Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability.

abstract：:Although inherited DNA sequences have a well-demonstrated role in psychiatric disease risk, for even the most heritable mental disorders, monozygotic twins are discordant at a significant rate. The genetic variation associated with mental disorders has heretofore been based on the search for rare or common variation i...

journal_title：Molecular psychiatry

authors： Insel TR

更新日期：2014-02-01 00:00:00

abstract：:Schizophrenia and bipolar disorder have both been linked to structural abnormalities of the hippocampus, which is consistent with a neurodevelopmental anomaly. One isoform of the neural cell adhesion molecule (N-CAM) protein, cytosolic N-CAM 105-115 kDa, was previously shown to be increased in schizophrenia in the hip...

journal_title：Molecular psychiatry

authors： Vawter MP,Howard AL,Hyde TM,Kleinman JE,Freed WJ

更新日期：1999-09-01 00:00:00

abstract：:Psychotropic medications target glycogen synthase kinase 3β (GSK3β), but the functional integration with other factors relevant for drug efficacy is poorly understood. We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3β at serine 9 (pGSK3β(S9))....

journal_title：Molecular psychiatry

authors： Gassen NC,Hartmann J,Zannas AS,Kretzschmar A,Zschocke J,Maccarrone G,Hafner K,Zellner A,Kollmannsberger LK,Wagner KV,Mehta D,Kloiber S,Turck CW,Lucae S,Chrousos GP,Holsboer F,Binder EB,Ising M,Schmidt MV,Rein T

更新日期：2016-02-01 00:00:00

abstract：:The catechol-O-methyl transferase (COMT) gene is considered a leading schizophrenia candidate gene. Although its role in increasing schizophrenia susceptibility has been conflicting, recent studies suggest the valine allele may contribute to poor cognitive function in schizophrenia. V(158)M COMT genotype was obtained ...

journal_title：Molecular psychiatry

authors： Ho BC,Wassink TH,O'Leary DS,Sheffield VC,Andreasen NC

更新日期：2005-03-01 00:00:00

abstract：:In developing his mature concept of hebephrenic dementia praecox (DP) in his 4th (1893) through 6th textbook editions (1899), Kraepelin worked from the hebephrenic syndrome first described by Hecker (1871) and then carefully studied by his student Daraszkiewicz (1892). Working under Kraepelin's supervision, Daraszkiew...

journal_title：Molecular psychiatry

authors： Kendler KS

更新日期：2020-01-01 00:00:00

abstract：:The molecular genetic research on panic disorder (PD) has grown tremendously in the past decade. Although the data from twin and family studies suggest an involvement of genetic factors in the familial transmission of PD with the heritability estimate near 40%, the genetic substrate underlying panicogenesis is not yet...

journal_title：Molecular psychiatry

authors： Maron E,Hettema JM,Shlik J

更新日期：2010-07-01 00:00:00

abstract：:Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification of predisposing genes has remained a challenge. Utilizing a large family-based schizophrenia study...

journal_title：Molecular psychiatry

authors： Wedenoja J,Loukola A,Tuulio-Henriksson A,Paunio T,Ekelund J,Silander K,Varilo T,Heikkilä K,Suvisaari J,Partonen T,Lönnqvist J,Peltonen L

更新日期：2008-07-01 00:00:00

abstract：:Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-inv...

journal_title：Molecular psychiatry

authors： Hadar R,Winter R,Edemann-Callesen H,Wieske F,Habelt B,Khadka N,Felgel-Farnholz V,Barroeta-Hlusicka E,Reis J,Tatarau CA,Funke K,Fritsch B,Bernhardt N,Bikson M,Nitsche MA,Winter C

更新日期：2020-04-01 00:00:00

abstract：:A recent study using a 'partial' rodent model of schizophrenia has employed amygdalar activation to induce reported changes in the expression of hippocampal genes associated with metabolic and signaling pathways in response to amygdalar activation. The amygdalo-hippocampal pathway plays a central role in the regulatio...

journal_title：Molecular psychiatry

authors： Burke RE,Walsh J,Matzilevich D,Benes FM

更新日期：2006-02-01 00:00:00

abstract：:The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with 'Western' diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched 'Western' ...

journal_title：Molecular psychiatry

authors： Cinquina V,Calvigioni D,Farlik M,Halbritter F,Fife-Gernedl V,Shirran SL,Fuszard MA,Botting CH,Poullet P,Piscitelli F,Máté Z,Szabó G,Yanagawa Y,Kasper S,Di Marzo V,Mackie K,McBain CJ,Bock C,Keimpema E,Harkany T

更新日期：2020-01-01 00:00:00

abstract：:Between 1997 and 2002, 48 data sets from the hippocampus were produced on samples from the Stanley Neuropathology Consortium. From these data sets, 224 total measures were available from the various subdivisions of the hippocampus. An integrative analysis of these measures was performed using a multivariate, nonparame...

journal_title：Molecular psychiatry

authors： Knable MB,Barci BM,Webster MJ,Meador-Woodruff J,Torrey EF,Stanley Neuropathology Consortium.

更新日期：2004-06-01 00:00:00

abstract：:Neurotrophins promote neuronal survival and synaptic plasticity via activating the tropomyosin receptor kinases. BDNF and its high-affinity receptor TrkB are reduced in Alzheimer's disease (AD), contributing to progressive cognitive decline. However, how the signaling mediates AD pathologies remains incompletely under...

journal_title：Molecular psychiatry

authors： Xia Y,Wang ZH,Liu P,Edgington-Mitchell L,Liu X,Wang XC,Ye K

更新日期：2020-08-11 00:00:00

abstract：:This corrects the article DOI: 10.1038/mp.2016.107. ...

journal_title：Molecular psychiatry

authors： Selzam S,Krapohl E,von Stumm S,O'Reilly PF,Rimfeld K,Kovas Y,Dale PS,Lee JJ,Plomin R

更新日期：2018-01-01 00:00:00

abstract：:Linkage disequilibrium (LD) mapping was used to follow up reports of linkage between reading disability (RD) and an 18 cM region of chromosome 6p21.3-22. Using a two-stage approach, we tested for association between RD and 22 microsatellite markers in two independent samples of 101 (Stage 1) and 77 (Stage 2) parent/pr...

journal_title：Molecular psychiatry

authors： Turic D,Robinson L,Duke M,Morris DW,Webb V,Hamshere M,Milham C,Hopkin E,Pound K,Fernando S,Grierson A,Easton M,Williams N,Van Den Bree M,Chowdhury R,Gruen J,Stevenson J,Krawczak M,Owen MJ,O'Donovan MC,Williams J

更新日期：2003-02-01 00:00:00

abstract：:Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate, and, thus, are reasonable candidate susceptibility genes for these conditions. In this study, we examined th...

journal_title：Molecular psychiatry

authors： Hettema JM,An SS,Neale MC,Bukszar J,van den Oord EJ,Kendler KS,Chen X

更新日期：2006-08-01 00:00:00

abstract：:Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar (BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, which have been vario...

journal_title：Molecular psychiatry

authors： Neves-Pereira M,Cheung JK,Pasdar A,Zhang F,Breen G,Yates P,Sinclair M,Crombie C,Walker N,St Clair DM

更新日期：2005-02-01 00:00:00

abstract：:The astrocytic cystine/glutamate antiporter system xc- represents an important source of extracellular glutamate in the central nervous system, with potential impact on excitatory neurotransmission. Yet, its function and importance in brain physiology remain incompletely understood. Employing slice electrophysiology a...

journal_title：Molecular psychiatry

authors： Bentea E,Villers A,Moore C,Funk AJ,O'Donovan SM,Verbruggen L,Lara O,Janssen P,De Pauw L,Declerck NB,DePasquale EAK,Churchill MJ,Sato H,Hermans E,Arckens L,Meshul CK,Ris L,McCullumsmith RE,Massie A

更新日期：2020-05-04 00:00:00

abstract：:The serotonergic neurons of the dorsal raphe (DR) nucleus in the CNS are involved in fear, anxiety and depression. Depression and anxiety occur quite frequently in postmenopausal women, but estrogen replacement to correct these CNS disorders is at present not favored because estrogen carries with it an increased risk ...

journal_title：Molecular psychiatry

authors： Suzuki H,Barros RP,Sugiyama N,Krishnan V,Yaden BC,Kim HJ,Warner M,Gustafsson JÅ

更新日期：2013-06-01 00:00:00

abstract：:Circulating inflammatory mediators can signal neurons through a pathway in which cytokine activation of the cells of the blood-brain barrier causes the induction of the nuclear factor kappa B (NF-kappaB), leading to the transcription of target genes, such as the one encoding cyclooxygenase 2 (COX-2), the enzyme that i...

journal_title：Molecular psychiatry

authors： Rivest S

更新日期：1999-11-01 00:00:00

abstract：:Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown. We found that widely used antidepressants such as amitriptyline and fluoxetine induce autoph...

journal_title：Molecular psychiatry

authors： Gulbins A,Schumacher F,Becker KA,Wilker B,Soddemann M,Boldrin F,Müller CP,Edwards MJ,Goodman M,Caldwell CC,Kleuser B,Kornhuber J,Szabo I,Gulbins E

更新日期：2018-12-01 00:00:00

abstract：:The hippocampus is critical to healthy cognition, yet results in the current study show that action video game players have reduced grey matter within the hippocampus. A subsequent randomised longitudinal training experiment demonstrated that first-person shooting games reduce grey matter within the hippocampus in par...

journal_title：Molecular psychiatry

authors： West GL,Konishi K,Diarra M,Benady-Chorney J,Drisdelle BL,Dahmani L,Sodums DJ,Lepore F,Jolicoeur P,Bohbot VD

更新日期：2018-07-01 00:00:00

abstract：:Long-term weight-restored patients with anorexia nervosa (AN) have lower norepinephrine levels than controls. Since this may reflect altered reuptake by the norepinephrine transporter (NET), we hypothesised that the NET gene was involved in the genetic component of AN. PCR-amplification of an AAGG repeat island (AAGG1...

journal_title：Molecular psychiatry

authors： Urwin RE,Bennetts B,Wilcken B,Lampropoulos B,Beumont P,Clarke S,Russell J,Tanner S,Nunn KP

更新日期：2002-01-01 00:00:00

abstract：:Anorexia nervosa (AN) and other eating disorders continue to constitute significant challenges for individual and public health. AN is thought to develop as a result of complex interactions between environmental triggers, psychological risk factors, sociocultural influences, and genetic vulnerability. Recent research ...

journal_title：Molecular psychiatry

authors： Sild M,Booij L

更新日期：2019-10-01 00:00:00

abstract：:There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety. We studied the association of CR...

journal_title：Molecular psychiatry

authors： Licinio J,O'Kirwan F,Irizarry K,Merriman B,Thakur S,Jepson R,Lake S,Tantisira KG,Weiss ST,Wong ML

更新日期：2004-12-01 00:00:00

abstract：:5-HT(2C) receptor (5HT(2C)R, serotonin-2C) RNA undergoes editing to produce several receptor variants, some with pharmacological differences. This investigation comprised two parts: the characterisation of 5-HT(2C)R RNA editing in a larger human control sample than previously examined, and a comparative study in subje...

journal_title：Molecular psychiatry

authors： Sodhi MS,Burnet PW,Makoff AJ,Kerwin RW,Harrison PJ

更新日期：2001-07-01 00:00:00

abstract：:Myo-inositol exerts behavioral effects in animal models of psychiatric disorders and is effective in clinical trials in psychiatric patients. Interestingly, epi-inositol exerts behavioral effects similar to myo-inositol, even though epi-inositol is not a substrate for synthesis of phosphatidylinositol. We postulated t...

journal_title：Molecular psychiatry

authors： Shaldubina A,Ju S,Vaden DL,Ding D,Belmaker RH,Greenberg ML

更新日期：2002-01-01 00:00:00

abstract：:A whole genome association study was performed in a phase 3 clinical trial conducted to evaluate a novel antipsychotic, iloperidone, administered to treat patients with schizophrenia. Genotypes of 407 patients were analyzed for 334,563 single nucleotide polymorphisms (SNPs). SNPs associated with iloperidone efficacy w...

journal_title：Molecular psychiatry

authors： Lavedan C,Licamele L,Volpi S,Hamilton J,Heaton C,Mack K,Lannan R,Thompson A,Wolfgang CD,Polymeropoulos MH

更新日期：2009-08-01 00:00:00

abstract：:Bipolar affective disorder is one of the most common mental illnesses with a population prevalence of approximately 1%. The disorder is genetically complex, with an increasing number of loci being implicated through genetic linkage studies. However, the specific genetic variations and molecules involved in bipolar sus...

journal_title：Molecular psychiatry

authors： Blair IP,Adams LJ,Badenhop RF,Moses MJ,Scimone A,Morris JA,Ma L,Austin CP,Donald JA,Mitchell PB,Schofield PR

更新日期：2002-01-01 00:00:00

abstract：:The Raf kinases Raf-1 and B-Raf are upstream activators of the extracellular signal-regulated kinase (ERK)-signaling pathway and therefore participates in many physiological functions in brain, including neuronal survival and synaptic plasticity. Previously, we observed that activation of ERK-1/2, the downstream compo...

journal_title：Molecular psychiatry

authors： Dwivedi Y,Rizavi HS,Conley RR,Pandey GN

更新日期：2006-01-01 00:00:00

abstract：:Epidermal growth factor (EGF) comprises a structurally related family of proteins containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that regulates the development of dopaminergic neurons as well as monoamine metabolism. We assessed the contribution of EGF to sch...

journal_title：Molecular psychiatry

authors： Futamura T,Toyooka K,Iritani S,Niizato K,Nakamura R,Tsuchiya K,Someya T,Kakita A,Takahashi H,Nawa H

更新日期：2002-01-01 00:00:00