Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function.

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the etiology of major depressive disorder (MDD). Although meta-analyses do confirm associations between depression and these biological systems, effect sizes vary greatl...

journal_title：Molecular psychiatry

authors： Lamers F,Vogelzangs N,Merikangas KR,de Jonge P,Beekman AT,Penninx BW

更新日期：2013-06-01 00:00:00

abstract：:Bipolar disorder (BD) is a progressive psychiatric disorder with more than 3% prevalence worldwide. Affected individuals experience recurrent episodes of depression and mania, disrupting normal life and increasing the risk of suicide greatly. The complexity and genetic heterogeneity of psychiatric disorders have chall...

journal_title：Molecular psychiatry

authors： Stern S,Santos R,Marchetto MC,Mendes APD,Rouleau GA,Biesmans S,Wang QW,Yao J,Charnay P,Bang AG,Alda M,Gage FH

更新日期：2018-06-01 00:00:00

abstract：:Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association is presently unknown. Both diseases are considered protein misfolding disorders associated with...

journal_title：Molecular psychiatry

authors： Moreno-Gonzalez I,Edwards Iii G,Salvadores N,Shahnawaz M,Diaz-Espinoza R,Soto C

更新日期：2017-09-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/mp.2017.5. ...

journal_title：Molecular psychiatry

authors： Deary V,Hagenaars SP,Harris SE,Hill WD,Davies G,Liewald DCM,International Consortium for Blood Pressure GWAS.,CHARGE consortium Aging and Longevity Group.,CHARGE consortium Inflammation Group.,McIntosh AM,Gale CR,Deary IJ

更新日期：2018-03-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA(A)) receptors are thought to play an important role in modulating the central nervous system in response to stress. Animal data have shown alterations in the GABA(A) receptor complex by uncontrollable stressors. SPECT imaging with benzodiazepine ligands showed lower distribution volumes o...

journal_title：Molecular psychiatry

authors： Geuze E,van Berckel BN,Lammertsma AA,Boellaard R,de Kloet CS,Vermetten E,Westenberg HG

更新日期：2008-01-01 00:00:00

abstract：:Activation of the inflammatory response system has been related to the pathophysiology of schizophrenia by several recent studies. Schizophrenic patients have varied levels of proinflammatory cytokines, such as interleukin (IL)-1, -6, and tumor necrosis factor (TNF)alpha in their peripheral blood or cerebrospinal flui...

journal_title：Molecular psychiatry

authors： Katila H,Hänninen K,Hurme M

更新日期：1999-03-01 00:00:00

abstract：:Among the most consistent results of studies of post-mortem brain tissue from schizophrenia patients (SZP) is the finding that in this disease, several genes expressed by GABAergic neurons are downregulated. This downregulation may be caused by hypermethylation of the relevant promoters in affected neurons. Indeed, in...

journal_title：Molecular psychiatry

authors： Ruzicka WB,Zhubi A,Veldic M,Grayson DR,Costa E,Guidotti A

更新日期：2007-04-01 00:00:00

abstract：:The amygdala is a key brain region that is critically involved in the processing and expression of anxiety and fear-related signals. In parallel, a growing number of preclinical and human studies have implicated the microbiome-gut-brain in regulating anxiety and stress-related responses. However, the role of the micro...

journal_title：Molecular psychiatry

authors： Hoban AE,Stilling RM,Moloney G,Shanahan F,Dinan TG,Clarke G,Cryan JF

更新日期：2018-05-01 00:00:00

abstract：:We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increased perception of p...

journal_title：Molecular psychiatry

authors： Niculescu AB,Le-Niculescu H,Levey DF,Roseberry K,Soe KC,Rogers J,Khan F,Jones T,Judd S,McCormick MA,Wessel AR,Williams A,Kurian SM,White FA

更新日期：2019-04-01 00:00:00

abstract：:Obscure work on the inheritance of two peculiar genetic traits in yeast has recently collided with work on infectious, neurodegenerative diseases in mammals. The impact illuminates both fields. The yeast work reveals a new mechanism of genetic variation that is based on differences in protein conformation rather than ...

journal_title：Molecular psychiatry

authors： Lindquist S

更新日期：1996-11-01 00:00:00

abstract：:The human 16p11.2 gene locus is a hot spot for copy number variations, which predispose carriers to a range of neuropsychiatric phenotypes. Microduplications of 16p11.2 are associated with autism spectrum disorder (ASD), intellectual disability (ID), and schizophrenia (SZ). Despite the debilitating nature of 16p11.2 d...

journal_title：Molecular psychiatry

authors： Rein B,Tan T,Yang F,Wang W,Williams J,Zhang F,Mills A,Yan Z

更新日期：2020-02-25 00:00:00

abstract：:Environmental enrichment (EE) is known to have an anxiolytic effect in several animal models; however, the molecular mechanisms underlying these behavioral changes are not understood. In this study, we have shown that the anxiolytic effect of EE is associated with alterations in the corticotropin-releasing factor rece...

journal_title：Molecular psychiatry

authors： Sztainberg Y,Kuperman Y,Tsoory M,Lebow M,Chen A

更新日期：2010-09-01 00:00:00

abstract：:Polymorphic variants of the dopamine D(4) receptor have been consistently associated with attention-deficit hyperactivity disorder (ADHD). However, the functional significance of the risk polymorphism (variable number of tandem repeats in exon 3) is still unclear. Here, we show that whereas the most frequent 4-repeat ...

journal_title：Molecular psychiatry

authors： González S,Rangel-Barajas C,Peper M,Lorenzo R,Moreno E,Ciruela F,Borycz J,Ortiz J,Lluís C,Franco R,McCormick PJ,Volkow ND,Rubinstein M,Floran B,Ferré S

更新日期：2012-06-01 00:00:00

abstract：:The dopamine transporter (DAT) plays a central role in dopaminergic neurotransmission in the human brain. Genetic association studies have used a variable number of tandem repeat (VNTR) polymorphism in the 3'-flanking region of the dopamine transporter gene (DAT1) to implicate the DAT in the development of various neu...

journal_title：Molecular psychiatry

authors： Grünhage F,Schulze TG,Müller DJ,Lanczik M,Franzek E,Albus M,Borrmann-Hassenbach M,Knapp M,Cichon S,Maier W,Rietschel M,Propping P,Nöthen MM

更新日期：2000-05-01 00:00:00

abstract：:The dorsolateral prefrontal cortex (dlpfc) is strongly implicated in the pathogenesis of schizophrenia (SCZ) and bipolar disorder (BPD) and, within this region, abnormalities in glutamatergic neurotransmission and synaptic function have been described. Proteins associated with these functions are enriched in membrane ...

journal_title：Molecular psychiatry

authors： Behan AT,Byrne C,Dunn MJ,Cagney G,Cotter DR

更新日期：2009-06-01 00:00:00

abstract：:A recent study has suggested a possible association of a polymorphism near the dopamine D5 receptor gene (DRD5) and attention-deficit hyperactivity disorder. The polymorphism studied was a (CA)n repeat located in the cosmid containing the D5 receptor gene2 and the allele that was reported to be associated with attenti...

journal_title：Molecular psychiatry

authors： Barr CL,Wigg KG,Feng Y,Zai G,Malone M,Roberts W,Schachar R,Tannock R,Kennedy JL

更新日期：2000-09-01 00:00:00

abstract：:Bipolar affective disorder (BPAD) is a common psychiatric disorder with complex genetic aetiology. We have undertaken a genome-wide scan in one of the largest samples of bipolar affected sibling pairs (ASPs) using a two-stage approach combining sample splitting and marker grid tightening. In this second stage analysis...

journal_title：Molecular psychiatry

authors： Lambert D,Middle F,Hamshere ML,Segurado R,Raybould R,Corvin A,Green E,O'Mahony E,Nikolov I,Mulcahy T,Haque S,Bort S,Bennett P,Norton N,Owen MJ,Kirov G,Lendon C,Jones L,Jones I,Holmans P,Gill M,Craddock N

更新日期：2005-09-01 00:00:00

abstract：:Serotonergic (5HT) neurons exert diverse and widespread functions in the brain. Dysfunction of the serotonergic system gives rise to a variety of mental illnesses including depression, anxiety, obsessive compulsive disorder, autism and eating disorders. Here we show that human primary fibroblasts were directly convert...

journal_title：Molecular psychiatry

authors： Xu Z,Jiang H,Zhong P,Yan Z,Chen S,Feng J

更新日期：2016-01-01 00:00:00

abstract：:The G-protein coupled metabotropic glutamate receptors (GRMs/mGluRs) have been implicated in the aetiology of schizophrenia as they modulate the NMDA response and that of other neurotransmitters including dopamine and GABA.(1-3) Electrophysiological studies in GRM subtype 5 knockout mice reveal, in one study, a sensor...

journal_title：Molecular psychiatry

authors： Devon RS,Anderson S,Teague PW,Muir WJ,Murray V,Pelosi AJ,Blackwood DH,Porteous DJ

更新日期：2001-05-01 00:00:00

abstract：:Several lines of evidence have suggested altered functions of the brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). In the search for polymorphisms in the 5'-flanking and 5'-noncoding regions of the BDNF gene, we found a novel nucleotide subs...

journal_title：Molecular psychiatry

authors： Kunugi H,Ueki A,Otsuka M,Isse K,Hirasawa H,Kato N,Nabika T,Kobayashi S,Nanko S

更新日期：2001-01-01 00:00:00

abstract：:Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and the concomitant impact on plasticity and critical periods, is hypothesized to be disrupted in neurodevelopmen...

journal_title：Molecular psychiatry

authors： Chen K,Ma X,Nehme A,Wei J,Cui Y,Cui Y,Yao D,Wu J,Anderson T,Ferguson D,Levitt P,Qiu S

更新日期：2020-01-03 00:00:00

abstract：:The serotonergic neurons of the dorsal raphe (DR) nucleus in the CNS are involved in fear, anxiety and depression. Depression and anxiety occur quite frequently in postmenopausal women, but estrogen replacement to correct these CNS disorders is at present not favored because estrogen carries with it an increased risk ...

journal_title：Molecular psychiatry

authors： Suzuki H,Barros RP,Sugiyama N,Krishnan V,Yaden BC,Kim HJ,Warner M,Gustafsson JÅ

更新日期：2013-06-01 00:00:00

abstract：:Categorizing people with late-onset Alzheimer's disease into biologically coherent subgroups is important for personalized medicine. We evaluated data from five studies (total n = 4050, of whom 2431 had genome-wide single-nucleotide polymorphism (SNP) data). We assigned people to cognitively defined subgroups on the b...

journal_title：Molecular psychiatry

authors： Mukherjee S,Mez J,Trittschuh EH,Saykin AJ,Gibbons LE,Fardo DW,Wessels M,Bauman J,Moore M,Choi SE,Gross AL,Rich J,Louden DKN,Sanders RE,Grabowski TJ,Bird TD,McCurry SM,Snitz BE,Kamboh MI,Lopez OL,De Jager PL,Benn

更新日期：2020-11-01 00:00:00

abstract：:Previous studies have implicated DTNBP1 as a schizophrenia susceptibility gene and its encoded protein, dysbindin, as a potential regulator of synaptic vesicle physiology. In this study, we found that endogenous levels of the dysbindin protein in the mouse brain are developmentally regulated, with higher levels observ...

journal_title：Molecular psychiatry

authors： Ghiani CA,Starcevic M,Rodriguez-Fernandez IA,Nazarian R,Cheli VT,Chan LN,Malvar JS,de Vellis J,Sabatti C,Dell'Angelica EC

更新日期：2010-02-01 00:00:00

abstract：:Anorexia nervosa (AN) and other eating disorders continue to constitute significant challenges for individual and public health. AN is thought to develop as a result of complex interactions between environmental triggers, psychological risk factors, sociocultural influences, and genetic vulnerability. Recent research ...

journal_title：Molecular psychiatry

authors： Sild M,Booij L

更新日期：2019-10-01 00:00:00

abstract：:Recent studies report association and linkage between attention deficit hyperactivity disorder (ADHD) and the 7-repeat allele of a 48 base-pair repeat in the dopamine D4 receptor gene (DRD4). We examined the frequency of this allele in a sample of probands with DSM-IV ADHD using a case-control design, as well as the t...

journal_title：Molecular psychiatry

authors： Mill J,Curran S,Kent L,Richards S,Gould A,Virdee V,Huckett L,Sharp J,Batten C,Fernando S,Simanoff E,Thompson M,Zhao J,Sham P,Taylor E,Asherson P

更新日期：2001-07-01 00:00:00

abstract：:The astrocytic cystine/glutamate antiporter system xc- represents an important source of extracellular glutamate in the central nervous system, with potential impact on excitatory neurotransmission. Yet, its function and importance in brain physiology remain incompletely understood. Employing slice electrophysiology a...

journal_title：Molecular psychiatry

authors： Bentea E,Villers A,Moore C,Funk AJ,O'Donovan SM,Verbruggen L,Lara O,Janssen P,De Pauw L,Declerck NB,DePasquale EAK,Churchill MJ,Sato H,Hermans E,Arckens L,Meshul CK,Ris L,McCullumsmith RE,Massie A

更新日期：2020-05-04 00:00:00

abstract：:We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which th...

journal_title：Molecular psychiatry

authors： Kishi T,Ikuta T,Matsuda Y,Sakuma K,Okuya M,Mishima K,Iwata N

更新日期：2020-11-11 00:00:00

abstract：:Gonadal hormones influence neuronal organization and plasticity. Yet the consequences of altering their concentrations by administering contraceptive agents, which are used by most reproductive-age women in the United States, are unclear. Cross-sectional studies have found both larger and smaller cortical regions alon...

journal_title：Molecular psychiatry

authors： Petersen N,Kearley NW,Ghahremani DG,Pochon JB,Fry ME,Rapkin AJ,London ED

更新日期：2021-01-08 00:00:00

abstract：:Although disrupted in schizophrenia 1 (DISC1) has been implicated in many psychiatric disorders, including schizophrenia, bipolar disorder, schizoaffective disorder and major depression, its biological role in these disorders is unclear. To better understand this gene and its role in psychiatric disease, we conducted ...

journal_title：Molecular psychiatry

authors： Carless MA,Glahn DC,Johnson MP,Curran JE,Bozaoglu K,Dyer TD,Winkler AM,Cole SA,Almasy L,MacCluer JW,Duggirala R,Moses EK,Göring HH,Blangero J

更新日期：2011-11-01 00:00:00