Abstract:
:Posttranscriptional regulation of gene expression plays an important role in the maturation, transport, stability and translation of coding and noncoding RNAs. RNA-binding protein (RBP) is a key factor of the regulation. Regulator of calcineurin 1 (RCAN1) is a multifunctional protein involved in neurodegeneration, mitochondrial dysfunction, inflammation and protein glycosylation, and plays an important role in the pathogenesis of Down syndrome and Alzheimer's disease. In this report, we discovered that RCNA1 is a novel RNA-binding protein. A 23 nucleotide sequence of adenine nucleotide translocator (ANT1) mRNA was identified as the binding motif of RCAN1. Furthermore, we found that R1SR13, as the RNA aptamer of RCAN1 identified by SELEX, blocked RCAN1-induced inhibition of the nuclear factor of activated T cells (NFAT) and NF-κB signaling pathways, and reduced neuronal apoptosis. Taken together, our results demonstrate that RCAN1 is a novel RNA-binding protein and the RNA aptamer of RCAN1 plays a neuroprotective role.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Yun Y,Zhang Y,Zhang C,Huang L,Tan S,Wang P,Vilariño-Gúell C,Song W,Sun Xdoi
10.1038/s41380-019-0487-0subject
Has Abstractpub_date
2019-08-27 00:00:00eissn
1359-4184issn
1476-5578pii
10.1038/s41380-019-0487-0pub_type
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