCL) and a molecular layer (M...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2016.262
更新日期：2017-09-01 00:00:00
abstract：:Eating disorders are complex heritable conditions influenced by both genetic and environmental factors. Given the progress of genomic discovery in anorexia nervosa, with the identification of the first genome-wide significant locus, as well as animated discussion of epigenetic mechanisms in linking environmental facto...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-018-0254-7
更新日期：2019-06-01 00:00:00
abstract：:Attention-deficit hyperactivity disorder (ADHD) is typically characterized as a disorder of inattention and hyperactivity/impulsivity but there is increasing evidence of deficits in motivation. Using positron emission tomography (PET), we showed decreased function in the brain dopamine reward pathway in adults with AD...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2010.97
更新日期：2011-11-01 00:00:00
abstract：:The search for susceptibility genes for bipolar disorder (BD) depends on appropriate definitions of the phenotype. In this paper, we review data on diagnosis and clinical features of BD that could be used in genetic studies to better characterize patients or to define homogeneous subgroups. Clinical symptoms, long-ter...
journal_title：Molecular psychiatry
pub_type： 杂志文章,评审
doi：10.1038/sj.mp.4001701
更新日期：2005-09-01 00:00:00
abstract：:We conducted a 10 centimorgan (cM) linkage genome scan in a set of American extended pedigrees ascertained through probands with panic disorder. Several anxiety disorders segregate in these families. In this article, we describe results for simple phobia from 14 of these families (including 129 subjects of whom 57 are...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/sj.mp.4001224
更新日期：2003-01-01 00:00:00
abstract：:Gonadal hormones influence neuronal organization and plasticity. Yet the consequences of altering their concentrations by administering contraceptive agents, which are used by most reproductive-age women in the United States, are unclear. Cross-sectional studies have found both larger and smaller cortical regions alon...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-020-00990-2
更新日期：2021-01-08 00:00:00
abstract：:Diverse studies have investigated the impact of prenatal exposure to vitamin D levels on brain development; however, evidence in humans has never been systematically reviewed. This article summarized evidence of the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or newborn bloo...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/s41380-019-0357-9
更新日期：2020-10-01 00:00:00
abstract：:Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose the effects of (partially) recessive deleterious mutations. Even among outbred populations, auto...
journal_title：Molecular psychiatry
pub_type： 杂志文章
doi：10.1038/mp.2015.120
更新日期：2016-06-01 00:00:00
