Abstract:
:Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-invasive transcranial direct current stimulation (tDCS) during adolescence, prior to schizophrenia-relevant behavioral manifestation, prevents the development of positive symptoms and related neurobiological alterations in the maternal immune stimulation (MIS) model of schizophrenia.
journal_name
Mol Psychiatryjournal_title
Molecular psychiatryauthors
Hadar R,Winter R,Edemann-Callesen H,Wieske F,Habelt B,Khadka N,Felgel-Farnholz V,Barroeta-Hlusicka E,Reis J,Tatarau CA,Funke K,Fritsch B,Bernhardt N,Bikson M,Nitsche MA,Winter Cdoi
10.1038/s41380-019-0356-xsubject
Has Abstractpub_date
2020-04-01 00:00:00pages
896-905issue
4eissn
1359-4184issn
1476-5578pii
10.1038/s41380-019-0356-xjournal_volume
25pub_type
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