当前位置： SCI文献检索 > MOLECULAR PSYCHIATRY期刊下所有文献 > Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: evidence of association but no linkage in a UK sample.

Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: evidence of association but no linkage in a UK sample.

Abstract：

:Recent studies report association and linkage between attention deficit hyperactivity disorder (ADHD) and the 7-repeat allele of a 48 base-pair repeat in the dopamine D4 receptor gene (DRD4). We examined the frequency of this allele in a sample of probands with DSM-IV ADHD using a case-control design, as well as the transmission disequilibrium test (TDT) and haplotype-based haplotype relative risk (HHRR) in the subset of probands with DNA available from both parents. One hundred and thirty-two ADHD probands were compared with 189 controls (chi(2) = 6.17, 1 df, P = 0.01, OR = 1.73, 95% CI = 1.11--2.71). A total of 85 complete trios were available for within-family tests of association and linkage. Fifty-two heterozygous parents carrying one copy of the 7-repeat were informative for the TDT (29 transmitted vs 23 non-transmitted, chi(2) = 0.69). Analysis of the entire sample of 132 probands using TRANSMIT provided no additional evidence for excess transmission of the 7-repeat allele (58 transmitted vs 54 non-transmitted). HHRR gave similar results. We conclude that the case-control findings are likely to be falsely positive, resulting from genetic stratification. However we can not rule out alternative explanations of low statistical power and gene-environment correlation.

journal_name

Mol Psychiatry

journal_title

Molecular psychiatry

authors

Mill J,Curran S,Kent L,Richards S,Gould A,Virdee V,Huckett L,Sharp J,Batten C,Fernando S,Simanoff E,Thompson M,Zhao J,Sham P,Taylor E,Asherson P

doi

10.1038/sj.mp.4000881

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

440-4

issue

4

eissn

1359-4184

issn

1476-5578

journal_volume

6

pub_type

杂志文章,多中心研究

相关文献

MOLECULAR PSYCHIATRY文献大全
  • Muscarinic1 and 2 receptor mRNA in the human caudate-putamen: no change in m1 mRNA in schizophrenia.

    abstract：:Studies using tissue obtained at autopsy suggest that changes in cholinergic neurons could be important in the pathology of schizophrenia.1-4 We have previously reported a decrease in [3H]pirenzepine binding5 and [3H]AF-DX 384 binding6 to caudate-putamen (CP) from subjects who had schizophrenia. Under the conditions c...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000684

    authors： Dean B,Crook JM,Pavey G,Opeskin K,Copolov DL

    更新日期：2000-03-01 00:00:00

  • Oligodendrocyte lineage cells and depression.

    abstract：:Depression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There are data to support several different theories of causation, including the mono...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/s41380-020-00930-0

    authors： Zhou B,Zhu Z,Ransom BR,Tong X

    更新日期：2021-01-01 00:00:00

  • Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia.

    abstract：:Amyloid-β peptide (Aβ) accumulation in the brain is a hallmark of Alzheimer's Disease. An important mechanism of Aβ clearance in the brain is uptake and degradation by microglia. Presenilin 1 (PS1) is the catalytic subunit of γ-secretase, an enzyme complex responsible for the maturation of multiple substrates, such as...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-0856-8

    authors： Ledo JH,Liebmann T,Zhang R,Chang JC,Azevedo EP,Wong E,Silva HM,Troyanskaya OG,Bustos V,Greengard P

    更新日期：2020-08-13 00:00:00

  • Liposome-based targeting of dopamine to the brain: a novel approach for the treatment of Parkinson's disease.

    abstract：:Delivery of drugs into the brain is poor due to the blood brain barrier (BBB). This study describes the development of a novel liposome-based brain-targeting drug delivery system. The liposomes incorporate a diacylglycerol moiety coupled through a linker to a peptide of 5 amino acids selected from amyloid precursor pr...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-0742-4

    authors： Kahana M,Weizman A,Gabay M,Loboda Y,Segal-Gavish H,Gavish A,Barhum Y,Offen D,Finberg J,Allon N,Gavish M

    更新日期：2020-05-05 00:00:00

  • Involvement of estrogen receptor β in maintenance of serotonergic neurons of the dorsal raphe.

    abstract：:The serotonergic neurons of the dorsal raphe (DR) nucleus in the CNS are involved in fear, anxiety and depression. Depression and anxiety occur quite frequently in postmenopausal women, but estrogen replacement to correct these CNS disorders is at present not favored because estrogen carries with it an increased risk ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2012.62

    authors： Suzuki H,Barros RP,Sugiyama N,Krishnan V,Yaden BC,Kim HJ,Warner M,Gustafsson JÅ

    更新日期：2013-06-01 00:00:00

  • Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.

    abstract：:Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia. This study comprises genome-wide association (GWA) and follow-up analyses of all individuals born in Denmark since 1...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2013.2

    authors： Børglum AD,Demontis D,Grove J,Pallesen J,Hollegaard MV,Pedersen CB,Hedemand A,Mattheisen M,GROUP investigators10.,Uitterlinden A,Nyegaard M,Ørntoft T,Wiuf C,Didriksen M,Nordentoft M,Nöthen MM,Rietschel M,Ophoff RA,Cic

    更新日期：2014-03-01 00:00:00

  • Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system.

    abstract：:Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The disease specificity of this risk has not been addressed and the possibility of confounding has not been excluded. Children with ASD or attention-deficit hypera...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2014.90

    authors： Clements CC,Castro VM,Blumenthal SR,Rosenfield HR,Murphy SN,Fava M,Erb JL,Churchill SE,Kaimal AJ,Doyle AE,Robinson EB,Smoller JW,Kohane IS,Perlis RH

    更新日期：2015-06-01 00:00:00

  • Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families.

    abstract：:Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification of predisposing genes has remained a challenge. Utilizing a large family-based schizophrenia study...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4002047

    authors： Wedenoja J,Loukola A,Tuulio-Henriksson A,Paunio T,Ekelund J,Silander K,Varilo T,Heikkilä K,Suvisaari J,Partonen T,Lönnqvist J,Peltonen L

    更新日期：2008-07-01 00:00:00

  • Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.

    abstract：:A whole genome association study was performed in a phase 3 clinical trial conducted to evaluate a novel antipsychotic, iloperidone, administered to treat patients with schizophrenia. Genotypes of 407 patients were analyzed for 334,563 single nucleotide polymorphisms (SNPs). SNPs associated with iloperidone efficacy w...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/mp.2008.56

    authors： Lavedan C,Licamele L,Volpi S,Hamilton J,Heaton C,Mack K,Lannan R,Thompson A,Wolfgang CD,Polymeropoulos MH

    更新日期：2009-08-01 00:00:00

  • The development of Kraepelin's mature diagnostic concept of hebephrenia: a close reading of relevant texts of Hecker, Daraszkiewicz, and Kraepelin.

    abstract：:In developing his mature concept of hebephrenic dementia praecox (DP) in his 4th (1893) through 6th textbook editions (1899), Kraepelin worked from the hebephrenic syndrome first described by Hecker (1871) and then carefully studied by his student Daraszkiewicz (1892). Working under Kraepelin's supervision, Daraszkiew...

    journal_title：Molecular psychiatry

    pub_type： 历史文章,杂志文章,评审

    doi：10.1038/s41380-019-0411-7

    authors： Kendler KS

    更新日期：2020-01-01 00:00:00

  • HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition.

    abstract：:The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated HPA axis overactivity in major depression, a relationship of HPA axis activity to cognitive performance and a potential role of HPA axis geneti...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.120

    authors： Keller J,Gomez R,Williams G,Lembke A,Lazzeroni L,Murphy GM Jr,Schatzberg AF

    更新日期：2017-04-01 00:00:00

  • Gene-environment correlations: a review of the evidence and implications for prevention of mental illness.

    abstract：:Family studies have demonstrated genetic influences on environmental exposure: the phenomenon of gene-environment correlation (rGE). A few molecular genetic studies have confirmed the results, but the identification of rGE in studies that measure genes and environments faces several challenges. Using examples from stu...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/sj.mp.4001950

    authors： Jaffee SR,Price TS

    更新日期：2007-05-01 00:00:00

  • Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.

    abstract：:The actions of CRF in the brain and in the periphery are mediated through multiple binding sites. There are three receptors, CRF1, CRF2 alpha and CRF2 beta, which encode 411, 415 and 431 amino acid proteins and transduce signals via the stimulation of intracellular cAMP production. The recent identification of high-af...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：

    authors： Behan DP,Grigoriadis DE,Lovenberg T,Chalmers D,Heinrichs S,Liaw C,De Souza EB

    更新日期：1996-09-01 00:00:00

  • Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis.

    abstract：:Diverse studies have investigated the impact of prenatal exposure to vitamin D levels on brain development; however, evidence in humans has never been systematically reviewed. This article summarized evidence of the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or newborn bloo...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0357-9

    authors： García-Serna AM,Morales E

    更新日期：2020-10-01 00:00:00

  • Effects of a novel corticotropin-releasing-hormone receptor type I antagonist on human adrenal function.

    abstract：:Corticotropin-releasing hormone (CRH) is the principal regulator of the hypothalamic-pituitary-adrenal (HPA) axis and an activator of the sympathoadrenal (SA) and systemic sympathetic (SS) systems. Mental disorders, including major depression and, more recently, Alzheimer's disease have been associated with dysregulat...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000720

    authors： Willenberg HS,Bornstein SR,Hiroi N,Päth G,Goretzki PE,Scherbaum WA,Chrousos GP

    更新日期：2000-03-01 00:00:00

  • Dopa decarboxylase genotypes may influence age at onset of schizophrenia.

    abstract：:Several lines of evidence implicate dopa decarboxylase (DDC) with schizophrenia. By analysis of two putative functional DDC variants in 173 schizophrenic patients and 204 controls we tested the hypotheses that DDC is involved in: (1) predisposition to schizophrenia; and (2) modulation of age at disease onset. No assoc...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4000902

    authors： Børglum AD,Hampson M,Kjeldsen TE,Muir W,Murray V,Ewald H,Mors O,Blackwood D,Kruse TA

    更新日期：2001-11-01 00:00:00

  • ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf.

    abstract：:The Raf kinases Raf-1 and B-Raf are upstream activators of the extracellular signal-regulated kinase (ERK)-signaling pathway and therefore participates in many physiological functions in brain, including neuronal survival and synaptic plasticity. Previously, we observed that activation of ERK-1/2, the downstream compo...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/sj.mp.4001744

    authors： Dwivedi Y,Rizavi HS,Conley RR,Pandey GN

    更新日期：2006-01-01 00:00:00

  • A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior.

    abstract：:The different serotonin (5-HT) receptors, including the serotonin transporter (5-HTT), are excellent candidate genes for suicide and suicidal behavior, and thus, they have been investigated in a large number of allelic association studies. The individual results of these studies have been inconsistent and definite con...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,meta分析,评审

    doi：10.1038/sj.mp.4001336

    authors： Anguelova M,Benkelfat C,Turecki G

    更新日期：2003-07-01 00:00:00

  • Hierarchical temporal processing deficit model of reality distortion and psychoses.

    abstract：:We posit in this article that hierarchical temporal processing deficit is the underlying basis of reality distortion and psychoses. Schizophrenia is a prototypical reality distortion disorder in which the patient manifests with auditory hallucinations, delusions, disorganized speech and thinking, cognitive impairment,...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2010.63

    authors： Krishnan RR,Fivaz M,Kraus MS,Keefe RS

    更新日期：2011-02-01 00:00:00

  • Striatal dopamine D1-type receptor availability: no difference from control but association with cortical thickness in methamphetamine users.

    abstract：:Chronic methamphetamine use poses potentially devastating consequences for directly affected individuals and for society. Lower dopamine D2-type receptor availability has been observed in striata of methamphetamine users as compared with controls, but an analogous comparison of D1-type receptors has been conducted onl...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2017.172

    authors： Okita K,Morales AM,Dean AC,Johnson MC,Lu V,Farahi J,Mandelkern MA,London ED

    更新日期：2018-05-01 00:00:00

  • MicroRNA regulation of persistent stress-enhanced memory.

    abstract：:Disruption of persistent, stress-associated memories is relevant for treating posttraumatic stress disorder (PTSD) and related syndromes, which develop in a subset of individuals following a traumatic event. We previously developed a stress-enhanced fear learning (SEFL) paradigm in inbred mice that produces PTSD-like ...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0432-2

    authors： Sillivan SE,Jamieson S,de Nijs L,Jones M,Snijders C,Klengel T,Joseph NF,Krauskopf J,Kleinjans J,Vinkers CH,Boks MPM,Geuze E,Vermetten E,Berretta S,Ressler KJ,Rutten BPF,Rumbaugh G,Miller CA

    更新日期：2020-05-01 00:00:00

  • Sex, trauma, stress hormones and depression.

    abstract：:Although few studies dispute that there are gender differences in depression, the etiology is still unknown. In this review, we cover a number of proposed factors and the evidences for and against these factors that may account for gender differences in depression. These include the possible role of estrogens at puber...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/mp.2009.94

    authors： Young E,Korszun A

    更新日期：2010-01-01 00:00:00

  • Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population.

    abstract：:Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people with ASD compared with controls, but consistent evidence is lacking. Few s...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2015.12

    authors： Clarke TK,Lupton MK,Fernandez-Pujals AM,Starr J,Davies G,Cox S,Pattie A,Liewald DC,Hall LS,MacIntyre DJ,Smith BH,Hocking LJ,Padmanabhan S,Thomson PA,Hayward C,Hansell NK,Montgomery GW,Medland SE,Martin NG,Wright MJ

    更新日期：2016-03-01 00:00:00

  • The role of the retinoids in schizophrenia: genomic and clinical perspectives.

    abstract：:Signalling by retinoid compounds is vital for embryonic development, with particular importance for neurogenesis in the human brain. Retinoids, metabolites of vitamin A, exert influence over the expression of thousands of transcripts genome wide, and thus, act as master regulators of many important biological processe...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/s41380-019-0566-2

    authors： Reay WR,Cairns MJ

    更新日期：2020-04-01 00:00:00

  • Vulnerability genes or plasticity genes?

    abstract：:The classic diathesis-stress framework, which views some individuals as particularly vulnerable to adversity, informs virtually all psychiatric research on behavior-gene-environment (G x E) interaction. An alternative framework of 'differential susceptibility' is proposed, one which regards those most susceptible to a...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/mp.2009.44

    authors： Belsky J,Jonassaint C,Pluess M,Stanton M,Brummett B,Williams R

    更新日期：2009-08-01 00:00:00

  • Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.

    abstract：:The lack of strong association between brain beta-amyloid deposition and cognitive impairment has been a challenge for the Alzheimer's disease (AD) field. Although beta-amyloid is necessary for the pathologic diagnosis of AD, it is not sufficient to make the pathologic diagnosis or cause dementia. We sought to identif...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2016.35

    authors： Roostaei T,Nazeri A,Felsky D,De Jager PL,Schneider JA,Pollock BG,Bennett DA,Voineskos AN,Alzheimer’s Disease Neuroimaging Initiative (ADNI).

    更新日期：2017-02-01 00:00:00

  • Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice.

    abstract：:The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed within the central nervous system. Previous work showed that this protein is upregulated in Alzheimer's disease (AD), and plays an active role in the development of brain amyloidosis in amyloid beta (Aβ)-precursor protein transgenic mice (Tg2576). In the pr...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/mp.2014.170

    authors： Chu J,Li JG,Giannopoulos PF,Blass BE,Childers W,Abou-Gharbia M,Praticò D

    更新日期：2015-11-01 00:00:00

  • Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice.

    abstract：:TET3 is a member of the ten-eleven translocation (TET) family of enzymes which oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Tet3 is highly expressed in the brain, where 5hmC levels are most abundant. In adult mice, we observed that TET3 is present in mature neurons and oligodendrocytes but is ab...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-020-0695-7

    authors： Antunes C,Da Silva JD,Guerra-Gomes S,Alves ND,Ferreira F,Loureiro-Campos E,Branco MR,Sousa N,Reik W,Pinto L,Marques CJ

    更新日期：2020-02-26 00:00:00

  • Treatment-resistant anxiety disorders.

    abstract：:Several epidemiological studies confirmed that Anxiety Disorders as a group are the most prevalent psychiatric conditions in the United States. The importance of these conditions is underlined by the fact that they cause significant disability, poor quality of life, alcohol and drug abuse. Anxiety disorders are treata...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章,评审

    doi：10.1038/sj.mp.4001852

    authors： Bystritsky A

    更新日期：2006-09-01 00:00:00

  • Childhood trauma, life-time self-harm, and suicidal behaviour and ideation are associated with polygenic scores for autism.

    abstract：:Autistic individuals experience significantly elevated rates of childhood trauma, self-harm and suicidal behaviour and ideation (SSBI). Is this purely the result of negative environmental experiences, or does this interact with genetic predisposition? In this study we investigated if a genetic predisposition for autis...

    journal_title：Molecular psychiatry

    pub_type： 杂志文章

    doi：10.1038/s41380-019-0550-x

    authors： Warrier V,Baron-Cohen S

    更新日期：2019-10-29 00:00:00