ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research.

abstract：:How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA-assessed from SA in s...

journal_title：Molecular psychiatry

authors： Kendler KS,Ohlsson H,Keefe RSE,Sundquist K,Sundquist J

更新日期：2018-04-01 00:00:00

abstract：:Several reports have suggested the presence of anticipation in bipolar affective disorder (BPAD). In addition, independent studies using the RED (repeat expansion detection) have shown association between BPAD and longer CAG/CTG repeats. Therefore loci with large CAG/CTG repeats are plausible candidates in the inherit...

journal_title：Molecular psychiatry

authors： Meira-Lima IV,Zhao J,Sham P,Pereira AC,Krieger JE,Vallada H

更新日期：2001-09-01 00:00:00

abstract：:Recent studies have shown an association between trinucleotide repeat expansions (TREs) and adult-onset schizophrenia (AOS). Childhood-onset schizophrenia (COS) is a severe variant of schizophrenia with onset of symptoms before age 12 years. We have used the repeat expansion detection (RED) method to investigate the o...

journal_title：Molecular psychiatry

authors： Burgess CE,Lindblad K,Sidransky E,Yuan QP,Long RT,Breschel T,Ross CA,McInnis M,Lee P,Ginns EI,Lenane M,Kumra S,Jacobsen L,Rapoport JL,Schalling M

更新日期：1998-07-01 00:00:00

abstract：:Niemann-Pick disease type A (NPA) is a rare lysosomal storage disorder characterized by severe neurological alterations that leads to death in childhood. Loss-of-function mutations in the acid sphingomyelinase (ASM) gene cause NPA, and result in the accumulation of sphingomyelin (SM) in lysosomes and plasma membrane o...

journal_title：Molecular psychiatry

authors： Pérez-Cañamás A,Benvegnù S,Rueda CB,Rábano A,Satrústegui J,Ledesma MD

更新日期：2017-05-01 00:00:00

abstract：:A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Molecular psychiatry

authors： Bis JC,Jian X,Kunkle BW,Chen Y,Hamilton-Nelson KL,Bush WS,Salerno WJ,Lancour D,Ma Y,Renton AE,Marcora E,Farrell JJ,Zhao Y,Qu L,Ahmad S,Amin N,Amouyel P,Beecham GW,Below JE,Campion D,Cantwell L,Charbonnier C,Ch

更新日期：2020-08-01 00:00:00

abstract：:The Wistar-Kyoto (WKY) rat strain demonstrates endogenous hormonal and behavioral abnormalities that emulate many of those found in symptom-presenting depressive patients. Evidence suggests that the WKY strain may harbor heterogeneity not found in other inbred strains, including greater behavioral and genetic variabil...

journal_title：Molecular psychiatry

authors： Will CC,Aird F,Redei EE

更新日期：2003-11-01 00:00:00

abstract：:It is essential to elucidate brain-adipocyte interactions in order to tackle obesity and its comorbidities, as the precise control of brain-adipose tissue cross-talk is crucial for energy and glucose homeostasis. Recent studies show that in the peripheral adipose tissue, adenosine induces adipogenesis through peripher...

journal_title：Molecular psychiatry

authors： Zhang J,Hou Y,Du XL,Chen D,Sui G,Qi Y,Licinio J,Wong ML,Yang Y

更新日期：2020-10-16 00:00:00

abstract：:Recent studies report association and linkage between attention deficit hyperactivity disorder (ADHD) and the 7-repeat allele of a 48 base-pair repeat in the dopamine D4 receptor gene (DRD4). We examined the frequency of this allele in a sample of probands with DSM-IV ADHD using a case-control design, as well as the t...

journal_title：Molecular psychiatry

authors： Mill J,Curran S,Kent L,Richards S,Gould A,Virdee V,Huckett L,Sharp J,Batten C,Fernando S,Simanoff E,Thompson M,Zhao J,Sham P,Taylor E,Asherson P

更新日期：2001-07-01 00:00:00

abstract：:We assessed the ability of lithium to reduce neurodegeneration and to stimulate cell proliferation in a rat model of Huntington's disease in which quinolinic acid (QA) was unilaterally infused into the striatum. LiCl (0.5-3.0 mEq/kg) was injected subcutaneously 24 h before and 1 h after QA infusion. At 7 days after QA...

journal_title：Molecular psychiatry

authors： Senatorov VV,Ren M,Kanai H,Wei H,Chuang DM

更新日期：2004-04-01 00:00:00

abstract：:Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The disease specificity of this risk has not been addressed and the possibility of confounding has not been excluded. Children with ASD or attention-deficit hypera...

journal_title：Molecular psychiatry

authors： Clements CC,Castro VM,Blumenthal SR,Rosenfield HR,Murphy SN,Fava M,Erb JL,Churchill SE,Kaimal AJ,Doyle AE,Robinson EB,Smoller JW,Kohane IS,Perlis RH

更新日期：2015-06-01 00:00:00

abstract：:A 3-day Nobel Conference entitled 'The role of genetics in promoting suicide prevention and the mental health of the population' was held at the Nobel Forum, Karolinska Institute (KI) in Stockholm, Sweden, during 8-10 June 2009. The conference was sponsored by the Nobel Assembly for Physiology or Medicine and organize...

journal_title：Molecular psychiatry

authors： Wasserman D,Terenius L,Wasserman J,Sokolowski M

更新日期：2010-01-01 00:00:00

abstract：:Retinoid metabolites of vitamin A are intrinsically linked to neural development, connectivity and plasticity, and have been implicated in the pathophysiology of schizophrenia. We hypothesised that a greater burden of common and rare genomic variation in genes involved with retinoid biogenesis and signalling could be ...

journal_title：Molecular psychiatry

authors： Reay WR,Atkins JR,Quidé Y,Carr VJ,Green MJ,Cairns MJ

更新日期：2020-04-01 00:00:00

abstract：:5-HT(2C) receptor (5HT(2C)R, serotonin-2C) RNA undergoes editing to produce several receptor variants, some with pharmacological differences. This investigation comprised two parts: the characterisation of 5-HT(2C)R RNA editing in a larger human control sample than previously examined, and a comparative study in subje...

journal_title：Molecular psychiatry

authors： Sodhi MS,Burnet PW,Makoff AJ,Kerwin RW,Harrison PJ

更新日期：2001-07-01 00:00:00

abstract：:We tested the hypothesis that, compared with subjects with no history of psychiatric illness (controls), changes in gene expression in the dorsolateral prefrontal cortex from two subgroups of subjects with schizophrenia, one with a marked deficit in muscarinic M1 receptors (muscarinic receptor-deficit schizophrenia (M...

journal_title：Molecular psychiatry

authors： Scarr E,Udawela M,Thomas EA,Dean B

更新日期：2018-02-01 00:00:00

abstract：:Population-based linkage analysis is a new method for analysing genomewide single nucleotide polymorphism (SNP) genotype data in case-control samples, which does not assume a common disease, common variant model. The genome is scanned for extended segments that show increased identity-by-descent sharing within case-ca...

journal_title：Molecular psychiatry

authors： Francks C,Tozzi F,Farmer A,Vincent JB,Rujescu D,St Clair D,Muglia P

更新日期：2010-03-01 00:00:00

abstract：:Use of substances such as cannabis, alcohol, and tobacco, has been associated with increased risk of suicide attempt in several observational studies. However, establishing whether these associations are causal is challenging when using observational designs. To evaluate the potential causal contributions of cannabis ...

journal_title：Molecular psychiatry

authors： Orri M,Séguin JR,Castellanos-Ryan N,Tremblay RE,Côté SM,Turecki G,Geoffroy MC

更新日期：2020-06-08 00:00:00

abstract：:Familial and twin studies have suggested that anorexia nervosa (AN) is a multifactorial disorder with a substantial genetic contribution. The hSKCa3 potassium channel gene, which contains polymorphic CAG repeats in the coding region and is involved in the regulation of neuronal activity, may be a candidate gene for AN...

journal_title：Molecular psychiatry

authors： Koronyo-Hamaoui M,Danziger Y,Frisch A,Stein D,Leor S,Laufer N,Carel C,Fennig S,Minoumi M,Apter A,Goldman B,Barkai G,Weizman A,Gak E

更新日期：2002-01-01 00:00:00

abstract：:Semi-starvation induced hyperactivity (SIH) occurs in rodents upon caloric restriction. We hypothesized that SIH is triggered by the decline in leptin secretion associated with food restriction. To test this hypothesis, rats, which had established a stable level of activity, were treated with leptin or vehicle via imp...

journal_title：Molecular psychiatry

authors： Exner C,Hebebrand J,Remschmidt H,Wewetzer C,Ziegler A,Herpertz S,Schweiger U,Blum WF,Preibisch G,Heldmaier G,Klingenspor M

更新日期：2000-09-01 00:00:00

abstract：:Although disrupted in schizophrenia 1 (DISC1) has been implicated in many psychiatric disorders, including schizophrenia, bipolar disorder, schizoaffective disorder and major depression, its biological role in these disorders is unclear. To better understand this gene and its role in psychiatric disease, we conducted ...

journal_title：Molecular psychiatry

authors： Carless MA,Glahn DC,Johnson MP,Curran JE,Bozaoglu K,Dyer TD,Winkler AM,Cole SA,Almasy L,MacCluer JW,Duggirala R,Moses EK,Göring HH,Blangero J

更新日期：2011-11-01 00:00:00

abstract：:The s allele variant of the serotonin transporter gene (5-HTT) has recently been observed to moderate the relationship of stress to depression and anxiety. To date no study has considered interactive effects of 5-HTT genotype, stress and hypothalamic-pituitary-adrenal (HPA) function on cognition in healthy, older adul...

journal_title：Molecular psychiatry

authors： O'Hara R,Schröder CM,Mahadevan R,Schatzberg AF,Lindley S,Fox S,Weiner M,Kraemer HC,Noda A,Lin X,Gray HL,Hallmayer JF

更新日期：2007-06-01 00:00:00

abstract：:The catechol-O-methyl transferase (COMT) gene is considered a leading schizophrenia candidate gene. Although its role in increasing schizophrenia susceptibility has been conflicting, recent studies suggest the valine allele may contribute to poor cognitive function in schizophrenia. V(158)M COMT genotype was obtained ...

journal_title：Molecular psychiatry

authors： Ho BC,Wassink TH,O'Leary DS,Sheffield VC,Andreasen NC

更新日期：2005-03-01 00:00:00

abstract：:Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar (BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, which have been vario...

journal_title：Molecular psychiatry

authors： Neves-Pereira M,Cheung JK,Pasdar A,Zhang F,Breen G,Yates P,Sinclair M,Crombie C,Walker N,St Clair DM

更新日期：2005-02-01 00:00:00

abstract：:Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. From the Enhanci...

journal_title：Molecular psychiatry

authors： Radonjić NV,Hess JL,Rovira P,Andreassen O,Buitelaar JK,Ching CRK,Franke B,Hoogman M,Jahanshad N,McDonald C,Schmaal L,Sisodiya SM,Stein DJ,van den Heuvel OA,van Erp TGM,van Rooij D,Veltman DJ,Thompson P,Faraone SV

更新日期：2021-01-17 00:00:00

abstract：:Accumulating research demonstrates the potential of intranasal delivery of psychopharmacological agents to treat a range of psychiatric disorders and symptoms. It is believed that intranasal administration offers both direct and indirect pathways to deliver psychopharmacological agents to the central nervous system. T...

journal_title：Molecular psychiatry

authors： Quintana DS,Guastella AJ,Westlye LT,Andreassen OA

更新日期：2016-01-01 00:00:00

abstract：:Exercise has a variety of beneficial effects on brain structure and function, such as hippocampal neurogenesis, mood and memory. Previous studies have shown that exercise enhances hippocampal neurogenesis, induces antidepressant effects and improves learning behavior. Brain serotonin (5-hydroxytryptamine, 5-HT) levels...

journal_title：Molecular psychiatry

authors： Kondo M,Nakamura Y,Ishida Y,Shimada S

更新日期：2015-11-01 00:00:00

abstract：:Critical periods are temporary windows of heightened neural plasticity early in development. For example, fear memories in juvenile rodents are subject to erasure following extinction training, while after closure of this critical period, extinction training only temporarily and weakly suppresses fear memories. Persis...

journal_title：Molecular psychiatry

authors： Bhagat SM,Butler SS,Taylor JR,McEwen BS,Strittmatter SM

更新日期：2016-09-01 00:00:00

abstract：:Schizophrenia is a chronic, severe and highly complex mental illness. Current treatments manage the positive symptoms, yet have minimal effects on the negative and cognitive symptoms, two prominent features of the disease with critical impact on the long-term morbidity. In addition, antipsychotic treatments trigger se...

journal_title：Molecular psychiatry

authors： Revel FG,Moreau JL,Pouzet B,Mory R,Bradaia A,Buchy D,Metzler V,Chaboz S,Groebke Zbinden K,Galley G,Norcross RD,Tuerck D,Bruns A,Morairty SR,Kilduff TS,Wallace TL,Risterucci C,Wettstein JG,Hoener MC

更新日期：2013-05-01 00:00:00

abstract：:Research on avoidance conditioning began in the late 1930s as a way to use laboratory experiments to better understand uncontrollable fear and anxiety. Avoidance was initially conceived of as a two-factor learning process in which fear is first acquired through Pavlovian aversive conditioning (so-called fear condition...

journal_title：Molecular psychiatry

authors： LeDoux JE,Moscarello J,Sears R,Campese V

更新日期：2017-01-01 00:00:00

abstract：:We conducted a 10 centimorgan (cM) linkage genome scan in a set of American extended pedigrees ascertained through probands with panic disorder. Several anxiety disorders segregate in these families. In this article, we describe results for simple phobia from 14 of these families (including 129 subjects of whom 57 are...

journal_title：Molecular psychiatry

authors： Gelernter J,Page GP,Bonvicini K,Woods SW,Pauls DL,Kruger S

更新日期：2003-01-01 00:00:00

abstract：:High impulsive and aggressive traits associate with poor behavioural self-control. Despite their importance in predicting behavioural negative outcomes including suicide, the molecular mechanisms underlying the expression of impulsive and aggressive traits remain poorly understood. Here, we identified and characterize...

journal_title：Molecular psychiatry

authors： Labonté B,Abdallah K,Maussion G,Yerko V,Yang J,Bittar T,Quessy F,Golden SA,Navarro L,Checknita D,Gigek C,Lopez JP,Neve RL,Russo SJ,Tremblay RE,Côté G,Meaney MJ,Mechawar N,Nestler EJ,Turecki G

更新日期：2020-01-06 00:00:00