The neuroinflammatory component of negative affect in patients with chronic pain.

abstract：:Volume reduction and shape abnormality of the hippocampus have been associated with mood disorders. However, the hippocampus is not a uniform structure and consists of several subfields, such as the cornu ammonis (CA) subfields CA1-4, the dentate gyrus (DG) including a granule cell layer (GCL) and a molecular layer (M...

journal_title：Molecular psychiatry

authors： Cao B,Passos IC,Mwangi B,Amaral-Silva H,Tannous J,Wu MJ,Zunta-Soares GB,Soares JC

更新日期：2017-09-01 00:00:00

abstract：:Posttranscriptional regulation of gene expression plays an important role in the maturation, transport, stability and translation of coding and noncoding RNAs. RNA-binding protein (RBP) is a key factor of the regulation. Regulator of calcineurin 1 (RCAN1) is a multifunctional protein involved in neurodegeneration, mit...

journal_title：Molecular psychiatry

authors： Yun Y,Zhang Y,Zhang C,Huang L,Tan S,Wang P,Vilariño-Gúell C,Song W,Sun X

更新日期：2019-08-27 00:00:00

abstract：:Many antidepressants stimulate adult hippocampal neurogenesis, but the mechanisms by which they increase neurogenesis and modulate behavior are incompletely understood. Here we show that hippocampal bone morphogenetic protein (BMP) signaling is modulated by antidepressant treatment, and that the changes in BMP signali...

journal_title：Molecular psychiatry

authors： Brooker SM,Gobeske KT,Chen J,Peng CY,Kessler JA

更新日期：2017-06-01 00:00:00

abstract：:Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each transmitter in the regulatio...

journal_title：Molecular psychiatry

authors： Sakae DY,Marti F,Lecca S,Vorspan F,Martín-García E,Morel LJ,Henrion A,Gutiérrez-Cuesta J,Besnard A,Heck N,Herzog E,Bolte S,Prado VF,Prado MA,Bellivier F,Eap CB,Crettol S,Vanhoutte P,Caboche J,Gratton A,Moquin L,

更新日期：2015-11-01 00:00:00

abstract：:Long-term weight-restored patients with anorexia nervosa (AN) have lower norepinephrine levels than controls. Since this may reflect altered reuptake by the norepinephrine transporter (NET), we hypothesised that the NET gene was involved in the genetic component of AN. PCR-amplification of an AAGG repeat island (AAGG1...

journal_title：Molecular psychiatry

authors： Urwin RE,Bennetts B,Wilcken B,Lampropoulos B,Beumont P,Clarke S,Russell J,Tanner S,Nunn KP

更新日期：2002-01-01 00:00:00

abstract：:Dysthymia is characterized by long-lasting periods of lowered mood. Epidemiological studies in the USA and Europe have demonstrated that the prevalence of dysthymia is at least 3% of the general population. Its pervasive occurrence makes dysthymia a public health problem worldwide. One feature of this disorder is its ...

journal_title：Molecular psychiatry

authors： Akiskal HS,Bolis CL,Cazzullo C,Costa e Silva JA,Gentil V,Lecrubier Y,Licinio J,Linden M,Lopez-Ibor JJ,Ndiaye IP,Pani L,Prilipko L,Robertson MM,Robinson RG,Starkstein SE,Thomas P,Wang Y,Wong ML

更新日期：1996-12-01 00:00:00

abstract：:Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations betwee...

journal_title：Molecular psychiatry

authors： Sammallahti S,Cortes Hidalgo AP,Tuominen S,Malmberg A,Mulder RH,Brunst KJ,Alemany S,McBride NS,Yousefi P,Heiss JA,McRae N,Page CM,Jin J,Pesce G,Caramaschi D,Rifas-Shiman SL,Koen N,Adams CD,Magnus MC,Baïz N,Ratanat

更新日期：2021-01-07 00:00:00

abstract：:Various neuropathological findings have been reported in bipolar disorder (BD). However, it is unclear which findings are well established. To address this gap, we carried out a systematic review of the literature. We searched over 5000 publications, identifying 103 data papers, of which 81 were eligible for inclusion...

journal_title：Molecular psychiatry

authors： Harrison PJ,Colbourne L,Harrison CH

更新日期：2020-08-01 00:00:00

abstract：:Exercise has a variety of beneficial effects on brain structure and function, such as hippocampal neurogenesis, mood and memory. Previous studies have shown that exercise enhances hippocampal neurogenesis, induces antidepressant effects and improves learning behavior. Brain serotonin (5-hydroxytryptamine, 5-HT) levels...

journal_title：Molecular psychiatry

authors： Kondo M,Nakamura Y,Ishida Y,Shimada S

更新日期：2015-11-01 00:00:00

abstract：:The 102-T/C polymorphism of the 5-HT(2A) receptor gene was analysed in 159 patients with major depression and 164 unrelated and healthy controls using a case-control design. Allele and genotype frequencies did not differ between cases and controls. No differences according to sex, age of onset, melancholia, suicidal b...

journal_title：Molecular psychiatry

authors： Arias B,Gutiérrez B,Pintor L,Gastó C,Fañanás L

更新日期：2001-03-01 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions regarding how the m...

journal_title：Molecular psychiatry

authors： Chase HW,Boudewyn MA,Carter CS,Phillips ML

更新日期：2020-02-01 00:00:00

abstract：:Large numbers of single nucleotide polymorphisms (SNPs) are being identified by several laboratories for the purpose of developing dense genetic maps. Single-strand conformation polymorphism (SSCP) analysis has been widely used as a method for detecting novel sequence variations in PCR products. Differences in migrati...

journal_title：Molecular psychiatry

authors： Gonen D,Veenstra-VanderWeele J,Yang Z,Leventhal B,Cook EH Jr

更新日期：1999-07-01 00:00:00

abstract：:Serotonergic (5HT) neurons exert diverse and widespread functions in the brain. Dysfunction of the serotonergic system gives rise to a variety of mental illnesses including depression, anxiety, obsessive compulsive disorder, autism and eating disorders. Here we show that human primary fibroblasts were directly convert...

journal_title：Molecular psychiatry

authors： Xu Z,Jiang H,Zhong P,Yan Z,Chen S,Feng J

更新日期：2016-01-01 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and sex using a 51-plex cyto...

journal_title：Molecular psychiatry

authors： Hornig M,Gottschalk G,Peterson DL,Knox KK,Schultz AF,Eddy ML,Che X,Lipkin WI

更新日期：2016-02-01 00:00:00

abstract：:Significant heterogeneity across aetiologies, neurobiology and clinical phenotypes have been observed in individuals with autism spectrum disorder (ASD). Neuroimaging-based neuroanatomical studies of ASD have often reported inconsistent findings which may, in part, be attributable to an insufficient understanding of t...

journal_title：Molecular psychiatry

authors： Bedford SA,Park MTM,Devenyi GA,Tullo S,Germann J,Patel R,Anagnostou E,Baron-Cohen S,Bullmore ET,Chura LR,Craig MC,Ecker C,Floris DL,Holt RJ,Lenroot R,Lerch JP,Lombardo MV,Murphy DGM,Raznahan A,Ruigrok ANV,Smith E

更新日期：2020-03-01 00:00:00

abstract：:The s allele variant of the serotonin transporter gene (5-HTT) has recently been observed to moderate the relationship of stress to depression and anxiety. To date no study has considered interactive effects of 5-HTT genotype, stress and hypothalamic-pituitary-adrenal (HPA) function on cognition in healthy, older adul...

journal_title：Molecular psychiatry

authors： O'Hara R,Schröder CM,Mahadevan R,Schatzberg AF,Lindley S,Fox S,Weiner M,Kraemer HC,Noda A,Lin X,Gray HL,Hallmayer JF

更新日期：2007-06-01 00:00:00

abstract：:Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and the concomitant impact on plasticity and critical periods, is hypothesized to be disrupted in neurodevelopmen...

journal_title：Molecular psychiatry

authors： Chen K,Ma X,Nehme A,Wei J,Cui Y,Cui Y,Yao D,Wu J,Anderson T,Ferguson D,Levitt P,Qiu S

更新日期：2020-01-03 00:00:00

abstract：:Psychiatric diseases have a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance alone but to also involve epigenetic factors in germ cells. Initial evidence suggested that sperm RNA is causally linked to the transmission of symptoms induced by traumatic experiences. Here, we...

journal_title：Molecular psychiatry

authors： Gapp K,van Steenwyk G,Germain PL,Matsushima W,Rudolph KLM,Manuella F,Roszkowski M,Vernaz G,Ghosh T,Pelczar P,Mansuy IM,Miska EA

更新日期：2020-09-01 00:00:00

abstract：:The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with 'Western' diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched 'Western' ...

journal_title：Molecular psychiatry

authors： Cinquina V,Calvigioni D,Farlik M,Halbritter F,Fife-Gernedl V,Shirran SL,Fuszard MA,Botting CH,Poullet P,Piscitelli F,Máté Z,Szabó G,Yanagawa Y,Kasper S,Di Marzo V,Mackie K,McBain CJ,Bock C,Keimpema E,Harkany T

更新日期：2020-01-01 00:00:00

abstract：:To identify loci associated with Alzheimer disease, we conducted a three-stage analysis using existing genome-wide association studies (GWAS) and genotyping in a new sample. In Stage I, all suggestive single-nucleotide polymorphisms (at P<0.001) in a previously reported GWAS of seven independent studies (8082 Alzheime...

journal_title：Molecular psychiatry

authors： Boada M,Antúnez C,Ramírez-Lorca R,DeStefano AL,González-Pérez A,Gayán J,López-Arrieta J,Ikram MA,Hernández I,Marín J,Galán JJ,Bis JC,Mauleón A,Rosende-Roca M,Moreno-Rey C,Gudnasson V,Morón FJ,Velasco J,Carrasco JM,A

更新日期：2014-06-01 00:00:00

abstract：:Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-inv...

journal_title：Molecular psychiatry

authors： Hadar R,Winter R,Edemann-Callesen H,Wieske F,Habelt B,Khadka N,Felgel-Farnholz V,Barroeta-Hlusicka E,Reis J,Tatarau CA,Funke K,Fritsch B,Bernhardt N,Bikson M,Nitsche MA,Winter C

更新日期：2020-04-01 00:00:00

abstract：:A genetic predisposition to the development of neuroleptic malignant syndrome (NMS) has been suggested by clinical studies. Although the molecular basis of NMS is unclear, a dopaminergic blockade mechanism has been considered the main cause. We therefore investigated the association between NMS and three functional po...

journal_title：Molecular psychiatry

authors： Kishida I,Kawanishi C,Furuno T,Kato D,Ishigami T,Kosaka K

更新日期：2004-03-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is characterized by neurocognitive dysfunctions, such as impaired social interaction and language learning. Gene-environment interactions have a pivotal role in ASD pathogenesis. Nuclear receptor corepressors (NCORs) are transcription co-regulators physically associated with histone deac...

journal_title：Molecular psychiatry

authors： Kong Y,Zhou W,Sun Z

更新日期：2020-10-01 00:00:00

abstract：:Cigarette smoking is more prevalent in subjects with schizophrenia compared to those with other psychiatric disorders or the general population and could therefore affect molecular pathways that impact the pathophysiology of this disorder. As smoking is also known to suppress immune responses, we investigated the effe...

journal_title：Molecular psychiatry

authors： Herberth M,Krzyszton DN,Koethe D,Craddock MR,Bulger E,Schwarz E,Guest P,Leweke FM,Bahn S

更新日期：2010-04-01 00:00:00

abstract：:Intellectual disability (ID) is a measurable phenotypic consequence of genetic and environmental factors. In this study, we prospectively assessed the diagnostic yield of genomic tools (molecular karyotyping, multi-gene panel and exome sequencing) in a cohort of 337 ID subjects as a first-tier test and compared it wit...

journal_title：Molecular psychiatry

authors： Anazi S,Maddirevula S,Faqeih E,Alsedairy H,Alzahrani F,Shamseldin HE,Patel N,Hashem M,Ibrahim N,Abdulwahab F,Ewida N,Alsaif HS,Al Sharif H,Alamoudi W,Kentab A,Bashiri FA,Alnaser M,AlWadei AH,Alfadhel M,Eyaid W,Has

更新日期：2017-04-01 00:00:00

abstract：:Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia. This study comprises genome-wide association (GWA) and follow-up analyses of all individuals born in Denmark since 1...

journal_title：Molecular psychiatry

authors： Børglum AD,Demontis D,Grove J,Pallesen J,Hollegaard MV,Pedersen CB,Hedemand A,Mattheisen M,GROUP investigators10.,Uitterlinden A,Nyegaard M,Ørntoft T,Wiuf C,Didriksen M,Nordentoft M,Nöthen MM,Rietschel M,Ophoff RA,Cic

更新日期：2014-03-01 00:00:00

abstract：:This paper summarizes recent research on mitochondrial DNA (mtDNA)--which might be described as the "other, forgotten genome". Recent studies suggest the possible pathophysiological significance of mtDNA in schizophrenia and neurodegenerative and mood disorders. Decreased activity of the mitochondrial electron transpo...

journal_title：Molecular psychiatry

authors： Kato T

更新日期：2001-11-01 00:00:00

abstract：:Critical periods are temporary windows of heightened neural plasticity early in development. For example, fear memories in juvenile rodents are subject to erasure following extinction training, while after closure of this critical period, extinction training only temporarily and weakly suppresses fear memories. Persis...

journal_title：Molecular psychiatry

authors： Bhagat SM,Butler SS,Taylor JR,McEwen BS,Strittmatter SM

更新日期：2016-09-01 00:00:00

abstract：:Medical treatment with various cytokines can provoke psychiatric symptoms. Conversely, psychiatric patients can display abnormalities in cytokine and neurotrophic factor expression. Such observations have pointed to the potential contribution of cytokines and growth factors to schizophrenic pathology and/or etiology. ...

journal_title：Molecular psychiatry

authors： Nawa H,Takahashi M,Patterson PH

更新日期：2000-11-01 00:00:00

abstract：:Nitric oxide (NO) is a widespread and multifunctional biological messenger molecule. It mediates vasodilation of blood vessels, host defence against infectious agents and tumors, and neurotransmission of the central and peripheral nervous systems. In the nervous system, NO is generated by three nitric oxide synthase (...

journal_title：Molecular psychiatry

authors： Yun HY,Dawson VL,Dawson TM

更新日期：1997-07-01 00:00:00