Serotonin inputs to the dorsal BNST modulate anxiety in a 5-HT1A receptor-dependent manner.

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and sex using a 51-plex cyto...

journal_title：Molecular psychiatry

authors： Hornig M,Gottschalk G,Peterson DL,Knox KK,Schultz AF,Eddy ML,Che X,Lipkin WI

更新日期：2016-02-01 00:00:00

abstract：:Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encod...

journal_title：Molecular psychiatry

authors： Toda T,Parylak SL,Linker SB,Gage FH

更新日期：2019-01-01 00:00:00

abstract：:Hyperactivation of the amygdala following chronic stress is believed to be one of the primary mechanisms underlying the increased propensity for anxiety-like behaviors and pathological states; however, the mechanisms by which chronic stress modulates amygdalar function are not well characterized. The aim of the curren...

journal_title：Molecular psychiatry

authors： Hill MN,Kumar SA,Filipski SB,Iverson M,Stuhr KL,Keith JM,Cravatt BF,Hillard CJ,Chattarji S,McEwen BS

更新日期：2013-10-01 00:00:00

abstract：:Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patie...

journal_title：Molecular psychiatry

authors： Albrecht DS,Kim M,Akeju O,Torrado-Carvajal A,Edwards RR,Zhang Y,Bergan C,Protsenko E,Kucyi A,Wasan AD,Hooker JM,Napadow V,Loggia ML

更新日期：2019-05-28 00:00:00

abstract：:Genomic risk profile scores (GRPSs) have been shown to predict case-control status of schizophrenia (SCZ), albeit with varying sensitivity and specificity. The extent to which this variability in prediction accuracy is related to differences in sampling strategies is unknown. Danish population-based registers and Neon...

journal_title：Molecular psychiatry

authors： Meier SM,Agerbo E,Maier R,Pedersen CB,Lang M,Grove J,Hollegaard MV,Demontis D,Trabjerg BB,Hjorthøj C,Ripke S,Degenhardt F,Nöthen MM,Rujescu D,Maier W,MooDS SCZ Consortium.,Werge T,Mors O,Hougaard DM,Børglum AD,Wra

更新日期：2016-07-01 00:00:00

abstract：:A recent study has suggested a possible association of a polymorphism near the dopamine D5 receptor gene (DRD5) and attention-deficit hyperactivity disorder. The polymorphism studied was a (CA)n repeat located in the cosmid containing the D5 receptor gene2 and the allele that was reported to be associated with attenti...

journal_title：Molecular psychiatry

authors： Barr CL,Wigg KG,Feng Y,Zai G,Malone M,Roberts W,Schachar R,Tannock R,Kennedy JL

更新日期：2000-09-01 00:00:00

abstract：:Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ~1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated association of genetic variants in expert-curated synaptic gene groups with schizophrenia in 4673 ca...

journal_title：Molecular psychiatry

authors： Lips ES,Cornelisse LN,Toonen RF,Min JL,Hultman CM,International Schizophrenia Consortium.,Holmans PA,O'Donovan MC,Purcell SM,Smit AB,Verhage M,Sullivan PF,Visscher PM,Posthuma D

更新日期：2012-10-01 00:00:00

abstract：:This Article was originally published under Nature Research's License to Publish, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the Article have been modified accordingly. ...

journal_title：Molecular psychiatry

authors： Perry A,Roberts G,Mitchell PB,Breakspear M

更新日期：2019-09-01 00:00:00

abstract：:Although few studies dispute that there are gender differences in depression, the etiology is still unknown. In this review, we cover a number of proposed factors and the evidences for and against these factors that may account for gender differences in depression. These include the possible role of estrogens at puber...

journal_title：Molecular psychiatry

authors： Young E,Korszun A

更新日期：2010-01-01 00:00:00

abstract：:Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) ...

journal_title：Molecular psychiatry

authors： Papassotiropoulos A,Stefanova E,Vogler C,Gschwind L,Ackermann S,Spalek K,Rasch B,Heck A,Aerni A,Hanser E,Demougin P,Huynh KD,Luechinger R,Klarhöfer M,Novakovic I,Kostic V,Boesiger P,Scheffler K,de Quervain DJ

更新日期：2013-02-01 00:00:00

abstract：:Disruption of persistent, stress-associated memories is relevant for treating posttraumatic stress disorder (PTSD) and related syndromes, which develop in a subset of individuals following a traumatic event. We previously developed a stress-enhanced fear learning (SEFL) paradigm in inbred mice that produces PTSD-like ...

journal_title：Molecular psychiatry

authors： Sillivan SE,Jamieson S,de Nijs L,Jones M,Snijders C,Klengel T,Joseph NF,Krauskopf J,Kleinjans J,Vinkers CH,Boks MPM,Geuze E,Vermetten E,Berretta S,Ressler KJ,Rutten BPF,Rumbaugh G,Miller CA

更新日期：2020-05-01 00:00:00

abstract：:Several lines of evidence have suggested altered functions of the brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). In the search for polymorphisms in the 5'-flanking and 5'-noncoding regions of the BDNF gene, we found a novel nucleotide subs...

journal_title：Molecular psychiatry

authors： Kunugi H,Ueki A,Otsuka M,Isse K,Hirasawa H,Kato N,Nabika T,Kobayashi S,Nanko S

更新日期：2001-01-01 00:00:00

abstract：:Cigarette smoking is more prevalent in subjects with schizophrenia compared to those with other psychiatric disorders or the general population and could therefore affect molecular pathways that impact the pathophysiology of this disorder. As smoking is also known to suppress immune responses, we investigated the effe...

journal_title：Molecular psychiatry

authors： Herberth M,Krzyszton DN,Koethe D,Craddock MR,Bulger E,Schwarz E,Guest P,Leweke FM,Bahn S

更新日期：2010-04-01 00:00:00

abstract：:Identifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group performed a large-scale meta-analysis and reported widespread white matter microstructural alterations in schizophr...

journal_title：Molecular psychiatry

authors： Koshiyama D,Fukunaga M,Okada N,Morita K,Nemoto K,Usui K,Yamamori H,Yasuda Y,Fujimoto M,Kudo N,Azechi H,Watanabe Y,Hashimoto N,Narita H,Kusumi I,Ohi K,Shimada T,Kataoka Y,Yamamoto M,Ozaki N,Okada G,Okamoto Y,Ha

更新日期：2020-04-01 00:00:00

abstract：:Many antidepressants stimulate adult hippocampal neurogenesis, but the mechanisms by which they increase neurogenesis and modulate behavior are incompletely understood. Here we show that hippocampal bone morphogenetic protein (BMP) signaling is modulated by antidepressant treatment, and that the changes in BMP signali...

journal_title：Molecular psychiatry

authors： Brooker SM,Gobeske KT,Chen J,Peng CY,Kessler JA

更新日期：2017-06-01 00:00:00

abstract：:Folate receptor alpha (FRα) autoantibodies have been associated with fetal abnormalities and cerebral folate deficiency-related developmental disorders. Over 70% of the children with autism spectrum disorders (ASD) are positive for these autoantibodies and high-dose folinic acid is beneficial in treating these childre...

journal_title：Molecular psychiatry

authors： Desai A,Sequeira JM,Quadros EV

更新日期：2017-09-01 00:00:00

abstract：:Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose the effects of (partially) recessive deleterious mutations. Even among outbred populations, auto...

journal_title：Molecular psychiatry

authors： Howrigan DP,Simonson MA,Davies G,Harris SE,Tenesa A,Starr JM,Liewald DC,Deary IJ,McRae A,Wright MJ,Montgomery GW,Hansell N,Martin NG,Payton A,Horan M,Ollier WE,Abdellaoui A,Boomsma DI,DeRosse P,Knowles EE,Glahn DC

更新日期：2016-06-01 00:00:00

abstract：:Binge drinking is associated with disease and death, and developing tools to identify risky drinkers could mitigate its damage. Brain processes underlie risky drinking, so we examined whether neural and psychosocial markers could identify binge drinkers. Reward is the most widely studied neural process in addiction, b...

journal_title：Molecular psychiatry

authors： Gowin JL,Manza P,Ramchandani VA,Volkow ND

更新日期：2020-05-12 00:00:00

abstract：:Intellectual disability (ID) is a measurable phenotypic consequence of genetic and environmental factors. In this study, we prospectively assessed the diagnostic yield of genomic tools (molecular karyotyping, multi-gene panel and exome sequencing) in a cohort of 337 ID subjects as a first-tier test and compared it wit...

journal_title：Molecular psychiatry

authors： Anazi S,Maddirevula S,Faqeih E,Alsedairy H,Alzahrani F,Shamseldin HE,Patel N,Hashem M,Ibrahim N,Abdulwahab F,Ewida N,Alsaif HS,Al Sharif H,Alamoudi W,Kentab A,Bashiri FA,Alnaser M,AlWadei AH,Alfadhel M,Eyaid W,Has

更新日期：2017-04-01 00:00:00

abstract：:A 3-day Nobel Conference entitled 'The role of genetics in promoting suicide prevention and the mental health of the population' was held at the Nobel Forum, Karolinska Institute (KI) in Stockholm, Sweden, during 8-10 June 2009. The conference was sponsored by the Nobel Assembly for Physiology or Medicine and organize...

journal_title：Molecular psychiatry

authors： Wasserman D,Terenius L,Wasserman J,Sokolowski M

更新日期：2010-01-01 00:00:00

abstract：:Emerging evidence suggests that psychiatric disorders are associated with disturbances in structural brain networks. Little is known, however, about brain networks in those at high risk (HR) of bipolar disorder (BD), with such disturbances carrying substantial predictive and etiological value. Whole-brain tractography...

journal_title：Molecular psychiatry

authors： Roberts G,Perry A,Lord A,Frankland A,Leung V,Holmes-Preston E,Levy F,Lenroot RK,Mitchell PB,Breakspear M

更新日期：2018-02-01 00:00:00

abstract：:Attention-deficit hyperactivity disorder (ADHD) is typically characterized as a disorder of inattention and hyperactivity/impulsivity but there is increasing evidence of deficits in motivation. Using positron emission tomography (PET), we showed decreased function in the brain dopamine reward pathway in adults with AD...

journal_title：Molecular psychiatry

authors： Volkow ND,Wang GJ,Newcorn JH,Kollins SH,Wigal TL,Telang F,Fowler JS,Goldstein RZ,Klein N,Logan J,Wong C,Swanson JM

更新日期：2011-11-01 00:00:00

abstract：:Niemann-Pick disease type A (NPA) is a rare lysosomal storage disorder characterized by severe neurological alterations that leads to death in childhood. Loss-of-function mutations in the acid sphingomyelinase (ASM) gene cause NPA, and result in the accumulation of sphingomyelin (SM) in lysosomes and plasma membrane o...

journal_title：Molecular psychiatry

authors： Pérez-Cañamás A,Benvegnù S,Rueda CB,Rábano A,Satrústegui J,Ledesma MD

更新日期：2017-05-01 00:00:00

abstract：:Anxiety disorders constitute a major disease and social burden worldwide; however, many questions concerning the underlying molecular mechanisms still remain open. Besides the involvement of the major excitatory (glutamate) and inhibitory (gamma aminobutyric acid (GABA)) neurotransmitter circuits in anxiety disorders,...

journal_title：Molecular psychiatry

authors： Hartmann J,Dedic N,Pöhlmann ML,Häusl A,Karst H,Engelhardt C,Westerholz S,Wagner KV,Labermaier C,Hoeijmakers L,Kertokarijo M,Chen A,Joëls M,Deussing JM,Schmidt MV

更新日期：2017-03-01 00:00:00

abstract：:The actions of CRF in the brain and in the periphery are mediated through multiple binding sites. There are three receptors, CRF1, CRF2 alpha and CRF2 beta, which encode 411, 415 and 431 amino acid proteins and transduce signals via the stimulation of intracellular cAMP production. The recent identification of high-af...

journal_title：Molecular psychiatry

authors： Behan DP,Grigoriadis DE,Lovenberg T,Chalmers D,Heinrichs S,Liaw C,De Souza EB

更新日期：1996-09-01 00:00:00

abstract：:Genetic variation underlying hypothalamic pituitary adrenal (HPA) axis overactivity in healthy controls (HCs) and patients with severe forms of major depression has not been well explored, but could explain risk for cortisol dysregulation. In total, 95 participants were studied: 40 patients with psychotic major depres...

journal_title：Molecular psychiatry

authors： Schatzberg AF,Keller J,Tennakoon L,Lembke A,Williams G,Kraemer FB,Sarginson JE,Lazzeroni LC,Murphy GM

更新日期：2014-02-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA(A)) receptors are thought to play an important role in modulating the central nervous system in response to stress. Animal data have shown alterations in the GABA(A) receptor complex by uncontrollable stressors. SPECT imaging with benzodiazepine ligands showed lower distribution volumes o...

journal_title：Molecular psychiatry

authors： Geuze E,van Berckel BN,Lammertsma AA,Boellaard R,de Kloet CS,Vermetten E,Westenberg HG

更新日期：2008-01-01 00:00:00

abstract：:Autistic individuals experience significantly elevated rates of childhood trauma, self-harm and suicidal behaviour and ideation (SSBI). Is this purely the result of negative environmental experiences, or does this interact with genetic predisposition? In this study we investigated if a genetic predisposition for autis...

journal_title：Molecular psychiatry

authors： Warrier V,Baron-Cohen S

更新日期：2019-10-29 00:00:00

abstract：:Peripheral blood brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in bipolar disorder, speculated to mirror alterations in brain expression of BDNF. The research area is rapidly evolving; however, recent investigations have yielded con...

journal_title：Molecular psychiatry

authors： Munkholm K,Vinberg M,Kessing LV

更新日期：2016-02-01 00:00:00

abstract：:Given the manifold ways that depression impairs Darwinian fitness, the persistence in the human genome of risk alleles for the disorder remains a much debated mystery. Evolutionary theories that view depressive symptoms as adaptive fail to provide parsimonious explanations for why even mild depressive symptoms impair ...

journal_title：Molecular psychiatry

authors： Raison CL,Miller AH

更新日期：2013-01-01 00:00:00