Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD.

abstract：:A recent study using a 'partial' rodent model of schizophrenia has employed amygdalar activation to induce reported changes in the expression of hippocampal genes associated with metabolic and signaling pathways in response to amygdalar activation. The amygdalo-hippocampal pathway plays a central role in the regulatio...

journal_title：Molecular psychiatry

authors： Burke RE,Walsh J,Matzilevich D,Benes FM

更新日期：2006-02-01 00:00:00

abstract：:Traumatic life experiences are associated with alcohol use problems, an association that is likely to be moderated by genetic predisposition. To understand these interactions, we conducted a gene-by-environment genome-wide interaction study (GEWIS) of alcohol use problems in two independent samples, the Army STARRS (S...

journal_title：Molecular psychiatry

authors： Polimanti R,Kaufman J,Zhao H,Kranzler HR,Ursano RJ,Kessler RC,Gelernter J,Stein MB

更新日期：2018-01-01 00:00:00

abstract：:Obscure work on the inheritance of two peculiar genetic traits in yeast has recently collided with work on infectious, neurodegenerative diseases in mammals. The impact illuminates both fields. The yeast work reveals a new mechanism of genetic variation that is based on differences in protein conformation rather than ...

journal_title：Molecular psychiatry

authors： Lindquist S

更新日期：1996-11-01 00:00:00

abstract：:Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with ...

journal_title：Molecular psychiatry

authors： Coleman JRI,Bryois J,Gaspar HA,Jansen PR,Savage JE,Skene N,Plomin R,Muñoz-Manchado AB,Linnarsson S,Crawford G,Hjerling-Leffler J,Sullivan PF,Posthuma D,Breen G

更新日期：2019-02-01 00:00:00

abstract：:Depression is a heritable disorder that is often precipitated by stress. Abnormalities of the stress-reactive hypothalamic-pituitary-adrenal (HPA) axis are also common in depressed patients. In animal models, the forced swim test (FST) is the most frequently used test of depressive-like behavior. We have used a propos...

journal_title：Molecular psychiatry

authors： Solberg LC,Ahmadiyeh N,Baum AE,Vitaterna MH,Takahashi JS,Turek FW,Redei EE

更新日期：2003-04-01 00:00:00

abstract：:Hyperactivation of the amygdala following chronic stress is believed to be one of the primary mechanisms underlying the increased propensity for anxiety-like behaviors and pathological states; however, the mechanisms by which chronic stress modulates amygdalar function are not well characterized. The aim of the curren...

journal_title：Molecular psychiatry

authors： Hill MN,Kumar SA,Filipski SB,Iverson M,Stuhr KL,Keith JM,Cravatt BF,Hillard CJ,Chattarji S,McEwen BS

更新日期：2013-10-01 00:00:00

abstract：:Mol Psychiatry 2000; 5: 77-84 ...

journal_title：Molecular psychiatry

authors： Li T,Ball D,Zhao J,Murray RM,Liu X,Sham PC,Collier DA

更新日期：2000-07-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not ju...

journal_title：Molecular psychiatry

authors： Dean KR,Hammamieh R,Mellon SH,Abu-Amara D,Flory JD,Guffanti G,Wang K,Daigle BJ Jr,Gautam A,Lee I,Yang R,Almli LM,Bersani FS,Chakraborty N,Donohue D,Kerley K,Kim TK,Laska E,Young Lee M,Lindqvist D,Lori A,Lu L,M

更新日期：2020-12-01 00:00:00

abstract：:This study explores whether inflammatory biomarkers act as moderators of clinical response to omega-3 (n-3) fatty acids in subjects with major depressive disorder (MDD). One hundred fifty-five subjects with Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) MDD, a baseline 17-item Hamilton Dep...

journal_title：Molecular psychiatry

authors： Rapaport MH,Nierenberg AA,Schettler PJ,Kinkead B,Cardoos A,Walker R,Mischoulon D

更新日期：2016-01-01 00:00:00

abstract：:Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and the concomitant impact on plasticity and critical periods, is hypothesized to be disrupted in neurodevelopmen...

journal_title：Molecular psychiatry

authors： Chen K,Ma X,Nehme A,Wei J,Cui Y,Cui Y,Yao D,Wu J,Anderson T,Ferguson D,Levitt P,Qiu S

更新日期：2020-01-03 00:00:00

abstract：:Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and mGluR5 signaling. We examined agonist-induced mGluR5 signaling in the postmortem dorsolateral ...

journal_title：Molecular psychiatry

authors： Wang HY,MacDonald ML,Borgmann-Winter KE,Banerjee A,Sleiman P,Tom A,Khan A,Lee KC,Roussos P,Siegel SJ,Hemby SE,Bilker WB,Gur RE,Hahn CG

更新日期：2020-04-01 00:00:00

abstract：:Impulsivity, a multifaceted behavioral hallmark of attention-deficit/hyperactivity disorder (ADHD), strongly influences addiction vulnerability and other psychiatric disorders that incur enormous medical and societal burdens yet the neurobiological underpinnings linking impulsivity to disease remain poorly understood....

journal_title：Molecular psychiatry

authors： Miller ML,Ren Y,Szutorisz H,Warren NA,Tessereau C,Egervari G,Mlodnicka A,Kapoor M,Chaarani B,Morris CV,Schumann G,Garavan H,Goate AM,Bannon MJ,IMAGEN Consortium.,Halperin JM,Hurd YL

更新日期：2018-05-01 00:00:00

abstract：:Various neuropathological findings have been reported in bipolar disorder (BD). However, it is unclear which findings are well established. To address this gap, we carried out a systematic review of the literature. We searched over 5000 publications, identifying 103 data papers, of which 81 were eligible for inclusion...

journal_title：Molecular psychiatry

authors： Harrison PJ,Colbourne L,Harrison CH

更新日期：2020-08-01 00:00:00

abstract：:Association between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of the dopamine transporter gene (DAT1) has been reported in independent clinical samples using a categorical clinical definition of ADHD. The present study adopts a quantitative trait loci (QTL) approach to examine the associ...

journal_title：Molecular psychiatry

authors： Cornish KM,Manly T,Savage R,Swanson J,Morisano D,Butler N,Grant C,Cross G,Bentley L,Hollis CP

更新日期：2005-07-01 00:00:00

abstract：:Accumulating evidence from both genetic and clinico-pharmacological studies suggests that D-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ). Although an association of genes for D-serine degradation, such as D-amino acid oxidase and G72, has been reported...

journal_title：Molecular psychiatry

authors： Fujii K,Maeda K,Hikida T,Mustafa AK,Balkissoon R,Xia J,Yamada T,Ozeki Y,Kawahara R,Okawa M,Huganir RL,Ujike H,Snyder SH,Sawa A

更新日期：2006-02-01 00:00:00

abstract：:An increase in corticotropin-releasing factor (CRF) is a putative factor in the pathophysiology of stress-related disorders. As CRF expression in the central nucleus of the amygdala (CeA) is important in adaptation to chronic stress, we hypothesized that unrestrained synthesis of CRF in CeA would mimic the consequence...

journal_title：Molecular psychiatry

authors： Keen-Rhinehart E,Michopoulos V,Toufexis DJ,Martin EI,Nair H,Ressler KJ,Davis M,Owens MJ,Nemeroff CB,Wilson ME

更新日期：2009-01-01 00:00:00

abstract：:Higher scores on the personality trait of neuroticism, the tendency to experience negative emotions, are associated with worse mental and physical health. Studies examining links between neuroticism and health typically operationalize neuroticism by summing the items from a neuroticism scale. However, neuroticism is m...

journal_title：Molecular psychiatry

authors： Hill WD,Weiss A,Liewald DC,Davies G,Porteous DJ,Hayward C,McIntosh AM,Gale CR,Deary IJ

更新日期：2020-11-01 00:00:00

abstract：:Anxiety disorders constitute a major disease and social burden worldwide; however, many questions concerning the underlying molecular mechanisms still remain open. Besides the involvement of the major excitatory (glutamate) and inhibitory (gamma aminobutyric acid (GABA)) neurotransmitter circuits in anxiety disorders,...

journal_title：Molecular psychiatry

authors： Hartmann J,Dedic N,Pöhlmann ML,Häusl A,Karst H,Engelhardt C,Westerholz S,Wagner KV,Labermaier C,Hoeijmakers L,Kertokarijo M,Chen A,Joëls M,Deussing JM,Schmidt MV

更新日期：2017-03-01 00:00:00

abstract：:Previous work has demonstrated associations between lower cognitive ability and childhood and adult non-psychotic psychopathology. As both cognitive ability (CA) and child psychopathology (CP) are influenced by genetic factors, one explanation for the association is that they are the pleiotropic manifestations of the ...

journal_title：Molecular psychiatry

authors： Jacobs N,Rijsdijk F,Derom C,Danckaerts M,Thiery E,Derom R,Vlietinck R,van Os J

更新日期：2002-01-01 00:00:00

abstract：:Induction of neuroprotective heat-shock proteins via pharmacological Hsp90 inhibitors is currently being investigated as a potential treatment for neurodegenerative diseases. Two major hurdles for therapeutic use of Hsp90 inhibitors are systemic toxicity and limited central nervous system permeability. We demonstrate ...

journal_title：Molecular psychiatry

authors： Wang B,Liu Y,Huang L,Chen J,Li JJ,Wang R,Kim E,Chen Y,Justicia C,Sakata K,Chen H,Planas A,Ostrom RS,Li W,Yang G,McDonald MP,Chen R,Heck DH,Liao FF

更新日期：2017-07-01 00:00:00

abstract：:Studies using tissue obtained at autopsy suggest that changes in cholinergic neurons could be important in the pathology of schizophrenia.1-4 We have previously reported a decrease in [3H]pirenzepine binding5 and [3H]AF-DX 384 binding6 to caudate-putamen (CP) from subjects who had schizophrenia. Under the conditions c...

journal_title：Molecular psychiatry

authors： Dean B,Crook JM,Pavey G,Opeskin K,Copolov DL

更新日期：2000-03-01 00:00:00

abstract：:The current study provides a novel in-depth assessment of the extent of antipsychotic drugs transport across the blood-brain barrier (BBB) into various brain regions, as well as across the blood-spinal cord barrier (BSCB) and the blood-cerebrospinal fluid barrier (BCSFB). This is combined with an estimation of cellula...

journal_title：Molecular psychiatry

authors： Loryan I,Melander E,Svensson M,Payan M,König F,Jansson B,Hammarlund-Udenaes M

更新日期：2016-11-01 00:00:00

abstract：:The serotonergic neurotransmitter system has been widely implicated in the pathophysiology of mood-related disorders such as anxiety and major depressive disorder (MDD). The onset of therapeutic efficacy of traditional antidepressants is delayed by several weeks. The 5-HT4 receptor has emerged as a new therapeutic tar...

journal_title：Molecular psychiatry

authors： Castello J,LeFrancois B,Flajolet M,Greengard P,Friedman E,Rebholz H

更新日期：2018-04-01 00:00:00

abstract：:Identifying biomarkers in schizophrenia during the first episode without the confounding effects of treatment has been challenging. Leveraging these biomarkers to establish diagnosis and make individualized predictions of future treatment responses to antipsychotics would be of great value, but there has been limited ...

journal_title：Molecular psychiatry

authors： Cao B,Cho RY,Chen D,Xiu M,Wang L,Soares JC,Zhang XY

更新日期：2020-04-01 00:00:00

abstract：:The endogenous opioid system, which alleviates physical pain, is also known to regulate social distress and reward in animal models. To test this hypothesis in humans (n=18), we used an μ-opioid receptor (MOR) radiotracer to measure changes in MOR availability in vivo with positron emission tomography during social re...

journal_title：Molecular psychiatry

authors： Hsu DT,Sanford BJ,Meyers KK,Love TM,Hazlett KE,Wang H,Ni L,Walker SJ,Mickey BJ,Korycinski ST,Koeppe RA,Crocker JK,Langenecker SA,Zubieta JK

更新日期：2013-11-01 00:00:00

abstract：:Semi-starvation induced hyperactivity (SIH) occurs in rodents upon caloric restriction. We hypothesized that SIH is triggered by the decline in leptin secretion associated with food restriction. To test this hypothesis, rats, which had established a stable level of activity, were treated with leptin or vehicle via imp...

journal_title：Molecular psychiatry

authors： Exner C,Hebebrand J,Remschmidt H,Wewetzer C,Ziegler A,Herpertz S,Schweiger U,Blum WF,Preibisch G,Heldmaier G,Klingenspor M

更新日期：2000-09-01 00:00:00

abstract：:Calcium, the most versatile second messenger, regulates essential biology including crucial cellular events in embryogenesis. We investigated impacts of calcium channels and purinoceptors on neuronal differentiation of normal mouse embryonic stem cells (ESCs), with outcomes being compared to those of in vitro models o...

journal_title：Molecular psychiatry

authors： Glaser T,Shimojo H,Ribeiro DE,Martins PPL,Beco RP,Kosinski M,Sampaio VFA,Corrêa-Velloso J,Oliveira-Giacomelli Á,Lameu C,de Jesus Santos AP,de Souza HDN,Teng YD,Kageyama R,Ulrich H

更新日期：2020-04-29 00:00:00

abstract：:Large numbers of single nucleotide polymorphisms (SNPs) are being identified by several laboratories for the purpose of developing dense genetic maps. Single-strand conformation polymorphism (SSCP) analysis has been widely used as a method for detecting novel sequence variations in PCR products. Differences in migrati...

journal_title：Molecular psychiatry

authors： Gonen D,Veenstra-VanderWeele J,Yang Z,Leventhal B,Cook EH Jr

更新日期：1999-07-01 00:00:00

abstract：:We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. Expression of LIM was decreased in the lymphoblastoid cells derived from patients with bipolar disorders and schizophrenia. LI...

journal_title：Molecular psychiatry

authors： Kato T,Iwayama Y,Kakiuchi C,Iwamoto K,Yamada K,Minabe Y,Nakamura K,Mori N,Fujii K,Nanko S,Yoshikawa T

更新日期：2005-11-01 00:00:00

abstract：:Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encod...

journal_title：Molecular psychiatry

authors： Toda T,Parylak SL,Linker SB,Gage FH

更新日期：2019-01-01 00:00:00